目的比较拉莫三嗪(LTG)与奥卡西平(OXC)作为初始单药治疗新诊断儿童良性癫痫伴中央颞区棘波(BECT)的药物保留率和疗效研究。方法收集初始LTG或OXC单药治疗的新诊断BECT患儿的临床资料,随访至停药或至少随访1年,评价两种药物1年的总药物...目的比较拉莫三嗪(LTG)与奥卡西平(OXC)作为初始单药治疗新诊断儿童良性癫痫伴中央颞区棘波(BECT)的药物保留率和疗效研究。方法收集初始LTG或OXC单药治疗的新诊断BECT患儿的临床资料,随访至停药或至少随访1年,评价两种药物1年的总药物保留率、单药保留率及疗效,探寻影响药物保留率的相关危险因素。结果共有240例新诊断BECT患儿纳入本次研究,至随访终点时,LTG组和OXC组1年总药物保留率分别为90.3%和80.2%,LTG组1年总药物保留率高于OXC组,差异有统计学意义(Log-Rank test χ^(2)=3.910,P<0.05);LTG组和OXC组1年单药保留率分别为80.6%和67.3%,LTG组1年单药保留率高于OXC组,差异有统计学意义(Log-Rank test χ^(2)=4.546,P<0.05);LTG组与OXC组无发作率分别为85.3%和82.4%,差异无统计学意义(χ^(2)=1.892,P>0.05)。BECT分型是BECT总药物保留率、单药保留率的影响因素(HR=2.61,95%CI=1.24~5.51,P<0.05;HR=4.32,95%CI=2.55~7.32,P<0.05)。结论LTG作为初始单药治疗BECT,疗效与OXC相似,但在1年单药保留率和总药物保留率方面,LTG高于OXC,具有较好的耐受性,可作为新诊断的BECT儿童的初始单药治疗选择。展开更多
Authors of the letter made an interesting and intriguing proposal: they introduce the concept that a child already affected by benign epilepsy with centrotemporal spikes (BECTS) when manifests contemporary or subseque...Authors of the letter made an interesting and intriguing proposal: they introduce the concept that a child already affected by benign epilepsy with centrotemporal spikes (BECTS) when manifests contemporary or subsequent the symptoms of childhood absence epilepsy (CAE), he/she could be affected by an atypical form of BECTS, despite the fact that the coexistence of these idiopathic epilepsy remains controversial and has been rarely observed. BECTS and CAE could be pathophysiologically linked, possibly with an underlying genetic mechanism.展开更多
文摘目的比较拉莫三嗪(LTG)与奥卡西平(OXC)作为初始单药治疗新诊断儿童良性癫痫伴中央颞区棘波(BECT)的药物保留率和疗效研究。方法收集初始LTG或OXC单药治疗的新诊断BECT患儿的临床资料,随访至停药或至少随访1年,评价两种药物1年的总药物保留率、单药保留率及疗效,探寻影响药物保留率的相关危险因素。结果共有240例新诊断BECT患儿纳入本次研究,至随访终点时,LTG组和OXC组1年总药物保留率分别为90.3%和80.2%,LTG组1年总药物保留率高于OXC组,差异有统计学意义(Log-Rank test χ^(2)=3.910,P<0.05);LTG组和OXC组1年单药保留率分别为80.6%和67.3%,LTG组1年单药保留率高于OXC组,差异有统计学意义(Log-Rank test χ^(2)=4.546,P<0.05);LTG组与OXC组无发作率分别为85.3%和82.4%,差异无统计学意义(χ^(2)=1.892,P>0.05)。BECT分型是BECT总药物保留率、单药保留率的影响因素(HR=2.61,95%CI=1.24~5.51,P<0.05;HR=4.32,95%CI=2.55~7.32,P<0.05)。结论LTG作为初始单药治疗BECT,疗效与OXC相似,但在1年单药保留率和总药物保留率方面,LTG高于OXC,具有较好的耐受性,可作为新诊断的BECT儿童的初始单药治疗选择。
文摘Authors of the letter made an interesting and intriguing proposal: they introduce the concept that a child already affected by benign epilepsy with centrotemporal spikes (BECTS) when manifests contemporary or subsequent the symptoms of childhood absence epilepsy (CAE), he/she could be affected by an atypical form of BECTS, despite the fact that the coexistence of these idiopathic epilepsy remains controversial and has been rarely observed. BECTS and CAE could be pathophysiologically linked, possibly with an underlying genetic mechanism.
