Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was ...Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was adapted from Figure 1d of Makarikov and Tkach(2013).In addition,Makarikov and Tkach(2013)should have been cited in the methods section.展开更多
As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert c...As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert can offer is but some pieces of advice. The keyfactor in language lies in hard work. No short way can be found. Theoretically, an expert展开更多
The lysosomal enzyme β-glucocerebrosidase(GCase) belongs to the family of glycosidases and hydrolyses the glycosphingolipid glucosylceramide(GluCer) into glucose and ceramide. The enzyme is of central importance for ...The lysosomal enzyme β-glucocerebrosidase(GCase) belongs to the family of glycosidases and hydrolyses the glycosphingolipid glucosylceramide(GluCer) into glucose and ceramide. The enzyme is of central importance for two pathologies:(1) the lysosomal storage disorder Gaucher's disease(GD) and(2) the neurodegenerative disorder Parkinson's disease(PD).展开更多
On the view point of herb research in the world traditional medicines, Digeda is used to vary the plants originated from different species and families, such as India Digeda （Hurghada） is Swertie chirayita （Buch. -...On the view point of herb research in the world traditional medicines, Digeda is used to vary the plants originated from different species and families, such as India Digeda （Hurghada） is Swertie chirayita （Buch. -Ham.）, Nepal Digeda （Hurghada） is Swertia cliete. Tibetan Digeda （Geda） are Saxifrage umbellulate Hook. f. ＆Thoms. and 5axifraga umbelluleta Hook. f. ＆Thoms. var. pectinata （C. Marq. ＆ Airy-Shaw） J. T. Pan. Alatan Digeda （Hurghada） is Saxifrage unguiculata Engl. Menken Digeda （Hurghada） now differs greatly. In Mongolia, Mongolian doctors use Parnassia palustris as the Digeda; Gisborne to Hurghada （Sandinista） are Swertia erythrosticta and Gentiana Ioureirii. Temuco uses Swertia pseudochineis as Digeda （Baghdad）. In Inner Mongolia Autonomous Region of China, Mongolian medicine Digeda is mainly originated from the three kinds of medicinal plants in Gentianaceae, Swertie pseudochinensis Hara, Gentianopsis barbata Froel Ma, and Lomatogonium rotetwn （L.） Friesex Nym. Additionally, in Inner Mongolia and Tibetan Autonomous Regions of China, the used Digeda is different from Inner Mongolia fork Medicine, Parnassia palustris and P. orepohila, Tibetan fork medicine is different from G. gilvostriata Flat Lei, G. barbara and G. paludosa. Halenia sibirica is recorded in Inner Mongolian Medicine 5tanderds. Therefore, herbal medicine Digede belongs to not only the nationality, but also the world.展开更多
The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strat...The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strategy(Huang et al.,2015).Subsequently,the donkey genome showed greater improvement in continuity and chromosome length than a previous assembly(Renaud et al.,2018).展开更多
Background:Academic achievement is an important indicator of student development,and its pursuit should be considered alongside students’mental health and overall quality of life.Traditional martial arts,as an educat...Background:Academic achievement is an important indicator of student development,and its pursuit should be considered alongside students’mental health and overall quality of life.Traditional martial arts,as an educational activity that emphasizes self-discipline,communal values,and positive emotional experiences,may support key psychological factors related to learning,such as optimism,school belonging,and well-being.However,how these factors are connected to academic achievement has not been fully examined.Therefore,this study investigated the associations between these psychological resources and academic achievement among students participating in traditional martial arts training.Methods:Data were collected from 331 elementary school students in South Korea who were enrolled in school-based traditional martial arts(taekkyeon)classes.The survey was administered on-site between August and November 2024.Confirmatory factor analysis and structural equation modeling with 5000 bootstrap resamples were performed to evaluate the measurement model and test the hypothesized relationships.Results:The measurement model showed acceptable fit,and the structural model supported most of the hypothesized relationships.Optimism showed significant positive associations with school belonging,well-being,and academic achievement;well-being was positively related to academic achievement.However,the direct relationship between school belonging and academic achievement was not statistically significant,suggesting that its influence may operate indirectly through well-being.Conclusion:The findings indicate that participation in traditional martial arts training is related to positive psychological processes and academic outcomes.This study underscores the broader contributions of traditional martial arts to students’well-being and academic adjustment,highlighting their relevance for school-based programs.展开更多
Dear Editor,Group B coxsackieviruses(CVBs),belonging to the genus Enterovirus(EV)of the family Picornaviridae,comprise six serotypes and share a typical picornaviral structure(Alhazmi et al.,2023).While most CVB infec...Dear Editor,Group B coxsackieviruses(CVBs),belonging to the genus Enterovirus(EV)of the family Picornaviridae,comprise six serotypes and share a typical picornaviral structure(Alhazmi et al.,2023).While most CVB infections are mild and self-limiting,they can cause severe or fatal illness,especially in children(Tracy and Gauntt,2008).展开更多
Dear Editor,Rabbit hemorrhagic disease(RHD)is a highly contagious disease of both wild and domesticated rabbits(Oryctolagus cuniculus).The causative agent of the disease is the rabbit hemorrhagic disease virus(RHDV),b...Dear Editor,Rabbit hemorrhagic disease(RHD)is a highly contagious disease of both wild and domesticated rabbits(Oryctolagus cuniculus).The causative agent of the disease is the rabbit hemorrhagic disease virus(RHDV),belongs to the genus Lagovirus within the family Caliciviridae(Granzow et al.,1996;Ohlinger et al.,1990).It is a small and non-enveloped virus with a 7.5 kb single stranded positive sense RNA genome(Meyers et al.,1991;Meyers et al.,2000).Based on an analysis of VP60展开更多
Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecula...Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecular mechanism had attracted lots of attention from investigators,but was still uncertain.Our present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major genes.We characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic pathways.PrMYBa1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’complex.The SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal blotches.The comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene silencing.The methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch area.We suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.展开更多
Pseudorabies,also known as Aujeszky's disease,is one of the most economically important viral diseases in pigs and is lethal to other susceptible animals(Ren et al.2020).The causative agent,pseudorabies virus(PRV)...Pseudorabies,also known as Aujeszky's disease,is one of the most economically important viral diseases in pigs and is lethal to other susceptible animals(Ren et al.2020).The causative agent,pseudorabies virus(PRV),is an enveloped virus with a large double-stranded DNA genome encoding at least 70 proteins(Wong et al.2019).PRV belongs to the family Herpesviridae,subfamily Alphaherpesvirinae,genus Varicellovirus and infects multiple animals,such as pigs,dogs,cats,rabbits,cattle,sheep,goats,minks.展开更多
Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,...Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,we identi fi ed an R2R3-MYB transcription factor,SlMYB72,that plays an important role in chlorophyll and carotenoid metabolism in tomato fruit.Here,we demonstrated that the SlMYB72-interacting protein SlZHD17,which belongs to the zinc-fi nger homeodomain transcription factor family,also functions in chlorophyll and carotenoid metabolism.Silencing SIZHD 17 in tomato improved multiple bene fi cial agronomic traits,including dwar fi sm,accelerated fl owering,and earlier fruit harvest.More importantly,downregulating SIZHD17 in fruits resulted in larger chloroplasts and a higher chlorophyll content.Dual-luciferase,yeast one-hybrid and electrophoretic mobility shift assays clari fi ed that SlZHD17 regulates the chlorophyll biosynthesis gene SIPOR-B and chloroplast developmental regulator SITKN2 in a direct manner.Chlorophyll degradation and plastid transformation were also retarded after suppression of SIZHD17 in fruits,which was caused by the inhibition of SISGR1,a crucial factor in chlorophyll degradation.On the other hand,the expression of the carotenoid biosynthesis genes SIPSY1 and SIZISO was also suppressed and directly regulated by SlZHD17,which induced uneven pigmentation and decreased the lycopene content in fruits with SIZHD17 suppression at the ripe stage.Furthermore,the protein-protein interactions between SlZHD17 and other pigment regulators,including SlARF4,SlBEL11,and SlTAGL1,were also presented.This study provides new insight into the complex pigment regulatory network and provides new options for breeding strategies aiming to improve fruit quality.展开更多
Dear Editor,Chikungunya virus(CHIKV),a single-stranded RNA virus that belongs to the genus Alphavirus,family Togaviridae,is transmitted by mosquitoes of the genus Aedes(Diptera:Culicidae),predominantly Aedes aegypti a...Dear Editor,Chikungunya virus(CHIKV),a single-stranded RNA virus that belongs to the genus Alphavirus,family Togaviridae,is transmitted by mosquitoes of the genus Aedes(Diptera:Culicidae),predominantly Aedes aegypti and A.albopictus(Staples et al.,2014).CHIKV infection is most often characterized by fever,headache,展开更多
Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is invol...Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is involved in many biochemical reactions critical for cell division,such as purine and pyrimidine biosynthesis,DNA/RNA biosynthesis,and amino acid metabolism(Iyer and Tomar,2009).Mammals cannot synthesize folic acid and thus they must acquire it from food.Although folic acid is ubiquitous in foods.展开更多
Wuxiang virus(WUXV),a new species of Phlebovirus from sandfly specimens(identified as Phlebotomus chinensis)collected in Wuxiang County,Shanxi Province,China,belongs to the order Bunyavirales,family Phenuiviridae.Like...Wuxiang virus(WUXV),a new species of Phlebovirus from sandfly specimens(identified as Phlebotomus chinensis)collected in Wuxiang County,Shanxi Province,China,belongs to the order Bunyavirales,family Phenuiviridae.Like other Bunyavirales,WUXV contains a negative-sense tripartite RNA genome comprising a small(S),a medium(M),and a large(L)segment.The S segment encodes nucleocapsid protein(NP)and a nonstructural protein(NSP).The M segment encodes a glycoprotein precursor(Gp),which is cleaved into mature N and C glycoproteins.The L segment encodes an RNA-dependent RNA polymerase(RdRp).展开更多
Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infection...Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infections. Coxsackievirus B6 (CV-B6)belongs to the species EV-B, which currently consists of 63 serotypes, including echovirus (serotypes 1–7,9, 11–21, 24–27, 29–33), coxsackievirus group A (CVA9), coxsackievirus group B (CV-B, serotypes 1–6),the newly identified EVs (serotypes EV-B69, B73–75,B77–88, B93, B97–98, B100–101, B106–107, and B110–113), and the simian enterovirus SA5.展开更多
Scalp acupuncture belongs to the cate-gory of small-needle therapy and is themethod of treating general diseases by need-ling Shu acupoints in the hair-area scalp.Since 1970s,it has been widely applied,andbecome so fa...Scalp acupuncture belongs to the cate-gory of small-needle therapy and is themethod of treating general diseases by need-ling Shu acupoints in the hair-area scalp.Since 1970s,it has been widely applied,andbecome so far an effective acupuncturetherapy accepted by acupuncturists all overthe world.Clinically,the therapy can beused to treat more than 80 diseases,with ma-rked therapeutic effects particularly on dis-eases of the central nervous system and onvarious acute or chronic pains.展开更多
SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family...SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].展开更多
文摘Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was adapted from Figure 1d of Makarikov and Tkach(2013).In addition,Makarikov and Tkach(2013)should have been cited in the methods section.
文摘As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert can offer is but some pieces of advice. The keyfactor in language lies in hard work. No short way can be found. Theoretically, an expert
基金supported by the Michael J Fox Foundation (to PA and FZ)。
文摘The lysosomal enzyme β-glucocerebrosidase(GCase) belongs to the family of glycosidases and hydrolyses the glycosphingolipid glucosylceramide(GluCer) into glucose and ceramide. The enzyme is of central importance for two pathologies:(1) the lysosomal storage disorder Gaucher's disease(GD) and(2) the neurodegenerative disorder Parkinson's disease(PD).
文摘On the view point of herb research in the world traditional medicines, Digeda is used to vary the plants originated from different species and families, such as India Digeda （Hurghada） is Swertie chirayita （Buch. -Ham.）, Nepal Digeda （Hurghada） is Swertia cliete. Tibetan Digeda （Geda） are Saxifrage umbellulate Hook. f. ＆Thoms. and 5axifraga umbelluleta Hook. f. ＆Thoms. var. pectinata （C. Marq. ＆ Airy-Shaw） J. T. Pan. Alatan Digeda （Hurghada） is Saxifrage unguiculata Engl. Menken Digeda （Hurghada） now differs greatly. In Mongolia, Mongolian doctors use Parnassia palustris as the Digeda; Gisborne to Hurghada （Sandinista） are Swertia erythrosticta and Gentiana Ioureirii. Temuco uses Swertia pseudochineis as Digeda （Baghdad）. In Inner Mongolia Autonomous Region of China, Mongolian medicine Digeda is mainly originated from the three kinds of medicinal plants in Gentianaceae, Swertie pseudochinensis Hara, Gentianopsis barbata Froel Ma, and Lomatogonium rotetwn （L.） Friesex Nym. Additionally, in Inner Mongolia and Tibetan Autonomous Regions of China, the used Digeda is different from Inner Mongolia fork Medicine, Parnassia palustris and P. orepohila, Tibetan fork medicine is different from G. gilvostriata Flat Lei, G. barbara and G. paludosa. Halenia sibirica is recorded in Inner Mongolian Medicine 5tanderds. Therefore, herbal medicine Digede belongs to not only the nationality, but also the world.
基金supported by the Third National Census of Livestock and Poultry Genetic Resources(K4050422227)the 2020 Scientist plus Engineer program of Shaanxi Province of Chinathe Central Guidance on Local Science and Technology Development Fund(K3030922098).
文摘The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strategy(Huang et al.,2015).Subsequently,the donkey genome showed greater improvement in continuity and chromosome length than a previous assembly(Renaud et al.,2018).
文摘Background:Academic achievement is an important indicator of student development,and its pursuit should be considered alongside students’mental health and overall quality of life.Traditional martial arts,as an educational activity that emphasizes self-discipline,communal values,and positive emotional experiences,may support key psychological factors related to learning,such as optimism,school belonging,and well-being.However,how these factors are connected to academic achievement has not been fully examined.Therefore,this study investigated the associations between these psychological resources and academic achievement among students participating in traditional martial arts training.Methods:Data were collected from 331 elementary school students in South Korea who were enrolled in school-based traditional martial arts(taekkyeon)classes.The survey was administered on-site between August and November 2024.Confirmatory factor analysis and structural equation modeling with 5000 bootstrap resamples were performed to evaluate the measurement model and test the hypothesized relationships.Results:The measurement model showed acceptable fit,and the structural model supported most of the hypothesized relationships.Optimism showed significant positive associations with school belonging,well-being,and academic achievement;well-being was positively related to academic achievement.However,the direct relationship between school belonging and academic achievement was not statistically significant,suggesting that its influence may operate indirectly through well-being.Conclusion:The findings indicate that participation in traditional martial arts training is related to positive psychological processes and academic outcomes.This study underscores the broader contributions of traditional martial arts to students’well-being and academic adjustment,highlighting their relevance for school-based programs.
基金supported by grants from the National Natural Science Foundation of China(82172248,82472253,82272310 and 32470996)the Xiamen Science and Technology Program(2022CXY0102)+1 种基金the Fundamental Research Funds for the Central Universities(20720250004)the Independent Research Project of the State Key Laboratory of Vaccine for Infectious Diseases(2024SKLVDzy03).
文摘Dear Editor,Group B coxsackieviruses(CVBs),belonging to the genus Enterovirus(EV)of the family Picornaviridae,comprise six serotypes and share a typical picornaviral structure(Alhazmi et al.,2023).While most CVB infections are mild and self-limiting,they can cause severe or fatal illness,especially in children(Tracy and Gauntt,2008).
基金supported by the Shaanxi Agriculture Science and Technology Research Projects (2014K02-06-01)
文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a highly contagious disease of both wild and domesticated rabbits(Oryctolagus cuniculus).The causative agent of the disease is the rabbit hemorrhagic disease virus(RHDV),belongs to the genus Lagovirus within the family Caliciviridae(Granzow et al.,1996;Ohlinger et al.,1990).It is a small and non-enveloped virus with a 7.5 kb single stranded positive sense RNA genome(Meyers et al.,1991;Meyers et al.,2000).Based on an analysis of VP60
基金This work was supported by the National Natural Science Foundation of China(No.32030095).
文摘Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecular mechanism had attracted lots of attention from investigators,but was still uncertain.Our present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major genes.We characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic pathways.PrMYBa1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’complex.The SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal blotches.The comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene silencing.The methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch area.We suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.
基金This work was supported by the National Natural Science Funds of China(31902281)the Science-Technology Foundation for Outstanding Young Scientists of Henan Academy of Agricultural Sciences(2020YQ15).
文摘Pseudorabies,also known as Aujeszky's disease,is one of the most economically important viral diseases in pigs and is lethal to other susceptible animals(Ren et al.2020).The causative agent,pseudorabies virus(PRV),is an enveloped virus with a large double-stranded DNA genome encoding at least 70 proteins(Wong et al.2019).PRV belongs to the family Herpesviridae,subfamily Alphaherpesvirinae,genus Varicellovirus and infects multiple animals,such as pigs,dogs,cats,rabbits,cattle,sheep,goats,minks.
基金This work was sponsored by the National Natural Science Foundation of China(No.32002100,31772370,31972470).
文摘Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,we identi fi ed an R2R3-MYB transcription factor,SlMYB72,that plays an important role in chlorophyll and carotenoid metabolism in tomato fruit.Here,we demonstrated that the SlMYB72-interacting protein SlZHD17,which belongs to the zinc-fi nger homeodomain transcription factor family,also functions in chlorophyll and carotenoid metabolism.Silencing SIZHD 17 in tomato improved multiple bene fi cial agronomic traits,including dwar fi sm,accelerated fl owering,and earlier fruit harvest.More importantly,downregulating SIZHD17 in fruits resulted in larger chloroplasts and a higher chlorophyll content.Dual-luciferase,yeast one-hybrid and electrophoretic mobility shift assays clari fi ed that SlZHD17 regulates the chlorophyll biosynthesis gene SIPOR-B and chloroplast developmental regulator SITKN2 in a direct manner.Chlorophyll degradation and plastid transformation were also retarded after suppression of SIZHD17 in fruits,which was caused by the inhibition of SISGR1,a crucial factor in chlorophyll degradation.On the other hand,the expression of the carotenoid biosynthesis genes SIPSY1 and SIZISO was also suppressed and directly regulated by SlZHD17,which induced uneven pigmentation and decreased the lycopene content in fruits with SIZHD17 suppression at the ripe stage.Furthermore,the protein-protein interactions between SlZHD17 and other pigment regulators,including SlARF4,SlBEL11,and SlTAGL1,were also presented.This study provides new insight into the complex pigment regulatory network and provides new options for breeding strategies aiming to improve fruit quality.
基金supported by the Department of International Affairs of the Institut Pasteur International Network(ACIP A12-2011)approved by the National Ethical Committee of Cameroon(permit number,255/CNE/SE/2011)
文摘Dear Editor,Chikungunya virus(CHIKV),a single-stranded RNA virus that belongs to the genus Alphavirus,family Togaviridae,is transmitted by mosquitoes of the genus Aedes(Diptera:Culicidae),predominantly Aedes aegypti and A.albopictus(Staples et al.,2014).CHIKV infection is most often characterized by fever,headache,
基金This work was supported by the National Basic Research Program(973)of China(No.2016YFF0200503)the National Natural Science Foundation of China(No.21876146).
文摘Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is involved in many biochemical reactions critical for cell division,such as purine and pyrimidine biosynthesis,DNA/RNA biosynthesis,and amino acid metabolism(Iyer and Tomar,2009).Mammals cannot synthesize folic acid and thus they must acquire it from food.Although folic acid is ubiquitous in foods.
基金funded by a development grant from the State Key Laboratory of Infectious Disease Prevention and Control [2015SKLID505 to HW]the project of the Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD]the United States National Institutes of Health U01 [AI151810]
文摘Wuxiang virus(WUXV),a new species of Phlebovirus from sandfly specimens(identified as Phlebotomus chinensis)collected in Wuxiang County,Shanxi Province,China,belongs to the order Bunyavirales,family Phenuiviridae.Like other Bunyavirales,WUXV contains a negative-sense tripartite RNA genome comprising a small(S),a medium(M),and a large(L)segment.The S segment encodes nucleocapsid protein(NP)and a nonstructural protein(NSP).The M segment encodes a glycoprotein precursor(Gp),which is cleaved into mature N and C glycoproteins.The L segment encodes an RNA-dependent RNA polymerase(RdRp).
基金supported by the National Key Science and Technology Projects of China [Project Nos.2017ZX10104001,2018ZX10711001,and 2018ZX10713002]
文摘Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infections. Coxsackievirus B6 (CV-B6)belongs to the species EV-B, which currently consists of 63 serotypes, including echovirus (serotypes 1–7,9, 11–21, 24–27, 29–33), coxsackievirus group A (CVA9), coxsackievirus group B (CV-B, serotypes 1–6),the newly identified EVs (serotypes EV-B69, B73–75,B77–88, B93, B97–98, B100–101, B106–107, and B110–113), and the simian enterovirus SA5.
文摘Scalp acupuncture belongs to the cate-gory of small-needle therapy and is themethod of treating general diseases by need-ling Shu acupoints in the hair-area scalp.Since 1970s,it has been widely applied,andbecome so far an effective acupuncturetherapy accepted by acupuncturists all overthe world.Clinically,the therapy can beused to treat more than 80 diseases,with ma-rked therapeutic effects particularly on dis-eases of the central nervous system and onvarious acute or chronic pains.
基金supported by grants from National Natural Science Foundation of China[81700920,81970894,and81870725]Natural Science Foundation of Jiangsu Province[BK20191229,BK20180048,and 17KJA180008]+3 种基金the Fifth‘333Project’Scientific Research Foundation of Jiangsu Province[BRA2019192 and BRA2019278]Medical Scientific Research Project from Health and Family Planning Commission of Jiangsu Province[H201666]Shanghai Municipal Education Commission–Gaofeng Clinical Medicine Grant[20152519]Science and Technology Commission of Shanghai Municipality[14DZ2260300]。
文摘SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].
