At 16:21 Beijing time on October 7,2011,China successfully launched the W3C commercial telecommunications satellite manufactured by Thales Alenia Space for Eutelsat Communications into geostationary transfer orbit by ...At 16:21 Beijing time on October 7,2011,China successfully launched the W3C commercial telecommunications satellite manufactured by Thales Alenia Space for Eutelsat Communications into geostationary transfer orbit by using an enhanced LM-3B (LM-3B/E) launch vehicle from Xichang Satellite Launch Center.展开更多
目的探讨核苷(酸)类似物(nucleoside/nucleotide analogues,NAs)治疗后乙型肝炎e抗原(hepatitis B e antigen,HBeAg)阳性慢性乙型肝炎低病毒血症(low-level viremia,LLV)患者的血清乙型肝炎病毒RNA(hepatitis B virus RNA,HBV RNA)水平...目的探讨核苷(酸)类似物(nucleoside/nucleotide analogues,NAs)治疗后乙型肝炎e抗原(hepatitis B e antigen,HBeAg)阳性慢性乙型肝炎低病毒血症(low-level viremia,LLV)患者的血清乙型肝炎病毒RNA(hepatitis B virus RNA,HBV RNA)水平及其在NAs干预后的变化。方法采用巢式病例对照研究,根据LLV病例数1∶1匹配抗病毒治疗后达到维持病毒学应答(maintained virological response,MVR)患者。共纳入62例LLV及62例MVR患者。根据患者治疗意愿将LLV患者分为NAs维持治疗组及更改方案组,收集其临床资料并进行随访。通过实时荧光恒温扩增检测技术(simultaneous amplification and testing,SAT)对血清HBV RNA进行定量检测。结果与MVR组患者相比,LLV组在基线、随访24周及48周时血清HBV RNA水平均较高(P均<0.001)。随访期间LLV患者血清HBV RNA水平较基线有所下降,差异无统计学意义(P均>0.05)。LLV患者在维持治疗组和更改方案组随访至24、48周时血清HBV RNA变化幅度仅在更改方案组的48时有所下降,差异无统计学意义(P均>0.05)。结论与MVR组相比,LLV患者血清HBV RNA水平更高且下降缓慢,调整NAs治疗后HBV RNA水平较维持方案组下降并不明显,提示需要联合其它干预措施以进一步降低HBV转录活性。展开更多
文摘At 16:21 Beijing time on October 7,2011,China successfully launched the W3C commercial telecommunications satellite manufactured by Thales Alenia Space for Eutelsat Communications into geostationary transfer orbit by using an enhanced LM-3B (LM-3B/E) launch vehicle from Xichang Satellite Launch Center.
