Temperature plays a crucial role in shaping microbial ecosystems during anaerobic digestion.However,the specific microbial communities and their functions across a wide temperature range still remain elusive.This stud...Temperature plays a crucial role in shaping microbial ecosystems during anaerobic digestion.However,the specific microbial communities and their functions across a wide temperature range still remain elusive.This study employed a genome-centric metagenomic approach to explore microbial metabolic pathways and synergistic networks at temperatures of 35,44,53,55,and 65℃.A total of 84 metagenome assembled genomes(MAGs)were assembled,with over 65%of these MAGs corresponding to novel bacterial and archaeal species(including Firmicutes,Chloroflexota,Bacteroidia and Methanobacteriota),greatly enhancing our current comprehension anaerobic digestion process.Notably,functional annotation identified that 44_bin.2(Methanothrix_A sp.001602645)harbors enzymes associated with hydrogenotrophic metabolism.Additionally,this microorganism exhibited diverse metabolic capabilities at 44℃,a temperature commonly employed in industrial practice yet less explored in bench studies.Consequently,it implies a promising potential for conducting anaerobic digestion at a moderate thermophilic temperature,as opposed to the conventional mesophilic range.The microorganism exhibited a variety of metabolic capabilities at 44℃,a temperature frequently employed in industrial applications but underexplored in laboratory investigations.The findings suggest that anaerobic digestion carried out at moderate thermophilic temperatures may have a higher potential for methane production.展开更多
A method was developed to restore degraded images to some extent after the pixel binning pro- cess in image sensors to improve the resolution. A pixel binning model was used to approximate the original un-binned image...A method was developed to restore degraded images to some extent after the pixel binning pro- cess in image sensors to improve the resolution. A pixel binning model was used to approximate the original un-binned image. Then, the least squares error criterion was used as a constraint to reconstruct the re- stored pixel values from the binning model. The technique achieves about a one-decibel increase in the peak signal-to-noise ratio compared with the original estimated image. The technique has good detail pre- servation performance as well as low computation load. Thus, this restoration technique provides valuable improvements in practical, real time image processing.展开更多
On August 20,the Xi Jinping Thought on Diplomacy Studies Center held a book launch event“Hand in Hand,Heart to Heart-Toward a Shared Future”for Stories of the SCO in the New Era in Beijing.China's Assistant Mini...On August 20,the Xi Jinping Thought on Diplomacy Studies Center held a book launch event“Hand in Hand,Heart to Heart-Toward a Shared Future”for Stories of the SCO in the New Era in Beijing.China's Assistant Minister of Foreign Affairs Liu Bin and Deputy Secretary-General of the Shanghai Cooperation Organization(SCO)Ahmad Saidmurodzoda delivered speeches at the event,which was also attended by Zhang Deguang,China's former Vice Foreign Minister and the SCO's inaugural Secretary-General.展开更多
The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA methylation.This review comprehensively surveys recent human-centere...The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA methylation.This review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease neuropathology.The examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease progression.The entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the hippocampus.Notably,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal cortex.Further,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory processes.The complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation patterns.Despite the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease pathology.Future research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.展开更多
基金supported by the National Natural Science Foundation of China(No.52270138)。
文摘Temperature plays a crucial role in shaping microbial ecosystems during anaerobic digestion.However,the specific microbial communities and their functions across a wide temperature range still remain elusive.This study employed a genome-centric metagenomic approach to explore microbial metabolic pathways and synergistic networks at temperatures of 35,44,53,55,and 65℃.A total of 84 metagenome assembled genomes(MAGs)were assembled,with over 65%of these MAGs corresponding to novel bacterial and archaeal species(including Firmicutes,Chloroflexota,Bacteroidia and Methanobacteriota),greatly enhancing our current comprehension anaerobic digestion process.Notably,functional annotation identified that 44_bin.2(Methanothrix_A sp.001602645)harbors enzymes associated with hydrogenotrophic metabolism.Additionally,this microorganism exhibited diverse metabolic capabilities at 44℃,a temperature commonly employed in industrial practice yet less explored in bench studies.Consequently,it implies a promising potential for conducting anaerobic digestion at a moderate thermophilic temperature,as opposed to the conventional mesophilic range.The microorganism exhibited a variety of metabolic capabilities at 44℃,a temperature frequently employed in industrial applications but underexplored in laboratory investigations.The findings suggest that anaerobic digestion carried out at moderate thermophilic temperatures may have a higher potential for methane production.
基金Supported by the National Key Basic Research and Development(973) Program of China (No. 2006CB705700)
文摘A method was developed to restore degraded images to some extent after the pixel binning pro- cess in image sensors to improve the resolution. A pixel binning model was used to approximate the original un-binned image. Then, the least squares error criterion was used as a constraint to reconstruct the re- stored pixel values from the binning model. The technique achieves about a one-decibel increase in the peak signal-to-noise ratio compared with the original estimated image. The technique has good detail pre- servation performance as well as low computation load. Thus, this restoration technique provides valuable improvements in practical, real time image processing.
文摘On August 20,the Xi Jinping Thought on Diplomacy Studies Center held a book launch event“Hand in Hand,Heart to Heart-Toward a Shared Future”for Stories of the SCO in the New Era in Beijing.China's Assistant Minister of Foreign Affairs Liu Bin and Deputy Secretary-General of the Shanghai Cooperation Organization(SCO)Ahmad Saidmurodzoda delivered speeches at the event,which was also attended by Zhang Deguang,China's former Vice Foreign Minister and the SCO's inaugural Secretary-General.
文摘The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA methylation.This review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease neuropathology.The examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease progression.The entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the hippocampus.Notably,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal cortex.Further,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory processes.The complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation patterns.Despite the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease pathology.Future research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.
