Binaphthalene-core phosphepine compounds with axial chirality belong to an important class of organocatalysts and ligands used in catalytic asymmetric synthesis.However,the number and application of these compounds ha...Binaphthalene-core phosphepine compounds with axial chirality belong to an important class of organocatalysts and ligands used in catalytic asymmetric synthesis.However,the number and application of these compounds have been limited due to the lack of efficient synthetic methods currently available to researchers.Herein,a simple and efficient palladium-catalyzed C—P cross-coupling reaction of enantiopure(R)-1 with a variety of aryl and heteroaryl halides is reported.The reaction provides access to a series of chiral binaphthalene-core phosphepine compounds using Pd(OAc)2/dippf as a catalyst,which allows most products to be formed in moderate to high yields(40%~92%)with excellent ee values(90%~99%ee).展开更多
The changes of the specific rotation and sign of optically active BINOL have been studied in polar/non polar solvents and at the different pH values of solvent. It is considered that these changes are determined by t...The changes of the specific rotation and sign of optically active BINOL have been studied in polar/non polar solvents and at the different pH values of solvent. It is considered that these changes are determined by the equilibrium studies between cisoid and transoid conformations of BINOL with the same configuration ( R or S ) which related to the change of the dihedral angle between two naphthalene ring planes of BINOL.展开更多
文摘Binaphthalene-core phosphepine compounds with axial chirality belong to an important class of organocatalysts and ligands used in catalytic asymmetric synthesis.However,the number and application of these compounds have been limited due to the lack of efficient synthetic methods currently available to researchers.Herein,a simple and efficient palladium-catalyzed C—P cross-coupling reaction of enantiopure(R)-1 with a variety of aryl and heteroaryl halides is reported.The reaction provides access to a series of chiral binaphthalene-core phosphepine compounds using Pd(OAc)2/dippf as a catalyst,which allows most products to be formed in moderate to high yields(40%~92%)with excellent ee values(90%~99%ee).
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 99740 3 4)
文摘The changes of the specific rotation and sign of optically active BINOL have been studied in polar/non polar solvents and at the different pH values of solvent. It is considered that these changes are determined by the equilibrium studies between cisoid and transoid conformations of BINOL with the same configuration ( R or S ) which related to the change of the dihedral angle between two naphthalene ring planes of BINOL.
