Phthalate(PAEs)and Bisphenols(BPs)are plasticizers or additives in consumer products.They are typical endocrine disruptors,and potential health hazards may occur when people are exposed to them through inhalation,inge...Phthalate(PAEs)and Bisphenols(BPs)are plasticizers or additives in consumer products.They are typical endocrine disruptors,and potential health hazards may occur when people are exposed to them through inhalation,ingestion,and dermal contact.The current research on inhalation exposure pays limited attention to the particle distribution of PAEs and BPs in air,although particulate-bound pollutants are usually size-dependent.In this study,we discussed the size resolution of PAEs and BPs in air particles from city waste recycling plants.With paired urine samples of the workers,we also compared the internal and external exposure of PAEs and BPs and related potential health risks.The particulatebound PAEs and BPs concentrated mainly on coarse particles(Dp>2.1μm),with a bimodal distribution,and the peak particle size ranged from 9–10 to 4.7–5.85μm,respectively.Model calculation revealed that the deposition fluxes of PAEs in different respiratory regions followed the sequence of head airways(167±92.8 ng/h)>alveolar region(18.9±9.96 ng/h)>tracheobronchial region(9.20±5.22 ng/h),and the similar trends went for BPs.The daily intakes of PAEs and BPs via dust ingestion were higher than those fromrespiratory inhalation and dermal contact,with mean value of 96 and 0.88 ng/(kg-bw day),respectively.For internal exposure,the estimated daily intakes of PAEs for waste recycling workers were higher than those in e-waste dismantling workers,while the exposure levels of bisphenols were comparable.Overall,the potential health risks from inhalation exposure to particulate-bound PAEs and BPs were low.展开更多
To establish an analytical method for determination of four bisphenols （BPA, BPB, BPF, and BPS） and two alkylphenols （4-n-OP, 4-n-NP） in water by ultra performance liquid chromatography- tandem mass spectrometry ...To establish an analytical method for determination of four bisphenols （BPA, BPB, BPF, and BPS） and two alkylphenols （4-n-OP, 4-n-NP） in water by ultra performance liquid chromatography- tandem mass spectrometry （UPLC/MS/MS）. The water samples were extracted and condensed with solid-phase extraction （SPE） using C18 cartridges and eluted by acetonitrile. Separation was carried out with Acquity BEH C8 column and detection were performed by UPLC/MS/MS. Quantification was calculated by using the internal standard BPA-d16 and 4-n-NP-d8. The linear correlation coefficients of these compounds in the range of 1.0-100.0μg/L were all over 0.999. The minimum detectable concentrations were 0.75-1.0 ng/L, and the recoveries ranged from 87.0% to 106.9%.展开更多
Bisphenols containing long aliphatic hydrocarbon side chains were synthesized by the condensation of phenol with aldehyde or ketone in the presence of heteropolyacid. Their structures were characterized by IR, 1H NMR,...Bisphenols containing long aliphatic hydrocarbon side chains were synthesized by the condensation of phenol with aldehyde or ketone in the presence of heteropolyacid. Their structures were characterized by IR, 1H NMR, 13C NMR and element analysis. The experiment results show that when heteropolyacid was used as a catalyst, these bisphenols were obtained in high selectivity and high yields.展开更多
In view of widespread existence and toxicity,removal and detection of bisphenols is imperative to asses environmental risks and reduce harm to human health.Although many techniques have been reported constructing fast...In view of widespread existence and toxicity,removal and detection of bisphenols is imperative to asses environmental risks and reduce harm to human health.Although many techniques have been reported constructing fast and sensitive method remains a challenge.Herein,porous poly(divinylbenzene)polyme was synthesized in-situ on the Fe_(3)O_(4)particles by means of distillation-precipitation polymerization and functioned as sorbents to extract bisphenols.Employing Fe_(3)O_(4)@poly(divinylbenzene)as sorbent,a mag netic solid-phase extraction coupling with liquid chromatography was developed to detect trace bisphe nols in water.This method presented low detection limits(0.01–0.03 ng/m L),high enrichment ability(en richment factor,327–343),and good reproducibility.Moreover,the method showed satisfactory recoverie in the detection of lake water(80.60%-116.2%)and egg sample(75.17%-120.0%).Impressively,Fe_(3)O_(4)@PDVB has excellent adsorption capacity,which can realize rapid kinetic adsorption of bisphenols with equi librium time all less than 10 s.The maximum adsorption capacities reached 1074.8,1049.7,1299.1 and 1329.5 mg/g for bisphenol F,bisphenol A,bisphenol B and bisphenol AF with Langmuir isotherm model The adsorption mechanism of Fe_(3)O_(4)@PDVB to bisphenols was investigated and demonstrated that hy drophobic interactions played a key role,together with assistance ofπ-πstacking interactions and hy drogen interactions.Overall,this work provides a promising sorbent material with ultra-fast and large adsorption capacities for extraction of bisphenols from water.展开更多
A polyclonal antibody against the currently concerned estrogenic bisphenol compounds was produced according to a new scheme. 4,4-Bis (4-hydroxyphenyl) valeric acid was used to synthesize the complete antigen in which...A polyclonal antibody against the currently concerned estrogenic bisphenol compounds was produced according to a new scheme. 4,4-Bis (4-hydroxyphenyl) valeric acid was used to synthesize the complete antigen in which the characteristic bisphenol structure was exposed to the largest extent. The produced polyclonal antibody showed high specificity and affinity for bisphenol A.展开更多
BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st century.In recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequen...BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st century.In recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPS,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the art.Subsequently,a meta-analysis was performed to unify the existing quantitative data.METHODS Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of results.Subsequently,three authors analyzed the set of articles.Finally,a meta-analysis was performed for each BP,using RevMan software.In addition,funnel plots were developed to study publication bias.RESULTS The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study paradigm.The qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPS,BPF and BPAF.Finally,the meta-analysis determined a positive relationship with BPS,BPF and BPAF,which was only statistically significant with BPS.CONCLUSION There is a need to apply the precautionary principle,regulating the use of new BPs.Therefore,replacing BPA with BPS,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.展开更多
Valorization of lignin is essential for establishing a profitable biorefining in-dustry,yet its efficiency is critically constrained by lignin condensation.Un-derstanding lignin condensation mechanisms and developing ...Valorization of lignin is essential for establishing a profitable biorefining in-dustry,yet its efficiency is critically constrained by lignin condensation.Un-derstanding lignin condensation mechanisms and developing effective strategies to inhibit condensation have emerged as a global research imperative.展开更多
A major concern from the scientific community has been raised since evidence of Bisphenol A(BP-A)can leach out from the products where they are incorporated as well as its endocrine disrupting effects observed in anim...A major concern from the scientific community has been raised since evidence of Bisphenol A(BP-A)can leach out from the products where they are incorporated as well as its endocrine disrupting effects observed in animals and humans.BP-A and several related chemicals such as Bisphenol AP(BP-AP),Bisphenol B(BPeB),Bisphenol S(BPeS),Bisphenol AF(BP-AF),Bisphenol(BPeP),Bisphenol Z(BP-Z)were analyzed in this study.BP-A and BP-S were the only bisphenols detected in the samples analyzed in this study.The median(range;mean)concentrations of BP-A found in this study was 321 ng/g(11-200932;4893 ng/g).The analysis was carried out by sonicating 0.1 g of a cryo-milled sample aliquot in methanol followed by UPLC-MS/MS determination.High concentrations of BP-A were found in several products labeled as BP-A free such as nursing bottles which are particularly problematic from the children's exposure point of view.This study presents the first reliable bisphenols in children's toys and baby products commercialized in the Middle East.There is,however,a need to continue monitoring these compounds,especially in low-cost toys,and the so-called BP-A-free products,which appear to have high levels of target contaminants and can pose an exposure risk for infants and children in the region.展开更多
Emerging synthetic or derivative chemicals have drawn global concern due to their potential endocrine-disrupting effects,either as agonists or antagonists or through indirect effects on enzymes of signal transduction ...Emerging synthetic or derivative chemicals have drawn global concern due to their potential endocrine-disrupting effects,either as agonists or antagonists or through indirect effects on enzymes of signal transduction pathways.Currently,in vitro screening models are limited to poor tolerance,robustness,high cost and need for sphisticated equipment or complex procedures that require high levels of expertise.Herein,a multiplex analysis platform based on autobioluminescent yeast strains,including BLYhERaS,BLYhERbS,BLYhPRS,BLYhARS,BLYhMRS,and BLYhGRS,was developed for use in easy,rapid,robust,and sensitive screening for potential modulation of endocrine systems.Methods were applied to assess endocrine-disrupting effects of Bisphenol A(BPA)and its alternatives.Disrupting activities of bisphenols(BPs)varied greatly,and some BPA substitutes exerted more potent activities than those of BPA.Most BPs were primarily agonists of ERa and ERb,while others were antagonists to AR,PR,GR,and MR.BPP and BPM exhibited non-monotonic dose-response relationships toward ERa and ERb,and BHPF and BPG displayed converse disrupting activities to ERa and ERb.Overall,the bioassay system provides an efficient tool for comprehensive evaluation of endocrine-disrupting activities of emerging contaminants.展开更多
Objective To observe the levels of four bisphenols(bisphenol A,B,S and F)and their correlation with renal function in chronic kidney disease(CKD)patients.Methods Patients with CKD were identified according to Kidney D...Objective To observe the levels of four bisphenols(bisphenol A,B,S and F)and their correlation with renal function in chronic kidney disease(CKD)patients.Methods Patients with CKD were identified according to Kidney Disease:Improving Global Outcomes(KDIGO)criteria.Sixty-three CKD patients and eleven healthy controls were enrolled.CKD patients were further classified as mild renal injury group(CKD stage 1 and 2,n=30),moderate renal injury group(CKD stage 3,n=19)and severe renal injury group(CKD stage 4 and 5,n=14).The levels of four bisphenols in serum were determined by high performance liquid chromatography(HPLC).The correlation between concentrations of four bisphenols and estimated glomerular filtration rate(eGFR)was assessed by Spearman's rank correlation analysis.The associations of four bisphenols with coronary heart disease,diabetes and hypertension in CKD patients were estimated by binary multivariate logistic regression.Results(1)Four bisphenols were not detected in serum of the healthy control.In the mild renal injury group the bisphenol A and bisphenol S were not detected,and patients had 5.24(5.24,9.38)μg/L bisphenol B and 0.74(0.74,0.74)μg/L bisphenol F.In the moderate renal injury group bisphenol S was not detected,and the patients had 2.79(1.01,4.53)μg/L bisphenol A,5.24(5.24,5.24)μg/L bisphenol B and 0.74(0.74,0.74)μg/L bisphenol F.In the severe renal injury group the patients had 14.30(7.97,18.17)μg/L bisphenol A,0 μg/L bisphenol B,23.73(23.73,136.59)μg/L bisphenol S and 0.74(0.74,1.42)μg/L bisphenol F.The levels of bisphenol A and bisphenol S in the severe renal injury group were higher than those in the healthy control group,the mild renal injury group and the moderate renal injury group(all P<0.05).Bisphenol B and bisphenol F were not statistically different among the four groups.(2)Bisphenol A and bisphenol S were negatively correlated with eGFR(r=-0.779,P<0.001;r=-0.546,P<0.001).(3)Among CKD patients,bisphenol A was correlated with diabetes(OR=4.951,95% CI 1.603-15.294,P=0.005),and bis-phenol S was correlated with hypertension(OR=4.466,95% CI 1.575-12.666,P=0.005).Conclusion CKD patients have a variety of bisphenol compounds,especially bisphenol A and bisphenol S.Bisphenol A and bisphenol S have high levels,and their exposures are correlated with renal function.展开更多
Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early childhood.These findings warrant an investigation of the relationship between p...Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early childhood.These findings warrant an investigation of the relationship between prenatal bisphenol exposure and the dynamic growth of offspring.This study aimed to evaluate the relationship of maternal bisphenol concentration in urine with the body mass index(BMI)growth trajectory of children aged up to two years and to identify the critical exposure periods.Methods A total of 826 mother–offspring pairs were recruited from Wuhan Children’s Hospital between November 2013 and March 2015.Maternal urine samples collected during the first,second,and third trimesters were analyzed for bisphenol A(BPA),bisphenol S,and bisphenol F(BPF)concentrations.Measurements of length and weight were taken at 0,1,3,6,8,12,18,and 24 months.Children's BMI was standardized using the World Health Organization reference,and group-based trajectory modeling was used to identify BMI growth trajectories.The associations between prenatal bisphenol exposure and BMI growth trajectory patterns were assessed using multinomial logistic regression models.Results The BMI growth trajectories of the 826 children were categorized into four patterns:low-stable(n=134,16.2%),low-increasing(n=142,17.2%),moderate-stable(n=350,42.4%),and moderate-increasing(n=200,24.2%).After adjusting for potential confounders,we observed that prenatal exposure to BPA during the second trimester[odds ratio(OR)=2.20,95%confidence interval(CI)=1.09–4.43]and BPF during the third trimester(OR=3.28,95%CI=1.55–6.95)at the highest quartile concentration were associated with an increased likelihood of the low-increasing BMI trajectory.Furthermore,in the subgroup analysis by infant sex,the positive association between the highest quartile of prenatal average urinary BPF concentration during the whole pregnancy and the low-increasing BMI trajectory was found only in girls(OR=2.82,95%CI=1.04–7.68).Conclusion Our study findings suggest that prenatal exposure to BPA and BPF(a commonly used substitute for BPA)is associated with BMI growth trajectories in offspring during the first two years,increasing the likelihood of the low-increasing pattern.展开更多
For decades,lignin-the rigid polymer that gives plants their structure-has been the“problem child”of green chemistry.When processed,its molecules tangle like stubborn knots,forming useless clumps.Then came 2024’s t...For decades,lignin-the rigid polymer that gives plants their structure-has been the“problem child”of green chemistry.When processed,its molecules tangle like stubborn knots,forming useless clumps.Then came 2024’s transformative solution-breaking lignin’s tangles at the molecular level.In that May,a team led by scientists from the Chinese Academy of Sciences(CAS)came up with an approach to make this“knotty problem”profitable by hacking lignin’s chemistry to spin it into bio-bisphenols.展开更多
Bisphenol A(BPA)is a pervasive endocrine disruptor that enters the environment through anthropogenic activities,posing significant risks to ecosystems and human health.Advanced oxidation processes(AOPs)are promising m...Bisphenol A(BPA)is a pervasive endocrine disruptor that enters the environment through anthropogenic activities,posing significant risks to ecosystems and human health.Advanced oxidation processes(AOPs)are promising methods for the removal of organic microcontaminants in the environment.Biogenic manganese oxides(BMO)are reported as catalysts due to their transitionmetal nature,and are also readily generated bymanganeseoxidizing microorganisms in the natural environment,and therefore their roles and effects in AOPs-based environmental remediation should be investigated.However,biogenic ironmanganese oxides(BFMO)are actually generated rather than BMO due to the coexistence of ferrous ionswhich can be oxidized to iron oxides.Therefore,this study produced BFMO originating from a highly efficientmanganese-oxidizing fungus Cladosporium sp.XM01 and chose peroxymonosulfate(PMS)as a typical oxidant for the degradation of bisphenol A(BPA),a model organic micropollutant.Characterization results indicate that the formed BFMO was amorphouswith a lowcrystallinity.The BFMO/PMS system achieved a high degradation performance that 85%BPA was rapidly degraded within 60min,and therefore the contribution of BFMO cannot be ignored during PMS-based environmental remediation.Different from the findings of previous studies(mostly radicals and singlet oxygen),the degradationmechanism was first proven as a 100%electron-transfer pathway mediated by high-valence Mn under acidic conditions provided by PMS.The findings of this study provide new insights into the degradation mechanisms of pollutants using biogenic metal oxides in PMS activation and the contribution of their coexistence in AOPs-based environmental remediation.展开更多
Bisphenol A(BPA)is an industrial pollutant that can cause immune impairment.Selenium acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ damage.This study is the first t...Bisphenol A(BPA)is an industrial pollutant that can cause immune impairment.Selenium acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ damage.This study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)stress.We established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 days.The results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,NADPH.In vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ferroptosis.Overall,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.展开更多
In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_...In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_(2),Pd/CeO_(2),Pd/TiO_(2)and Pd/Al2O3),Pd/TiO_(2)exhibited the highest catalytic activity due to the high isoelectric point and high Pd0 content.Pd/TiO_(2)prepared by the deposition method leads to high Pd dispersion,which are the key factors for efficient BPF degradation.The influencing factors were investigated during the reaction process and two possible degradation pathways were proposed.Density functional theory(DFT)calculations demonstrate that stronger BPF adsorption and BPF degradation with lower reaction barrier occurs on smaller Pd particles.The catalytic activities are strongly dependent on the structural features of the catalysts.Both experiments and theoretical calculations prove that the reaction is actuated by electron transfer rather than radicals.展开更多
Bisphenol compounds(BPs)have various industrial uses and can enter the environment through various sources.To evaluate the ecotoxicity of BPs and identify potential gene candidates involved in the plant toxicity,Arabi...Bisphenol compounds(BPs)have various industrial uses and can enter the environment through various sources.To evaluate the ecotoxicity of BPs and identify potential gene candidates involved in the plant toxicity,Arabidopsis thaliana was exposed to bisphenol A(BPA),BPB,BPE,BPF,and BPS at 1,3,10 mg/L for a duration of 14 days,and their growth status were monitored.At day 14,roots and leaves were collected for internal BPs exposure concentration detection,RNA-seq(only roots),and morphological observations.As shown in the results,exposure to BPs significantly disturbed root elongation,exhibiting a trend of stimulation at low concentration and inhibition at high concentration.Additionally,BPs exhibited pronounced generation of reactive oxygen species,while none of the pollutants caused significant changes in root morphology.Internal exposure concentration analysis indicated that BPs tended to accumulate in the roots,with BPS exhibiting the highest level of accumulation.The results of RNA-seq indicated that the shared 211 differently expressed genes(DEGs)of these 5 exposure groups were enriched in defense response,generation of precursormetabolites,response to organic substance,response to oxygen-containing,response to hormone,oxidation-reduction process and so on.Regarding unique DEGs in each group,BPS wasmainly associated with the redox pathway,BPB primarily influenced seed germination,and BPA,BPE and BPF were primarily involved in metabolic signaling pathways.Our results provide newinsights for BPs induced adverse effects on Arabidopsis thaliana and suggest that the ecological risks associated with BPA alternatives cannot be ignored.展开更多
Bisphenol A(BPA)has threatened ecological safety and human health due to its endocrine disrupting effect and widely diffused in the environment.Peroxymonosulfate(PMS)based on oxidation technology exhibits good potenti...Bisphenol A(BPA)has threatened ecological safety and human health due to its endocrine disrupting effect and widely diffused in the environment.Peroxymonosulfate(PMS)based on oxidation technology exhibits good potential for environmental remediation whereas the highly efficient activator needs to be developed.Herein,the Bi OBr(BOB)was synthesized to efficiently activate PMS to remove 95.6%of BPA within 60 min.The observed rate constant of BPA removal in BOB/PMS system is 0.049 min^(-1),which is 60 and 148 times to that of the BOB and PMS processes separately and 129 times to the compared Bi OCl(BOC)/PMS system,respectively.Comparison experiments and analytic methods demonstrate that BOB with a larger content of oxygen vacancies(Ov)can act as the bridge of electron transfer between Bi^(3+)/Bi^(4+)with PMS to enhance the activation ability for PMS,resulting in the production of abundant reactive oxygen species(O_(2)^(·-)and ^(1)O_(2)).Additionally,the breakdown processes of BPA and the toxicity of its byproducts were uncovered,and the potential for actual water treatment was evaluated to confirm the detoxification,efficiency,stability and practical use of the BOB/PMS system for eliminating BPA.This study may widen the application of traditional semiconductors and develop the cost-effective PMS activation methods for environmental remediation.展开更多
Wastewater contains various high-risk trace organic pollutants,such as antibiotics and endocrine disruptors,which seriously restrict wastewater reuse.Cyclodextrin-based functional materials show great potential in the...Wastewater contains various high-risk trace organic pollutants,such as antibiotics and endocrine disruptors,which seriously restrict wastewater reuse.Cyclodextrin-based functional materials show great potential in the removal of trace pollutants because of their adsorption catalytic synergy.Clarifying the synergistic mechanism of cyclodextrin in oxidation is the key issue in confined catalytic oxidation process design.In this work,we fabricated a BiOIO_(3)@BiOBr/β-CD heterojunction photocatalyst to study the synergistic mechanism of cyclodextrin in the photocatalytic oxidation process.The synergistic mechanism of cyclodextrin was investigated by combining radical chemistry,electrochemistry,spectroscopy,and timedependent density functional theory.Results showed that the excited intermediate free radicals played an important role in promoting the photocatalytic degradation process.The heterojunction photocatalyst loaded withβ-cyclodextrin(β-CD)at the electronic end(C[Cat.]=0.2mg/mL)removed about 97%of bisphenol A(BPA)within 30min,and the first-order kinetic constant(k_(CDBIB)=0.112 min^(−1))was about twice that of the unloadedβ-CD(k_(BIB)=0.057 min^(−1)).Cyclodextrin loading improved the photocatalytic performance of the heterojunction and stimulated the intermediate to increase the free radical yield and regulate the reaction path.展开更多
Bisphenol A(BPA)is a recognized estrogenic endocrine disruptor that poses a threat to the reproductive health of fish.However,it remains unclear whether and how paternal BPA exposure can lead to developmental toxicity...Bisphenol A(BPA)is a recognized estrogenic endocrine disruptor that poses a threat to the reproductive health of fish.However,it remains unclear whether and how paternal BPA exposure can lead to developmental toxicity in offspring.To explore the potential paternal BPA exposure impacts on craniofacial cartilage growth in offspring,male rare minnows were subjected to BPA and subsequently mated with normal females to produce progeny.Our results demonstrated that paternal BPA exposure resulted in increased malformation and delayed craniofacial cartilage development in the F1 offspring.Furthermore,BPA exposure led to differential expression of 28 miRNAs in paternal sperm in F0 generation(13 upregulated and 15 downregulated),among which 7 miRNAs were involved in the regulation of bone development.BPA also downregulated the expression of bmp2a and Runx1 during F1 embryonic development.The inhibited bmp2a expression might derive from BPA's stimulation of one miRNA,aca-miR-16a-5P,due to bmp2a being one of its target genes.Notably,paternal BPA exposure did not affect craniofacial cartilage development or gonadal development in the F2 generation.Overall,our study sheds light on the molecular mechanisms underlying the impact of paternal BPA exposure on facial chondrogenesis in offspring and provides theoretical support for the ecological protection of fish populations.展开更多
Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several ha...Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several harmful outcomes,such as diabetes mellitus and cardiovascular diseases[1].展开更多
基金supported by the National Natural Science Foundation of China(No.22176071)the Natural Science Foundation of Guangdong Province,China(No.2023A1515011879).
文摘Phthalate(PAEs)and Bisphenols(BPs)are plasticizers or additives in consumer products.They are typical endocrine disruptors,and potential health hazards may occur when people are exposed to them through inhalation,ingestion,and dermal contact.The current research on inhalation exposure pays limited attention to the particle distribution of PAEs and BPs in air,although particulate-bound pollutants are usually size-dependent.In this study,we discussed the size resolution of PAEs and BPs in air particles from city waste recycling plants.With paired urine samples of the workers,we also compared the internal and external exposure of PAEs and BPs and related potential health risks.The particulatebound PAEs and BPs concentrated mainly on coarse particles(Dp>2.1μm),with a bimodal distribution,and the peak particle size ranged from 9–10 to 4.7–5.85μm,respectively.Model calculation revealed that the deposition fluxes of PAEs in different respiratory regions followed the sequence of head airways(167±92.8 ng/h)>alveolar region(18.9±9.96 ng/h)>tracheobronchial region(9.20±5.22 ng/h),and the similar trends went for BPs.The daily intakes of PAEs and BPs via dust ingestion were higher than those fromrespiratory inhalation and dermal contact,with mean value of 96 and 0.88 ng/(kg-bw day),respectively.For internal exposure,the estimated daily intakes of PAEs for waste recycling workers were higher than those in e-waste dismantling workers,while the exposure levels of bisphenols were comparable.Overall,the potential health risks from inhalation exposure to particulate-bound PAEs and BPs were low.
基金supported by the Preventive medicine and public health research project of Anhui,China(No.2011Y0103)the Natural Science Foundation of Anhui,China(No.11040606M216)
文摘To establish an analytical method for determination of four bisphenols （BPA, BPB, BPF, and BPS） and two alkylphenols （4-n-OP, 4-n-NP） in water by ultra performance liquid chromatography- tandem mass spectrometry （UPLC/MS/MS）. The water samples were extracted and condensed with solid-phase extraction （SPE） using C18 cartridges and eluted by acetonitrile. Separation was carried out with Acquity BEH C8 column and detection were performed by UPLC/MS/MS. Quantification was calculated by using the internal standard BPA-d16 and 4-n-NP-d8. The linear correlation coefficients of these compounds in the range of 1.0-100.0μg/L were all over 0.999. The minimum detectable concentrations were 0.75-1.0 ng/L, and the recoveries ranged from 87.0% to 106.9%.
基金Supported by the National Natural Science Foundation of China(No.5 94 6 30 0 1)
文摘Bisphenols containing long aliphatic hydrocarbon side chains were synthesized by the condensation of phenol with aldehyde or ketone in the presence of heteropolyacid. Their structures were characterized by IR, 1H NMR, 13C NMR and element analysis. The experiment results show that when heteropolyacid was used as a catalyst, these bisphenols were obtained in high selectivity and high yields.
基金sponsored by the National Natural Science Foundation of China(Nos.22076038 and 22376053)Henan key scientific research programs to Universities and Colleges(No.22ZX003)。
文摘In view of widespread existence and toxicity,removal and detection of bisphenols is imperative to asses environmental risks and reduce harm to human health.Although many techniques have been reported constructing fast and sensitive method remains a challenge.Herein,porous poly(divinylbenzene)polyme was synthesized in-situ on the Fe_(3)O_(4)particles by means of distillation-precipitation polymerization and functioned as sorbents to extract bisphenols.Employing Fe_(3)O_(4)@poly(divinylbenzene)as sorbent,a mag netic solid-phase extraction coupling with liquid chromatography was developed to detect trace bisphe nols in water.This method presented low detection limits(0.01–0.03 ng/m L),high enrichment ability(en richment factor,327–343),and good reproducibility.Moreover,the method showed satisfactory recoverie in the detection of lake water(80.60%-116.2%)and egg sample(75.17%-120.0%).Impressively,Fe_(3)O_(4)@PDVB has excellent adsorption capacity,which can realize rapid kinetic adsorption of bisphenols with equi librium time all less than 10 s.The maximum adsorption capacities reached 1074.8,1049.7,1299.1 and 1329.5 mg/g for bisphenol F,bisphenol A,bisphenol B and bisphenol AF with Langmuir isotherm model The adsorption mechanism of Fe_(3)O_(4)@PDVB to bisphenols was investigated and demonstrated that hy drophobic interactions played a key role,together with assistance ofπ-πstacking interactions and hy drogen interactions.Overall,this work provides a promising sorbent material with ultra-fast and large adsorption capacities for extraction of bisphenols from water.
基金This work was financially supported by the National Natural Science Foundation of China(Grant No.20075001).
文摘A polyclonal antibody against the currently concerned estrogenic bisphenol compounds was produced according to a new scheme. 4,4-Bis (4-hydroxyphenyl) valeric acid was used to synthesize the complete antigen in which the characteristic bisphenol structure was exposed to the largest extent. The produced polyclonal antibody showed high specificity and affinity for bisphenol A.
基金the“Margarita Salas”postdoctoral fellowship from the Universidad de Alcaláand FPI fellowships from the Universidad de Alcalá.
文摘BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st century.In recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPS,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the art.Subsequently,a meta-analysis was performed to unify the existing quantitative data.METHODS Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of results.Subsequently,three authors analyzed the set of articles.Finally,a meta-analysis was performed for each BP,using RevMan software.In addition,funnel plots were developed to study publication bias.RESULTS The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study paradigm.The qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPS,BPF and BPAF.Finally,the meta-analysis determined a positive relationship with BPS,BPF and BPAF,which was only statistically significant with BPS.CONCLUSION There is a need to apply the precautionary principle,regulating the use of new BPs.Therefore,replacing BPA with BPS,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.
基金the National Natural Science Foundation of China for Distinguished Young Scholars(grant no.32425039)Youth Fund(grant no.32301543)the Outstanding Youth Fund of the National Forestry and Grassland Administration(grant no.20201326005).
文摘Valorization of lignin is essential for establishing a profitable biorefining in-dustry,yet its efficiency is critically constrained by lignin condensation.Un-derstanding lignin condensation mechanisms and developing effective strategies to inhibit condensation have emerged as a global research imperative.
基金Foundation for the Advancement of Sciences(KFAS)for funding the project Chemical Safety of Children's Toys and Baby Products Sold in the State of Kuwait:A Preliminary Assessment(PR17-41BO-01).
文摘A major concern from the scientific community has been raised since evidence of Bisphenol A(BP-A)can leach out from the products where they are incorporated as well as its endocrine disrupting effects observed in animals and humans.BP-A and several related chemicals such as Bisphenol AP(BP-AP),Bisphenol B(BPeB),Bisphenol S(BPeS),Bisphenol AF(BP-AF),Bisphenol(BPeP),Bisphenol Z(BP-Z)were analyzed in this study.BP-A and BP-S were the only bisphenols detected in the samples analyzed in this study.The median(range;mean)concentrations of BP-A found in this study was 321 ng/g(11-200932;4893 ng/g).The analysis was carried out by sonicating 0.1 g of a cryo-milled sample aliquot in methanol followed by UPLC-MS/MS determination.High concentrations of BP-A were found in several products labeled as BP-A free such as nursing bottles which are particularly problematic from the children's exposure point of view.This study presents the first reliable bisphenols in children's toys and baby products commercialized in the Middle East.There is,however,a need to continue monitoring these compounds,especially in low-cost toys,and the so-called BP-A-free products,which appear to have high levels of target contaminants and can pose an exposure risk for infants and children in the region.
基金supported by the National Key Research and Development Program of China(NO.2023YFD1301505,No.2017YFC1600303)the Agricultural Science and Technology Innovation Program of CAAS(CAAS-ASTIP-IQSTAP-04)Prof.Giesy was supported by the Canada Research Chair program,the 2012"High Level Foreign Experts"(#GDT20143200016)program,funded by the State Administration of Foreign Experts Affairs,the P.R.China to Nanjing University and the Einstein Professor Program of the Chinese Academy of Sciences and a Distinguished Visiting Professorship in the Department of Environmental Sciences,Baylor University in Waco,TX,USA.
文摘Emerging synthetic or derivative chemicals have drawn global concern due to their potential endocrine-disrupting effects,either as agonists or antagonists or through indirect effects on enzymes of signal transduction pathways.Currently,in vitro screening models are limited to poor tolerance,robustness,high cost and need for sphisticated equipment or complex procedures that require high levels of expertise.Herein,a multiplex analysis platform based on autobioluminescent yeast strains,including BLYhERaS,BLYhERbS,BLYhPRS,BLYhARS,BLYhMRS,and BLYhGRS,was developed for use in easy,rapid,robust,and sensitive screening for potential modulation of endocrine systems.Methods were applied to assess endocrine-disrupting effects of Bisphenol A(BPA)and its alternatives.Disrupting activities of bisphenols(BPs)varied greatly,and some BPA substitutes exerted more potent activities than those of BPA.Most BPs were primarily agonists of ERa and ERb,while others were antagonists to AR,PR,GR,and MR.BPP and BPM exhibited non-monotonic dose-response relationships toward ERa and ERb,and BHPF and BPG displayed converse disrupting activities to ERa and ERb.Overall,the bioassay system provides an efficient tool for comprehensive evaluation of endocrine-disrupting activities of emerging contaminants.
文摘Objective To observe the levels of four bisphenols(bisphenol A,B,S and F)and their correlation with renal function in chronic kidney disease(CKD)patients.Methods Patients with CKD were identified according to Kidney Disease:Improving Global Outcomes(KDIGO)criteria.Sixty-three CKD patients and eleven healthy controls were enrolled.CKD patients were further classified as mild renal injury group(CKD stage 1 and 2,n=30),moderate renal injury group(CKD stage 3,n=19)and severe renal injury group(CKD stage 4 and 5,n=14).The levels of four bisphenols in serum were determined by high performance liquid chromatography(HPLC).The correlation between concentrations of four bisphenols and estimated glomerular filtration rate(eGFR)was assessed by Spearman's rank correlation analysis.The associations of four bisphenols with coronary heart disease,diabetes and hypertension in CKD patients were estimated by binary multivariate logistic regression.Results(1)Four bisphenols were not detected in serum of the healthy control.In the mild renal injury group the bisphenol A and bisphenol S were not detected,and patients had 5.24(5.24,9.38)μg/L bisphenol B and 0.74(0.74,0.74)μg/L bisphenol F.In the moderate renal injury group bisphenol S was not detected,and the patients had 2.79(1.01,4.53)μg/L bisphenol A,5.24(5.24,5.24)μg/L bisphenol B and 0.74(0.74,0.74)μg/L bisphenol F.In the severe renal injury group the patients had 14.30(7.97,18.17)μg/L bisphenol A,0 μg/L bisphenol B,23.73(23.73,136.59)μg/L bisphenol S and 0.74(0.74,1.42)μg/L bisphenol F.The levels of bisphenol A and bisphenol S in the severe renal injury group were higher than those in the healthy control group,the mild renal injury group and the moderate renal injury group(all P<0.05).Bisphenol B and bisphenol F were not statistically different among the four groups.(2)Bisphenol A and bisphenol S were negatively correlated with eGFR(r=-0.779,P<0.001;r=-0.546,P<0.001).(3)Among CKD patients,bisphenol A was correlated with diabetes(OR=4.951,95% CI 1.603-15.294,P=0.005),and bis-phenol S was correlated with hypertension(OR=4.466,95% CI 1.575-12.666,P=0.005).Conclusion CKD patients have a variety of bisphenol compounds,especially bisphenol A and bisphenol S.Bisphenol A and bisphenol S have high levels,and their exposures are correlated with renal function.
基金supported by the National Natural Science Foundation of China(81903331 and 82073660)Open Project of Key Laboratory of Environment and Health,Ministry of Education(2022GWKFJJ05).
文摘Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early childhood.These findings warrant an investigation of the relationship between prenatal bisphenol exposure and the dynamic growth of offspring.This study aimed to evaluate the relationship of maternal bisphenol concentration in urine with the body mass index(BMI)growth trajectory of children aged up to two years and to identify the critical exposure periods.Methods A total of 826 mother–offspring pairs were recruited from Wuhan Children’s Hospital between November 2013 and March 2015.Maternal urine samples collected during the first,second,and third trimesters were analyzed for bisphenol A(BPA),bisphenol S,and bisphenol F(BPF)concentrations.Measurements of length and weight were taken at 0,1,3,6,8,12,18,and 24 months.Children's BMI was standardized using the World Health Organization reference,and group-based trajectory modeling was used to identify BMI growth trajectories.The associations between prenatal bisphenol exposure and BMI growth trajectory patterns were assessed using multinomial logistic regression models.Results The BMI growth trajectories of the 826 children were categorized into four patterns:low-stable(n=134,16.2%),low-increasing(n=142,17.2%),moderate-stable(n=350,42.4%),and moderate-increasing(n=200,24.2%).After adjusting for potential confounders,we observed that prenatal exposure to BPA during the second trimester[odds ratio(OR)=2.20,95%confidence interval(CI)=1.09–4.43]and BPF during the third trimester(OR=3.28,95%CI=1.55–6.95)at the highest quartile concentration were associated with an increased likelihood of the low-increasing BMI trajectory.Furthermore,in the subgroup analysis by infant sex,the positive association between the highest quartile of prenatal average urinary BPF concentration during the whole pregnancy and the low-increasing BMI trajectory was found only in girls(OR=2.82,95%CI=1.04–7.68).Conclusion Our study findings suggest that prenatal exposure to BPA and BPF(a commonly used substitute for BPA)is associated with BMI growth trajectories in offspring during the first two years,increasing the likelihood of the low-increasing pattern.
文摘For decades,lignin-the rigid polymer that gives plants their structure-has been the“problem child”of green chemistry.When processed,its molecules tangle like stubborn knots,forming useless clumps.Then came 2024’s transformative solution-breaking lignin’s tangles at the molecular level.In that May,a team led by scientists from the Chinese Academy of Sciences(CAS)came up with an approach to make this“knotty problem”profitable by hacking lignin’s chemistry to spin it into bio-bisphenols.
基金supported by the National Key Research and Development Program of China(No.2021YFC3200700)the National Natural Science Foundation of China(No.52400010)+1 种基金the Science and Technology Commission of Shanghai Municipality(No.24ZR1472300)the Fundamental Research Funds for the Central Universities.
文摘Bisphenol A(BPA)is a pervasive endocrine disruptor that enters the environment through anthropogenic activities,posing significant risks to ecosystems and human health.Advanced oxidation processes(AOPs)are promising methods for the removal of organic microcontaminants in the environment.Biogenic manganese oxides(BMO)are reported as catalysts due to their transitionmetal nature,and are also readily generated bymanganeseoxidizing microorganisms in the natural environment,and therefore their roles and effects in AOPs-based environmental remediation should be investigated.However,biogenic ironmanganese oxides(BFMO)are actually generated rather than BMO due to the coexistence of ferrous ionswhich can be oxidized to iron oxides.Therefore,this study produced BFMO originating from a highly efficientmanganese-oxidizing fungus Cladosporium sp.XM01 and chose peroxymonosulfate(PMS)as a typical oxidant for the degradation of bisphenol A(BPA),a model organic micropollutant.Characterization results indicate that the formed BFMO was amorphouswith a lowcrystallinity.The BFMO/PMS system achieved a high degradation performance that 85%BPA was rapidly degraded within 60min,and therefore the contribution of BFMO cannot be ignored during PMS-based environmental remediation.Different from the findings of previous studies(mostly radicals and singlet oxygen),the degradationmechanism was first proven as a 100%electron-transfer pathway mediated by high-valence Mn under acidic conditions provided by PMS.The findings of this study provide new insights into the degradation mechanisms of pollutants using biogenic metal oxides in PMS activation and the contribution of their coexistence in AOPs-based environmental remediation.
基金supported by the National Natural Science Foundation of China Regional Joint Innovation Fund (No.U22A20524)the Heilongjiang Province Natural Science Foundation Key projects (No.ZD2023C002).
文摘Bisphenol A(BPA)is an industrial pollutant that can cause immune impairment.Selenium acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ damage.This study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)stress.We established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 days.The results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,NADPH.In vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ferroptosis.Overall,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.
基金supported by the National Natural Science Foundation of China(NSFC)(No.21978137).
文摘In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_(2),Pd/CeO_(2),Pd/TiO_(2)and Pd/Al2O3),Pd/TiO_(2)exhibited the highest catalytic activity due to the high isoelectric point and high Pd0 content.Pd/TiO_(2)prepared by the deposition method leads to high Pd dispersion,which are the key factors for efficient BPF degradation.The influencing factors were investigated during the reaction process and two possible degradation pathways were proposed.Density functional theory(DFT)calculations demonstrate that stronger BPF adsorption and BPF degradation with lower reaction barrier occurs on smaller Pd particles.The catalytic activities are strongly dependent on the structural features of the catalysts.Both experiments and theoretical calculations prove that the reaction is actuated by electron transfer rather than radicals.
基金supported by the National Science Foundation of China (No.22106098)the Youth Science and Technology Research Foundation of Shanxi Province (No.20210302124298)+2 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (Nos.2020L0174,and 2020L0025)the Startup Foundation for Doctors of Shanxi Province (No.SD1917)the Startup Foundation for Doctors of Shanxi Medical University (No.XD1917).
文摘Bisphenol compounds(BPs)have various industrial uses and can enter the environment through various sources.To evaluate the ecotoxicity of BPs and identify potential gene candidates involved in the plant toxicity,Arabidopsis thaliana was exposed to bisphenol A(BPA),BPB,BPE,BPF,and BPS at 1,3,10 mg/L for a duration of 14 days,and their growth status were monitored.At day 14,roots and leaves were collected for internal BPs exposure concentration detection,RNA-seq(only roots),and morphological observations.As shown in the results,exposure to BPs significantly disturbed root elongation,exhibiting a trend of stimulation at low concentration and inhibition at high concentration.Additionally,BPs exhibited pronounced generation of reactive oxygen species,while none of the pollutants caused significant changes in root morphology.Internal exposure concentration analysis indicated that BPs tended to accumulate in the roots,with BPS exhibiting the highest level of accumulation.The results of RNA-seq indicated that the shared 211 differently expressed genes(DEGs)of these 5 exposure groups were enriched in defense response,generation of precursormetabolites,response to organic substance,response to oxygen-containing,response to hormone,oxidation-reduction process and so on.Regarding unique DEGs in each group,BPS wasmainly associated with the redox pathway,BPB primarily influenced seed germination,and BPA,BPE and BPF were primarily involved in metabolic signaling pathways.Our results provide newinsights for BPs induced adverse effects on Arabidopsis thaliana and suggest that the ecological risks associated with BPA alternatives cannot be ignored.
基金financially supported by the National Key Research and Development Program of China(No.2022YFC3703103)National Natural Science Foundation of China(Nos.22206053,42277427)the Guangzhou Science and Technology Plan Project(No.2024A04J4058)。
文摘Bisphenol A(BPA)has threatened ecological safety and human health due to its endocrine disrupting effect and widely diffused in the environment.Peroxymonosulfate(PMS)based on oxidation technology exhibits good potential for environmental remediation whereas the highly efficient activator needs to be developed.Herein,the Bi OBr(BOB)was synthesized to efficiently activate PMS to remove 95.6%of BPA within 60 min.The observed rate constant of BPA removal in BOB/PMS system is 0.049 min^(-1),which is 60 and 148 times to that of the BOB and PMS processes separately and 129 times to the compared Bi OCl(BOC)/PMS system,respectively.Comparison experiments and analytic methods demonstrate that BOB with a larger content of oxygen vacancies(Ov)can act as the bridge of electron transfer between Bi^(3+)/Bi^(4+)with PMS to enhance the activation ability for PMS,resulting in the production of abundant reactive oxygen species(O_(2)^(·-)and ^(1)O_(2)).Additionally,the breakdown processes of BPA and the toxicity of its byproducts were uncovered,and the potential for actual water treatment was evaluated to confirm the detoxification,efficiency,stability and practical use of the BOB/PMS system for eliminating BPA.This study may widen the application of traditional semiconductors and develop the cost-effective PMS activation methods for environmental remediation.
基金supported by Program of Shanghai Outstanding Technology Leaders(No.20XD1433900)the National Natural Science Foundation of China(No.52370168).
文摘Wastewater contains various high-risk trace organic pollutants,such as antibiotics and endocrine disruptors,which seriously restrict wastewater reuse.Cyclodextrin-based functional materials show great potential in the removal of trace pollutants because of their adsorption catalytic synergy.Clarifying the synergistic mechanism of cyclodextrin in oxidation is the key issue in confined catalytic oxidation process design.In this work,we fabricated a BiOIO_(3)@BiOBr/β-CD heterojunction photocatalyst to study the synergistic mechanism of cyclodextrin in the photocatalytic oxidation process.The synergistic mechanism of cyclodextrin was investigated by combining radical chemistry,electrochemistry,spectroscopy,and timedependent density functional theory.Results showed that the excited intermediate free radicals played an important role in promoting the photocatalytic degradation process.The heterojunction photocatalyst loaded withβ-cyclodextrin(β-CD)at the electronic end(C[Cat.]=0.2mg/mL)removed about 97%of bisphenol A(BPA)within 30min,and the first-order kinetic constant(k_(CDBIB)=0.112 min^(−1))was about twice that of the unloadedβ-CD(k_(BIB)=0.057 min^(−1)).Cyclodextrin loading improved the photocatalytic performance of the heterojunction and stimulated the intermediate to increase the free radical yield and regulate the reaction path.
基金supported by the National Natural Science Foundation of China(No.31670523)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.23KJB180005)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20230690)Jiangsu Ocean University Graduate Research and Practice Innovation Program Project(No.KYCX2023-105).
文摘Bisphenol A(BPA)is a recognized estrogenic endocrine disruptor that poses a threat to the reproductive health of fish.However,it remains unclear whether and how paternal BPA exposure can lead to developmental toxicity in offspring.To explore the potential paternal BPA exposure impacts on craniofacial cartilage growth in offspring,male rare minnows were subjected to BPA and subsequently mated with normal females to produce progeny.Our results demonstrated that paternal BPA exposure resulted in increased malformation and delayed craniofacial cartilage development in the F1 offspring.Furthermore,BPA exposure led to differential expression of 28 miRNAs in paternal sperm in F0 generation(13 upregulated and 15 downregulated),among which 7 miRNAs were involved in the regulation of bone development.BPA also downregulated the expression of bmp2a and Runx1 during F1 embryonic development.The inhibited bmp2a expression might derive from BPA's stimulation of one miRNA,aca-miR-16a-5P,due to bmp2a being one of its target genes.Notably,paternal BPA exposure did not affect craniofacial cartilage development or gonadal development in the F2 generation.Overall,our study sheds light on the molecular mechanisms underlying the impact of paternal BPA exposure on facial chondrogenesis in offspring and provides theoretical support for the ecological protection of fish populations.
基金supported in part by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.82304253).
文摘Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several harmful outcomes,such as diabetes mellitus and cardiovascular diseases[1].
