目的:探讨全身免疫炎症指数(Systemic Immune Inflammation Index,SII)与急性重症胰腺炎(Acute Severe Pancreatitis,SAP)的相关性,并评估SII联合急性胰腺炎严重程度床边指数(Bedside Index for Severity in Acute Pancreatitis,BISAP)...目的:探讨全身免疫炎症指数(Systemic Immune Inflammation Index,SII)与急性重症胰腺炎(Acute Severe Pancreatitis,SAP)的相关性,并评估SII联合急性胰腺炎严重程度床边指数(Bedside Index for Severity in Acute Pancreatitis,BISAP)对SAP的早期预测价值。方法:选取149名急性胰腺炎(Acute Pancreatitis,AP)患者,根据病情严重程度分为SAP组和非SAP组,比较2组患者SII和BISAP评分,分析各项实验室指标对SAP的早期预测价值。结果:SAP组患者SII、BISAP评分均高于非SAP组(P<0.05)。ROC曲线展示SII、BISAP评分及两者联合预测SAP的曲线下面积(AUC)分别为0.818(95%CI:0.747~0.890),0.878(95%CI:0.821~0.935)和0.923(95%CI:0.879~0.967)。结论:SII结合BISAP评分对SAP的早期预测有着一定的临床价值。展开更多
Objective:To investigate the value of dynamic monitoring of serum interleukin(IL)-33 and tumor necrosis factor(TNF)-αlevels in the early diagnosis,severity assessment and prognosis of acute pancreatitis(AP)combined w...Objective:To investigate the value of dynamic monitoring of serum interleukin(IL)-33 and tumor necrosis factor(TNF)-αlevels in the early diagnosis,severity assessment and prognosis of acute pancreatitis(AP)combined with abdominal CT radiomics and intestinal microbiota data.Methods:A total of 170 AP patients were admitted immediately after the onset of the disease and divided into MAP group(85 cases)and SAP group(85 cases).The levels of serum IL-33,TNF-α,IL-6,and HMGB1,as well as the expression of miRNA-155 in extracellular vesicles(EVs),were dynamically monitored at multiple time points(0 h,6 h,12 h,24 h,3 d,5 d,7 d,14 d)after admission.Abdominal CT radiomics analyzed the texture characteristics of pancreatic necrosis,and stool samples collected at admission were metagenomic sequencing of the gut microbiome.The Acute Pancreatitis Severity Bedside Index(BISAP)score is calculated within 48 hours of admission.Multivariate regression analysis assessed the independent effects of various factors on the prognosis of mortality groups.Results:Serum IL-33 and TNF-αlevels in SAP patients were significantly higher than those in MAP patients(p<0.05)at all time points,peaked on day 3,and decreased with treatment.The levels of these cytokines in patients with SIRS were also higher than in patients without SIRS(p<0.05).The serum IL-33,TNF-αlevels and BISAP scores in the mortality group were higher than those in the survival group(p<0.05).Multivariate regression analysis showed that serum IL-33(OR=3.21,95%CI:1.12–9.23,p=0.03),TNF-α(OR=4.05,95%CI:1.37–11.96,p=0.01),and BISAP score(OR=5.67,95%CI:1.83–17.54,p<0.01)were independent prognostic risk factors.Spearman correlation analysis showed that serum IL-33 and TNF-αlevels were positively correlated with BISAP scores(r=0.68,p<0.01;r=0.73,p<0.01).Conclusion:Dynamic monitoring of serum IL-33 and TNF-αlevels combined with BISAP score has important clinical value for early diagnosis,severity assessment,treatment guidance and prognosis evaluation of AP,and provides a basis for accurate diagnosis and treatment.展开更多
目的比较BISAP评分与Ranson’s评分在预测急性胰腺炎(acute pancreatitis,AP)的严重度及病死率方面的运用价值。方法以2007年6月到2010年10月入住本院的AP患者为研究对象,资料完整诊断明确者共有652例,采用BISAP(the bedside index for ...目的比较BISAP评分与Ranson’s评分在预测急性胰腺炎(acute pancreatitis,AP)的严重度及病死率方面的运用价值。方法以2007年6月到2010年10月入住本院的AP患者为研究对象,资料完整诊断明确者共有652例,采用BISAP(the bedside index for severity in AP)评分与Ranson’s评分比较,受试者工作特性曲线(receiver-operating curve,ROC)行回顾性分析,在预计AP的严重度及病死率方面的差异。结果在652例患者中,通过发病48 h内出现器官衰竭确定为重症者108例(16.6%),共死亡21例(3.2%),BISAP评分≥3分的44例(6.7%),入院48 h内Ranson’s评分≥3分者213例(32.7%)。BISAP与Ranson’s评分二者在评价预后方面的差异有统计学意义,其中严重度的曲线下面积BISAP、Ranson’s评分系统分别为:0.846(95%CI 0.808～0.883),0.771(95%CI 0.722～0.820);死亡率分别是:0.809(95%CI 0.699～0.920),0.762(95%CI 0.638～0.885)。结论 BISAP评分系统在急性胰腺炎早期,针对患者严重度、死亡率的预后评估的准确性明显高于Ranson’s评分,是目前最简易、及时、连续性强并且对患者而言经济花费少的评分系统,可在临床广泛推广。展开更多
目的:研究BISAP(bedside index for severity in AP)评分联合凝血指标对急性胰腺炎(acute pancreatitis,AP)严重程度评估的意义.方法:回顾2008-2012年中国医科大学附属盛京医院收治的166例AP患者的临床资料.对所有患者进行入院24h的BISA...目的:研究BISAP(bedside index for severity in AP)评分联合凝血指标对急性胰腺炎(acute pancreatitis,AP)严重程度评估的意义.方法:回顾2008-2012年中国医科大学附属盛京医院收治的166例AP患者的临床资料.对所有患者进行入院24h的BISAP、APACHE-Ⅱ评分,48h的Ranson's及发病72h内CTSI评分,入院24h内抽取静脉血测定部分凝血活酶活化时间、凝血酶原时间、D-二聚体(D-dimer)、纤维蛋白原及血小板水平.分析凝血指标及BISAP评分对AP严重程度判断的意义,并通过ROC曲线分析二者联合对AP严重程度评估的意义.结果:多因素Logistic回归分析发现,D-dimer对AP严重程度评估具有独立预测意义;随着BISAP评分增加,SAP的比率增加;BISAP评分系统评估AP严重程度以2为临界点时Youden指数最大(0.541),ROC曲线下面积为0.836(0.776-0.896),并不逊于传统评分系统;BISAP评分系统联合D-dimer能更好地评估AP患者的严重程度.结论:BISAP是临床判断AP轻重程度的简单有效的指标,将BISAP与D-dimer联合应用使得对AP严重程度的评估更为准确.展开更多
目的探讨新型BISAP评分体系(bedside index for severity in AP)对重症急性胰腺炎(SAP)的评估价值。方法选取2008年9月-2012年2月我科收治的重症急性胰腺炎的患者68例,进行BISAP评分。BISAP评分标准包括患者入院24 h内的尿素氮水平、受...目的探讨新型BISAP评分体系(bedside index for severity in AP)对重症急性胰腺炎(SAP)的评估价值。方法选取2008年9月-2012年2月我科收治的重症急性胰腺炎的患者68例,进行BISAP评分。BISAP评分标准包括患者入院24 h内的尿素氮水平、受损精神状态、全身炎症反应综合征、年龄、胸腔积液5项内容。结果 68例SAP患者中,BISAP评分1分的0人(0),2分的21人(30.9%),3分的30人(44.1%),4分的15人(22.1%),5分的2人(2.9%)。68例患者中死亡6例,病死率8.8%,其中BISAP评分4分的死亡4人,占26.7%,BISAP评分5分的死亡2人,占100%,不同评分之间病死率差异有显著统计学意义(P<0.01)。而在相同评分中,不同CT分级对预后没有显著差异。结论 BISAP评分系统作为一种新型的、简便的评分体系可推广应用于SAP预后的评估。展开更多
目的:探讨并比较不同评分系统对急性胰腺炎(acute pancreatitis,AP)患者病情严重程度预测价值的差异性.方法:回顾分析2011-06/2013-12在辽宁医学院附属第三医院住院并治疗的120例AP患者的临床资料,分别进行床旁急性胰腺炎严重度评分(bed...目的:探讨并比较不同评分系统对急性胰腺炎(acute pancreatitis,AP)患者病情严重程度预测价值的差异性.方法:回顾分析2011-06/2013-12在辽宁医学院附属第三医院住院并治疗的120例AP患者的临床资料,分别进行床旁急性胰腺炎严重度评分(bedside index for severity in acute pancreatitis,BISAP)及与急性生理学及慢性健康状况评分Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ),并绘制受试者工作曲线,比较两者对AP病情严重程度的预测价值.结果:BISAP评分及与APACHEⅡ评分的分值均随着病情的价值、局部并发症、器官衰竭及死亡率的增加而增加,差异具有统计学意义(P<0.05).BISAP评分及与APACHEⅡ评分在预测AP患者病情严重程度时,曲线下面积分别为0.821,0.903,前者的敏感度为74.5%,特异度为71.3%,阳性预测值为57.1%,阴性预测值为84.6%,均显著低于APACHEⅡ评分的对应值(分别为87.5%、83.0%、70.8%、90.2%),且差异有统计学意义(P<0.05).结论:BISAP评分及与APACHEⅡ评分均能对A P患者病情的严重程度进行预测,但前者操作更简单,易于临床推广.展开更多
文摘目的:探讨全身免疫炎症指数(Systemic Immune Inflammation Index,SII)与急性重症胰腺炎(Acute Severe Pancreatitis,SAP)的相关性,并评估SII联合急性胰腺炎严重程度床边指数(Bedside Index for Severity in Acute Pancreatitis,BISAP)对SAP的早期预测价值。方法:选取149名急性胰腺炎(Acute Pancreatitis,AP)患者,根据病情严重程度分为SAP组和非SAP组,比较2组患者SII和BISAP评分,分析各项实验室指标对SAP的早期预测价值。结果:SAP组患者SII、BISAP评分均高于非SAP组(P<0.05)。ROC曲线展示SII、BISAP评分及两者联合预测SAP的曲线下面积(AUC)分别为0.818(95%CI:0.747~0.890),0.878(95%CI:0.821~0.935)和0.923(95%CI:0.879~0.967)。结论:SII结合BISAP评分对SAP的早期预测有着一定的临床价值。
文摘Objective:To investigate the value of dynamic monitoring of serum interleukin(IL)-33 and tumor necrosis factor(TNF)-αlevels in the early diagnosis,severity assessment and prognosis of acute pancreatitis(AP)combined with abdominal CT radiomics and intestinal microbiota data.Methods:A total of 170 AP patients were admitted immediately after the onset of the disease and divided into MAP group(85 cases)and SAP group(85 cases).The levels of serum IL-33,TNF-α,IL-6,and HMGB1,as well as the expression of miRNA-155 in extracellular vesicles(EVs),were dynamically monitored at multiple time points(0 h,6 h,12 h,24 h,3 d,5 d,7 d,14 d)after admission.Abdominal CT radiomics analyzed the texture characteristics of pancreatic necrosis,and stool samples collected at admission were metagenomic sequencing of the gut microbiome.The Acute Pancreatitis Severity Bedside Index(BISAP)score is calculated within 48 hours of admission.Multivariate regression analysis assessed the independent effects of various factors on the prognosis of mortality groups.Results:Serum IL-33 and TNF-αlevels in SAP patients were significantly higher than those in MAP patients(p<0.05)at all time points,peaked on day 3,and decreased with treatment.The levels of these cytokines in patients with SIRS were also higher than in patients without SIRS(p<0.05).The serum IL-33,TNF-αlevels and BISAP scores in the mortality group were higher than those in the survival group(p<0.05).Multivariate regression analysis showed that serum IL-33(OR=3.21,95%CI:1.12–9.23,p=0.03),TNF-α(OR=4.05,95%CI:1.37–11.96,p=0.01),and BISAP score(OR=5.67,95%CI:1.83–17.54,p<0.01)were independent prognostic risk factors.Spearman correlation analysis showed that serum IL-33 and TNF-αlevels were positively correlated with BISAP scores(r=0.68,p<0.01;r=0.73,p<0.01).Conclusion:Dynamic monitoring of serum IL-33 and TNF-αlevels combined with BISAP score has important clinical value for early diagnosis,severity assessment,treatment guidance and prognosis evaluation of AP,and provides a basis for accurate diagnosis and treatment.
文摘目的:研究BISAP(bedside index for severity in AP)评分联合凝血指标对急性胰腺炎(acute pancreatitis,AP)严重程度评估的意义.方法:回顾2008-2012年中国医科大学附属盛京医院收治的166例AP患者的临床资料.对所有患者进行入院24h的BISAP、APACHE-Ⅱ评分,48h的Ranson's及发病72h内CTSI评分,入院24h内抽取静脉血测定部分凝血活酶活化时间、凝血酶原时间、D-二聚体(D-dimer)、纤维蛋白原及血小板水平.分析凝血指标及BISAP评分对AP严重程度判断的意义,并通过ROC曲线分析二者联合对AP严重程度评估的意义.结果:多因素Logistic回归分析发现,D-dimer对AP严重程度评估具有独立预测意义;随着BISAP评分增加,SAP的比率增加;BISAP评分系统评估AP严重程度以2为临界点时Youden指数最大(0.541),ROC曲线下面积为0.836(0.776-0.896),并不逊于传统评分系统;BISAP评分系统联合D-dimer能更好地评估AP患者的严重程度.结论:BISAP是临床判断AP轻重程度的简单有效的指标,将BISAP与D-dimer联合应用使得对AP严重程度的评估更为准确.
文摘目的探讨新型BISAP评分体系(bedside index for severity in AP)对重症急性胰腺炎(SAP)的评估价值。方法选取2008年9月-2012年2月我科收治的重症急性胰腺炎的患者68例,进行BISAP评分。BISAP评分标准包括患者入院24 h内的尿素氮水平、受损精神状态、全身炎症反应综合征、年龄、胸腔积液5项内容。结果 68例SAP患者中,BISAP评分1分的0人(0),2分的21人(30.9%),3分的30人(44.1%),4分的15人(22.1%),5分的2人(2.9%)。68例患者中死亡6例,病死率8.8%,其中BISAP评分4分的死亡4人,占26.7%,BISAP评分5分的死亡2人,占100%,不同评分之间病死率差异有显著统计学意义(P<0.01)。而在相同评分中,不同CT分级对预后没有显著差异。结论 BISAP评分系统作为一种新型的、简便的评分体系可推广应用于SAP预后的评估。
文摘目的:探讨并比较不同评分系统对急性胰腺炎(acute pancreatitis,AP)患者病情严重程度预测价值的差异性.方法:回顾分析2011-06/2013-12在辽宁医学院附属第三医院住院并治疗的120例AP患者的临床资料,分别进行床旁急性胰腺炎严重度评分(bedside index for severity in acute pancreatitis,BISAP)及与急性生理学及慢性健康状况评分Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ),并绘制受试者工作曲线,比较两者对AP病情严重程度的预测价值.结果:BISAP评分及与APACHEⅡ评分的分值均随着病情的价值、局部并发症、器官衰竭及死亡率的增加而增加,差异具有统计学意义(P<0.05).BISAP评分及与APACHEⅡ评分在预测AP患者病情严重程度时,曲线下面积分别为0.821,0.903,前者的敏感度为74.5%,特异度为71.3%,阳性预测值为57.1%,阴性预测值为84.6%,均显著低于APACHEⅡ评分的对应值(分别为87.5%、83.0%、70.8%、90.2%),且差异有统计学意义(P<0.05).结论:BISAP评分及与APACHEⅡ评分均能对A P患者病情的严重程度进行预测,但前者操作更简单,易于临床推广.
