Objective:To investigate the correlation of BI-RADS grading with cancer cell proliferation and invasion.Methods: A total of 138 patients who were diagnosed with breast cancer in our hospital between August 2015 and Oc...Objective:To investigate the correlation of BI-RADS grading with cancer cell proliferation and invasion.Methods: A total of 138 patients who were diagnosed with breast cancer in our hospital between August 2015 and October 2017 were divided into 2 cases at stage Ⅲ, 51 cases at stage Ⅳ and 85 cases at stage Ⅴ after the BI-RADS grading was reviewed. Differences in the expression of proliferation-related genes and invasion-related genes were compared among the three groups of patients.Results: Expressions of pro-proliferation genes MTA2, mTOR, PKM2, Notch1 and FSCN1 mRNA in lesion tissue of patients at stage Ⅴ and Ⅳ were higher than those of patients at stage Ⅲ whereas expressions of anti-proliferation genes BRCA1 and PTEN mRNA were lower than those of patients at stage Ⅲ;expressions of pro-invasion genes Gab2 and NUAK1 mRNA were higher than those of patients at stage Ⅲ whereas expressions of anti-invasion genes EBP50, EDN3, FBXW7 and NDRG1 mRNA were lower than those of patients at stage Ⅲ. With the increase of BI-RADS grades, the expression levels of pro-proliferation genes and pro-invasion genes further increased while the expression levels of anti-proliferation and anti-invasion genes further decreased in the lesion tissue.Conclusions: BI-RADS grading of patients with breast cancer is positively correlated with the proliferation and invasion activity of cancer cells.展开更多
目的探讨超微血流成像(SMI)联合高级动态血流成像(ADF)鉴别最大径≤10 mm BI-RADS 4类乳腺结节良恶性的临床价值。方法选取我院经手术病理证实的78例女性乳腺结节患者(共81个病灶),其中良性结节47个,恶性结节34个,均行SMI和ADF获取病灶...目的探讨超微血流成像(SMI)联合高级动态血流成像(ADF)鉴别最大径≤10 mm BI-RADS 4类乳腺结节良恶性的临床价值。方法选取我院经手术病理证实的78例女性乳腺结节患者(共81个病灶),其中良性结节47个,恶性结节34个,均行SMI和ADF获取病灶血流分级和血管形态特征,比较良恶性结节上述检查结果的差异。分析SMI、ADF及两者联合应用鉴别BI-RADS 4类乳腺结节良恶性的诊断效能,采用Kappa检验分析其与病理结果的一致性。结果SMI检查显示乳腺良恶性结节血流分级和血管形态特征比较差异均有统计学意义(均P<0.001);ADF检查显示乳腺良恶性结节血流分级和血管形态特征比较差异均有统计学意义(均P<0.001)。SMI准确诊断BI-RADS 4类乳腺良性结节38个,恶性结节28个,诊断灵敏度、特异度、准确率分别为82.35%、80.85%、81.48%;ADF准确诊断BIRADS 4类乳腺良性结节32个,恶性结节25个,诊断灵敏度、特异度、准确率分别为73.53%、68.09%、70.37%;两者联合应用准确诊断BI-RADS 4类乳腺良性结节35个,恶性结节33个,诊断灵敏度、特异度、准确率分别为97.06%、74.47%、83.95%。SMI、ADF及两者联合应用与病理结果的一致性均中等(Kappa=0.632、0.406、0.685,均P<0.05)。结论SMI联合ADF可以提高最大径≤10 mm BI-RADS 4类乳腺结节良恶性的鉴别诊断效能,具有一定的临床价值。展开更多
超声因其便捷、无辐射等优势成为乳腺癌早期筛查的重要方式^([1]),根据美国放射学会发布的第5版乳腺影像报告与数据系统(breast imaging reporting and data system,BI-RADS),4类乳腺病变的恶性可能性为2%~95%,其跨度相对较大,且病变的...超声因其便捷、无辐射等优势成为乳腺癌早期筛查的重要方式^([1]),根据美国放射学会发布的第5版乳腺影像报告与数据系统(breast imaging reporting and data system,BI-RADS),4类乳腺病变的恶性可能性为2%~95%,其跨度相对较大,且病变的超声特征多样,易受诊断医师主观判断影响。在乳腺癌诊治指南中^([2]),BI-RADS 4类结节均建议行细胞学检查或病理活检,最终导致非必要穿刺活检及手术率较高。展开更多
文摘Objective:To investigate the correlation of BI-RADS grading with cancer cell proliferation and invasion.Methods: A total of 138 patients who were diagnosed with breast cancer in our hospital between August 2015 and October 2017 were divided into 2 cases at stage Ⅲ, 51 cases at stage Ⅳ and 85 cases at stage Ⅴ after the BI-RADS grading was reviewed. Differences in the expression of proliferation-related genes and invasion-related genes were compared among the three groups of patients.Results: Expressions of pro-proliferation genes MTA2, mTOR, PKM2, Notch1 and FSCN1 mRNA in lesion tissue of patients at stage Ⅴ and Ⅳ were higher than those of patients at stage Ⅲ whereas expressions of anti-proliferation genes BRCA1 and PTEN mRNA were lower than those of patients at stage Ⅲ;expressions of pro-invasion genes Gab2 and NUAK1 mRNA were higher than those of patients at stage Ⅲ whereas expressions of anti-invasion genes EBP50, EDN3, FBXW7 and NDRG1 mRNA were lower than those of patients at stage Ⅲ. With the increase of BI-RADS grades, the expression levels of pro-proliferation genes and pro-invasion genes further increased while the expression levels of anti-proliferation and anti-invasion genes further decreased in the lesion tissue.Conclusions: BI-RADS grading of patients with breast cancer is positively correlated with the proliferation and invasion activity of cancer cells.
文摘超声因其便捷、无辐射等优势成为乳腺癌早期筛查的重要方式^([1]),根据美国放射学会发布的第5版乳腺影像报告与数据系统(breast imaging reporting and data system,BI-RADS),4类乳腺病变的恶性可能性为2%~95%,其跨度相对较大,且病变的超声特征多样,易受诊断医师主观判断影响。在乳腺癌诊治指南中^([2]),BI-RADS 4类结节均建议行细胞学检查或病理活检,最终导致非必要穿刺活检及手术率较高。
