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补阳还五汤通过小窝蛋白1调控YAP1/HIF-1α信号通路促进bEnd.3细胞糖氧剥夺/复氧损伤后血管新生的机制研究 被引量:1
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作者 陈博威 欧阳银 +5 位作者 曾繁佐 刘英飞 田丰铭 徐雅倩 易健 刘柏炎 《中国中药杂志》 北大核心 2025年第14期3847-3856,共10页
基于小窝蛋白1(Cav1)/Yes-相关蛋白同源癌蛋白1(YAP1)/缺氧诱导因子-1α(HIF-1α)信号通路探讨补阳还五汤促进小鼠脑微血管内皮细胞株(bEnd.3)糖氧剥夺/复氧(OGD/R)损伤后血管新生的作用机制。运用超高效液相色谱-四极杆-飞行时间质谱... 基于小窝蛋白1(Cav1)/Yes-相关蛋白同源癌蛋白1(YAP1)/缺氧诱导因子-1α(HIF-1α)信号通路探讨补阳还五汤促进小鼠脑微血管内皮细胞株(bEnd.3)糖氧剥夺/复氧(OGD/R)损伤后血管新生的作用机制。运用超高效液相色谱-四极杆-飞行时间质谱联用仪(UPLC-Q-TOF-MS)分析补阳还五汤入血成分。采用胆囊收缩素八肽(CCK-8)法检测bEnd.3细胞OGD/R损伤后补阳还五汤含药血清的最佳干预浓度。慢病毒转染的方式构建Cav1沉默稳转株,Western blot法及PCR法验证沉默效率。将对照bEnd.3细胞分为正常组(sh-NC control组)、OGD/R模型+空白血清组(sh-NC OGD/R组)及OGD/R模型+含药血清组(sh-NC BHD组),Cav1沉默细胞分为OGD/R模型+空白血清组(sh-Cav1 OGD/R组)及OGD/R模型+含药血清组(sh-Cav1 BHD组),通过CCK-8法检测细胞存活率,细胞迁移实验检测细胞迁移能力,管腔形成实验检测细胞成管能力,流式细胞术检测细胞凋亡率,Western blot法检测各组细胞YAP1/HIF-1α信号通路相关蛋白的表达情况,最后运用免疫共沉淀法验证YAP1与HIF-1α之间的互作关系。结果显示补阳还五汤中黄芪甲苷、芒柄花素、阿魏酸及芍药内酯苷均能入血。质量分数10%的补阳还五汤含药血清可能是OGD/R诱导损伤bEnd.3细胞的最佳干预浓度。与sh-NC control组比较,sh-NC OGD/R组细胞存活率、细胞迁移率、网眼数、节点数和管腔长度明显下降,细胞凋亡率明显上升,YAP1的S127位点磷酸化水平明显下降,YAP1的核位移水平与HIF-1α、血管内皮生长因子(VEGF)及VEGFR2的蛋白表达明显上升;与同类型OGD/R组比较,sh-NC BHD组及sh-Cav1 BHD组细胞存活率、细胞迁移率、网眼数、节点数和管腔长度明显升高,细胞凋亡率明显下降,YAP1的S127位点磷酸化水平进一步下降,YAP1的核位移水平与HIF-1α、血管内皮生长因子(VEGF)及VEGFR2的蛋白表达明显上升;与sh-NC OGD/R组比较,sh-Cav1 OGD/R组细胞存活率、细胞迁移率、网眼数、节点数和管腔长度明显下降,细胞凋亡率明显上升,YAP1的S127位点磷酸化水平明显上升,YAP1的核位移水平与HIF-1α、VEGF及VEGFR2的蛋白表达明显下降;与sh-NC BHD组比较,sh-Cav1 BHD组细胞存活率、细胞迁移率、网眼数、节点数和管腔长度明显下降,细胞凋亡率明显上升,YAP1的S127位点磷酸化水平明显上升,YAP1的核位移水平与HIF-1α、VEGF及VEGFR2的蛋白表达明显下降。在HIF-1α抗体沉淀的蛋白复合物中存在YAP1蛋白,而在YAP1抗体沉淀的蛋白复合物中亦存在HIF-1α蛋白。结论证实补阳还五汤含药血清能够通过Cav1提高OGD/R损伤bEnd.3细胞YAP1/HIF-1α通路的活性,促进体外血管新生。 展开更多
关键词 补阳还五汤 小窝蛋白1 YAP1/HIF-1α信号通路 bend.3细胞 糖氧剥夺/复氧损伤 血管新生
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Galerkin-Vlasov approach for bending analysis of flexoelectric doubly-curved sandwich nanoshells with piezoelectric/FGP/piezoelectric layers using the nonlocal strain theory 被引量:1
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作者 Tran Van Ke Do Van Thom +2 位作者 Nguyen Thai Dung Nguyen Van Chinh Phung Van Minh 《Acta Mechanica Sinica》 2025年第2期7-40,共34页
Flexoelectricity refers to the link between electrical polarization and strain gradient fields in piezoelectric materials,particularly at the nano-scale.The present investigation aims to comprehensively focus on the s... Flexoelectricity refers to the link between electrical polarization and strain gradient fields in piezoelectric materials,particularly at the nano-scale.The present investigation aims to comprehensively focus on the static bending analysis of a piezoelectric sandwich functionally graded porous(FGP)double-curved shallow nanoshell based on the flexoelectric effect and nonlocal strain gradient theory.Two coefficients that reduce or increase the stiffness of the nanoshell,including nonlocal and length-scale parameters,are considered to change along the nanoshell thickness direction,and three different porosity rules are novel points in this study.The nanoshell structure is placed on a Pasternak elastic foundation and is made up of three separate layers of material.The outermost layers consist of piezoelectric smart material with flexoelectric effects,while the core layer is composed of FGP material.Hamilton’s principle was used in conjunction with a unique refined higher-order shear deformation theory to derive general equilibrium equations that provide more precise outcomes.The Navier and Galerkin-Vlasov methodology is used to get the static bending characteristics of nanoshells that have various boundary conditions.The program’s correctness is assessed by comparison with published dependable findings in specific instances of the model described in the article.In addition,the influence of parameters such as flexoelectric effect,nonlocal and length scale parameters,elastic foundation stiffness coefficient,porosity coefficient,and boundary conditions on the static bending response of the nanoshell is detected and comprehensively studied.The findings of this study have practical implications for the efficient design and control of comparable systems,such as micro-electromechanical and nano-electromechanical devices. 展开更多
关键词 Analytical solution Flexoelectric effect Nonlocal strain gradient theory Static bending of nanoshell
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Bending Characteristics of Folded Multi-celled Tubes with Square and Circular Section Geometries
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作者 Rui Liang Fengxiang Xu +3 位作者 Zhen Zou Xiaoqiang Niu Xuebang Tang Tingpeng Li 《Acta Mechanica Solida Sinica》 2025年第1期125-141,共17页
This research investigates the bending response of folded multi-celled tubes(FMTs)fabricated by folded metal sheets.A three-point bending test for FMTs with circular and square sections is designed and introduced.The ... This research investigates the bending response of folded multi-celled tubes(FMTs)fabricated by folded metal sheets.A three-point bending test for FMTs with circular and square sections is designed and introduced.The base numerical models are correlated with physical experiments and a static crashworthiness analysis of six FMT configurations to assess their energy absorption characteristics.The influences of thickness,sectional shape,and load direction on the bending response are studied.Results indicate that increasing the thickness of the tube and radian of the inner tube enhances the crashworthiness performance of FMT,yielding a 20.50%increase in mean crushing force,a 55.53%increase in specific energy absorption,and an 18.05%decrease in peak crushing force compared to traditional multi-celled tubes(TMTs).A theoretical analysis of the specific energy absorption indicates that FMTs outperform TMTs,particularly when the peak crushing force is prominent.This study highlights the innovative and practical potential of FMTs to improve the crashworthiness of thin-walled structures. 展开更多
关键词 bendING Folded Multi-celled tube Energy absorption Numerical
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Texture-dependent bending behaviors of extruded AZ31 magnesium alloy plates
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作者 Kecheng Zhou Xiaochuan Sun +6 位作者 Hongwei Wang Xiaodan Zhang Ding Tang Weiqin Tang Yaodong Jiang Peidong Wu Huamiao Wang 《Journal of Magnesium and Alloys》 2025年第8期3617-3631,共15页
The relatively insufficient knowledge of the deformation behavior has limited the wide application of the lightest structure material-Mg alloys.Among others,bending behavior is of great importance because it is unavoi... The relatively insufficient knowledge of the deformation behavior has limited the wide application of the lightest structure material-Mg alloys.Among others,bending behavior is of great importance because it is unavoidably involved in various forming processes,such as folding,stamping,etc.The hexagonal close-packed structure makes it even a strong texture-dependent behavior and even hard to capture and predict.In this regard,the bending behaviors are investigated in terms of both experiments and simulations in the current work.Bending samples with longitudinal directions inclined from the transverse direction by different angles have been prepared from an extruded AZ31 plate,respectively.The moment-curvature curves and strain distribution have been recorded in the four-point bending tests assisted with an in-situ digital image correlation(DIC)system.A crystal-plasticity-based bending-specific approach named EVPSC-BEND was applied to bridge the mechanical response to the microstructure evolution and underlying deformation mechanisms.The flow stress,texture,twin volume fraction,stress distribution,and strain distribution evolve differently from sample to sample,manifesting strong texture-dependent bending behaviors.The underlying mechanisms associated with this texture dependency,especially the occurrence of both twinning and detwinning during the monotonic bending,are carefully discussed.Besides,the simulation has been conducted to reveal the moment-inclination angle relation of the investigated AZ31 extruded plate in terms of the polar coordinate,which intuitively shows the texture-dependent behaviors.Specifically,the samples with longitudinal directions parallel to the extruded direction bear the biggest initial yielding moment. 展开更多
关键词 Magnesium alloy bending Texture-dependency Crystal plasticity Twinning and detwinning
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Research on Birdcage Buckling in the Armor Wire of A Damaged Umbilical Cable Under Compression and Bending Cyclic Load
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作者 CHEN Si-yuan DENG Yu +2 位作者 LIANG Xu DENG Xue-jiao WANG Zhen-kui 《China Ocean Engineering》 2025年第1期86-99,共14页
Buckling failure in submarine cables presents a prevalent challenge in ocean engineering.This work aims to explore the buckling behavior of umbilical cables with damaged sheaths subjected to compression and bending cy... Buckling failure in submarine cables presents a prevalent challenge in ocean engineering.This work aims to explore the buckling behavior of umbilical cables with damaged sheaths subjected to compression and bending cyclic loads.A finite element model is devised,incorporating a singular armor wire,a rigid core,and a damaged sheath.To scrutinize the buckling progression and corresponding deformation,axial compression and bending cyclic loads are introduced.The observations reveal that a reduction in axial compression results in a larger number of cycles before buckling ensues and progressively shifts the buckling position toward the extrados and fixed end.Decreasing the bending radius precipitates a reduction in the buckling cycle number and minimizes the deformation in the armor wire.Furthermore,an empirical model is presented to predict the occurrence of birdcage buckling,providing a means to anticipate buckling events and to estimate the requisite number of cycles leading to buckling. 展开更多
关键词 umbilical cable armor wire birdcage buckling bending cycle damaged sheath
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Experimental study on unsteady flow of hydraulic conveying of a single coarse particle through a 90°bend
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作者 Hui Cheng Hong Xiong +4 位作者 Yuxiang Chen Hong Zhu Chunliang Yu Guodong Zheng Yiyang Xing 《Acta Mechanica Sinica》 2025年第5期93-103,共11页
Bends contribute to a flexible layout of pipeline system,but also lead to intensive energy costs due to the complex flow characteristic.This experimental study is conducted to investigate the impact of a single coarse... Bends contribute to a flexible layout of pipeline system,but also lead to intensive energy costs due to the complex flow characteristic.This experimental study is conducted to investigate the impact of a single coarse particle on the flow field in a bend.The velocity profiles of fluid on the axial symmetry plane of the bend are measured using time-resolved particle image velocimetry.The flow structures are extracted using the proper orthogonal decomposition method.The results reveal that there is a shear-layer flow in the bend during the transportation.With the increase in particle size,the particle has a dominant influence on the flow energy distribution of the overall flow.The impact of particles on the first few energetic flows is mainly in the latter part of the transportation,both temporally and spatially.As the particle size decreases,the most energetic unsteady flow within the bend changes from the convective flow to the flow of the shear layer. 展开更多
关键词 Hydraulic conveying bend Flow characteristic Particle image velocimetry Proper orthogonal decomposition
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基于TCGA数据库探讨BEND5表达对膀胱癌患者生存及癌细胞迁移能力的影响
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作者 李智强 陈从其 +4 位作者 陈锦添 陈伟 董菲艳 周素娟 林云侨 《福建医药杂志》 2025年第7期1-5,共5页
目的探讨膀胱癌组织与癌旁组织中BEN结构域蛋白5(BEND5)表达差异及BEND5对膀胱癌细胞迁移能力和雷帕霉素靶蛋白(mTOR)通路的影响。方法利用癌症基因组图集(TCGA)数据库分析BEND5表达与膀胱癌患者生存的关系;收集40例膀胱癌患者的癌及癌... 目的探讨膀胱癌组织与癌旁组织中BEN结构域蛋白5(BEND5)表达差异及BEND5对膀胱癌细胞迁移能力和雷帕霉素靶蛋白(mTOR)通路的影响。方法利用癌症基因组图集(TCGA)数据库分析BEND5表达与膀胱癌患者生存的关系;收集40例膀胱癌患者的癌及癌旁组织,采用荧光定量PCR(qPCR)及蛋白免疫印迹法(Western blot,WB)检测BEND5mRNA及蛋白表达差异;膀胱癌5637和UMUC3细胞转染BEND5-siRNA后,划痕-愈合实验检测迁移能力的差异,WB法检测mTOR通路蛋白及波形蛋白(Vimentin)表达差异。结果通过TCGA分析发现,在膀胱癌中BEND5表达下调,且低表达的膀胱癌患者生存率更低。实验显示膀胱癌组织中BEND5 mRNA和蛋白表达均低于癌旁组织;沉默BEND5提高了膀胱癌细胞的迁移能力,并上调mTOR通路蛋白及波形蛋白表达。结论在膀胱癌组织中BEND5基因低表达,可能通过激活mTOR通路及促进癌细胞迁移的方式降低患者的生存率。 展开更多
关键词 膀胱癌 bend5 抗癌 mTOR通路 TCGA数据库
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Fracture behavior of sandstone with partial filling flaw under mixed-mode loading: Three-point bending tests and discrete element method
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作者 Dongdong Ma Yu Wu +4 位作者 Xiao Ma Xunjian Hu Wenbao Dong Decheng Li Lingyu Li 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期291-308,共18页
The fracture behavior of natural fracture in the geological reservoir subjected to filling property,affects the crack initiation and propagation under stress perturbation.Partial filling flaws were intermediate betwee... The fracture behavior of natural fracture in the geological reservoir subjected to filling property,affects the crack initiation and propagation under stress perturbation.Partial filling flaws were intermediate between open fractures and filled fractures,the fracture response may be worth exploring.In this work,the effect of the filling property of sandstone with partial filling flaws on the fracture behavior was systematically investigated based on three-point bending tests and the numerical approach of discrete element method(DEM).In the laboratory,semi-circular three-point bending tests were carried out with partial filling flaws of various filling strengths.Based on this,numerical simulations were used to further investigate the effect of the filling ratio and the inclination of the partial filling flaw on the mechanical and fracture responses,and the effect of the partial filling flaw under mixed-mode loading on the fracture mechanism was elucidated coupled with acoustic emission(AE)characteristics.The obtained results showed that the increase in filling strength and filling ratio of partial filling flaw led to an increase in peak strength,with a decreasing trend in peak strength with the inclination of partial filling flaw.In terms of crack propagation pattern,the increasing filling strength of the partial filling flaw induced the transformation of the fracture mechanism toward deflection,with a tortuosity path,while the filling ratio and inclination of partial filling flaw led to fracture mechanism change from deflection to penetration and attraction,accompanied with a larger AE event source in filler.Accordingly,the b-value based on the Gutenberg-Richter equation fluctuated between 5 and 4 at low filling ratio and inclination and remained around 5 at high filling ratio and inclination of partial filling flaw.Related results may provide an application prospective for reservoir stimulation using the natural fracture system. 展开更多
关键词 Partial filling flaw Mixed-mode loading Semi-circular three-point bending Acoustic emission(AE) B-VALUE
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A smart finger patch with coupled magnetoelastic and resistive bending sensors
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作者 Ziyi Dai Mingrui Wang +4 位作者 Yu Wang Zechuan Yu Yan Li Weidong Qin Kai Qian 《Journal of Semiconductors》 2025年第1期194-203,共10页
In the era of Metaverse and virtual reality(VR)/augmented reality(AR),capturing finger motion and force interactions is crucial for immersive human-machine interfaces.This study introduces a flexible electronic skin f... In the era of Metaverse and virtual reality(VR)/augmented reality(AR),capturing finger motion and force interactions is crucial for immersive human-machine interfaces.This study introduces a flexible electronic skin for the index finger,addressing coupled perception of both state and process in dynamic tactile sensing.The device integrates resistive and giant magnetoelastic sensors,enabling detection of surface pressure and finger joint bending.This e-skin identifies three phases of finger action:bending state,dynamic normal force and tangential force(sweeping).The system comprises resistive carbon nanotubes(CNT)/polydimethylsiloxane(PDMS)films for bending sensing and magnetoelastic sensors(NdFeB particles,EcoFlex,and flexible coils)for pressure detection.The inward bending resistive sensor,based on self-assembled microstructures,exhibits directional specificity with a response time under 120 ms and bending sensitivity from 0°to 120°.The magnetoelastic sensors demonstrate specific responses to frequency and deformation magnitude,as well as sensitivity to surface roughness during sliding and material hardness.The system’s capability is demonstrated through tactile-based bread type and condition recognition,achieving 92%accuracy.This intelligent patch shows broad potential in enhancing interactions across various fields,from VR/AR interfaces and medical diagnostics to smart manufacturing and industrial automation. 展开更多
关键词 human machine interface flexible sensor wearable sensor giant magnetoelastic effect inward bending sensor
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Bending Crashworthiness of Thin⁃Walled Square Tubes Partially Filled with Metallic Foams
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作者 Zhongyou Xie Limin Guo +1 位作者 Cheng Li Jianwen Cai 《Journal of Harbin Institute of Technology(New Series)》 2025年第2期24-37,共14页
Two cross⁃sectional configurations of thin⁃walled square tubes partially filled with lightweight metallic foams are proposed,and termed as double⁃cell configuration partially filled with foam(DC⁃PF)and double⁃tube con... Two cross⁃sectional configurations of thin⁃walled square tubes partially filled with lightweight metallic foams are proposed,and termed as double⁃cell configuration partially filled with foam(DC⁃PF)and double⁃tube configuration partially filled with foam(DT⁃PF),respectively.The bending crashworthiness is investigated based on three⁃point bending tests using finite element ABAQUS/Explicit code.The two key mechanical indicators including Crash Load Efficiency(CLE)and Specific Energy Absorption(SEA)are introduced to evaluate the effect of foams in comparison with empty square tubes and fully filled square tubes.The numerical results show that the two partially filled configurations,especially DT⁃PF,display dramatically excellent bending crashworthiness compared with empty and fully filled square tubes.There exists a foam density threshold,beyond which the CLE of DT⁃PF achieves a maximum constant.In addition,there seems to be another foam density threshold,beyond which the SEA of DT⁃PF gets to the maximum value.It is also shown that the foam density threshold corresponding to the maximum SEA varies with the thickness of thin⁃walled square tubes. 展开更多
关键词 thin⁃walled tube lightweight foam bending crashworthiness energy absorption finite element analysis
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A tactile glove for object recognition based on palmar pressure and joint bending strain sensing
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作者 ZHANG Xuefeng ZHANG Shaojie +1 位作者 CHEN Xin ZHANG Jinhua 《Journal of Measurement Science and Instrumentation》 2025年第2期173-185,共13页
With the rapid development of flexible electronics,the tactile systems for object recognition are becoming increasingly delicate.This paper presents the design of a tactile glove for object recognition,integrating 243... With the rapid development of flexible electronics,the tactile systems for object recognition are becoming increasingly delicate.This paper presents the design of a tactile glove for object recognition,integrating 243 palm pressure units and 126 finger joint strain units that are implemented by piezoresistive Velostat film.The palm pressure and joint bending strain data from the glove were collected using a two-dimensional resistance array scanning circuit and further converted into tactile images with a resolution of 32×32.To verify the effect of tactile data types on recognition precision,three datasets of tactile images were respectively built by palm pressure data,joint bending strain data,and a tactile data combing of both palm pressure and joint bending strain.An improved residual convolutional neural network(CNN)model,SP-ResNet,was developed by light-weighting ResNet-18 to classify these tactile images.Experimental results show that the data collection method combining palm pressure and joint bending strain demonstrates a 4.33%improvement in recognition precision compared to the best results obtained by using only palm pressure or joint bending strain.The recognition precision of 95.50%for 16 objects can be achieved by the presented tactile glove with SP-ResNet of less computation cost.The presented tactile system can serve as a sensing platform for intelligent prosthetics and robot grippers. 展开更多
关键词 tactile glove object recognition Velostat joint bending strain sensors palmar pressure sensors convolutional neural network
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A Numerical Study on Erosion and Wear Mechanisms in Variable Diameter Bend Pipes
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作者 Li Wang Haipeng Mu +1 位作者 Jiming Zhu Zhongchang Wang 《Fluid Dynamics & Materials Processing》 2025年第4期989-1005,共17页
To elucidate the relationship between pipeline erosion and wear during slurry transportation,this study considers three key influencing parameters,namely,the ratio of inlet to outlet pipe diameter,the length of the va... To elucidate the relationship between pipeline erosion and wear during slurry transportation,this study considers three key influencing parameters,namely,the ratio of inlet to outlet pipe diameter,the length of the variable diameter section,and the roughness of the pipe wall.The impact of these factors on pipeline erosion and wear is analyzed using a single-factor analysis approach.In particular,the Fluent software is employed to conduct the required numerical simulations for variable diameter elbows of varying morphologies.The results indicate that as the inlet to outlet diameter ratio increases,the wear on the pipe inlet and the outer wall of the elbow becomes increasingly pronounced.Notably,when the diameter ratio exceeds 0.8,there is a significant escalation in wear on both the inner and outer elbow walls.Initially,the maximum erosion rate decreases sharply with increasing diameter ratio before a stable condition is attained.Erosion wear in the variable diameter section exhibits a distinct layered distribution pattern.In this region,the wear range for a 40 mm length of the pipe body is relatively small;however,once this length exceeds 40 mm,the wear range expands,ultimately covering the entire pipe section.The length of the variable diameter section significantly influences the maximum erosion rate of the pipeline,with sections shorter than 80 mm experiencing the most severe effects,and showing an exponential decline in erosion rate.As the wall roughness gradually increases,the wear area on both cheeks of the bend section rapidly expands and tends to deepen further.When the roughness reaches 4 mm,the pipeline wear experiences a dramatic shift,resulting in extensive“spot-like”wear patterns emerging at the bottom and sides of the horizontal flow section,which previously exhibited no wear. 展开更多
关键词 Filling slurry variable diameter bend pipe erosion and wear conveying characteristics influence factor
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Nonlinear Bending of FG-CNTR Curved Nanobeams in Thermal Environments
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作者 Yuanyuan Zhang Yanxin Li +1 位作者 Guoyong Zhang Xin Zhang 《Acta Mechanica Solida Sinica》 2025年第1期166-180,共15页
By focusing on the nonlinear bending behavior of functionally graded carbon nanotube-reinforced(FG-CNTR)curved nanobeams under thermal loads while considering size effects,this paper fills the apparent void by compreh... By focusing on the nonlinear bending behavior of functionally graded carbon nanotube-reinforced(FG-CNTR)curved nanobeams under thermal loads while considering size effects,this paper fills the apparent void by comprehensively incorporating the Chen-Yao surface elasticity theory and modified couple-stress theory.A tri-parameter elastic substrate model is introduced,and the temperature dependence of material properties is considered.Through a two-step perturbation technique,the asymptotic solutions for the temperature-deflection relationship are obtained.After that,novel numerical results are provided to explore the impacts of temperature,size effects,geometric characteristics of the curved beams,elastic substrates,properties of the CNT reinforcements,and boundary conditions.The results indicate that surface effects,couple stress effects,and the elastic foundation enhance the bending stiffness of FG-CNTR curved nanobeams.By considering both size effect theories,this study provides a more comprehensive and precise description of the nonlinear bending of FG-CNTR curved nanobeams under thermal loads. 展开更多
关键词 Nonlinear bending Carbon nanotube-reinforced composites Size effect Two step perturbation technique
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Enhancement of bending toughness for Fe-based amorphous nanocrystalline alloy with deep cryogenic-cycling treatment
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作者 Yi-ran Zhang Dong Yang +5 位作者 Qing-chun Xiang Hong-yu Liu Jing Pang Ying-lei Ren Xiao-yu Li Ke-qiang Qiu 《China Foundry》 2025年第1期99-107,共9页
The effects of deep cryogenic-cycling treatment(DCT)on the mechanical properties,soft magnetic properties,and atomic scale structure of the Fe_(73.5)Si_(13.5)B_(9)Nb_(3)Cu_(1)amorphous nanocrystalline alloy were inves... The effects of deep cryogenic-cycling treatment(DCT)on the mechanical properties,soft magnetic properties,and atomic scale structure of the Fe_(73.5)Si_(13.5)B_(9)Nb_(3)Cu_(1)amorphous nanocrystalline alloy were investigated.The DCT samples were obtained by subjecting the as-annealed samples to a thermal cycling process between the temperature of the supercooled liquid zone and the temperature of liquid nitrogen.Through flat plate bending testing,hardness measurements,and nanoindentation experiment,it is found that the bending toughness of the DCT samples is improved and the soft magnetic properties are also slightly enhanced.These are attributed to the rejuvenation behavior of the DCT samples,which demonstrate a higher enthalpy of relaxation.Therefore,DCT is an effective method to enhance the bending toughness of Fe-based amorphous nanocrystalline alloys without degrading the soft magnetic properties. 展开更多
关键词 deep cryogenic-cycling treatment Fe-based amorphous nanocrystalline alloy bending toughness REJUVENATION
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Effect of Compound Energy Field with Laser and Ultrasonic Assisted Molding on Bending Performance of TC4 Titanium Alloy
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作者 GAO Tiejun ZHAO Kexiang +2 位作者 LI Weijie WANG Kaifeng WANG Xiaokang 《Journal of Wuhan University of Technology(Materials Science)》 2025年第3期852-858,共7页
Aiming at solve the difficulty and low dimensional accuracy in bending titanium alloy specimens at room temperature,we proposed a compound energy field(CEF)with laser and ultrasonic forming method.Through the conventi... Aiming at solve the difficulty and low dimensional accuracy in bending titanium alloy specimens at room temperature,we proposed a compound energy field(CEF)with laser and ultrasonic forming method.Through the conventional bending,laser-assisted energy field bending and CEF-assisted bending experiments on TC4 titanium alloy,the effects of bending force,laser-assisted energy field and CEF on the springback angle and fillet radius of TC4 titanium alloy specimens in V-shape bending were analyzed.The impact of the CEF-assisted bending process on the microstructure of TC4 titanium alloy was also investigated.The results show that CEF-assisted bending process has the advantages of high energy density,simple operation process and small influence area of the microstructure performances.It is effective in reducing the springback and fillet radius of bending specimens.Thus,CEF-assisted bending effectively improves the formability and surface quality of titanium alloy specimens. 展开更多
关键词 TC4 titanium alloy laser and ultrasonic compound energy field bending performances MICROSTRUCTURE
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Significant Influence on Residual Bending Strength by Cracks Generation During Grinding of Ceramics
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作者 Jinshuo Zhang Tianyi Sui +3 位作者 Bin Lin Bingrui Lv Jingming Li Jingguo Zhou 《Chinese Journal of Mechanical Engineering》 2025年第2期60-83,共24页
Any product must undergo precise manufacturing before use.The damage incurred during the manufacturing process can significantly impact the residual strength of the product post-manufacturing.However,the relationship ... Any product must undergo precise manufacturing before use.The damage incurred during the manufacturing process can significantly impact the residual strength of the product post-manufacturing.However,the relationship between residual bending strength and manufacturing-induced damage remains unclear,despite being a crucial parameter for assessing material service life and performance,leading to a decrease in product performance reliability.This study focuses on investigating the impact of crack generation on residual bending strength through theoretical and experimental analyses of scratching,grinding,and three-point bending.The research first elucidates the forms and mechanisms of material damage through scratch experiments.Subsequently,using resin-bonded and electroplated wheels as case studies,the influence of different process parameters on grinding damage and residual bending strength is explored.The reduction of brittle removal can lead to a 50%–60%decrease in residual bending strength.Lastly,a model is developed to delineate the relationship between processing parameters and the residual bending strength of the product,with the model exhibiting an error margin of less than 11%.This model clearly reveals the effect of crack generation under different process parameters on residual flexural strength. 展开更多
关键词 Hot isostatic pressing sinter SI3N4 SCRATCHING GRINDING Residual bending strength
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A sixth-order method for large deflection bending analysis of complex plates with multiple holes
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作者 Yonggu Feng Youhe Zhou Jizeng Wang 《Acta Mechanica Sinica》 2025年第6期105-124,共20页
The challenge of solving nonlinear problems in multi-connected domains with high accuracy has garnered significant interest.In this paper,we propose a unified wavelet solution method for accurately solving nonlinear b... The challenge of solving nonlinear problems in multi-connected domains with high accuracy has garnered significant interest.In this paper,we propose a unified wavelet solution method for accurately solving nonlinear boundary value problems on a two-dimensional(2D)arbitrary multi-connected domain.We apply this method to solve large deflection bending problems of complex plates with holes.Our solution method simplifies the treatment of the 2D multi-connected domain by utilizing a natural discretization approach that divides it into a series of one-dimensional(1D)intervals.This approach establishes a fundamental relationship between the highest-order derivative in the governing equation of the problem and the remaining lower-order derivatives.By combining a wavelet high accuracy integral approximation format on 1D intervals,where the convergence order remains constant regardless of the number of integration folds,with the collocation method,we obtain a system of algebraic equations that only includes discrete point values of the highest order derivative.In this process,the boundary conditions are automatically replaced using integration constants,eliminating the need for additional processing.Error estimation and numerical results demonstrate that the accuracy of this method is unaffected by the degree of nonlinearity of the equations.When solving the bending problem of multi-perforated complex-shaped plates under consideration,it is evident that directly using higher-order derivatives as unknown functions significantly improves the accuracy of stress calculation,even when the stress exhibits large gradient variations.Moreover,compared to the finite element method,the wavelet method requires significantly fewer nodes to achieve the same level of accuracy.Ultimately,the method achieves a sixth-order accuracy and resembles the treatment of one-dimensional problems during the solution process,effectively avoiding the need for the complex 2D meshing process typically required by conventional methods when solving problems with multi-connected domains. 展开更多
关键词 Wavelet integral collocation method Multi-connected domain Large deflection bending Plate with holes Highaccuracy
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Three-Point Bending Deformation Behavior of a High Plasticity Mg–2.6Er–0.6Zr Alloy Sheet
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作者 Yuanxiao Dai Yue Zhang +3 位作者 Mei Wang Jie Liu Yaobo Hu Bin Jiang 《Acta Metallurgica Sinica(English Letters)》 2025年第7期1109-1126,共18页
Bending is a crucial deformation process in metal sheet forming.In this study,the microstructural evolution of a highly ductile Mg–Er–Zr alloy sheet was examined in various bending regions under different bending st... Bending is a crucial deformation process in metal sheet forming.In this study,the microstructural evolution of a highly ductile Mg–Er–Zr alloy sheet was examined in various bending regions under different bending strains using electron backscatter diffraction and optical microscopy.The results show that the Mg–Er–Zr extruded sheet has excellent bending properties,with a failure bending strain of 39.3%,bending yield strength,and ultimate bending strength of 75.1 MPa and 250.5 MPa,respectively.The exceptional bending properties of the Mg–Er–Zr extruded sheets are primarily due to their fine grain size and the formation of rare-earth(RE)textures resulting from Er addition.Specifically,the in-grain misorientation axes(IGMA)and the twinning behaviors in various regions of the specimen during bending were thoroughly analyzed.Due to the polarity of the tensile twins and their low activation stress,a significant number of tensile twins are activated in the compression zone to regulate plastic deformation.The addition of Er weakens the basal texture of the sheet and reduces the critical resolved shear stress difference between non-basal slip and basal slip.Consequently,in the tensile zone,the basal and non-basal slips co-operate to coordinate the plastic deformation,effectively impeding crack initiation and propagation,and thereby enhancing the bending toughness of the Mg–Er–Zr sheet. 展开更多
关键词 Mg alloy sheet Three-point bending Deformation mechanism In-grain misorientation axis(IGMA)
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Multiscale analysis of microstructure-based bending characteristics of advanced high strength dual-phase steel
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作者 Ming-shuai Huo Hai-bo Xie +10 位作者 Tao Zhang Guan-qiao Su Lian-jie Li Meng-yuan Ren Zhou Li Jing-bao Liu Ting Yang Xi Zhang Yan-bin Du Valerie Linton Zheng-yi Jiang 《Journal of Iron and Steel Research International》 2025年第7期2054-2063,共10页
Different stress states have a significant influence on the magnitude of the microscopic plastic strain and result in the development of the microstructure evolution.As a result,a comprehensive understanding of the di... Different stress states have a significant influence on the magnitude of the microscopic plastic strain and result in the development of the microstructure evolution.As a result,a comprehensive understanding of the different scale variation on microstructure evolution during bending deformation is essential.The advanced high strength dual-phase(DP1180)steel was investigated using multiscale microstructure-based 3D representative volume element(RVE)modelling technology with emphasis on understanding the relationship between the microstructure,localised stress-strain evolution as well as the deformation characteristics in the bending process.It is demonstrated that the localised development in bending can be more accurately described by microscopic deformation when taking into account microstructural properties.Microstructure-based 3D RVEs from each chosen bending condition generally have comparable localisation properties,whilst the magnitudes and intensities differ.In addition,the most severe localised bands are predicted to occur close to the ferrite and martensite phase boundaries where the martensite grains are close together or have a somewhat sharp edge.The numerically predicted results for the microstructure evolution,shear bands development and stress and strain distribution after 3-point bending exhibit a good agreement with the relevant experimental observations. 展开更多
关键词 Advanced high strength dual-phase steel 3D representative volume element Microstructure-based modelling bending characteristics Multiscaleanalysis
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UHPC Reinforcement of Damaged RC Beams under Load Conditions Cracking and Bending Performance
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作者 Xuezhi Wang Sanzhao Xiao +1 位作者 Shixun Wang Shuwen Deng 《Journal of World Architecture》 2025年第4期103-109,共7页
In order to study the mechanical properties of damaged reinforced concrete(RC)beams reinforced with ultra-high-performance concrete(UHPC),a four-point bending test was conducted to systematically investigate the influ... In order to study the mechanical properties of damaged reinforced concrete(RC)beams reinforced with ultra-high-performance concrete(UHPC),a four-point bending test was conducted to systematically investigate the influence of factors such as the number of reinforcement surfaces and the degree of damage.The results indicate that single-sided repaired beams have certain advantages in crack resistance performance,but are more disadvantageous in ultimate bearing capacity,with obvious debonding phenomenon before the end of loading.Compared with single-sided reinforcement,the cracking load of the three-sided reinforced beam increased by an average of 1.85 times,the ultimate bearing capacity increased by an average of 177.5%,and a good UHPC-RC combination effect could be formed,which could work synergistically until the end of loading.The degree of pre damage has a significant impact on the crack resistance performance of reinforced beams,while its impact on the ultimate bearing capacity is relatively limited.When the pre splitting width of the RC beam increases from 0.2 mm to 0.4 mm,the ultimate bearing capacity decreases by 28.33%. 展开更多
关键词 UHPC reinforcement Three-sided repair bending performance:Cracking characteristics Ultimate bearing capacity
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