Labubu has become a global star,from Paris and New York to London and Milan.These charming figurines from Chinese toy manufacturer Pop Mart,with their soft fur,expressive eyes,pointed teeth and rabbit ears,have captiv...Labubu has become a global star,from Paris and New York to London and Milan.These charming figurines from Chinese toy manufacturer Pop Mart,with their soft fur,expressive eyes,pointed teeth and rabbit ears,have captivated buyers both in shops and online.展开更多
文摘Labubu has become a global star,from Paris and New York to London and Milan.These charming figurines from Chinese toy manufacturer Pop Mart,with their soft fur,expressive eyes,pointed teeth and rabbit ears,have captivated buyers both in shops and online.
文摘目的 利用血氧水平依赖磁共振成像(blood oxygenation level dependent MRI,BOLD MRI)评估2型糖尿病肾脏病患者肾功能与肾组织氧合水平的关系。方法 选取2023年4月~2024年8月内分泌科收治的80例2型糖尿病肾病患者。根据尿微量白蛋白比尿肌酐(the ratio of urinary albumin and creatinine, ACR)将患者分为正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组。所有患者均记录相关临床资料,完善BOLD MRI检查,由两名影像科医师分别测定3组患者双侧肾脏皮、髓质R2*值,计算双肾皮质R2*值(CR2*)、髓质R2*值(MR2*)的平均值及比值(R2*ratio between medulla and cortex, MCR)。比较两名医师测得CR2*、MR2*的一致性以及3组患者CR2*、MR2*、MCR的差异,分析其与临床指标的相关性。结果 3组患者临床资料示血肌酐和肾小球滤过率比较,差异有统计学意义(P<0.05)。ACR、尿微量白蛋白及尿N-乙酰-β-D氨基葡萄糖苷酶(urinary N-acetyl-β-D glucosaminase, UNAG)在3组间差异有统计学意义(P均<0.01)。3组患者基于空腹C肽的胰岛素抵抗指数(insulin resistance index, HOMA2-IR)比较,差异有统计学意义(P<0.05)。3组间CR2*、MR2*、MCR比较,差异有统计学意义(P均<0.05)。相关性分析表明,CR2*、MR2*与肌酐、ACR、尿微量白蛋白、UNAG、HOMA2-IR呈正相关,与肾小球滤过率呈负相关。结论 BOLD MRI是一种评估糖尿病肾病氧合的无创方法,CR2*、MR2*与不同肾功能指标具有一定相关性。
