Inflammatory bowel disease(IBD)is a chronic inflammatory condition characterized by recurrent inflammation of the gastrointestinal tract.Its pathogenesis is multifactorial,but accumulating evidence has highlighted tha...Inflammatory bowel disease(IBD)is a chronic inflammatory condition characterized by recurrent inflammation of the gastrointestinal tract.Its pathogenesis is multifactorial,but accumulating evidence has highlighted that the homeostasis of the microbiome plays a remarkable role in the development and treatment of IBD.The commensal microbiome supports the development of the mucosal immune system as well as the proper function of the intestinal epithelial barrier.However,the pathogenic microbiome leads to inflammation and intestinal epithelial barrier dysfunction,resulting in disease development.Natural food bioactives,including polyphenols,polysaccharides,terpenoids,glycosides,etc.,provide a protective benefit for IBD by exerting immunomodulatory effects and barrier repair function by altering gut microbiota.Therefore,in this review,we focused on the antiinflammatory mechanisms and intestinal barrier repair mechanisms of natural food bioactives behind the action of the gut microbiota.The improved understanding of the properties of food bioactives in regulating gut microbiota will facilitate their application in improving nutritional strategies and management of IBD.展开更多
Micronization is an evolving technique used to reduce the particle size and improve the nutritional quality,functionality,and encapsulation efficiency(EE)of food derived bioactives.Micronization by supercritical fluid...Micronization is an evolving technique used to reduce the particle size and improve the nutritional quality,functionality,and encapsulation efficiency(EE)of food derived bioactives.Micronization by supercritical fluid technology(SCF)is an emerging green process that is an effective method for stabilizing bioactive compounds with controlled sizes and shapes,with merits such as continuous processing over conventional methods.This review briefly outlines the properties of SCFs and comprises all the SCFs along with their underlying working,mechanism,components,process,advantages and limitations.Additionally,it provides a detailed overview of SCF technology applications,which has been extensively applied on fruits and vegetables derived bioactives along with herbs,species,meat,fish,dairy,cereal,and legumes derived bioactives.This study further covers the factors influencing micronized particle size and EE,such as temperature,pressure,and mass ratio.SCF technologies have been successfully applied to different food bioactives because of their high diffusivity,rapid mass transfer,and effective solubilization.These technologies have proven to be valuable in particle formation processes where different processing conditions,including pressure and temperature,significantly influence the resulting particle characteristics.SCF applications have led to significant improvements,including a 100%increase in EE and particle size reduction to less than 10μm.Future research should focus on sectors such as dairy,meat and cereals,which are less explored for enhancing the stability of compounds along with their encapsulation.展开更多
Background:Herbal lozenges offer convenient nutraceutical release,yet limited studies have systematically evaluated the combined effect of encapsulating agents on bioactive retention,release kinetics,and functional pr...Background:Herbal lozenges offer convenient nutraceutical release,yet limited studies have systematically evaluated the combined effect of encapsulating agents on bioactive retention,release kinetics,and functional properties.This study addresses this gap by developing liquorice root-,clove-,and ginger-based lozenges using cornstarch and guar gum.Methods:Lozenges with varying formulations were prepared and characterized for physicochemical properties(hardness,friability,disintegration,color),proximate composition,phytochemical content,bioactive retention(total phenolics,antioxidant activity,glycyrrhizin),sensory attributes,microbiological stability,and In vitro release kinetics.FTIR and SEM analyses assessed molecular interactions and microstructure.Results:Cornstarch lozenges were harder,less friable,and delivered more sustained release,while guar gum matrices released bioactives faster and disintegrated more slowly.Phytochemical analysis confirmed glycosides,flavonoids,phenolics,saponins,phytosterols,coumarins,and tannins,with higher retention in liquorice-rich formulations.Bioactive evaluation revealed maximal total phenolic content,antioxidant activity,and glycyrrhizin in S2C and S2G.Release kinetics followed a biphasic,concentration-dependent pattern(first-order and Korsmeyer-Peppas models).Sensory evaluation identified S2C as the most acceptable option(8.6±0.3),and microbiological stability indicated a shelf life of 49 days.Conclusion:Cornstarch and guar gum differentially modulate the lozenge microstructure,bioactive stability,and sustained release,providing a novel strategy for the oral release of nutraceutical herbal compounds.Future work may focus on extending shelf life,incorporating additional bioactives,and exploring targeted oral release of nutraceutical bioactives for enhanced therapeutic efficacy.展开更多
The food industry is vigorously searching for bioactive compounds with therapeutic potential that are derived from unexplored natural sources.Ankol plant(Alangium salvifolium)is an underutilized small deciduous shrub ...The food industry is vigorously searching for bioactive compounds with therapeutic potential that are derived from unexplored natural sources.Ankol plant(Alangium salvifolium)is an underutilized small deciduous shrub that reaches a height of 10 m and is underutilized as a culinary plant.It can be found largely in the plains and lower mountain regions throughout India and elsewhere in East Africa to China,New Guinea,Indonesia,and Vietnam.This plant is a vital source of high value-added ingredients,including anthocyanin and flavonoid pigments,alkaloid,tannin,and phenols that can be of great interest to the food industry as functional colorants and additives.The present review highlights the potential of Ankol plant(A.salvifolium)as valuable source of bioactive compounds for the development of functional foods.A.salvifolium is an important source of structurally varied bioactive compounds with distinct anti-diabetic,anti-cancer,anti-spasmodic,anti-inflammatory,analgesic,anti-arthritic,anti-protozoal,anti-hypertensive and cardio-protective properties.The results of molecular tests indicate the presence of numerous novel phytochemicals and biochemical substances,paving the way for future scientific discoveries for various aspects.展开更多
Poor nutrition predisposes to infection,and various food compounds,such as micronutrients,are key elements of immune competence.A large number of scientific publications have suggested a role of phytochemicals,food bi...Poor nutrition predisposes to infection,and various food compounds,such as micronutrients,are key elements of immune competence.A large number of scientific publications have suggested a role of phytochemicals,food bioactives and nutrition in combating the current coronavirus pandemic.Various dietary components and specific food supplements have been proposed to be helpful in the prevention or therapy of COVID-19.While findings in preclinical models suggest that food bioactives and micronutrients may potentially augment viral defense,evidence supporting antiviral and immunomodulatory efficacy of these compounds in the prevention or management of COVID-19 is non-existent.Large-scale epidemiological and well-designed clinical studies investigating dosage and combinations of food compounds in different age groups and populations are needed before any recommendations can be made.Both malnutrition and overnutrition can adversely affect the immune system.Malnutrition at population level appears to be associated with elevated rates of fatal outcomes of COVID-19.Obesity and non-communicable diseases have been found to be a prognostic risk factor associated with worse COVID-19 outcomes.A focus on obesity and nutrition-related chronic diseases should be a key element of public health.This approach would be more effective than the far less promising search for food bioactives with potential immune-supportive efficacy.展开更多
Type 2 diabetes mellitus(T2DM)was identified as the most prevalent form of diabetes.This study employed an integrated strategy combining network pharmacology,metabolomics,and experimental validation to elucidate the t...Type 2 diabetes mellitus(T2DM)was identified as the most prevalent form of diabetes.This study employed an integrated strategy combining network pharmacology,metabolomics,and experimental validation to elucidate the therapeutic mechanisms of red mulberry water extract(RMW)in T2DM.Systematic analysis identified six bioactive constituents,with four key components(cyanidin,quercetin,morin,andβ-carotene)demonstrating significant interactions with diabetes-related targets.Network pharmacology revealed these compounds modulate critical pathways including AMPK(P=2.3×10^(−5)),PI3K-Akt(P=1.8×10^(−4)),and PPAR signaling(P=3.1×10^(−3)).In diabetic mice,treatment significantly improved glycemic control(32.5%reduction in fasting glucose,P<0.01),lipid profiles(36.7%lower TG,P<0.05),antioxidant activity(2.1-fold increased SOD,P<0.05),and inflammation(42%reduced TNF-α,P<0.05).Metabolomic analysis further confirmed alterations in catecholamine and lipid metabolism pathways.These findings collectively demonstrate mulberry's multi-target therapeutic potential through synergistic regulation of glucose metabolism,lipid homeostasis,oxidative stress,and inflammatory responses in diabetes.展开更多
In the current study,agro-industrial waste(banana peels and de-oiled groundnut cake)was valorised through submerged fermentation employing Calocybe indica.The fermented agro-waste revealed an increase in Ergosta-compo...In the current study,agro-industrial waste(banana peels and de-oiled groundnut cake)was valorised through submerged fermentation employing Calocybe indica.The fermented agro-waste revealed an increase in Ergosta-compounds,(3.57%),which include Ergosta-5,7,9(11),22-tetraen-3-ol,(3.beta.,22E)-(1.87%),Ergosta-5,7,22-trien-3-ol,(3.beta.,22e)-(1.24%)and Ergosta-7,22-dien-3-ol,(3.beta.,5.alpha.,22E)-(0.46%).A reduction of phytic acid(26.25-6.84 mg/100g),oxalate(81.82-18.69 mg/100g),water holding capacity(34.29-30.97 ml/g),least gelation concentration(18-12.5%),bulk density(6.82-2.28 g/ml)and swelling volume(9.5-6.1 ml/g)with an increase inβ-glucan(8-24.57%),dispersibility(78.27-92.92%),oil holding capacity(0.59-1.73 ml/g),valine(ten-fold)and threonine(four-fold)seen in the fermented product makes it suitable for the food industry.GC-MS analysis confirmed the enriched levels of bioactive compounds namely,(S)-(-)-Perillyl alcohol,α.-Longipinene,isozonarol,widdrol,hydroxy valerenic acid,reynosin,β-Eudesmol,lupenone,etc.in fermented agro-waste mixture.The valorised agro-waste-mycelia mixture can be used as a potential nutraceutically enriched health supplement in the food and pharma industries.展开更多
Curcuma is a traditional Chinese medicine that has been utilized for centuries in the treatment of various diseases. Terpenoids, particularly monoterpenes and sesquiterpenes, constitute the primary bioactive component...Curcuma is a traditional Chinese medicine that has been utilized for centuries in the treatment of various diseases. Terpenoids, particularly monoterpenes and sesquiterpenes, constitute the primary bioactive components of the essential oil derived from Curcuma species.Among these, curdione—one of the key active constituents—has been identified in 25 Curcuma species, with the highest concentration reported in the rhizome essential oil of Curcuma trichosantha Gagnep. Curdione can also be synthesized through chemical methods,and its regio-and stereo-selectivity can be further optimized via chemo-bio transformations.This compound demonstrates significant therapeutic potential, including anticancer, antithrombotic, anti-inflammatory, anti-viral, anti-fungal, anti-diabetic, and multi-organ protective properties. Despite these promising biological activities, its clinical application is hindered by poor water solubility and potential toxicity. This review summarizes current knowledge on the natural sources, chemical synthesis, chemo-bio transformations, metabolism, pharmacokinetics, pharmacological effects, potential toxicities, and molecular mechanisms of curdione. Furthermore, perspectives on future drug development are discussed with the aim of promoting the clinical translation of this promising natural compound.展开更多
Arisaema propinquum(A.propinquum)is a medicinal tuberous plant native to the Himalayan region,belonging to the family Araceae.It has a unique appearance due to its inflorescence,which is strikingly elegant and resembl...Arisaema propinquum(A.propinquum)is a medicinal tuberous plant native to the Himalayan region,belonging to the family Araceae.It has a unique appearance due to its inflorescence,which is strikingly elegant and resembles that of Arisaema triphyllum,also known as“Jack-in-the-pulpit”.This review provides a comprehensive overview of A.propinquum,covering its taxonomy,geographic distribution,and traditional uses.While ethnobotanical information on A.propinquum is relatively well documented,species-specific pharmacological,mechanistic,and in vivo studies remain limited.Accordingly,evidence from related Arisaema species is discussed cautiously as contextual support for phytochemical similarity rather than as direct proof of bioactivity in A.propinquum.This study seeks to establish a relationship between ethnopharmacological use and scientific enquiries into A.propinquum,including a comparison of the various species of the family Araceae and their recent contributions to traditional medicinal advancements.The review mainly emphasises the traditional uses,phytochemistry,safety and toxicity data,and future techniques for its conservation,with increased yield and impact.It highlights A.propinquum as an underexplored yet promising candidate for focused phytochemical characterisation,experimental validation of traditional claims,and conservation-oriented research.Overall,the available evidence indicates that while direct experimental data on the plant remain limited,its placement within a genus rich in bioactive secondary metabolites makes it a strong candidate for focused,species-specific future research.展开更多
Eucommia ulmoides is an important economic forest tree species in China,of which the different tissues and organs are widely used in traditional medicine for their abundant bioactive ingredients.Previous studies alway...Eucommia ulmoides is an important economic forest tree species in China,of which the different tissues and organs are widely used in traditional medicine for their abundant bioactive ingredients.Previous studies always focused on the Eucommia gum,a potential alternative to natural rubber because of its“rubber plastic duality”.In recent years,Eucommia has increasingly attracted more attention and interest for its excellent nutritional and economic value,with the deepening of research and the development of products involving in the application of bioactive ingredients.However,the dietary health effects and future application prospects of the bioactive components of E.ulmoides have not been systematically summarized.Therefore,we firstly reviewed the main bioactive ingredients category,structural characteristics,extraction methods and nutritive value.Furthermore,we also summarized the wide application of bioactive ingredients in food and medicine fields.Finally,this review provides a comprehensive overview of the safety and future development of products derived from E.ulmoides,as well as exploring potential applications for its bioactive constituents,aiming to facilitate further extensive investigation into its utilization.展开更多
Delivery carriers serve as a highly efficient approach for precision nutrition and medicine;however,artificial delivery carriers are prone to triggering the immune response and have the disadvantages of poor stability...Delivery carriers serve as a highly efficient approach for precision nutrition and medicine;however,artificial delivery carriers are prone to triggering the immune response and have the disadvantages of poor stability and low bioavailability.Extracellular vesicles(EVs),nucleus-free biological particles composed of phospholipid bilayers secreted by living cells,are a new generation of targeted delivery carriers.In recent years,an increasing number of species have been reported to contain EVs.Among them,food-derived extracellular vesicles(FDEVs)show outstanding comprehensive properties.FDEVs are considered to have great application potential due to their wide range of sources,high yields,absence of human pathogenic pathogens,and ethical concerns.In this review,the preparation,nomenclature,physicochemical characteristics,and preservation methods of FDEVs are discussed,as well as their potential protein markers,bioactivities,and applications as novel targeted delivery carriers of FDEVs from animals,plants,and microorganisms.We also summarized the adverse consequences of FDEVs in current studies,and put forward the problems and challenges in the process of FDEVs research and commercialization.In short,the importance of FDEVs has been highlighted,and FDEVs have good application prospects as a new class of targeted delivery carriers.The current problems should be paid attention to and actively solved.展开更多
Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which h...Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which have been associated with multiple health-promoting properties(Azuma et al.,2008;Gurbuz et al.,2018).Given its significant hybrid vigor,F1 hybrid varieties are widely preferred in commercial cultivation(Mistry et al.,2018).However,traditional breeding practices predominantly rely on phenotypic selection,a process that is not only labor-intensive but also time-consuming.展开更多
Members of genus Chrysanthemum,comprising approximately 40 species,hold economic significance as edible,medicinal,and ornamental plants.Among these species,Chrysanthemum indicum and the cultivated chrysanthemum C.mori...Members of genus Chrysanthemum,comprising approximately 40 species,hold economic significance as edible,medicinal,and ornamental plants.Among these species,Chrysanthemum indicum and the cultivated chrysanthemum C.morifolium have been used for tea and traditional Chinese medicine to treat common cold symptoms,impaired vision,dizziness,and skin irritation.The medicinal properties of chrysanthemum are primarily derived from its bioactive compounds,including flavonoids.展开更多
Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights...Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights recent progress in implant design,material development,additive manufacturing,and preclinical evaluation.Emerging biomaterials,including bioresorbable polymers,magnesium alloys,and composites with bioactive ceramics,enable patient-specific solutions with improved safety and functionality.Triply periodic minimal surface(TPMS) architectures exemplify how structural design can enhance both mechanical performance and biological integration.Additive manufacturing technologies further allow the fabrication of geometrically complex,customized impla nts that meet individual anatomical and pathological needs.In parallel,multiscale evaluation techniques—from mechanical testing to in vitro and in vivo models—provide comprehensive insights into implant performance and safety.Looking ahead,the field is poised to benefit from several transformative trends:the development of smart and multifunctional biomaterials;Al-driven design frameworks that leverage patient-specific data and computational modeling;predictive additive manufacturing with real-time quality control;and advanced biological testing platforms for preclinical evaluation.Together,these advances form the foundation of a data-informed,translational pipeline from bench to bedside.Realizing the full potential of nextgene ration CMFIs will require close interdisciplina ry collaboration across mate rials science,computational engineering,and clinical medicine.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.展开更多
Herbal bioactives have been shown to influence the pathogenesis of homocysteine associated vascular complications.However,there are no simple cellular models to study their role in preventing angiogenesis impairment b...Herbal bioactives have been shown to influence the pathogenesis of homocysteine associated vascular complications.However,there are no simple cellular models to study their role in preventing angiogenesis impairment by homocysteine and adenosine.Using dipyridamole,an inhibitor for nucleoside transport,we examined its mechanism of action on impaired展开更多
Salinization of agricultural land is becoming increasingly severe worldwide,posing a significant threat to food security.The exogenous application of bioactive substances has been widely used to enhance plant resistan...Salinization of agricultural land is becoming increasingly severe worldwide,posing a significant threat to food security.The exogenous application of bioactive substances has been widely used to enhance plant resistance to salt stress.In this study,we used corn steep liquor(CSL),myo-inositol(MI),and their combination to improve salt tolerance in Chinese cabbage(Brassica rapa L.ssp.pekinensis)under salt stress conditions.All three treatments significantly increased plant biomass and nutrient uptake,and improved soil physicochemical properties,while alleviating oxidative damage and ion toxicity.展开更多
Co-encapsulation of bioactive is an emerging field which shows promising approach to develop functionally active food products. Health-promoting components including antioxidants, vitamins, essential oils or flavors, ...Co-encapsulation of bioactive is an emerging field which shows promising approach to develop functionally active food products. Health-promoting components including antioxidants, vitamins, essential oils or flavors, and antimicrobials could be successfully delivered in functional foods by co-encapsulating in suitable wall matrix. Co-encapsulation is especially useful as this concept takes into account the synergistic effect of multiple bioactives in enhancing bioactivity to target specific health benefits. The review focusses on various factors governing the stability of the microencapsulated system such as drying methods and temperature, selection of wall material, surfactant, co-excipient, emulsion homogenizing speed, and appropriate combination of the bioactive for co-encapsulation to get synergistic effects. Effective results have been demonstrated by several researchers, but further studies would help in unravelling the full potential of this technique in food system.展开更多
Fruits are a rich source of bioactive compounds and form a major component of the total horticultural produce.Unfortunately,fruit wastes that contains a wide range of bioactive compounds such as phenolics,minerals,die...Fruits are a rich source of bioactive compounds and form a major component of the total horticultural produce.Unfortunately,fruit wastes that contains a wide range of bioactive compounds such as phenolics,minerals,dietary fibre,vitamins,oils,and enzymes,to name a few,are discarded.The post-processing by-products of fruit processing industries include the peel,pomace,and seeds.Owing to the presence substantial contents of bioactive compounds,these fruit by-products have been explored for the recovery of bioactives using several extraction techniques.Amongst the various techniques studied for the extraction of bioactives,supercritical fluid extraction(SCFE)has captured the interest of researchers,mainly because it overcomes the limitations posed by conventional extraction methods.This review discusses SCFE as a green technique for the extraction of bioactives(polyphenols,vitamins,pigments and fatty acids)from fruit wastes,and factors that affect SCFE therefrom.Furthermore,the bioactivities of these components such as anti-diabetic,anti-oxidants,anti-inflammatory,anti-microbial,anti-cancer,cardioprotective,and neuroprotective agents have been highlighted.Lastly,future prospects of using SCFE for ensuring optimal extraction of bioactives and their potential biological and food applications have been discussed.展开更多
Jamun(Syzygium cumini Skeels)is a nutritious fruit and has historically been used as both as an edible and a traditional medicine.The jamun seed is an inedible by-product of the fruit.However,their high concentration ...Jamun(Syzygium cumini Skeels)is a nutritious fruit and has historically been used as both as an edible and a traditional medicine.The jamun seed is an inedible by-product of the fruit.However,their high concentration of phytochemicals makes them valuable components of nutraceuticals.Various studies on diverse biological activities of jamun seeds have warranted their application in human health and biomedical fields.This review paper discusses critically the phytochemical composition of jamun seeds and the bioactivities,including their antioxidant,anti-inflammatory,anti-cancer,antidiabetic,anti-microbial,anti-obesity,hepato-protective,cardio and gastro-protective properties.The bioactivity of jamun seed is related to the presence of phenols,flavonoids,steroids,alkaloids,triterpenoids,tannins,and saponins.Animal research in vivo,and in vitro experiments with human and animal cell models support the idea that jamun seed extract can be valuable additions in food and biomedical fields due to the diverse bio-functional properties.However,in-depth and systematic in vivo clinical trials using human subjects must be conducted to confirm the safe consumption limit and establish other therapeutic roles of jamun seeds for their abundant utilization as a nutraceutical or pharmacological component.Moreover,research is required to understand the exact mechanisms of the bioactivities exhibited by jamun seeds.展开更多
基金the support of the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine.(No:ZYYCXTD-C-202009)Tianjin Municipal Health Commission Project(No.2024009)Science&Technology Devel-opment Fund of Tianjin Education Commission for Higher Education(2021KJ132).
文摘Inflammatory bowel disease(IBD)is a chronic inflammatory condition characterized by recurrent inflammation of the gastrointestinal tract.Its pathogenesis is multifactorial,but accumulating evidence has highlighted that the homeostasis of the microbiome plays a remarkable role in the development and treatment of IBD.The commensal microbiome supports the development of the mucosal immune system as well as the proper function of the intestinal epithelial barrier.However,the pathogenic microbiome leads to inflammation and intestinal epithelial barrier dysfunction,resulting in disease development.Natural food bioactives,including polyphenols,polysaccharides,terpenoids,glycosides,etc.,provide a protective benefit for IBD by exerting immunomodulatory effects and barrier repair function by altering gut microbiota.Therefore,in this review,we focused on the antiinflammatory mechanisms and intestinal barrier repair mechanisms of natural food bioactives behind the action of the gut microbiota.The improved understanding of the properties of food bioactives in regulating gut microbiota will facilitate their application in improving nutritional strategies and management of IBD.
文摘Micronization is an evolving technique used to reduce the particle size and improve the nutritional quality,functionality,and encapsulation efficiency(EE)of food derived bioactives.Micronization by supercritical fluid technology(SCF)is an emerging green process that is an effective method for stabilizing bioactive compounds with controlled sizes and shapes,with merits such as continuous processing over conventional methods.This review briefly outlines the properties of SCFs and comprises all the SCFs along with their underlying working,mechanism,components,process,advantages and limitations.Additionally,it provides a detailed overview of SCF technology applications,which has been extensively applied on fruits and vegetables derived bioactives along with herbs,species,meat,fish,dairy,cereal,and legumes derived bioactives.This study further covers the factors influencing micronized particle size and EE,such as temperature,pressure,and mass ratio.SCF technologies have been successfully applied to different food bioactives because of their high diffusivity,rapid mass transfer,and effective solubilization.These technologies have proven to be valuable in particle formation processes where different processing conditions,including pressure and temperature,significantly influence the resulting particle characteristics.SCF applications have led to significant improvements,including a 100%increase in EE and particle size reduction to less than 10μm.Future research should focus on sectors such as dairy,meat and cereals,which are less explored for enhancing the stability of compounds along with their encapsulation.
文摘Background:Herbal lozenges offer convenient nutraceutical release,yet limited studies have systematically evaluated the combined effect of encapsulating agents on bioactive retention,release kinetics,and functional properties.This study addresses this gap by developing liquorice root-,clove-,and ginger-based lozenges using cornstarch and guar gum.Methods:Lozenges with varying formulations were prepared and characterized for physicochemical properties(hardness,friability,disintegration,color),proximate composition,phytochemical content,bioactive retention(total phenolics,antioxidant activity,glycyrrhizin),sensory attributes,microbiological stability,and In vitro release kinetics.FTIR and SEM analyses assessed molecular interactions and microstructure.Results:Cornstarch lozenges were harder,less friable,and delivered more sustained release,while guar gum matrices released bioactives faster and disintegrated more slowly.Phytochemical analysis confirmed glycosides,flavonoids,phenolics,saponins,phytosterols,coumarins,and tannins,with higher retention in liquorice-rich formulations.Bioactive evaluation revealed maximal total phenolic content,antioxidant activity,and glycyrrhizin in S2C and S2G.Release kinetics followed a biphasic,concentration-dependent pattern(first-order and Korsmeyer-Peppas models).Sensory evaluation identified S2C as the most acceptable option(8.6±0.3),and microbiological stability indicated a shelf life of 49 days.Conclusion:Cornstarch and guar gum differentially modulate the lozenge microstructure,bioactive stability,and sustained release,providing a novel strategy for the oral release of nutraceutical herbal compounds.Future work may focus on extending shelf life,incorporating additional bioactives,and exploring targeted oral release of nutraceutical bioactives for enhanced therapeutic efficacy.
文摘The food industry is vigorously searching for bioactive compounds with therapeutic potential that are derived from unexplored natural sources.Ankol plant(Alangium salvifolium)is an underutilized small deciduous shrub that reaches a height of 10 m and is underutilized as a culinary plant.It can be found largely in the plains and lower mountain regions throughout India and elsewhere in East Africa to China,New Guinea,Indonesia,and Vietnam.This plant is a vital source of high value-added ingredients,including anthocyanin and flavonoid pigments,alkaloid,tannin,and phenols that can be of great interest to the food industry as functional colorants and additives.The present review highlights the potential of Ankol plant(A.salvifolium)as valuable source of bioactive compounds for the development of functional foods.A.salvifolium is an important source of structurally varied bioactive compounds with distinct anti-diabetic,anti-cancer,anti-spasmodic,anti-inflammatory,analgesic,anti-arthritic,anti-protozoal,anti-hypertensive and cardio-protective properties.The results of molecular tests indicate the presence of numerous novel phytochemicals and biochemical substances,paving the way for future scientific discoveries for various aspects.
文摘Poor nutrition predisposes to infection,and various food compounds,such as micronutrients,are key elements of immune competence.A large number of scientific publications have suggested a role of phytochemicals,food bioactives and nutrition in combating the current coronavirus pandemic.Various dietary components and specific food supplements have been proposed to be helpful in the prevention or therapy of COVID-19.While findings in preclinical models suggest that food bioactives and micronutrients may potentially augment viral defense,evidence supporting antiviral and immunomodulatory efficacy of these compounds in the prevention or management of COVID-19 is non-existent.Large-scale epidemiological and well-designed clinical studies investigating dosage and combinations of food compounds in different age groups and populations are needed before any recommendations can be made.Both malnutrition and overnutrition can adversely affect the immune system.Malnutrition at population level appears to be associated with elevated rates of fatal outcomes of COVID-19.Obesity and non-communicable diseases have been found to be a prognostic risk factor associated with worse COVID-19 outcomes.A focus on obesity and nutrition-related chronic diseases should be a key element of public health.This approach would be more effective than the far less promising search for food bioactives with potential immune-supportive efficacy.
文摘Type 2 diabetes mellitus(T2DM)was identified as the most prevalent form of diabetes.This study employed an integrated strategy combining network pharmacology,metabolomics,and experimental validation to elucidate the therapeutic mechanisms of red mulberry water extract(RMW)in T2DM.Systematic analysis identified six bioactive constituents,with four key components(cyanidin,quercetin,morin,andβ-carotene)demonstrating significant interactions with diabetes-related targets.Network pharmacology revealed these compounds modulate critical pathways including AMPK(P=2.3×10^(−5)),PI3K-Akt(P=1.8×10^(−4)),and PPAR signaling(P=3.1×10^(−3)).In diabetic mice,treatment significantly improved glycemic control(32.5%reduction in fasting glucose,P<0.01),lipid profiles(36.7%lower TG,P<0.05),antioxidant activity(2.1-fold increased SOD,P<0.05),and inflammation(42%reduced TNF-α,P<0.05).Metabolomic analysis further confirmed alterations in catecholamine and lipid metabolism pathways.These findings collectively demonstrate mulberry's multi-target therapeutic potential through synergistic regulation of glucose metabolism,lipid homeostasis,oxidative stress,and inflammatory responses in diabetes.
基金supported by“DST INSPIRE[DST/INSPIRE/03/2015/005291]GOI,New Delhi,Indian Institute of Technology(IIT)Delhi,Ministry of Food Processing Industries(MoFPI),GOI[Sanctioned number F.No.Q-11/9/2018-RandD dt.17 Dec 2018]Chaman Lal Setia Exports Ltd.,Karnal,Haryana”.
文摘In the current study,agro-industrial waste(banana peels and de-oiled groundnut cake)was valorised through submerged fermentation employing Calocybe indica.The fermented agro-waste revealed an increase in Ergosta-compounds,(3.57%),which include Ergosta-5,7,9(11),22-tetraen-3-ol,(3.beta.,22E)-(1.87%),Ergosta-5,7,22-trien-3-ol,(3.beta.,22e)-(1.24%)and Ergosta-7,22-dien-3-ol,(3.beta.,5.alpha.,22E)-(0.46%).A reduction of phytic acid(26.25-6.84 mg/100g),oxalate(81.82-18.69 mg/100g),water holding capacity(34.29-30.97 ml/g),least gelation concentration(18-12.5%),bulk density(6.82-2.28 g/ml)and swelling volume(9.5-6.1 ml/g)with an increase inβ-glucan(8-24.57%),dispersibility(78.27-92.92%),oil holding capacity(0.59-1.73 ml/g),valine(ten-fold)and threonine(four-fold)seen in the fermented product makes it suitable for the food industry.GC-MS analysis confirmed the enriched levels of bioactive compounds namely,(S)-(-)-Perillyl alcohol,α.-Longipinene,isozonarol,widdrol,hydroxy valerenic acid,reynosin,β-Eudesmol,lupenone,etc.in fermented agro-waste mixture.The valorised agro-waste-mycelia mixture can be used as a potential nutraceutically enriched health supplement in the food and pharma industries.
基金supported by the National Natural Science Foundation of China (Nos. 82192913 and 82304851)the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (Nos. CI2023E002, CI2021B016, and CI2021A04801)the Fundamental Research Funds for the Central Public Welfare Research Institutes (Nos. ZZ13-YQ-055 and ZXKT22044)。
文摘Curcuma is a traditional Chinese medicine that has been utilized for centuries in the treatment of various diseases. Terpenoids, particularly monoterpenes and sesquiterpenes, constitute the primary bioactive components of the essential oil derived from Curcuma species.Among these, curdione—one of the key active constituents—has been identified in 25 Curcuma species, with the highest concentration reported in the rhizome essential oil of Curcuma trichosantha Gagnep. Curdione can also be synthesized through chemical methods,and its regio-and stereo-selectivity can be further optimized via chemo-bio transformations.This compound demonstrates significant therapeutic potential, including anticancer, antithrombotic, anti-inflammatory, anti-viral, anti-fungal, anti-diabetic, and multi-organ protective properties. Despite these promising biological activities, its clinical application is hindered by poor water solubility and potential toxicity. This review summarizes current knowledge on the natural sources, chemical synthesis, chemo-bio transformations, metabolism, pharmacokinetics, pharmacological effects, potential toxicities, and molecular mechanisms of curdione. Furthermore, perspectives on future drug development are discussed with the aim of promoting the clinical translation of this promising natural compound.
基金Financial support provided by CUHP to DB in the form of a Ph.D.fellowship is also acknowledged.
文摘Arisaema propinquum(A.propinquum)is a medicinal tuberous plant native to the Himalayan region,belonging to the family Araceae.It has a unique appearance due to its inflorescence,which is strikingly elegant and resembles that of Arisaema triphyllum,also known as“Jack-in-the-pulpit”.This review provides a comprehensive overview of A.propinquum,covering its taxonomy,geographic distribution,and traditional uses.While ethnobotanical information on A.propinquum is relatively well documented,species-specific pharmacological,mechanistic,and in vivo studies remain limited.Accordingly,evidence from related Arisaema species is discussed cautiously as contextual support for phytochemical similarity rather than as direct proof of bioactivity in A.propinquum.This study seeks to establish a relationship between ethnopharmacological use and scientific enquiries into A.propinquum,including a comparison of the various species of the family Araceae and their recent contributions to traditional medicinal advancements.The review mainly emphasises the traditional uses,phytochemistry,safety and toxicity data,and future techniques for its conservation,with increased yield and impact.It highlights A.propinquum as an underexplored yet promising candidate for focused phytochemical characterisation,experimental validation of traditional claims,and conservation-oriented research.Overall,the available evidence indicates that while direct experimental data on the plant remain limited,its placement within a genus rich in bioactive secondary metabolites makes it a strong candidate for focused,species-specific future research.
基金financially supported by the National Natural Science Foundation of China(32201586 and 32301760)Key Specialized Research and Development Program in Henan Province(232102110218)+1 种基金Postdoctoral Research Start-Up Fund of Henan Province(HN2022112)Special Fund for Young Talents in Henan Agricultural University(30501318).
文摘Eucommia ulmoides is an important economic forest tree species in China,of which the different tissues and organs are widely used in traditional medicine for their abundant bioactive ingredients.Previous studies always focused on the Eucommia gum,a potential alternative to natural rubber because of its“rubber plastic duality”.In recent years,Eucommia has increasingly attracted more attention and interest for its excellent nutritional and economic value,with the deepening of research and the development of products involving in the application of bioactive ingredients.However,the dietary health effects and future application prospects of the bioactive components of E.ulmoides have not been systematically summarized.Therefore,we firstly reviewed the main bioactive ingredients category,structural characteristics,extraction methods and nutritive value.Furthermore,we also summarized the wide application of bioactive ingredients in food and medicine fields.Finally,this review provides a comprehensive overview of the safety and future development of products derived from E.ulmoides,as well as exploring potential applications for its bioactive constituents,aiming to facilitate further extensive investigation into its utilization.
基金supported by the National Natural Science Foundation of China(82373277).
文摘Delivery carriers serve as a highly efficient approach for precision nutrition and medicine;however,artificial delivery carriers are prone to triggering the immune response and have the disadvantages of poor stability and low bioavailability.Extracellular vesicles(EVs),nucleus-free biological particles composed of phospholipid bilayers secreted by living cells,are a new generation of targeted delivery carriers.In recent years,an increasing number of species have been reported to contain EVs.Among them,food-derived extracellular vesicles(FDEVs)show outstanding comprehensive properties.FDEVs are considered to have great application potential due to their wide range of sources,high yields,absence of human pathogenic pathogens,and ethical concerns.In this review,the preparation,nomenclature,physicochemical characteristics,and preservation methods of FDEVs are discussed,as well as their potential protein markers,bioactivities,and applications as novel targeted delivery carriers of FDEVs from animals,plants,and microorganisms.We also summarized the adverse consequences of FDEVs in current studies,and put forward the problems and challenges in the process of FDEVs research and commercialization.In short,the importance of FDEVs has been highlighted,and FDEVs have good application prospects as a new class of targeted delivery carriers.The current problems should be paid attention to and actively solved.
基金supported by Yuelushan Laboratory Breeding Program(Grant No.YLS-2025-ZY02013)The Project of National Key Laboratory for Tropical Crop Breeding(Grant No.NKLTCB202341)+4 种基金The New Variety Breeding Project of the Major Science and Technology Projects of Zhejiang(Grant No.2021C02065-1-3)Hunan Provincial Agricultural Science and Technology Innovation Fund Project(Grant No.2025CX115)Key R&D Projects in Hainan Province(Grant No.ZDYF2023XDNY041)Central Public-interest Scientific Institution Basal Research Fund(Grant No.1630062022003)2024 Sanya Technology Stars Program(Grant No.2024KJFX022).
文摘Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which have been associated with multiple health-promoting properties(Azuma et al.,2008;Gurbuz et al.,2018).Given its significant hybrid vigor,F1 hybrid varieties are widely preferred in commercial cultivation(Mistry et al.,2018).However,traditional breeding practices predominantly rely on phenotypic selection,a process that is not only labor-intensive but also time-consuming.
基金supported by The Scientific and technological innovation capacity building project of Beijing Academy of Agriculture and Forestry Sciences(Grant Nos.KJCX20251011,PT2025-31)the National Natural Science Foundation of China(Grant No.32402610)Chinese Universities Scientific Fund(Grant Nos.2024TC162,2025TC154).
文摘Members of genus Chrysanthemum,comprising approximately 40 species,hold economic significance as edible,medicinal,and ornamental plants.Among these species,Chrysanthemum indicum and the cultivated chrysanthemum C.morifolium have been used for tea and traditional Chinese medicine to treat common cold symptoms,impaired vision,dizziness,and skin irritation.The medicinal properties of chrysanthemum are primarily derived from its bioactive compounds,including flavonoids.
基金Financial support from National University of Singapore (NUS)(AcRF A-8000-126-00-00)。
文摘Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights recent progress in implant design,material development,additive manufacturing,and preclinical evaluation.Emerging biomaterials,including bioresorbable polymers,magnesium alloys,and composites with bioactive ceramics,enable patient-specific solutions with improved safety and functionality.Triply periodic minimal surface(TPMS) architectures exemplify how structural design can enhance both mechanical performance and biological integration.Additive manufacturing technologies further allow the fabrication of geometrically complex,customized impla nts that meet individual anatomical and pathological needs.In parallel,multiscale evaluation techniques—from mechanical testing to in vitro and in vivo models—provide comprehensive insights into implant performance and safety.Looking ahead,the field is poised to benefit from several transformative trends:the development of smart and multifunctional biomaterials;Al-driven design frameworks that leverage patient-specific data and computational modeling;predictive additive manufacturing with real-time quality control;and advanced biological testing platforms for preclinical evaluation.Together,these advances form the foundation of a data-informed,translational pipeline from bench to bedside.Realizing the full potential of nextgene ration CMFIs will require close interdisciplina ry collaboration across mate rials science,computational engineering,and clinical medicine.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.
文摘Herbal bioactives have been shown to influence the pathogenesis of homocysteine associated vascular complications.However,there are no simple cellular models to study their role in preventing angiogenesis impairment by homocysteine and adenosine.Using dipyridamole,an inhibitor for nucleoside transport,we examined its mechanism of action on impaired
基金supported by the sub-project“Research and Application of In-Situ Value-Added Water-Soluble Fertilizer Application Technology”(Grant No.2023YFD1700204-3)under the 14th Five-Year National Key R&D Program Project“Development and Industrialization of Novel Green Value-Added Fertilizers”.
文摘Salinization of agricultural land is becoming increasingly severe worldwide,posing a significant threat to food security.The exogenous application of bioactive substances has been widely used to enhance plant resistance to salt stress.In this study,we used corn steep liquor(CSL),myo-inositol(MI),and their combination to improve salt tolerance in Chinese cabbage(Brassica rapa L.ssp.pekinensis)under salt stress conditions.All three treatments significantly increased plant biomass and nutrient uptake,and improved soil physicochemical properties,while alleviating oxidative damage and ion toxicity.
文摘Co-encapsulation of bioactive is an emerging field which shows promising approach to develop functionally active food products. Health-promoting components including antioxidants, vitamins, essential oils or flavors, and antimicrobials could be successfully delivered in functional foods by co-encapsulating in suitable wall matrix. Co-encapsulation is especially useful as this concept takes into account the synergistic effect of multiple bioactives in enhancing bioactivity to target specific health benefits. The review focusses on various factors governing the stability of the microencapsulated system such as drying methods and temperature, selection of wall material, surfactant, co-excipient, emulsion homogenizing speed, and appropriate combination of the bioactive for co-encapsulation to get synergistic effects. Effective results have been demonstrated by several researchers, but further studies would help in unravelling the full potential of this technique in food system.
文摘Fruits are a rich source of bioactive compounds and form a major component of the total horticultural produce.Unfortunately,fruit wastes that contains a wide range of bioactive compounds such as phenolics,minerals,dietary fibre,vitamins,oils,and enzymes,to name a few,are discarded.The post-processing by-products of fruit processing industries include the peel,pomace,and seeds.Owing to the presence substantial contents of bioactive compounds,these fruit by-products have been explored for the recovery of bioactives using several extraction techniques.Amongst the various techniques studied for the extraction of bioactives,supercritical fluid extraction(SCFE)has captured the interest of researchers,mainly because it overcomes the limitations posed by conventional extraction methods.This review discusses SCFE as a green technique for the extraction of bioactives(polyphenols,vitamins,pigments and fatty acids)from fruit wastes,and factors that affect SCFE therefrom.Furthermore,the bioactivities of these components such as anti-diabetic,anti-oxidants,anti-inflammatory,anti-microbial,anti-cancer,cardioprotective,and neuroprotective agents have been highlighted.Lastly,future prospects of using SCFE for ensuring optimal extraction of bioactives and their potential biological and food applications have been discussed.
文摘Jamun(Syzygium cumini Skeels)is a nutritious fruit and has historically been used as both as an edible and a traditional medicine.The jamun seed is an inedible by-product of the fruit.However,their high concentration of phytochemicals makes them valuable components of nutraceuticals.Various studies on diverse biological activities of jamun seeds have warranted their application in human health and biomedical fields.This review paper discusses critically the phytochemical composition of jamun seeds and the bioactivities,including their antioxidant,anti-inflammatory,anti-cancer,antidiabetic,anti-microbial,anti-obesity,hepato-protective,cardio and gastro-protective properties.The bioactivity of jamun seed is related to the presence of phenols,flavonoids,steroids,alkaloids,triterpenoids,tannins,and saponins.Animal research in vivo,and in vitro experiments with human and animal cell models support the idea that jamun seed extract can be valuable additions in food and biomedical fields due to the diverse bio-functional properties.However,in-depth and systematic in vivo clinical trials using human subjects must be conducted to confirm the safe consumption limit and establish other therapeutic roles of jamun seeds for their abundant utilization as a nutraceutical or pharmacological component.Moreover,research is required to understand the exact mechanisms of the bioactivities exhibited by jamun seeds.
