[Objective]The aim was to prove that the mitochondrial genes of Cyt b and 12S rRNA with different evolutional rates have effects on the topological structures of phylogenetic trees.[Method]The complete sequences of Cy...[Objective]The aim was to prove that the mitochondrial genes of Cyt b and 12S rRNA with different evolutional rates have effects on the topological structures of phylogenetic trees.[Method]The complete sequences of Cyt b and 12S rRNA from 15 species in 12 families of snakes were downloaded and extracted from GenBank,while their molecular phylogenetic trees were constructed by Maximum Likelihood（ML） method with GTR ＋I ＋G substitute model based on PAUP4.0 software.[Result]With the same software,methods and species,the difference in topological structures of phylogenetic trees was mainly due to different evolutional rates of Cyt b and 12S rRNA genes.[Conclusion]In studies on phylogenetic trees,aimed to different research species and purposes,phylogenetic trees should be constructed by choosing the correct and appropriate genes.展开更多
文摘川崎病是儿童最常见的以全身性血管炎为主要特征的心血管疾病,其主要并发症冠状动脉病变(coronary artery lesions,CAL)显著增加了长期心血管事件的风险。CAL的发病机制复杂,涉及炎症反应、免疫调控及内皮损伤等多个信号通路,但其潜在机制仍未完全阐明。近年来,关于核因子κB(nuclear factor kappa-B,NF-κB)、S100钙结合蛋白A12(S100A12)、钙调神经磷酸酶(calcineurin,CaN)/活化T细胞核因子(nuclear factors of activated T cells,NFAT)信号通路在川崎病中的作用研究取得了一定进展,为揭示川崎病CAL的发病机制提供了重要线索。本文就上述信号通路的研究进展做一综述,旨在深化对川崎病CAL分子机制的理解,并为未来的临床干预提供参考依据。
基金Supported by Natural Science Fund in Guangdong(915102600100-0003)Project for Excellent Young Scientists and Engineers in Guangdong Academy of Sciences(200804)Fund of Open Laboratory for Protection and Utilization of Wildlife in Guangdong(200901)~~
文摘[Objective]The aim was to prove that the mitochondrial genes of Cyt b and 12S rRNA with different evolutional rates have effects on the topological structures of phylogenetic trees.[Method]The complete sequences of Cyt b and 12S rRNA from 15 species in 12 families of snakes were downloaded and extracted from GenBank,while their molecular phylogenetic trees were constructed by Maximum Likelihood（ML） method with GTR ＋I ＋G substitute model based on PAUP4.0 software.[Result]With the same software,methods and species,the difference in topological structures of phylogenetic trees was mainly due to different evolutional rates of Cyt b and 12S rRNA genes.[Conclusion]In studies on phylogenetic trees,aimed to different research species and purposes,phylogenetic trees should be constructed by choosing the correct and appropriate genes.
