随着楼宇综合能源系统(integrated energy system of building,BIES)的增多及其提升能源利用率的作用日益凸显,研究提升BIES内各设备耦合程度及与电网协调程度、降低BIES日综合运行成本具有重要意义。为此,提出基于前馈神经网络(feedfor...随着楼宇综合能源系统(integrated energy system of building,BIES)的增多及其提升能源利用率的作用日益凸显,研究提升BIES内各设备耦合程度及与电网协调程度、降低BIES日综合运行成本具有重要意义。为此,提出基于前馈神经网络(feedforward neural network,FNN)的BIES日前优化调度模型。首先,分析含屋顶光伏的BIES的结构;其次,提出基于FNN的光伏出力日前预测方法及流程,为BIES优化调度提供可靠光伏发电数据;最后,以BIES购电成本、购气成本、设备运行维护成本组成的日综合运行成本最低为目标,提出基于BIES日前调度模型。算例结果表明,所提光伏出力预测方法能有效提高光伏发电出力预测精度,基于FNN的BIES日前优化调度模型能够有效提高BIES运行经济性。展开更多
目的探讨病种成本可视化分析系统的设计与构建。方法选择Power BI作为可视化分析工具。采集病种成本相关数据,导入Power BI并建立数据模型,编写度量值。采用Power BI Desktop设计可视化界面,对分析结果进行可视化展示,构建完整的病种成...目的探讨病种成本可视化分析系统的设计与构建。方法选择Power BI作为可视化分析工具。采集病种成本相关数据,导入Power BI并建立数据模型,编写度量值。采用Power BI Desktop设计可视化界面,对分析结果进行可视化展示,构建完整的病种成本可视化分析系统。结果可视化分析系统从总体概况、科室成本分析、DRG成本分析、DIP成本分析及病种成本分析五个角度进行分析展示,展示内容丰富,具有良好的洞察与分析效果。结论本研究应用Power BI快速实现了病种成本可视化分析系统的构建。病种成本可视化分析系统可为精细化管理和决策提供有效支持。展开更多
Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupli...Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupling,and 1T-VTe_(2)monolayer theoretically predicted to host an intrinsic magnetism as experimentally suggested.In this work,we successfully constructed a vertical heterostructure composed of the two-dimensional Bi(110)monolayer and 1T-VTe_(2)monolayer by using molecular beam epitaxy(MBE).Scanning tunneling microscopy(STM)measurements revealed that the growth of Bi preferably occurs along the step edges of the VTe_(2)monolayer,forming a Bi(110)monolayer on top of the VTe_(2)monolayer next to a peripheral Bi bilayer.The Bi(100)/VTe_(2)heterostructure exhibits a specific lattice registry with a well-defined moiréperiodicity.Scanning tunneling spectroscopy(STS)measurements further unveiled an universal suppression in the local density-of-states at the boundary of the Bi(110)/VTe_(2)bilayer.By examining the atomic structures of Bi(110)boundaries,we found this effect does not originate from the previously proposed atomic reconstruction at the step edge of Bi(110),but is likely related to the magnetic properties of the VTe_(2)monolayer.展开更多
目的:探讨传统开颅手术与神经内镜微创手术对脑出血患者美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale Score,NIHSS)及巴塞尔指数评分(Barthel Index Score,BI)的影响。方法:回顾性收集2022年1月至2023年...目的:探讨传统开颅手术与神经内镜微创手术对脑出血患者美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale Score,NIHSS)及巴塞尔指数评分(Barthel Index Score,BI)的影响。方法:回顾性收集2022年1月至2023年1月期间本院收治的200例脑出血患者的临床资料。根据治疗方式不同将患者分为对照组(实施传统开颅手术,150例)和观察组(实施神经内镜微创手术,50例)。收集并比较两组术后神经功能恢复情况、术后日常生活活动能力、手术相关指标、术后并发症发生情况。结果:随着术后时间增长,两组NIHSS评分均降低;术后2、3、6、12 m,观察组NIHSS评分均低于对照组(P<0.05)。随着术后时间增长,两组BI评分均提高;术后2、3、6、12 m,观察组BI评分均高于对照组(P<0.05)。观察组手术时间、术后住院时间均短于对照组,术中出血量少于对照组(P<0.05)。观察组术后并发症发生率低于对照组(P<0.05)。结论:与传统开颅手术比较,神经内镜微创手术更有利于促进脑出血患者神经功能恢复、提升日常生活活动能力,且兼具操作时间短、出血量少、住院时间短、并发症发生率低等优势,预后情况良好,值得临床推广应用。展开更多
Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-k...Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.展开更多
The Crop Journal is a bi-monthly,international,peer-reviewed research journal co-sponsored by Crop Science Society of China,Institute of Crop Sciences,Chinese Academy of Agricultural Sciences,and China Science Publish...The Crop Journal is a bi-monthly,international,peer-reviewed research journal co-sponsored by Crop Science Society of China,Institute of Crop Sciences,Chinese Academy of Agricultural Sciences,and China Science Publishing&Media Group Ltd.(Science Press).展开更多
Rising temperatures and increased droughts caused by climate change significantly reduce crop yields.Halophytes with different photosynthetic metabolism types have specific mechanisms for resistance to climatic factor...Rising temperatures and increased droughts caused by climate change significantly reduce crop yields.Halophytes with different photosynthetic metabolism types have specific mechanisms for resistance to climatic factors.This study analyzed the morphophysiological,biochemical,and molecular-genetic mechanisms of tolerance and adaptation in halophytes,promising candidates for the restoration of salt affected lands in arid and semi-arid areas.Experiments under drought(D)and elevated temperature(eT),as well as their combined action(eT+D),were performed on Atriplex verrucifera M.Bied.(C_(3)plant)and Climacoptera crassa(M.Bieb.)Botsch.(C_(4)-NAD-ME plant)with different types of photosynthesis.The activity of photosystem I(PSI)and the efficiency of photosystem II(PSII)were measured,along with the expression of genes involved in the light(psaA,psaB,psbA,CAB,Fd1,PGR5,and ndhH)and dark(rbcL,Ppc2,and PPDK)reactions of photosynthesis.The content of key carboxylating enzymes ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)and phosphoenolpyruvate carboxylase(PEPC),as well as the photorespiration enzyme glycine decarboxylase(GDC),were assessed.Plant growth and water-salt balance parameters,and activity of enzymes in the malate dehydrogenase(MDH)system nicotinamide adenine dinucleotide(phosphate)(NAD(P))-MDH and NAD(P)-malic enzyme(ME)were also examined.A multivariate analysis of the experimental results revealed that A.verrucifera and C.crassa were both resistant to the effects of these climatic stressors.The tolerance mechanisms of both species were significantly influenced by a high level of photosynthetic plasticity.Nevertheless,differences were observed in the protective mechanisms underlying tolerance.In the C_(3)species,dissipative processes associated with non-photochemical quenching(NPQ)of PSII and MDH system enzymes(malate valves)were activated,particularly under osmotic stress.The negative effects in the C_(3)plants were caused by the combined action of eT+D,which was compensated by an increased expression of rbcL,psaA,CAB,and especially PGR5,i.e.,genes encoding Rubisco large subunit and PSI components:apoproteins A,chlorophyll a/b-associated protein(CAB)of light-harvesting complex,and proton gradient regulation 5(PGR5)protein of the main pathway of cyclic electron transport(CET)around PSI.In C_(4)species,the protective MDH complex was expressed to a lesser extent,but activation of the C_(4)carbon-concentrating mechanism(CCM)and upregulation of PGR5 expression were observed,particularly under the individual action of the factors.Under the combined stress of eT+D,C.crassa exhibited a synergistic effect,where the increase in NPQ level and NAD-ME activity,as well as decrease in NADP-ME activity was less pronounced compared with the effect of singular factors.Comparative physiological,biochemical,and molecular analyses of how C_(3)and C_(4)species response to individual and combined climatic factors provide new insights into sustainable plant adaptation strategies in the face of global climate change.Considering the high nutritional value of these two fodder species,a technological approach could be developed to improve the productivity of salt affected lands.展开更多
The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines...The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines of evidence,including epidemiological studies of the"stomach-knee axis",investigations into the pathological mechanisms linking"Hp infection and arthritis",as well as research on co-treatment drugs and the anti-inflammatory mechanisms relevant to"gastritis and arthritis".The investigation into"stomach and knee joint treatment"is grounded in the concept that the"stomach-knee axis"aligns with the"combined bi of body constituents and zang organs"theory.Clinical cases have demonstrated that therapeutic strategies of"stomach and knee joint treatment"can mitigate KOA damage by modulating the"stomach-knee axis"and eradicating Hp infection in the stomach.This study aims to contribute novel insights into the cross-system treatment of KOA.Further investigation into the"stomach-knee axis"may yield innovative strategies for the prevention and management of KOA,potentially through the eradication of Hp.展开更多
文摘随着楼宇综合能源系统(integrated energy system of building,BIES)的增多及其提升能源利用率的作用日益凸显,研究提升BIES内各设备耦合程度及与电网协调程度、降低BIES日综合运行成本具有重要意义。为此,提出基于前馈神经网络(feedforward neural network,FNN)的BIES日前优化调度模型。首先,分析含屋顶光伏的BIES的结构;其次,提出基于FNN的光伏出力日前预测方法及流程,为BIES优化调度提供可靠光伏发电数据;最后,以BIES购电成本、购气成本、设备运行维护成本组成的日综合运行成本最低为目标,提出基于BIES日前调度模型。算例结果表明,所提光伏出力预测方法能有效提高光伏发电出力预测精度,基于FNN的BIES日前优化调度模型能够有效提高BIES运行经济性。
基金financially supported by the National Key Research and Development Program of China(Grant No.2021YFA1400403)the National Natural Science Foundation of China(Grant Nos.12374183,92165205)+2 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20233001)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302800)the Fundamental Research Funds for the Central Universities(Grant No.020414380207).
文摘Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupling,and 1T-VTe_(2)monolayer theoretically predicted to host an intrinsic magnetism as experimentally suggested.In this work,we successfully constructed a vertical heterostructure composed of the two-dimensional Bi(110)monolayer and 1T-VTe_(2)monolayer by using molecular beam epitaxy(MBE).Scanning tunneling microscopy(STM)measurements revealed that the growth of Bi preferably occurs along the step edges of the VTe_(2)monolayer,forming a Bi(110)monolayer on top of the VTe_(2)monolayer next to a peripheral Bi bilayer.The Bi(100)/VTe_(2)heterostructure exhibits a specific lattice registry with a well-defined moiréperiodicity.Scanning tunneling spectroscopy(STS)measurements further unveiled an universal suppression in the local density-of-states at the boundary of the Bi(110)/VTe_(2)bilayer.By examining the atomic structures of Bi(110)boundaries,we found this effect does not originate from the previously proposed atomic reconstruction at the step edge of Bi(110),but is likely related to the magnetic properties of the VTe_(2)monolayer.
文摘目的:探讨传统开颅手术与神经内镜微创手术对脑出血患者美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale Score,NIHSS)及巴塞尔指数评分(Barthel Index Score,BI)的影响。方法:回顾性收集2022年1月至2023年1月期间本院收治的200例脑出血患者的临床资料。根据治疗方式不同将患者分为对照组(实施传统开颅手术,150例)和观察组(实施神经内镜微创手术,50例)。收集并比较两组术后神经功能恢复情况、术后日常生活活动能力、手术相关指标、术后并发症发生情况。结果:随着术后时间增长,两组NIHSS评分均降低;术后2、3、6、12 m,观察组NIHSS评分均低于对照组(P<0.05)。随着术后时间增长,两组BI评分均提高;术后2、3、6、12 m,观察组BI评分均高于对照组(P<0.05)。观察组手术时间、术后住院时间均短于对照组,术中出血量少于对照组(P<0.05)。观察组术后并发症发生率低于对照组(P<0.05)。结论:与传统开颅手术比较,神经内镜微创手术更有利于促进脑出血患者神经功能恢复、提升日常生活活动能力,且兼具操作时间短、出血量少、住院时间短、并发症发生率低等优势,预后情况良好,值得临床推广应用。
基金funded by grants from the Suzhou Gusu Health Talents Project(grant No.GSWS2024050 to Liu W)Natural Science Foundation Project of Nanjing University of Chinese Medicine(grant No.XZR2021043 to Liu W and grant No.XZR2023021 to Huang F)+1 种基金Suzhou Science Education Health Youth Project(grant No.KJXW2021046 to Liu W)Suzhou Major Disease Multi-center Clinical Research Project(grant No.DZXYJ202410 to Huang F).
文摘Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.
文摘The Crop Journal is a bi-monthly,international,peer-reviewed research journal co-sponsored by Crop Science Society of China,Institute of Crop Sciences,Chinese Academy of Agricultural Sciences,and China Science Publishing&Media Group Ltd.(Science Press).
基金supported by the state assignment of Ministry of Science and Higher Education of the Russian Federation(122042700044-6)the Science and Technology Research Partnership for Sustainable Development(SATREPS)project(JPMJSA2001).
文摘Rising temperatures and increased droughts caused by climate change significantly reduce crop yields.Halophytes with different photosynthetic metabolism types have specific mechanisms for resistance to climatic factors.This study analyzed the morphophysiological,biochemical,and molecular-genetic mechanisms of tolerance and adaptation in halophytes,promising candidates for the restoration of salt affected lands in arid and semi-arid areas.Experiments under drought(D)and elevated temperature(eT),as well as their combined action(eT+D),were performed on Atriplex verrucifera M.Bied.(C_(3)plant)and Climacoptera crassa(M.Bieb.)Botsch.(C_(4)-NAD-ME plant)with different types of photosynthesis.The activity of photosystem I(PSI)and the efficiency of photosystem II(PSII)were measured,along with the expression of genes involved in the light(psaA,psaB,psbA,CAB,Fd1,PGR5,and ndhH)and dark(rbcL,Ppc2,and PPDK)reactions of photosynthesis.The content of key carboxylating enzymes ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)and phosphoenolpyruvate carboxylase(PEPC),as well as the photorespiration enzyme glycine decarboxylase(GDC),were assessed.Plant growth and water-salt balance parameters,and activity of enzymes in the malate dehydrogenase(MDH)system nicotinamide adenine dinucleotide(phosphate)(NAD(P))-MDH and NAD(P)-malic enzyme(ME)were also examined.A multivariate analysis of the experimental results revealed that A.verrucifera and C.crassa were both resistant to the effects of these climatic stressors.The tolerance mechanisms of both species were significantly influenced by a high level of photosynthetic plasticity.Nevertheless,differences were observed in the protective mechanisms underlying tolerance.In the C_(3)species,dissipative processes associated with non-photochemical quenching(NPQ)of PSII and MDH system enzymes(malate valves)were activated,particularly under osmotic stress.The negative effects in the C_(3)plants were caused by the combined action of eT+D,which was compensated by an increased expression of rbcL,psaA,CAB,and especially PGR5,i.e.,genes encoding Rubisco large subunit and PSI components:apoproteins A,chlorophyll a/b-associated protein(CAB)of light-harvesting complex,and proton gradient regulation 5(PGR5)protein of the main pathway of cyclic electron transport(CET)around PSI.In C_(4)species,the protective MDH complex was expressed to a lesser extent,but activation of the C_(4)carbon-concentrating mechanism(CCM)and upregulation of PGR5 expression were observed,particularly under the individual action of the factors.Under the combined stress of eT+D,C.crassa exhibited a synergistic effect,where the increase in NPQ level and NAD-ME activity,as well as decrease in NADP-ME activity was less pronounced compared with the effect of singular factors.Comparative physiological,biochemical,and molecular analyses of how C_(3)and C_(4)species response to individual and combined climatic factors provide new insights into sustainable plant adaptation strategies in the face of global climate change.Considering the high nutritional value of these two fodder species,a technological approach could be developed to improve the productivity of salt affected lands.
基金Supported by Discipline Construction Project of Shanxi University of Chinese Medicine—Internal Medicine of Traditional Chinese Medicine(2025XK02).
文摘The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines of evidence,including epidemiological studies of the"stomach-knee axis",investigations into the pathological mechanisms linking"Hp infection and arthritis",as well as research on co-treatment drugs and the anti-inflammatory mechanisms relevant to"gastritis and arthritis".The investigation into"stomach and knee joint treatment"is grounded in the concept that the"stomach-knee axis"aligns with the"combined bi of body constituents and zang organs"theory.Clinical cases have demonstrated that therapeutic strategies of"stomach and knee joint treatment"can mitigate KOA damage by modulating the"stomach-knee axis"and eradicating Hp infection in the stomach.This study aims to contribute novel insights into the cross-system treatment of KOA.Further investigation into the"stomach-knee axis"may yield innovative strategies for the prevention and management of KOA,potentially through the eradication of Hp.
