Bcl-2 family proteins(BFPs)are essential regulators of regulated cell death(RCD),and their dysregulation is implicated in a wide range of disorders,including cancer,neurodegenerative diseases,and autoimmune conditions...Bcl-2 family proteins(BFPs)are essential regulators of regulated cell death(RCD),and their dysregulation is implicated in a wide range of disorders,including cancer,neurodegenerative diseases,and autoimmune conditions.Recent studies have shown that BFPs also play critical roles in autophagy,calcium homeostasis,neuronal function,and mitochondrial dynamics,underscoring their multifaceted contributions to cellular health.In this review,we summarize the current knowledge concerning the physiological roles and structural diversity of BFPs,with a particular focus on key multidomain proteins such as Bak,Bax,and Bok.Our findings highlight persistent challenges and knowledge gaps,especially concerning the interactions between BFPs and diverse cellular pathways.In conclusion,BFPs act as fundamental regulators of cell survival and apoptosis.While significant progress has been made in elucidating their molecular mechanisms,important questions remain—particularly regarding the precise structural dynamics of pore formation,the influence of the mitochondrial lipid composition,and the balance between pro-and anti-apoptotic members.Finally,the therapeutic potential of BFP-targeted drugs,including BH3 mimetics,offers promising avenues for treating cancer and other diseases characterized by aberrant regulation of apoptosis.展开更多
本文使用一些较为精确的量子化学方法(SCF ab initio、能量梯度法优化几何构型、CID和Morokuma的能量分解方案)研究了星际分子CH_3CO^+和它的等电子体系BH_3CO。通过比较BH_3CO和CH_3CO^+的几何构型和电子结构,可得CH_3CO^+为一个EDA络...本文使用一些较为精确的量子化学方法(SCF ab initio、能量梯度法优化几何构型、CID和Morokuma的能量分解方案)研究了星际分子CH_3CO^+和它的等电子体系BH_3CO。通过比较BH_3CO和CH_3CO^+的几何构型和电子结构,可得CH_3CO^+为一个EDA络合物的结论,还发现CH_3^+同CO的相互作用比BH_3与CO的相互作用要强得多,并从前线轨道的观点分析了这些相互作用的本质。展开更多
文摘Bcl-2 family proteins(BFPs)are essential regulators of regulated cell death(RCD),and their dysregulation is implicated in a wide range of disorders,including cancer,neurodegenerative diseases,and autoimmune conditions.Recent studies have shown that BFPs also play critical roles in autophagy,calcium homeostasis,neuronal function,and mitochondrial dynamics,underscoring their multifaceted contributions to cellular health.In this review,we summarize the current knowledge concerning the physiological roles and structural diversity of BFPs,with a particular focus on key multidomain proteins such as Bak,Bax,and Bok.Our findings highlight persistent challenges and knowledge gaps,especially concerning the interactions between BFPs and diverse cellular pathways.In conclusion,BFPs act as fundamental regulators of cell survival and apoptosis.While significant progress has been made in elucidating their molecular mechanisms,important questions remain—particularly regarding the precise structural dynamics of pore formation,the influence of the mitochondrial lipid composition,and the balance between pro-and anti-apoptotic members.Finally,the therapeutic potential of BFP-targeted drugs,including BH3 mimetics,offers promising avenues for treating cancer and other diseases characterized by aberrant regulation of apoptosis.
文摘本文使用一些较为精确的量子化学方法(SCF ab initio、能量梯度法优化几何构型、CID和Morokuma的能量分解方案)研究了星际分子CH_3CO^+和它的等电子体系BH_3CO。通过比较BH_3CO和CH_3CO^+的几何构型和电子结构,可得CH_3CO^+为一个EDA络合物的结论,还发现CH_3^+同CO的相互作用比BH_3与CO的相互作用要强得多,并从前线轨道的观点分析了这些相互作用的本质。
