The purpose of this study is to analyze factors affecting the purchasing behavior of low-income Vietnamese on e-commerce platforms.700 questionnaires were dispersed among universities,coffee shops,and Facebook communi...The purpose of this study is to analyze factors affecting the purchasing behavior of low-income Vietnamese on e-commerce platforms.700 questionnaires were dispersed among universities,coffee shops,and Facebook community groups in Vietnam.Respondents to the questionnaires were consumers of those places in Vietnam,which were randomly selected.Finally,SEM analysis was used on the data to test the hypotheses of the study.The study identified that“Subjective norms”and“Consumer attitudes”have no effect on shopping behavior on e-commerce platforms,while“Perceived behavioral control”is most affected and“Perceived risks”are least affected on shopping behavior.展开更多
Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-targe...Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases.展开更多
This paper first introduced current situations of agricultural enterprises using B2C e-commerce to sell agricultural products.Then,using SWOT method,it analyzed strengths,weaknesses,opportunities,and threats of Wuding...This paper first introduced current situations of agricultural enterprises using B2C e-commerce to sell agricultural products.Then,using SWOT method,it analyzed strengths,weaknesses,opportunities,and threats of Wuding strong chicken farming enterprises implementing B2C e-commerce.Finally,it came up with recommendations for Wuding strong chicken farming enterprises implementing B2C e-commerce.展开更多
The rapid development of the“Internet+”has ushered in a new era of global digital technology innovation.Concurrent with the deepening trends of economic globalization and integration,international trade is progressi...The rapid development of the“Internet+”has ushered in a new era of global digital technology innovation.Concurrent with the deepening trends of economic globalization and integration,international trade is progressively undergoing extensive digitization,with cross-border e-commerce emerging as a significant manifestation of this transformation.Within this landscape,the cross-border e-commerce B2B platform is anticipated to become a pivotal driver for China’s cross-border trade growth,representing a strategic opportunity for trade transformation.This paper provides a comprehensive examination of the concepts,characteristics,and development status of cross-border e-commerce and B2B platforms,considering both global and Chinese perspectives.Focusing on a prominent case study,Alibaba International Station,a B2B cross-border e-commerce platform,the paper delves into its business model and core competencies,offering a thorough analysis of its role in the intricacies of international e-commerce and its contribution to the field.Drawing on insights gained,the paper concludes by presenting targeted recommendations from both the platform and government perspectives.These suggestions are informed by a nuanced understanding of the development opportunities and challenges facing China’s cross-border e-commerce B2B platforms.展开更多
The objective of this study is to compare the ranking of the quality of e-commerce B2C portals in Brazil according to explicit criteria described in the article with the ranking according to the INFO 100 ranking. Theo...The objective of this study is to compare the ranking of the quality of e-commerce B2C portals in Brazil according to explicit criteria described in the article with the ranking according to the INFO 100 ranking. Theoretical research is first described, followed by the construction of eight self-established criteria of B2C portal quality measures and identification and compilation of requirements used by the I-Best, Opinia, E-bit and other institutes. After that, a portal quality evaluation is made by the web site content analysis;finally, a comparison of the rankings is presented. The obtained results showed that in spite of the lack of knowledge of the criteria adopted by INFO100 [1], there could be agreement with the criteria adopted in this study, because there was agreement with the results for the Ponto Frio portal. Therefore, it was concluded that the eight criteria used in this study can be useful in a quality analysis of B2C electronic portals.展开更多
The objective of this paper was to analyze the impact of online reviews on sales. Based on dual path model of commodity sales, an online reviews impact on the relationship between various factors, and then the theoret...The objective of this paper was to analyze the impact of online reviews on sales. Based on dual path model of commodity sales, an online reviews impact on the relationship between various factors, and then the theoretical hypothesis of each factor has been put forward in the model. As it is intuitive and strongly supported empirically, data including Chinese texts captured from Tmall.com was utilized, and then analyzed by SPSS and ROST CM6. Our empirical study on the reviews of Tmall.com indicated that the hypotheses are verified.展开更多
The objective of this paper was to analyze the impact of online reviews on sales. Based on dual path model of commodity sales, an online reviews impact on the relationship between various factors, and then the theoret...The objective of this paper was to analyze the impact of online reviews on sales. Based on dual path model of commodity sales, an online reviews impact on the relationship between various factors, and then the theoretical hypothesis of each factor has been put forward in the model. As it is intuitive and strongly supported empirically, data including Chinese texts captured from Tmall. com was utilized, and then analyzed by SPSS and ROST CM6. Our empirical study on the reviews of TmalLcom indicated that the hypotheses are verified.展开更多
Taking B2C E-commerce enterprises as the center, it can be divided into a set of logistics activities upstream supply chain logistics producer to B2C e-commerce enterprises, and the B2C e-commerce enterprise logistics...Taking B2C E-commerce enterprises as the center, it can be divided into a set of logistics activities upstream supply chain logistics producer to B2C e-commerce enterprises, and the B2C e-commerce enterprise logistics to client consumer, and the paper focuses on the study of self-supporting logistics for the E-commerce enterprise. According to the development status of current B2C electronic commerce enterprise in our country and logistics, the paper study B2C electric business enterprise how to correctly choose the logistics mode and how to promote the business logistics operation level.展开更多
This paper proposes the assumption of E-commerce platform of the agricultural products based on the F2C2B mode. The whole e-commerce model is guided by the idea of the supply chain management from the perspective of t...This paper proposes the assumption of E-commerce platform of the agricultural products based on the F2C2B mode. The whole e-commerce model is guided by the idea of the supply chain management from the perspective of the modern system, and the e-commerce integration model from customer to supplier is implemented, and the whole is optimized. E-commerce to cloud computing as the basic environment, the construction of public cloud services and private cloud resources, based on public cloud to the SaaS way to provide services to customers, focus on business search and business collaboration, make full use of the lnternet, modern communications technology to provide the real- service. The development of agricultural economy, no longer depends only on the number of some traditional agricultural resources, but also depends on the modern technology, information access and use. Through the development of basic network technology, by virtue of some modern electronic information technology and some other means that can improve the intelligence of agricultural use of the information resources, the proposed model provides the new methodology of the solution.展开更多
Objective To analyze the problems of pharmaceutical e-commerce and provide strategies for its development in the future B2C mode since drug network management has great potential in China.Methods By collecting,identif...Objective To analyze the problems of pharmaceutical e-commerce and provide strategies for its development in the future B2C mode since drug network management has great potential in China.Methods By collecting,identifying,and conducting literature research,PEST-SWOT identification and positioning of pharmaceutical e-commerce in the B2C mode were carried out.Results and Conclusion A PEST-SWOT analysis matrix was established to analyze the status of B2C pharmaceutical e-commerce,and to summarize its advantages,disadvantages,opportunities and threats from four perspectives of politics,economy,society and technology.Suggestions on cultivating compound talents proficient in medicine and e-commerce,exploring online payment methods for medical insurance,integration of upstream and downstream of the industrial chain and data sharing are put forward to promote the healthy and long-term development of pharmaceutical e-commerce under the background of big data.展开更多
Purpose： This research attempts to examine the relationship between B2C interaction and customer loyalty in Business-to-Customer（B2C） context from a new perspective of the interactive tool.Design/methodology/appro...Purpose： This research attempts to examine the relationship between B2C interaction and customer loyalty in Business-to-Customer（B2C） context from a new perspective of the interactive tool.Design/methodology/approach： The scale for B2C interactive tools is of seven dimensions： efficiency, security, fulfillment, mobility, community, cultivation, and customization. A model reflecting the influences of these attributes on customer loyalty is developed and empirically examined based on data collected from 265 B2C customers. Findings： Results reveal that the fulfillment, mobility, community, and customization of B2C interactive tools can enhance customer loyalty directly and significantly. Efficiency and security, serving as the premise for possible purchase behavior, facilitate fulfillment. In addition, cultivation promotes the formation of customization, which directly strengthens customer loyalty.Research limitations： Models considering individual-level indicators and combined with classic loyalty mechanisms in B2C context may lead to a deeper understanding of the tested effects of interaction on customer loyalty.Practical implications： To strengthen B2C interaction and further cultivate loyal customers, making interactive tools more fundamental, flexible, and personalized is critical for B2C enterprises. Originality/value： This study proposes a new perspective from interactive tools when measuring the relationship between B2C interaction and customer loyalty, and offers a useful theoretical lens and reasonable explanations for investigating customer loyalty in B2C e-commerce context.展开更多
Recent studies have shown that the perceived lack of security is a major obstacle to the wider acceptance of e-commerce. To overcome this barrier, businesses need to implement comprehensive consumer protection systems...Recent studies have shown that the perceived lack of security is a major obstacle to the wider acceptance of e-commerce. To overcome this barrier, businesses need to implement comprehensive consumer protection systems that protect consumers during every stage of the purchasing process. This paper used the consumer behaviour model as the basis for analysing risks in Bussiness-to-Consumer (B2C) transactions. Four categories of risks were identified: information, agreement, payment and delivery risk. By combining these risk categories with the three dimensions of management, technology and legislation, a comprehensive B2C consumer protection framework is developed.展开更多
BACKGROUND Ulcerative colitis(UC),a chronic and challenging condition,necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications...BACKGROUND Ulcerative colitis(UC),a chronic and challenging condition,necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications.Traditional Chinese medicine(TCM),known for its multi-stage and multi-targeted approach,has a long history in treating gastrointestinal diseases and offering a promising alternative UC treatment.Panax ginseng(P.ginseng),a commonly used remedy for UC in TCM,exemplifies this potential,although the specific components and mechanisms through which its therapeutic effects are exerted remain to be fully elucidated,highlighting the need for further research to unlock its full potential as a treatment option.AIM To investigate the key constituents and biological pathways through which P.ginseng exerts therapeutic effects on UC.METHODS Network pharmacology investigated the UC-alleviating mechanism of P.ginseng,including“active ingredient-target-disease”network analysis,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses.Panaxadiol(PD;active ingredient of P.ginseng)was tested in a mouse model of 3%dextran sulfate sodium-induced UC,with assessments of body weight,Disease Activity Index scores,and colon length.Colitis and intestinal barrier integrity were analyzed via hematoxylin-eosin and Alcian blue and periodic acid-Schiff staining,immunohistochemistry,real time-quantitative PCR,and western blotting.RESULTS By integrating and analyzing the targets of P.ginseng and UC,15 critical hub genes were discovered.Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed the mechanisms involved to be linked to MAPK and PI3K-Akt signaling.Among the 10 main active ingredients identified as potentially effective,PD was most abundant and was validated in vivo to mitigate weight loss,reduce Disease Activity Index scores,and prevent colon shortening.PD also reduced inflammation and suppressed expression of pro-inflammatory cytokines and mediators.In addition,PD increased expression of mucin and tight junction proteins.Ultimately,PD counteracted effects of dextran sulfate sodium by inhibiting phosphorylation of NF-кB and MAPK,while increasing phosphorylation of AMPK and expression of NRF2 and NQO1.CONCLUSION PD alleviates colitis and aids intestinal barrier repair,partly via modulation of the MAPK/NF-кB and AMPK/NRF2/NQO1 pathways.These findings also suggest new research methods for treatment of UC with TCM.展开更多
文摘The purpose of this study is to analyze factors affecting the purchasing behavior of low-income Vietnamese on e-commerce platforms.700 questionnaires were dispersed among universities,coffee shops,and Facebook community groups in Vietnam.Respondents to the questionnaires were consumers of those places in Vietnam,which were randomly selected.Finally,SEM analysis was used on the data to test the hypotheses of the study.The study identified that“Subjective norms”and“Consumer attitudes”have no effect on shopping behavior on e-commerce platforms,while“Perceived behavioral control”is most affected and“Perceived risks”are least affected on shopping behavior.
基金supported by the National Natural Science Foundation of China(Grant Nos.:32271292,31872723,32200778,and 22377089)the Jiangsu Students Innovation and Entrepre-neurship Training Program,China(Program No.:202210285081Z)+6 种基金the Project of MOE Key Laboratory of Geriatric Diseases and Immunology,China(Project No.:JYN202404)Proj-ect Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,Natural Science Foundation of Jiangsu Province,China(Project No.:BK20220494)Suzhou Medical and Health Technology Innovation Project,China(Grant No.:SKY2022107)the Clinical Research Center of Neuro-logical Disease in The Second Affiliated Hospital of Soochow University,China(Grant No.:ND2022A04)State Key Laboratory of Drug Research(Grant No.:SKLDR-2023-KF-05)Jiangsu Shuang-chuang Program for Doctor,Young Science Talents Promotion Project of Jiangsu Science and Technology Association(Program No.:TJ-2023-019)Young Science Talents Promotion Project of Suzhou Science and Technology Association,Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,and startup funding(Grant Nos.:NH21500221,NH21500122,and NH21500123)to Qifei Cong.
文摘Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases.
文摘This paper first introduced current situations of agricultural enterprises using B2C e-commerce to sell agricultural products.Then,using SWOT method,it analyzed strengths,weaknesses,opportunities,and threats of Wuding strong chicken farming enterprises implementing B2C e-commerce.Finally,it came up with recommendations for Wuding strong chicken farming enterprises implementing B2C e-commerce.
文摘The rapid development of the“Internet+”has ushered in a new era of global digital technology innovation.Concurrent with the deepening trends of economic globalization and integration,international trade is progressively undergoing extensive digitization,with cross-border e-commerce emerging as a significant manifestation of this transformation.Within this landscape,the cross-border e-commerce B2B platform is anticipated to become a pivotal driver for China’s cross-border trade growth,representing a strategic opportunity for trade transformation.This paper provides a comprehensive examination of the concepts,characteristics,and development status of cross-border e-commerce and B2B platforms,considering both global and Chinese perspectives.Focusing on a prominent case study,Alibaba International Station,a B2B cross-border e-commerce platform,the paper delves into its business model and core competencies,offering a thorough analysis of its role in the intricacies of international e-commerce and its contribution to the field.Drawing on insights gained,the paper concludes by presenting targeted recommendations from both the platform and government perspectives.These suggestions are informed by a nuanced understanding of the development opportunities and challenges facing China’s cross-border e-commerce B2B platforms.
文摘The objective of this study is to compare the ranking of the quality of e-commerce B2C portals in Brazil according to explicit criteria described in the article with the ranking according to the INFO 100 ranking. Theoretical research is first described, followed by the construction of eight self-established criteria of B2C portal quality measures and identification and compilation of requirements used by the I-Best, Opinia, E-bit and other institutes. After that, a portal quality evaluation is made by the web site content analysis;finally, a comparison of the rankings is presented. The obtained results showed that in spite of the lack of knowledge of the criteria adopted by INFO100 [1], there could be agreement with the criteria adopted in this study, because there was agreement with the results for the Ponto Frio portal. Therefore, it was concluded that the eight criteria used in this study can be useful in a quality analysis of B2C electronic portals.
文摘The objective of this paper was to analyze the impact of online reviews on sales. Based on dual path model of commodity sales, an online reviews impact on the relationship between various factors, and then the theoretical hypothesis of each factor has been put forward in the model. As it is intuitive and strongly supported empirically, data including Chinese texts captured from Tmall.com was utilized, and then analyzed by SPSS and ROST CM6. Our empirical study on the reviews of Tmall.com indicated that the hypotheses are verified.
基金Supported by National Natural Science Foundation of China under Grant （No.61075115）, Soft Science Key issues of Shanghai Science and Technology Commission（No. 13692104900）, Innovation Program of Shanghai Municipal Education Commission （12YZ152）, Humanities and Social Science Fund of Ministry of Education （No. 13YJCZH 122） and Course Construction of SUES （No.K201203005）.
文摘The objective of this paper was to analyze the impact of online reviews on sales. Based on dual path model of commodity sales, an online reviews impact on the relationship between various factors, and then the theoretical hypothesis of each factor has been put forward in the model. As it is intuitive and strongly supported empirically, data including Chinese texts captured from Tmall. com was utilized, and then analyzed by SPSS and ROST CM6. Our empirical study on the reviews of TmalLcom indicated that the hypotheses are verified.
文摘Taking B2C E-commerce enterprises as the center, it can be divided into a set of logistics activities upstream supply chain logistics producer to B2C e-commerce enterprises, and the B2C e-commerce enterprise logistics to client consumer, and the paper focuses on the study of self-supporting logistics for the E-commerce enterprise. According to the development status of current B2C electronic commerce enterprise in our country and logistics, the paper study B2C electric business enterprise how to correctly choose the logistics mode and how to promote the business logistics operation level.
文摘This paper proposes the assumption of E-commerce platform of the agricultural products based on the F2C2B mode. The whole e-commerce model is guided by the idea of the supply chain management from the perspective of the modern system, and the e-commerce integration model from customer to supplier is implemented, and the whole is optimized. E-commerce to cloud computing as the basic environment, the construction of public cloud services and private cloud resources, based on public cloud to the SaaS way to provide services to customers, focus on business search and business collaboration, make full use of the lnternet, modern communications technology to provide the real- service. The development of agricultural economy, no longer depends only on the number of some traditional agricultural resources, but also depends on the modern technology, information access and use. Through the development of basic network technology, by virtue of some modern electronic information technology and some other means that can improve the intelligence of agricultural use of the information resources, the proposed model provides the new methodology of the solution.
基金2021 General Scientific Research Project of Liaoning Provincial Department of Education(No.LJKR0298)Liaoning Provincial Social Science Planning Fund Office(2019)(No.L19BGL034).
文摘Objective To analyze the problems of pharmaceutical e-commerce and provide strategies for its development in the future B2C mode since drug network management has great potential in China.Methods By collecting,identifying,and conducting literature research,PEST-SWOT identification and positioning of pharmaceutical e-commerce in the B2C mode were carried out.Results and Conclusion A PEST-SWOT analysis matrix was established to analyze the status of B2C pharmaceutical e-commerce,and to summarize its advantages,disadvantages,opportunities and threats from four perspectives of politics,economy,society and technology.Suggestions on cultivating compound talents proficient in medicine and e-commerce,exploring online payment methods for medical insurance,integration of upstream and downstream of the industrial chain and data sharing are put forward to promote the healthy and long-term development of pharmaceutical e-commerce under the background of big data.
基金supported in part by the Social Science Foundation of Jiangsu (Grant No.: 17TQB003)
文摘Purpose： This research attempts to examine the relationship between B2C interaction and customer loyalty in Business-to-Customer（B2C） context from a new perspective of the interactive tool.Design/methodology/approach： The scale for B2C interactive tools is of seven dimensions： efficiency, security, fulfillment, mobility, community, cultivation, and customization. A model reflecting the influences of these attributes on customer loyalty is developed and empirically examined based on data collected from 265 B2C customers. Findings： Results reveal that the fulfillment, mobility, community, and customization of B2C interactive tools can enhance customer loyalty directly and significantly. Efficiency and security, serving as the premise for possible purchase behavior, facilitate fulfillment. In addition, cultivation promotes the formation of customization, which directly strengthens customer loyalty.Research limitations： Models considering individual-level indicators and combined with classic loyalty mechanisms in B2C context may lead to a deeper understanding of the tested effects of interaction on customer loyalty.Practical implications： To strengthen B2C interaction and further cultivate loyal customers, making interactive tools more fundamental, flexible, and personalized is critical for B2C enterprises. Originality/value： This study proposes a new perspective from interactive tools when measuring the relationship between B2C interaction and customer loyalty, and offers a useful theoretical lens and reasonable explanations for investigating customer loyalty in B2C e-commerce context.
文摘Recent studies have shown that the perceived lack of security is a major obstacle to the wider acceptance of e-commerce. To overcome this barrier, businesses need to implement comprehensive consumer protection systems that protect consumers during every stage of the purchasing process. This paper used the consumer behaviour model as the basis for analysing risks in Bussiness-to-Consumer (B2C) transactions. Four categories of risks were identified: information, agreement, payment and delivery risk. By combining these risk categories with the three dimensions of management, technology and legislation, a comprehensive B2C consumer protection framework is developed.
基金Supported by Provincial Key Cultivation Laboratory for Digestive Disease Research,Shanxi Province’s“Si Ge Yi Pi”Science and Technology Driven Medical Innovation Project,No.2021SYS13,No.2020SYS13 and No.2021MX03.
文摘BACKGROUND Ulcerative colitis(UC),a chronic and challenging condition,necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications.Traditional Chinese medicine(TCM),known for its multi-stage and multi-targeted approach,has a long history in treating gastrointestinal diseases and offering a promising alternative UC treatment.Panax ginseng(P.ginseng),a commonly used remedy for UC in TCM,exemplifies this potential,although the specific components and mechanisms through which its therapeutic effects are exerted remain to be fully elucidated,highlighting the need for further research to unlock its full potential as a treatment option.AIM To investigate the key constituents and biological pathways through which P.ginseng exerts therapeutic effects on UC.METHODS Network pharmacology investigated the UC-alleviating mechanism of P.ginseng,including“active ingredient-target-disease”network analysis,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses.Panaxadiol(PD;active ingredient of P.ginseng)was tested in a mouse model of 3%dextran sulfate sodium-induced UC,with assessments of body weight,Disease Activity Index scores,and colon length.Colitis and intestinal barrier integrity were analyzed via hematoxylin-eosin and Alcian blue and periodic acid-Schiff staining,immunohistochemistry,real time-quantitative PCR,and western blotting.RESULTS By integrating and analyzing the targets of P.ginseng and UC,15 critical hub genes were discovered.Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed the mechanisms involved to be linked to MAPK and PI3K-Akt signaling.Among the 10 main active ingredients identified as potentially effective,PD was most abundant and was validated in vivo to mitigate weight loss,reduce Disease Activity Index scores,and prevent colon shortening.PD also reduced inflammation and suppressed expression of pro-inflammatory cytokines and mediators.In addition,PD increased expression of mucin and tight junction proteins.Ultimately,PD counteracted effects of dextran sulfate sodium by inhibiting phosphorylation of NF-кB and MAPK,while increasing phosphorylation of AMPK and expression of NRF2 and NQO1.CONCLUSION PD alleviates colitis and aids intestinal barrier repair,partly via modulation of the MAPK/NF-кB and AMPK/NRF2/NQO1 pathways.These findings also suggest new research methods for treatment of UC with TCM.
