中国有着世界上最大的金字塔底层(bottom of the pyramid,BOP)市场,但国内企业针对这一市场的BOP创新却一直没有得到现有研究的重视。在“双循环”新发展格局下,BOP市场的开发对于我国制造业科技企业的创新发展至关重要。基于双元性理论...中国有着世界上最大的金字塔底层(bottom of the pyramid,BOP)市场,但国内企业针对这一市场的BOP创新却一直没有得到现有研究的重视。在“双循环”新发展格局下,BOP市场的开发对于我国制造业科技企业的创新发展至关重要。基于双元性理论,将BOP市场开发分为BOP市场探索和BOP市场利用两种策略,并针对国内制造业科技企业面临的资源约束和BOP市场对于产品可负担性的要求,提出“拼凑式创新(应对创新资源不足)+朴素式创新(应对BOP顾客支付能力不足)”组合的BOP创新思路,进而构建“BOP市场双元→拼凑式创新+朴素式创新→新产品绩效”的理论框架。基于对珠三角地区制造业科技企业的调查数据来进行假设检验,分析结果显示拼凑式创新和朴素式创新对于制造业科技企业的新产品绩效均具有显著的正向影响;BOP市场探索和BOP市场利用也会正向作用于拼凑式创新和朴素式创新,在拼凑式创新中BOP市场探索的影响要比BOP市场利用更强;在BOP市场探索和BOP市场利用对新产品绩效的影响中,拼凑式创新和朴素式创新会起到完全的中介作用,说明拼凑式创新和朴素式创新在制造业科技企业根植本土市场推进新产品开发的过程中扮演着关键角色。展开更多
消费者体验需求的提升促使零售商不断探索新渠道模式,以提高原有实体店效益的同时优化线上经营策略。本文分别考虑传统BORO(buy online and return online)和开通BOPS(buy online and pickup in store)两种渠道情形,构建零售商针对消费...消费者体验需求的提升促使零售商不断探索新渠道模式,以提高原有实体店效益的同时优化线上经营策略。本文分别考虑传统BORO(buy online and return online)和开通BOPS(buy online and pickup in store)两种渠道情形,构建零售商针对消费者线上购买并在线上或线下退款的差异化退货策略利润模型,分析两种渠道情形下的最优定价和最优退货策略,进而考虑BOPS渠道的溢出效应,分析零售商在相同退货策略下是否应该开通BOPS渠道。结果表明:(1)在两种情形下,随着线下商店数量的增多,零售商均会倾向于在低开店成本下选择全额退款策略,倾向于在高开店成本下选择部分退款策略;(2)在同渠道情形下,全额退款策略的定价始终低于部分退款策略。在同退货策略下,BOPS情形下的定价始终低于BORO情形;(3)高溢出效应和多商店数量都促使零售商选择开通BOPS渠道,但商店数量决定了BOPS线下麻烦成本规模因子对零售商开通BOPS渠道起推动还是抑制作用。本文为既定商店数量下多渠道零售商退货策略与渠道选择提供了决策支持。展开更多
Background:Kidney renal clear cell carcinoma(KIRC),a prevalent urological malignancy,represents about 3%of all adult malignancies.KIRC,accounting for~75%of renal malignancies,has poor prognosis in metastatic stages.Id...Background:Kidney renal clear cell carcinoma(KIRC),a prevalent urological malignancy,represents about 3%of all adult malignancies.KIRC,accounting for~75%of renal malignancies,has poor prognosis in metastatic stages.Identifying robust prognostic markers remains urgent.Block of proliferation 1(BOP1),a WD40-repeat protein,is implicated in cancer pathogenesis,but its role in KIRC is unclear.This study aimed to characterize BOP1 expression in KIRC and evaluate its prognostic value.Methods:BOP1 transcriptional levels were assessed through TCGA-KIRC RNA sequencing datasets.ROC curve construction was implemented via R statistical packages for diagnostic evaluation.Patient survival outcomes were visualized through Kaplan-Meier plotting with log-rank testing.Multivariate logistic regression models quantified associations between BOP1 expression and clinicopathological parameters.TIMER algorithm analyzed immune microenvironment composition.Genomic alterations and epigenetic modifications were investigated using cBioPortal and MethSurv platforms respectively.BOP1 protein levels in 786-O clear cell renal cell carcinoma(ccRCC)versus HK-2(normal renal)cell lines were validated by immunoblotting.Results:Evaluation of the TCGA database demonstrated that BOP1 mRNA abundance was higher in tumor specimens than in corresponding adjacent tissues.Patients with KIRC who had high BOP1 expression had differential overall survival(OS),disease-specific survival(DSS),and disease-free interval(DFI).BOP1 expression accurately recognised tumour tissues versus normal tissues(AUC=0.858),and the area under the ROCs for survival at 1,3,and 5 years were all greater than 0.6.The BOP1 gene variant rate was<1%.Out of the 15 DNA methylation CpG sites examined,7 exhibited prognostic significance in KIRC.BOP1 displayed a distinct relationship with immune cell infiltration in KIRC.The 786-O experimental group exhibited substantially higher BOP1 expression,as confirmed by Western blot detection.Conclusion:This study indicates that heightened BOP1 expression is linked to an adverse prognosis in KIRC,establishing it as an independent risk factor for this disease.These findings establish BOP1 as a novel and independent prognostic biomarker for KIRC,offering potential clinical utility for risk stratification and personalized therapeutic strategies.展开更多
文摘中国有着世界上最大的金字塔底层(bottom of the pyramid,BOP)市场,但国内企业针对这一市场的BOP创新却一直没有得到现有研究的重视。在“双循环”新发展格局下,BOP市场的开发对于我国制造业科技企业的创新发展至关重要。基于双元性理论,将BOP市场开发分为BOP市场探索和BOP市场利用两种策略,并针对国内制造业科技企业面临的资源约束和BOP市场对于产品可负担性的要求,提出“拼凑式创新(应对创新资源不足)+朴素式创新(应对BOP顾客支付能力不足)”组合的BOP创新思路,进而构建“BOP市场双元→拼凑式创新+朴素式创新→新产品绩效”的理论框架。基于对珠三角地区制造业科技企业的调查数据来进行假设检验,分析结果显示拼凑式创新和朴素式创新对于制造业科技企业的新产品绩效均具有显著的正向影响;BOP市场探索和BOP市场利用也会正向作用于拼凑式创新和朴素式创新,在拼凑式创新中BOP市场探索的影响要比BOP市场利用更强;在BOP市场探索和BOP市场利用对新产品绩效的影响中,拼凑式创新和朴素式创新会起到完全的中介作用,说明拼凑式创新和朴素式创新在制造业科技企业根植本土市场推进新产品开发的过程中扮演着关键角色。
文摘消费者体验需求的提升促使零售商不断探索新渠道模式,以提高原有实体店效益的同时优化线上经营策略。本文分别考虑传统BORO(buy online and return online)和开通BOPS(buy online and pickup in store)两种渠道情形,构建零售商针对消费者线上购买并在线上或线下退款的差异化退货策略利润模型,分析两种渠道情形下的最优定价和最优退货策略,进而考虑BOPS渠道的溢出效应,分析零售商在相同退货策略下是否应该开通BOPS渠道。结果表明:(1)在两种情形下,随着线下商店数量的增多,零售商均会倾向于在低开店成本下选择全额退款策略,倾向于在高开店成本下选择部分退款策略;(2)在同渠道情形下,全额退款策略的定价始终低于部分退款策略。在同退货策略下,BOPS情形下的定价始终低于BORO情形;(3)高溢出效应和多商店数量都促使零售商选择开通BOPS渠道,但商店数量决定了BOPS线下麻烦成本规模因子对零售商开通BOPS渠道起推动还是抑制作用。本文为既定商店数量下多渠道零售商退货策略与渠道选择提供了决策支持。
基金supported by Young Talents Cultivation Program of Xianning City,the Natural Science Foundation of Hubei Province,China(No.2024AFB502)Ph.D.Start-up Funding(No.BK202413)Medical Fund(No.2023YKY04)of Hubei University of Science and Technology.
文摘Background:Kidney renal clear cell carcinoma(KIRC),a prevalent urological malignancy,represents about 3%of all adult malignancies.KIRC,accounting for~75%of renal malignancies,has poor prognosis in metastatic stages.Identifying robust prognostic markers remains urgent.Block of proliferation 1(BOP1),a WD40-repeat protein,is implicated in cancer pathogenesis,but its role in KIRC is unclear.This study aimed to characterize BOP1 expression in KIRC and evaluate its prognostic value.Methods:BOP1 transcriptional levels were assessed through TCGA-KIRC RNA sequencing datasets.ROC curve construction was implemented via R statistical packages for diagnostic evaluation.Patient survival outcomes were visualized through Kaplan-Meier plotting with log-rank testing.Multivariate logistic regression models quantified associations between BOP1 expression and clinicopathological parameters.TIMER algorithm analyzed immune microenvironment composition.Genomic alterations and epigenetic modifications were investigated using cBioPortal and MethSurv platforms respectively.BOP1 protein levels in 786-O clear cell renal cell carcinoma(ccRCC)versus HK-2(normal renal)cell lines were validated by immunoblotting.Results:Evaluation of the TCGA database demonstrated that BOP1 mRNA abundance was higher in tumor specimens than in corresponding adjacent tissues.Patients with KIRC who had high BOP1 expression had differential overall survival(OS),disease-specific survival(DSS),and disease-free interval(DFI).BOP1 expression accurately recognised tumour tissues versus normal tissues(AUC=0.858),and the area under the ROCs for survival at 1,3,and 5 years were all greater than 0.6.The BOP1 gene variant rate was<1%.Out of the 15 DNA methylation CpG sites examined,7 exhibited prognostic significance in KIRC.BOP1 displayed a distinct relationship with immune cell infiltration in KIRC.The 786-O experimental group exhibited substantially higher BOP1 expression,as confirmed by Western blot detection.Conclusion:This study indicates that heightened BOP1 expression is linked to an adverse prognosis in KIRC,establishing it as an independent risk factor for this disease.These findings establish BOP1 as a novel and independent prognostic biomarker for KIRC,offering potential clinical utility for risk stratification and personalized therapeutic strategies.
