Herein,we present a copper-catalyzed carbonylative cross-coupling of unactivated alkyl bromides with aryl boronates under CO atmosphere which enabling the efficient synthesis of C(sp3)-C(sp2)ketones with extensive fun...Herein,we present a copper-catalyzed carbonylative cross-coupling of unactivated alkyl bromides with aryl boronates under CO atmosphere which enabling the efficient synthesis of C(sp3)-C(sp2)ketones with extensive functional group compatibility.This strategy represents a significant advance in copper-catalyzed carbonylation involving alkyl bromides and C(sp2)-nucleophiles.The protocol addresses key challenges commonly encountered in the coupling of C(sp3)-alkyl halides with aryl boron reagents,such as sluggish oxidative addition of alkyl halides,competing Suzuki-Miyaura cross-coupling,undesired dehalogenation and so on.Distinguished by its broad substrate scope and high functional group tolerance,this approach offers a robust and versatile platform for the streamlined synthesis of alkyl aryl ketones.展开更多
Highly active, air-stable and water-soluble palladium-phosphinous acid complexes have been applied to Suzuki cross-coupling reaction of heteroaryl bromides under mild conditions in water/alcoholic solvents. Suzuki cro...Highly active, air-stable and water-soluble palladium-phosphinous acid complexes have been applied to Suzuki cross-coupling reaction of heteroaryl bromides under mild conditions in water/alcoholic solvents. Suzuki cross-coupling reaction of heteroaryl bromides with phenylboronic acid occurred efficiently using palladium phosphinous acid complexes （POPd） and phase transfer catalyst （tetrabutylammonium bromide and polyethylene glycol） in water/ethanol mixture, water/propanol mixture and neat water respectively, the corresponding yields of cross-coupling heteroaryl-aryls were satisfied. The tert-butyl substituted ligand di-tert-butylphosphino in combination with POPd was found to be more active than the same family derived catalysts dipalladium complexes POPdl and POPd2, and other two kinds of Pd-catalysts Pd（PPh3）4 and Pd2（dba）3. The mechanism of Suzuki cross-coupling reaction between heteroaryl bromides and phenylboronic acid in water was proposed with respect to the key role of phase transfer catalyst on the transmetallation step. Compared with other solid phase transfer catalysts, TBAB was tested as the ideal one. The alkalinity of base and the molar proportion between POPd and TBAB were investigated in water and alcoholic solvents. Notably, in the presence of TBAB adding alcoholic solvents into water enhanced the yields of target products. However in terms of the liquid phase transfer catalyst of PEGs, mixing water into PEGs could slightly decrease the yields with respect to the water free PEGs bulk phase, which was probably due to the homogenous liquid conditions in pure PEGs and weak interactions between PEGs and heteroaryl bromide molecules in water depending on their molecular chain lengths.展开更多
The catalytic effects for the oxidative methylation of toluene with methane over the basic zeolite catalysts prepared by promoting KY, KX, KM, KZSM-5 or KP with alkali-metal bromides and alkali-metal oxides have been ...The catalytic effects for the oxidative methylation of toluene with methane over the basic zeolite catalysts prepared by promoting KY, KX, KM, KZSM-5 or KP with alkali-metal bromides and alkali-metal oxides have been investigated comparatively. The alkali-metal bromides promoted substrates are more effective than the alkali-metal oxides promoted systems. Moreover, the NaBr promoted systems are more active than KBr promoted systems. The most effective catalytic system (8wt%NaBr)/KZSM-5 gave a toluene conversion as high as 76.3% and a total C-8 selectivity of 76.4% (styrene/ethylbenzene=9.76) resulting in a total C-8 yield of 58.3%.展开更多
The integral heat of solution of REBr 3·3Gly·3H 2O(RE=La, Pr, Nd, Sm, Eu, Gd, Tb, Dy and Y; Gly is glycine) in water, REBr 3· n H 2O(RE=La, Ce and Pr, n =7; RE=Nd, Sm, Eu, Gd, Tb, Dy and Y, n...The integral heat of solution of REBr 3·3Gly·3H 2O(RE=La, Pr, Nd, Sm, Eu, Gd, Tb, Dy and Y; Gly is glycine) in water, REBr 3· n H 2O(RE=La, Ce and Pr, n =7; RE=Nd, Sm, Eu, Gd, Tb, Dy and Y, n =6) in aqueous glycine solution and glycine in water have been measured calorimetrically at 298 15±0 15 K. By means of a thermochemical cycle suggested in this paper, the standard molar enthalpies of formation of REBr 3·3Gly·3H 2O have been obtained and their lattice energies have been calculated.展开更多
Alkali and alkaline‐earth metals from fly ash have a significant deactivation effect on catalysts used for selective catalytic reduction of NOx by NH3(NH3‐SCR).Bromides are considered effective additives to improve ...Alkali and alkaline‐earth metals from fly ash have a significant deactivation effect on catalysts used for selective catalytic reduction of NOx by NH3(NH3‐SCR).Bromides are considered effective additives to improve Hg0 oxidation on SCR catalysts.In this work,the effects of different bromides(NH4Br,NaBr,KBr,and CaBr2)on a commercial V2O5‐WO3/TiO2 catalyst were studied.NOx conversion decreased significantly over the KBr‐poisoned catalyst(denoted as L‐KBr),while that over NaBr‐and CaBr2‐poisoned catalysts(denoted as L‐NaBr and L‐CaBr,respectivity)decreased to a lesser extent compared with the fresh sample.Poor N2 selectivity was observed over L‐NaBr,L‐KBr and L‐CaBr catalysts.The decrease in the ratio of chemisorbed oxygen to total surface oxygen(Oα/(Oα+Oβ+Ow)),reducibility and surface acidity might contribute to the poor activity and N2 selectivity over L‐KBr catalyst.The increased Oαratio was conducive to the enhanced reducibility of L‐CaBr.Combined with enhanced surface acidity,this might offset the negative effect of the loss of active sites by CaBr2 covering.The overoxidation of NH3 and poor N2 selectivity in NH3 oxidation should retard the SCR activity at high temperatures over L‐CaBr catalyst.The increased basicity might contribute to increased NOx adsorption on L‐KBr and L‐CaBr catalysts.A correlation between the acid‐basic and redox properties of bromide‐poisoned catalysts and their catalytic properties is established.展开更多
A palladium catalyst immobilized on superparaganetic nanoparticles was prepared with a palladium loading of 0.30 mmol/g. The catalyst was characterized using X-ray diffraction, scanning electron microscopy, transmissi...A palladium catalyst immobilized on superparaganetic nanoparticles was prepared with a palladium loading of 0.30 mmol/g. The catalyst was characterized using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric analysis, Fourier transform infrared, atomic absorption spectrophotometry, and nitrogen adsorption. The immobilized palladium catalyst was an efficient catalyst without added phosphine ligands for the Suzuki cross-coupling reaction of several aryl bromides with phenylboronic acid. The recovery of catalyst was simply by magnetic decantation in the presence of a magnet. The immobilized palladium catalyst can be reused many times without significant degradation in catalytic activity. No leaching of active palladium species into the reaction solution was detected.展开更多
A convenient one-pot synthesis of functionalized （E）-2-arylvinyl bromides was achieved by microwave-induced deacetylation and subsequent acylation using dicyclohexyl carbodiimide （DCC） and dimethylamino-pyridine ...A convenient one-pot synthesis of functionalized （E）-2-arylvinyl bromides was achieved by microwave-induced deacetylation and subsequent acylation using dicyclohexyl carbodiimide （DCC） and dimethylamino-pyridine （DMAP） at room temperature from （E）-4-（2-bromovinyl）phenyl acetate.展开更多
This paper reports that the reaction of the propargyl bromides with aldehydes promoted by powdered lead in aqueous media. The selectivity and possible mechanism of these reactions are discussed. The yields of products...This paper reports that the reaction of the propargyl bromides with aldehydes promoted by powdered lead in aqueous media. The selectivity and possible mechanism of these reactions are discussed. The yields of products for reaction of propargyl bromide are 31 similar to 71%. The ratios of allenyl alcohol and homopropargyl alcohol are 1:1.5 to 1:3. The product for reaction of phenyl propargyl bromide is allenyl alcohol and the yields are 52 similar to 84%.展开更多
An alternative method for synthesis of biaryls has been developed through the Pd catalyzed desulfitative coupling reaction of sodium arylsulfinates with aryl bromides and chlorides. The procedure tolerates a variety o...An alternative method for synthesis of biaryls has been developed through the Pd catalyzed desulfitative coupling reaction of sodium arylsulfinates with aryl bromides and chlorides. The procedure tolerates a variety of functional groups, such as cyano, formyl, acetyl, chloro, methoxy, trifluoromethyl and heteroaromatic unit. The desired products were obtained in moderate to excellent yields under relatively mild reaction conditions without additives, base or co-catalyst.展开更多
A new protocol for the NiC12-catalyzed cross-electrophile coupling of aryl bromides with pyrimidin-2-yl tosyl- ates to give the corresponding C2-arylation pyrimidine derivatives has been developed. This study provides...A new protocol for the NiC12-catalyzed cross-electrophile coupling of aryl bromides with pyrimidin-2-yl tosyl- ates to give the corresponding C2-arylation pyrimidine derivatives has been developed. This study provides an improvement over previous methods by using pyrimidin-2-yl tosylates instead of halides as coupling partners that are stable and easily available.展开更多
Comprehensive Summary A novel visible-light-induced radical cascade 6-endo cyclization of dienes(N-(2-vinylphenyl)acryl amides)is developed utilizingα-carbonyl bromides as alkyl reagents.This approach affords an effi...Comprehensive Summary A novel visible-light-induced radical cascade 6-endo cyclization of dienes(N-(2-vinylphenyl)acryl amides)is developed utilizingα-carbonyl bromides as alkyl reagents.This approach affords an efficient way for synthesizing six-membered benzo-fused lactam derivatives with chemo-and regio-selectivity and good functional group tolerance.Primary,secondary,and tertiary bromides are well-compatible with this cascade cyclization reaction.展开更多
Aromatic nitriles were synthesized through copper-catalyzed cyanations of aromatic bromides using benzoyl cyanide as the cyanide source.A series of functional groups were tolerated under the reaction conditions to pro...Aromatic nitriles were synthesized through copper-catalyzed cyanations of aromatic bromides using benzoyl cyanide as the cyanide source.A series of functional groups were tolerated under the reaction conditions to provide the products in good yields.Moreover,this protocol avoids using of highly toxic alkali cyanides and expensive palladium catalysts.展开更多
A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper（I）-catalyzed intra- molecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanth...A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper（I）-catalyzed intra- molecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanth- roline as ligand, and K3PO4 as base, the reactions of 1-（2-bromobenzyl）-IH-imidazoles in DMF/o-xylene （I ： 1, V ： V） at 145 ℃ afford the corresponding substituted 5H-imidazo[2,1-a]isoindoles in high yields via intramolecu- lar C-arylation.展开更多
Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-a...Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-aryl-but-2-en-l- ols with high selectivity. However, there is no method to obtain （Z）-4-aryl-but-2-en-1-ols with high selectivity now. We developed a Suzuki-Miyaura cross-coupling reaction of 1,2-oxaborol-2（5H）-ols with benzyl bromides to synthesize （Z）-4-aryl-but-2-en-1-ols, the products were obtained in up to 94% isolated yield.展开更多
The simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge.In this work,we disclose an electroreductive carboarylation of activated alkenes under mild,transition metal-free c...The simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge.In this work,we disclose an electroreductive carboarylation of activated alkenes under mild,transition metal-free conditions.Utilizing readily available starting materials(electron-deficient aryl bromides,activated alkenes,and CO_(2)),this method demonstrates broad substrate scope and good functional group tolerance.Notably,this strategy enables the addition of two distinct electrophiles across an alkene in a highly chemo-and regioselective manner.展开更多
The reaction of TbCl_3 with K[2,4-(CH_2)_2C_5H_5] at 0℃ in THF followed by crystalliza- tion at -90℃ led to a pale yellow hexagonal prismatic crystalline product [2,4-[CH_3)_2-η~5-C_5H_5]_(2-) Tb·1/2THF, which...The reaction of TbCl_3 with K[2,4-(CH_2)_2C_5H_5] at 0℃ in THF followed by crystalliza- tion at -90℃ led to a pale yellow hexagonal prismatic crystalline product [2,4-[CH_3)_2-η~5-C_5H_5]_(2-) Tb·1/2THF, which is highly sensitive to air and water and rapidly efflorescent at ambient temper- ature. The single Crystal X-ray diffraction data of the compound have been collected at low tem- perature (-60℃) and the crystal structure has been solved by heavy atom method. It belongs to triclinic system, space group Pl with lattice parameters a=8.477 (?),b=12.583 (?),c=12.858 (?), a=118.08°,β=91.38°,γ=108.75°,V=1120.36 (?)~ 3 and Z=2. Least-squares refinement converged to a final value R=0.043. The compound possesses an idealized G_(2h) symmetry、with three 2,4- dimethylpentadienyl ligands bound to the central terbium atom in a pentahapto mode (η~5). Each unit cell contains two molecules of[2,4-(CH_3)_2-η~5-C_5H_5]_3Tb and one molecule of solvent THF, of which the role in the lattice has been discussed in detail.展开更多
Herein, we report that a series of novel palladium（II）-NHC complexes （NHC=N-heterocyclic carbene） were synthesized. The structures of all novel complexes were characterized by ^1H NMR, ^13C NMR, FT-IR spectroscopy...Herein, we report that a series of novel palladium（II）-NHC complexes （NHC=N-heterocyclic carbene） were synthesized. The structures of all novel complexes were characterized by ^1H NMR, ^13C NMR, FT-IR spectroscopy and elemental analysis techniques. These palladium（ll）-NHC complexes were tested as efficient catalysts in the direct C-H bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 ℃ for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2-arylbenzoxazoles and 2-arylbenzothiazoles in acceptable to high yields.展开更多
An efficient Pd-catalyzed method for C—O cross-coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo-chalcones has been developed.All oxime ethers were obtained in good to excellent yields ...An efficient Pd-catalyzed method for C—O cross-coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo-chalcones has been developed.All oxime ethers were obtained in good to excellent yields by[(π-allyl)PdCl]2/tBuXPhos(L7)catalyst system.TrixiePhos(L11)was also found to be effective for the oxime coupling.This method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo-chalcones,which has not been previously explored.展开更多
Pyridine was used as a solvent for homocoupling of aryl bromides catalyzed by nickel chloride/triarylphosphine in the presence of zinc and recycled easily. Triphenylphosphine was the best ligand for nickel in this cou...Pyridine was used as a solvent for homocoupling of aryl bromides catalyzed by nickel chloride/triarylphosphine in the presence of zinc and recycled easily. Triphenylphosphine was the best ligand for nickel in this coupling reaction.展开更多
文摘Herein,we present a copper-catalyzed carbonylative cross-coupling of unactivated alkyl bromides with aryl boronates under CO atmosphere which enabling the efficient synthesis of C(sp3)-C(sp2)ketones with extensive functional group compatibility.This strategy represents a significant advance in copper-catalyzed carbonylation involving alkyl bromides and C(sp2)-nucleophiles.The protocol addresses key challenges commonly encountered in the coupling of C(sp3)-alkyl halides with aryl boron reagents,such as sluggish oxidative addition of alkyl halides,competing Suzuki-Miyaura cross-coupling,undesired dehalogenation and so on.Distinguished by its broad substrate scope and high functional group tolerance,this approach offers a robust and versatile platform for the streamlined synthesis of alkyl aryl ketones.
基金supported by the Natural Science Foundation of Liaoning Education Department (No. 2008T094)
文摘Highly active, air-stable and water-soluble palladium-phosphinous acid complexes have been applied to Suzuki cross-coupling reaction of heteroaryl bromides under mild conditions in water/alcoholic solvents. Suzuki cross-coupling reaction of heteroaryl bromides with phenylboronic acid occurred efficiently using palladium phosphinous acid complexes （POPd） and phase transfer catalyst （tetrabutylammonium bromide and polyethylene glycol） in water/ethanol mixture, water/propanol mixture and neat water respectively, the corresponding yields of cross-coupling heteroaryl-aryls were satisfied. The tert-butyl substituted ligand di-tert-butylphosphino in combination with POPd was found to be more active than the same family derived catalysts dipalladium complexes POPdl and POPd2, and other two kinds of Pd-catalysts Pd（PPh3）4 and Pd2（dba）3. The mechanism of Suzuki cross-coupling reaction between heteroaryl bromides and phenylboronic acid in water was proposed with respect to the key role of phase transfer catalyst on the transmetallation step. Compared with other solid phase transfer catalysts, TBAB was tested as the ideal one. The alkalinity of base and the molar proportion between POPd and TBAB were investigated in water and alcoholic solvents. Notably, in the presence of TBAB adding alcoholic solvents into water enhanced the yields of target products. However in terms of the liquid phase transfer catalyst of PEGs, mixing water into PEGs could slightly decrease the yields with respect to the water free PEGs bulk phase, which was probably due to the homogenous liquid conditions in pure PEGs and weak interactions between PEGs and heteroaryl bromide molecules in water depending on their molecular chain lengths.
基金The project was supported by the National Natural Science Foundation of China !(GrantNo.29803005) China Postdoctoral Science
文摘The catalytic effects for the oxidative methylation of toluene with methane over the basic zeolite catalysts prepared by promoting KY, KX, KM, KZSM-5 or KP with alkali-metal bromides and alkali-metal oxides have been investigated comparatively. The alkali-metal bromides promoted substrates are more effective than the alkali-metal oxides promoted systems. Moreover, the NaBr promoted systems are more active than KBr promoted systems. The most effective catalytic system (8wt%NaBr)/KZSM-5 gave a toluene conversion as high as 76.3% and a total C-8 selectivity of 76.4% (styrene/ethylbenzene=9.76) resulting in a total C-8 yield of 58.3%.
文摘The integral heat of solution of REBr 3·3Gly·3H 2O(RE=La, Pr, Nd, Sm, Eu, Gd, Tb, Dy and Y; Gly is glycine) in water, REBr 3· n H 2O(RE=La, Ce and Pr, n =7; RE=Nd, Sm, Eu, Gd, Tb, Dy and Y, n =6) in aqueous glycine solution and glycine in water have been measured calorimetrically at 298 15±0 15 K. By means of a thermochemical cycle suggested in this paper, the standard molar enthalpies of formation of REBr 3·3Gly·3H 2O have been obtained and their lattice energies have been calculated.
基金supported by the National Key R&D Program of China(2016YFC0203900,2016YFC0203901)National Natural Science Foundation of China(51778619,21577173)~~
文摘Alkali and alkaline‐earth metals from fly ash have a significant deactivation effect on catalysts used for selective catalytic reduction of NOx by NH3(NH3‐SCR).Bromides are considered effective additives to improve Hg0 oxidation on SCR catalysts.In this work,the effects of different bromides(NH4Br,NaBr,KBr,and CaBr2)on a commercial V2O5‐WO3/TiO2 catalyst were studied.NOx conversion decreased significantly over the KBr‐poisoned catalyst(denoted as L‐KBr),while that over NaBr‐and CaBr2‐poisoned catalysts(denoted as L‐NaBr and L‐CaBr,respectivity)decreased to a lesser extent compared with the fresh sample.Poor N2 selectivity was observed over L‐NaBr,L‐KBr and L‐CaBr catalysts.The decrease in the ratio of chemisorbed oxygen to total surface oxygen(Oα/(Oα+Oβ+Ow)),reducibility and surface acidity might contribute to the poor activity and N2 selectivity over L‐KBr catalyst.The increased Oαratio was conducive to the enhanced reducibility of L‐CaBr.Combined with enhanced surface acidity,this might offset the negative effect of the loss of active sites by CaBr2 covering.The overoxidation of NH3 and poor N2 selectivity in NH3 oxidation should retard the SCR activity at high temperatures over L‐CaBr catalyst.The increased basicity might contribute to increased NOx adsorption on L‐KBr and L‐CaBr catalysts.A correlation between the acid‐basic and redox properties of bromide‐poisoned catalysts and their catalytic properties is established.
基金supported by the Ho Chi Minh City Department of Science and Technology, Viet Nam
文摘A palladium catalyst immobilized on superparaganetic nanoparticles was prepared with a palladium loading of 0.30 mmol/g. The catalyst was characterized using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric analysis, Fourier transform infrared, atomic absorption spectrophotometry, and nitrogen adsorption. The immobilized palladium catalyst was an efficient catalyst without added phosphine ligands for the Suzuki cross-coupling reaction of several aryl bromides with phenylboronic acid. The recovery of catalyst was simply by magnetic decantation in the presence of a magnet. The immobilized palladium catalyst can be reused many times without significant degradation in catalytic activity. No leaching of active palladium species into the reaction solution was detected.
基金supported by the Natural Science Foundation of Shanghai,China(No.06ZR14085)the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry.
文摘A convenient one-pot synthesis of functionalized （E）-2-arylvinyl bromides was achieved by microwave-induced deacetylation and subsequent acylation using dicyclohexyl carbodiimide （DCC） and dimethylamino-pyridine （DMAP） at room temperature from （E）-4-（2-bromovinyl）phenyl acetate.
文摘This paper reports that the reaction of the propargyl bromides with aldehydes promoted by powdered lead in aqueous media. The selectivity and possible mechanism of these reactions are discussed. The yields of products for reaction of propargyl bromide are 31 similar to 71%. The ratios of allenyl alcohol and homopropargyl alcohol are 1:1.5 to 1:3. The product for reaction of phenyl propargyl bromide is allenyl alcohol and the yields are 52 similar to 84%.
基金Acknowledgement This work was supported by the National Natural Science Foundation of China （Nos. 21176039, 20876021 and 20923006）.
文摘An alternative method for synthesis of biaryls has been developed through the Pd catalyzed desulfitative coupling reaction of sodium arylsulfinates with aryl bromides and chlorides. The procedure tolerates a variety of functional groups, such as cyano, formyl, acetyl, chloro, methoxy, trifluoromethyl and heteroaromatic unit. The desired products were obtained in moderate to excellent yields under relatively mild reaction conditions without additives, base or co-catalyst.
基金We are thankful for the financial support from the National Natural Science Foundation of China （Nos. 21362032, 21362031 and 21562036） and Northwest Normal University （No. NWNU-LKQN- 15-1 ）.
文摘A new protocol for the NiC12-catalyzed cross-electrophile coupling of aryl bromides with pyrimidin-2-yl tosyl- ates to give the corresponding C2-arylation pyrimidine derivatives has been developed. This study provides an improvement over previous methods by using pyrimidin-2-yl tosylates instead of halides as coupling partners that are stable and easily available.
基金supported by the National Natural Science Foundation of China(22078084 and 51874132)the Scientific Research Fund of Hunan Provincial Education Department(22B0674)the Science and Natural Science Foundation of Hunan Province(No.2023JJ30273 and 2023JJ40301).
文摘Comprehensive Summary A novel visible-light-induced radical cascade 6-endo cyclization of dienes(N-(2-vinylphenyl)acryl amides)is developed utilizingα-carbonyl bromides as alkyl reagents.This approach affords an efficient way for synthesizing six-membered benzo-fused lactam derivatives with chemo-and regio-selectivity and good functional group tolerance.Primary,secondary,and tertiary bromides are well-compatible with this cascade cyclization reaction.
基金This project was financially supported by the National Natural Science Foundation of China(No.21302014)the Natural Science Foundation for Colleges and Universities of Jiangsu Province(13KJB150002)the Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology(grant No.BM2012110).
文摘Aromatic nitriles were synthesized through copper-catalyzed cyanations of aromatic bromides using benzoyl cyanide as the cyanide source.A series of functional groups were tolerated under the reaction conditions to provide the products in good yields.Moreover,this protocol avoids using of highly toxic alkali cyanides and expensive palladium catalysts.
文摘A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper（I）-catalyzed intra- molecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanth- roline as ligand, and K3PO4 as base, the reactions of 1-（2-bromobenzyl）-IH-imidazoles in DMF/o-xylene （I ： 1, V ： V） at 145 ℃ afford the corresponding substituted 5H-imidazo[2,1-a]isoindoles in high yields via intramolecu- lar C-arylation.
基金support from National Natural Science Foundation of China （Nos. 20802088, 91017006, 90917017） and the Fundamental Research Funds for the Central Universities.
文摘Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-aryl-but-2-en-l- ols with high selectivity. However, there is no method to obtain （Z）-4-aryl-but-2-en-1-ols with high selectivity now. We developed a Suzuki-Miyaura cross-coupling reaction of 1,2-oxaborol-2（5H）-ols with benzyl bromides to synthesize （Z）-4-aryl-but-2-en-1-ols, the products were obtained in up to 94% isolated yield.
基金supported by the National Key R&D Program of China(2022YFA1505100,2021YFA1500104)National Natural Science Foundation of China(22031008,22201222)+1 种基金Science Foundation of Wuhan(2023020201020266,2020010601012192)Jiangxi Normal University Doctoral Research Initiation Fund Project(12017081,12022796).
文摘The simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge.In this work,we disclose an electroreductive carboarylation of activated alkenes under mild,transition metal-free conditions.Utilizing readily available starting materials(electron-deficient aryl bromides,activated alkenes,and CO_(2)),this method demonstrates broad substrate scope and good functional group tolerance.Notably,this strategy enables the addition of two distinct electrophiles across an alkene in a highly chemo-and regioselective manner.
基金This research was supported by the National Natural Science Foundation of China as an item of major project.
文摘The reaction of TbCl_3 with K[2,4-(CH_2)_2C_5H_5] at 0℃ in THF followed by crystalliza- tion at -90℃ led to a pale yellow hexagonal prismatic crystalline product [2,4-[CH_3)_2-η~5-C_5H_5]_(2-) Tb·1/2THF, which is highly sensitive to air and water and rapidly efflorescent at ambient temper- ature. The single Crystal X-ray diffraction data of the compound have been collected at low tem- perature (-60℃) and the crystal structure has been solved by heavy atom method. It belongs to triclinic system, space group Pl with lattice parameters a=8.477 (?),b=12.583 (?),c=12.858 (?), a=118.08°,β=91.38°,γ=108.75°,V=1120.36 (?)~ 3 and Z=2. Least-squares refinement converged to a final value R=0.043. The compound possesses an idealized G_(2h) symmetry、with three 2,4- dimethylpentadienyl ligands bound to the central terbium atom in a pentahapto mode (η~5). Each unit cell contains two molecules of[2,4-(CH_3)_2-η~5-C_5H_5]_3Tb and one molecule of solvent THF, of which the role in the lattice has been discussed in detail.
文摘Herein, we report that a series of novel palladium（II）-NHC complexes （NHC=N-heterocyclic carbene） were synthesized. The structures of all novel complexes were characterized by ^1H NMR, ^13C NMR, FT-IR spectroscopy and elemental analysis techniques. These palladium（ll）-NHC complexes were tested as efficient catalysts in the direct C-H bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 ℃ for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2-arylbenzoxazoles and 2-arylbenzothiazoles in acceptable to high yields.
文摘An efficient Pd-catalyzed method for C—O cross-coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo-chalcones has been developed.All oxime ethers were obtained in good to excellent yields by[(π-allyl)PdCl]2/tBuXPhos(L7)catalyst system.TrixiePhos(L11)was also found to be effective for the oxime coupling.This method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo-chalcones,which has not been previously explored.
文摘Pyridine was used as a solvent for homocoupling of aryl bromides catalyzed by nickel chloride/triarylphosphine in the presence of zinc and recycled easily. Triphenylphosphine was the best ligand for nickel in this coupling reaction.
