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Q355B钢在武汉与库尔勒典型土壤环境中的腐蚀行为研究
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作者 周庆军 李育霖 +2 位作者 宋凤明 陈志坚 周学杰 《材料保护》 2026年第1期95-101,共7页
为了研究常用埋地结构钢在不同土壤环境中的腐蚀差异,为不同地区埋地材料选择提供理论依据,采用失重法、扫描电镜(SEM)、能谱(EDS)及X射线衍射(XRD)对比分析了Q355B钢在武汉与库尔勒典型土壤环境中的腐蚀性能、腐蚀形貌及腐蚀产物,结合... 为了研究常用埋地结构钢在不同土壤环境中的腐蚀差异,为不同地区埋地材料选择提供理论依据,采用失重法、扫描电镜(SEM)、能谱(EDS)及X射线衍射(XRD)对比分析了Q355B钢在武汉与库尔勒典型土壤环境中的腐蚀性能、腐蚀形貌及腐蚀产物,结合电化学分析对比研究了Q355B钢在2种土壤中的腐蚀行为。结果表明:库尔勒土壤环境中Q355B钢为全面腐蚀,腐蚀更加严重,失重量约为武汉土壤的1.65倍;武汉土壤环境中Q355B钢局部点蚀更加严重,平均点蚀深度是库尔勒土壤的1.25倍;2种土壤中Q355B钢腐蚀产物主要为Fe的氧化物,包括α-FeOOH、γ-FeOOH、Fe_(3)O_(4);土壤类型的不同导致了Q355B钢腐蚀产物保护性的不同。 展开更多
关键词 Q355b 土壤腐蚀 腐蚀特性
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奥司他韦联合重组人干扰素α1b雾化治疗儿童流行性感冒的疗效分析
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作者 杜月荷 孙莉莉 +2 位作者 殷爱云 柯群刚 李海朋 《中国实用医药》 2026年第5期92-95,共4页
目的研究奥司他韦联合重组人干扰素α1b雾化治疗儿童流行性感冒(流感)的效果及安全性。方法选取流感患儿80例为研究对象,采用随机数字表法将患儿分成对照组(n=40,应用磷酸奥司他韦口服治疗)和观察组(n=40,在对照组的基础上予以重组人干... 目的研究奥司他韦联合重组人干扰素α1b雾化治疗儿童流行性感冒(流感)的效果及安全性。方法选取流感患儿80例为研究对象,采用随机数字表法将患儿分成对照组(n=40,应用磷酸奥司他韦口服治疗)和观察组(n=40,在对照组的基础上予以重组人干扰素α1b注射液雾化吸入治疗)。比较两组的治疗效果、临床症状缓解时间、血清炎性因子[血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、干扰素γ(IFN-γ)以及肿瘤坏死因子-α(TNF-α)]水平、不良反应发生率。结果两组的总有效率比较,观察组(95.00%)高于对照组(75.00%)(P<0.05)。两组患儿的退烧时间、咳嗽缓解时间、鼻塞缓解时间以及肌肉酸痛缓解时间比较,观察组的(1.93±0.29)、(3.81±0.37)、(3.49±0.33)、(2.78±0.31)d均比对照组的(3.17±0.34)、(4.64±0.45)、(4.88±0.54)、(3.58±0.39)d短(P<0.05)。两组患儿治疗5 d后的血清IL-6、IL-8、IFN-γ、TNF-α水平均较治疗前有一定程度的降低,且观察组治疗5 d后的血清IL-6(13.67±1.66)pg/ml、IL-8(22.39±2.39)ng/ml、IFN-γ(14.38±1.21)pg/ml、TNF-α(9.54±1.02)ng/L均低于对照组的(20.17±2.01)pg/ml、(31.28±2.94)ng/ml、(21.23±1.87)pg/ml、(14.39±1.45)ng/L(P<0.05)。两组不良反应发生率比较差异无统计学意义(χ2=0.157,P=0.692>0.05)。结论磷酸奥司他韦颗粒口服联合重组人干扰素α1b注射液雾化吸入应用在儿童流感治疗中有助于促进临床症状缓解,控制炎症反应,且用药安全性较高。 展开更多
关键词 儿童流行性感冒 磷酸奥司他韦 重组人干扰素Α1b 炎性因子
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海藻玉壶汤调节磷酯酰肌醇3-激酶/蛋白激酶B信号通路对甲状腺癌细胞上皮间质转化和糖代谢的影响
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作者 刘英 孙建 +4 位作者 詹维 杨小兰 徐敏 蒋崔楠 刘虹 《河北中医》 2026年第1期75-79,86,共6页
目的探讨海藻玉壶汤调节磷酯酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路对甲状腺癌细胞上皮间质转化(EMT)和糖代谢的影响。方法体外培养甲状腺癌TCP-1细胞,将TCP-1细胞接种于BALB/c裸鼠,再将荷瘤成功的40只裸鼠分为模型组、海藻玉壶汤... 目的探讨海藻玉壶汤调节磷酯酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路对甲状腺癌细胞上皮间质转化(EMT)和糖代谢的影响。方法体外培养甲状腺癌TCP-1细胞,将TCP-1细胞接种于BALB/c裸鼠,再将荷瘤成功的40只裸鼠分为模型组、海藻玉壶汤低剂量组、海藻玉壶汤高剂量组、海藻玉壶汤高剂量+740Y-P组,每组10只,另选10只正常裸鼠为对照组。海藻玉壶汤低、高剂量组分别予200、400 mg/kg的海藻玉壶汤灌胃,海藻玉壶汤高剂量+740Y-P组灌胃予400 mg/kg的海藻玉壶汤灌胃再腹腔注射10 mg/kg的740Y-P,对照组和模型组予等容积0.9%氯化钠注射液灌胃。均持续灌胃21 d后,比较各组裸鼠血清乳酸脱氢酶(LDH)水平,裸鼠肿瘤体积、质量情况,苏木精-伊红(HE)染色观察肿瘤病理形态,实时荧光定量反转录聚合酶链反应(qRT-PCR)检测各组肿瘤组织中PI3K、Akt基因表达水平,蛋白免疫印迹法(Western blot)检测肿瘤组织中p-PI3K、PI3K、p-Akt、Akt、缺氧诱导因子-1ɑ(HIF-1ɑ)、葡萄糖转运蛋白1(GLUT1)、E-钙黏蛋白(E-cadherin)、N-cadherin、波形蛋白(Vimentin)表达水平。结果与对照组比较,模型组裸鼠肿瘤细胞排列致密,血清LDH水平、肿瘤质量、肿瘤体积、PI3K mRNA、Akt mRNA、N-cadherin、vimentin、p-PI3K/PI3K、p-Akt/Akt、HIF-1ɑ、GLUT1水平均显著升高(P<0.05),E-cadherin水平显著降低(P<0.05)。与模型组比较,海藻玉壶汤低、高剂量组裸鼠肿瘤细胞排列分散,血清LDH、肿瘤质量、肿瘤体积、PI3K mRNA、Akt mRNA、N-cadherin、vimentin、p-PI3K/PI3K、p-Akt/Akt、HIF-1ɑ、GLUT1水平均显著降低,E-cadherin水平显著升高(P<0.05)。与海藻玉壶汤高剂量组比较,海藻玉壶汤高剂量+740Y-P组能逆转海藻玉壶汤高剂量组对上述指标的改善作用。结论海藻玉壶汤可通过阻断PI3K/Akt信号通路抑制甲状腺癌细胞EMT和糖代谢过程,进而抑制肿瘤生长。 展开更多
关键词 甲状腺癌 动物实验 海藻玉壶汤 磷酯酰肌醇3-激酶 蛋白激酶b
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Method for Estimating the State of Health of Lithium-ion Batteries Based on Differential Thermal Voltammetry and Sparrow Search Algorithm-Elman Neural Network 被引量:1
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作者 Yu Zhang Daoyu Zhang TiezhouWu 《Energy Engineering》 EI 2025年第1期203-220,共18页
Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,curr... Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity degradation.Additionally,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model performance.To address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural network.Firstly,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity curves.Next,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network model.To validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging dataset.The experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%. 展开更多
关键词 Lithium-ion battery state of health differential thermal voltammetry Sparrow Search algorithm
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Robustness Optimization Algorithm with Multi-Granularity Integration for Scale-Free Networks Against Malicious Attacks 被引量:1
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作者 ZHANG Yiheng LI Jinhai 《昆明理工大学学报(自然科学版)》 北大核心 2025年第1期54-71,共18页
Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently... Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms. 展开更多
关键词 complex network model MULTI-GRANULARITY scale-free networks RObUSTNESS algorithm integration
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Short-TermWind Power Forecast Based on STL-IAOA-iTransformer Algorithm:A Case Study in Northwest China 被引量:2
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作者 Zhaowei Yang Bo Yang +5 位作者 Wenqi Liu Miwei Li Jiarong Wang Lin Jiang Yiyan Sang Zhenning Pan 《Energy Engineering》 2025年第2期405-430,共26页
Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart grids.Although numerous studies have employed various methods to forecast wind power,th... Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart grids.Although numerous studies have employed various methods to forecast wind power,there remains a research gap in leveraging swarm intelligence algorithms to optimize the hyperparameters of the Transformer model for wind power prediction.To improve the accuracy of short-term wind power forecast,this paper proposes a hybrid short-term wind power forecast approach named STL-IAOA-iTransformer,which is based on seasonal and trend decomposition using LOESS(STL)and iTransformer model optimized by improved arithmetic optimization algorithm(IAOA).First,to fully extract the power data features,STL is used to decompose the original data into components with less redundant information.The extracted components as well as the weather data are then input into iTransformer for short-term wind power forecast.The final predicted short-term wind power curve is obtained by combining the predicted components.To improve the model accuracy,IAOA is employed to optimize the hyperparameters of iTransformer.The proposed approach is validated using real-generation data from different seasons and different power stations inNorthwest China,and ablation experiments have been conducted.Furthermore,to validate the superiority of the proposed approach under different wind characteristics,real power generation data fromsouthwestChina are utilized for experiments.Thecomparative results with the other six state-of-the-art prediction models in experiments show that the proposed model well fits the true value of generation series and achieves high prediction accuracy. 展开更多
关键词 Short-termwind power forecast improved arithmetic optimization algorithm iTransformer algorithm SimuNPS
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B超下腹八针穴位埋线对脾虚湿阻型女性中心性肥胖患者的疗效观察
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作者 徐珊珊 王敏磊 曾友华 《浙江中西医结合杂志》 2026年第1期42-46,共5页
中心性肥胖又称腹型肥胖,是指腹部皮下和内脏脂肪堆积过多,导致腰围和体脂率超标的一种肥胖类型[1]。流行病学调查显示,亚洲人群如日本、印度和我国人群,脂肪分布以中心性为主,中心性肥胖人群比例高于外周肥胖人群[2]。与外周性肥胖患... 中心性肥胖又称腹型肥胖,是指腹部皮下和内脏脂肪堆积过多,导致腰围和体脂率超标的一种肥胖类型[1]。流行病学调查显示,亚洲人群如日本、印度和我国人群,脂肪分布以中心性为主,中心性肥胖人群比例高于外周肥胖人群[2]。与外周性肥胖患者相比,中心性肥胖患者更易产生血压、血糖、血脂、尿酸等代谢紊乱,易诱发心脑血管疾病[3]。有研究指出,内脏脂肪含量是与代谢综合征、冠心病等疾病直接相关的危险因素[4]。穴位埋线是在针刺疗法的基础上发展而来的一种新的治疗方法,与针刺相比,其治疗时间短,疗效稳定,不易复发。既往研究显示,线体埋置于腹部深层肌肉,减肥疗效优于埋置于浅层脂肪层[5]。 展开更多
关键词 女性 中心性肥胖 b超引导 不同深度 腹八针穴位埋线 内脏脂肪 腹白线弹性 脾虚湿阻型
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A LODBO algorithm for multi-UAV search and rescue path planning in disaster areas 被引量:1
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作者 Liman Yang Xiangyu Zhang +2 位作者 Zhiping Li Lei Li Yan Shi 《Chinese Journal of Aeronautics》 2025年第2期200-213,共14页
In disaster relief operations,multiple UAVs can be used to search for trapped people.In recent years,many researchers have proposed machine le arning-based algorithms,sampling-based algorithms,and heuristic algorithms... In disaster relief operations,multiple UAVs can be used to search for trapped people.In recent years,many researchers have proposed machine le arning-based algorithms,sampling-based algorithms,and heuristic algorithms to solve the problem of multi-UAV path planning.The Dung Beetle Optimization(DBO)algorithm has been widely applied due to its diverse search patterns in the above algorithms.However,the update strategies for the rolling and thieving dung beetles of the DBO algorithm are overly simplistic,potentially leading to an inability to fully explore the search space and a tendency to converge to local optima,thereby not guaranteeing the discovery of the optimal path.To address these issues,we propose an improved DBO algorithm guided by the Landmark Operator(LODBO).Specifically,we first use tent mapping to update the population strategy,which enables the algorithm to generate initial solutions with enhanced diversity within the search space.Second,we expand the search range of the rolling ball dung beetle by using the landmark factor.Finally,by using the adaptive factor that changes with the number of iterations.,we improve the global search ability of the stealing dung beetle,making it more likely to escape from local optima.To verify the effectiveness of the proposed method,extensive simulation experiments are conducted,and the result shows that the LODBO algorithm can obtain the optimal path using the shortest time compared with the Genetic Algorithm(GA),the Gray Wolf Optimizer(GWO),the Whale Optimization Algorithm(WOA)and the original DBO algorithm in the disaster search and rescue task set. 展开更多
关键词 Unmanned aerial vehicle Path planning Meta heuristic algorithm DbO algorithm NP-hard problems
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BOPPPS-B-PBL教学法在内分泌科临床见习教学中的应用
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作者 杨丽娟 周炜玮 陶红 《安徽医药》 2026年第1期205-208,共4页
目的探讨课程导入-学习目标-课前测验-参与式学习-课后测验-总结(bridge-objective-pre-assessment-participationpost-assessment-summary,beside problem-based learning,BOPPPS-B-PBL)教学法在内分泌科临床见习教学中的应用效果。方... 目的探讨课程导入-学习目标-课前测验-参与式学习-课后测验-总结(bridge-objective-pre-assessment-participationpost-assessment-summary,beside problem-based learning,BOPPPS-B-PBL)教学法在内分泌科临床见习教学中的应用效果。方法选择2023年11月至2024年6月在首都医科大学附属北京安贞医院临床见习的临床医疗专业、精神专业和预防专业本科学生共152名,按照实习组别使用随机数字表法分为对照组(B-PBL模式教学)和研究组(BOPPPS-B-PBL模式教学)进行临床见习,每组76人,并通过双向问卷评分评估教学效果。结果学生问卷评分中,研究组在“课堂导入效果”“学习目标明确”“学生参与度、归纳总结[(8.99±1.01)分比(8.50±1.47)分]”“巩固知识和技能”“获得临床实践技能”“促进今后提升”方面评分均显著高于对照组(P<0.05)。教师评分中,在“积极参与互动”“病史采集和查体”“选择治疗方案”“医患沟通”“总结归纳能力”方面,研究组的评分显著高于对照组(P<0.05)。结论BOPPPS-B-PBL教学法应用于内分泌科的临床见习教学中,能够更有效地提高学生学习参与度,更有助于理解记忆抽象的理论知识并获得临床实践技能,值得推广。 展开更多
关键词 教育 医学 bOPPPS教学 基于问题的床旁教学法 内分泌学 临床见习 教学模式
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DDoS Attack Autonomous Detection Model Based on Multi-Strategy Integrate Zebra Optimization Algorithm
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作者 Chunhui Li Xiaoying Wang +2 位作者 Qingjie Zhang Jiaye Liang Aijing Zhang 《Computers, Materials & Continua》 SCIE EI 2025年第1期645-674,共30页
Previous studies have shown that deep learning is very effective in detecting known attacks.However,when facing unknown attacks,models such as Deep Neural Networks(DNN)combined with Long Short-Term Memory(LSTM),Convol... Previous studies have shown that deep learning is very effective in detecting known attacks.However,when facing unknown attacks,models such as Deep Neural Networks(DNN)combined with Long Short-Term Memory(LSTM),Convolutional Neural Networks(CNN)combined with LSTM,and so on are built by simple stacking,which has the problems of feature loss,low efficiency,and low accuracy.Therefore,this paper proposes an autonomous detectionmodel for Distributed Denial of Service attacks,Multi-Scale Convolutional Neural Network-Bidirectional Gated Recurrent Units-Single Headed Attention(MSCNN-BiGRU-SHA),which is based on a Multistrategy Integrated Zebra Optimization Algorithm(MI-ZOA).The model undergoes training and testing with the CICDDoS2019 dataset,and its performance is evaluated on a new GINKS2023 dataset.The hyperparameters for Conv_filter and GRU_unit are optimized using the Multi-strategy Integrated Zebra Optimization Algorithm(MIZOA).The experimental results show that the test accuracy of the MSCNN-BiGRU-SHA model based on the MIZOA proposed in this paper is as high as 0.9971 in the CICDDoS 2019 dataset.The evaluation accuracy of the new dataset GINKS2023 created in this paper is 0.9386.Compared to the MSCNN-BiGRU-SHA model based on the Zebra Optimization Algorithm(ZOA),the detection accuracy on the GINKS2023 dataset has improved by 5.81%,precisionhas increasedby 1.35%,the recallhas improvedby 9%,and theF1scorehas increasedby 5.55%.Compared to the MSCNN-BiGRU-SHA models developed using Grid Search,Random Search,and Bayesian Optimization,the MSCNN-BiGRU-SHA model optimized with the MI-ZOA exhibits better performance in terms of accuracy,precision,recall,and F1 score. 展开更多
关键词 Distributed denial of service attack intrusion detection deep learning zebra optimization algorithm multi-strategy integrated zebra optimization algorithm
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Bearing capacity prediction of open caissons in two-layered clays using five tree-based machine learning algorithms 被引量:1
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作者 Rungroad Suppakul Kongtawan Sangjinda +3 位作者 Wittaya Jitchaijaroen Natakorn Phuksuksakul Suraparb Keawsawasvong Peem Nuaklong 《Intelligent Geoengineering》 2025年第2期55-65,共11页
Open caissons are widely used in foundation engineering because of their load-bearing efficiency and adaptability in diverse soil conditions.However,accurately predicting their undrained bearing capacity in layered so... Open caissons are widely used in foundation engineering because of their load-bearing efficiency and adaptability in diverse soil conditions.However,accurately predicting their undrained bearing capacity in layered soils remains a complex challenge.This study presents a novel application of five ensemble machine(ML)algorithms-random forest(RF),gradient boosting machine(GBM),extreme gradient boosting(XGBoost),adaptive boosting(AdaBoost),and categorical boosting(CatBoost)-to predict the undrained bearing capacity factor(Nc)of circular open caissons embedded in two-layered clay on the basis of results from finite element limit analysis(FELA).The input dataset consists of 1188 numerical simulations using the Tresca failure criterion,varying in geometrical and soil parameters.The FELA was performed via OptumG2 software with adaptive meshing techniques and verified against existing benchmark studies.The ML models were trained on 70% of the dataset and tested on the remaining 30%.Their performance was evaluated using six statistical metrics:coefficient of determination(R²),mean absolute error(MAE),root mean squared error(RMSE),index of scatter(IOS),RMSE-to-standard deviation ratio(RSR),and variance explained factor(VAF).The results indicate that all the models achieved high accuracy,with R²values exceeding 97.6%and RMSE values below 0.02.Among them,AdaBoost and CatBoost consistently outperformed the other methods across both the training and testing datasets,demonstrating superior generalizability and robustness.The proposed ML framework offers an efficient,accurate,and data-driven alternative to traditional methods for estimating caisson capacity in stratified soils.This approach can aid in reducing computational costs while improving reliability in the early stages of foundation design. 展开更多
关键词 Two-layered clay Open caisson Tree-based algorithms FELA Machine learning
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弥漫性大B细胞淋巴瘤细胞条件培养液对人骨髓间充质干细胞增殖、凋亡的影响
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作者 袁小霜 杨姁 +6 位作者 杨波 陈晓旭 田婷 王飞清 李艳菊 刘洋 杨文秀 《中国组织工程研究》 北大核心 2026年第7期1632-1640,共9页
背景:骨髓微环境与弥漫性大B细胞淋巴瘤生长、存活和耐药性之间的关系是近些年的研究热点,而弥漫性大B细胞淋巴瘤细胞条件培养液对骨髓间充质干细胞的影响未见报道。目的:探讨弥漫性大B细胞淋巴瘤细胞条件培养液对骨髓间充质干细胞增殖... 背景:骨髓微环境与弥漫性大B细胞淋巴瘤生长、存活和耐药性之间的关系是近些年的研究热点,而弥漫性大B细胞淋巴瘤细胞条件培养液对骨髓间充质干细胞的影响未见报道。目的:探讨弥漫性大B细胞淋巴瘤细胞条件培养液对骨髓间充质干细胞增殖和凋亡的影响。方法:采用Ficoll密度梯度离心法从健康供者骨髓血中分离骨髓间充质干细胞,并通过贴壁法进行纯化;使用SU-DHL-2和OCI-LY3两种弥漫性大B细胞淋巴瘤细胞培养上清液制备条件培养液。按培养基的不同进行细胞分组:对照组骨髓间充质干细胞仅用L-DMEM完全培养液培养,CM-SU-DHL-2组、CM-OCI-LY3组骨髓间充质干细胞用20%SU-DHL-2细胞条件培养液或20%OCI-LY3细胞条件培养液和80%L-DMEM完全培养液培养。通过CCK-8、EDU、结晶紫染色观察骨髓间充质干细胞的增殖情况,划痕实验评估骨髓间充质干细胞的迁移情况,流式细胞术检测骨髓间充质干细胞的细胞周期、凋亡情况,Real-time PCR和Western blot检测骨髓间充质干细胞中P21、P16、Bcl-2、BTK mRNA和蛋白表达水平。结果与结论:①与对照组相比,SU-DHL-2和OCI-LY3细胞条件培养液显著促进骨髓间充质干细胞的增殖(P<0.05),可能与P21和P16蛋白低表达密切相关(P<0.05);②与对照组相比,SU-DHL-2和OCI-LY3细胞条件培养液显著促进骨髓间充质干细胞的迁移(P<0.05);③与对照组相比,SU-DHL-2和OCI-LY3细胞条件培养液抑制骨髓间充质干细胞的凋亡(P<0.05),可能与Bcl-2、BTK mRNA和蛋白高表达密切相关(P<0.05)。研究结果表明,弥漫性大B细胞淋巴瘤细胞条件培养液可促进骨髓间充质干细胞的增殖并抑制凋亡。 展开更多
关键词 弥漫性大b细胞淋巴瘤 骨髓间充质干细胞 条件培养液 增殖 凋亡 工程化干细胞
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Path Planning for Thermal Power Plant Fan Inspection Robot Based on Improved A^(*)Algorithm 被引量:1
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作者 Wei Zhang Tingfeng Zhang 《Journal of Electronic Research and Application》 2025年第1期233-239,共7页
To improve the efficiency and accuracy of path planning for fan inspection tasks in thermal power plants,this paper proposes an intelligent inspection robot path planning scheme based on an improved A^(*)algorithm.The... To improve the efficiency and accuracy of path planning for fan inspection tasks in thermal power plants,this paper proposes an intelligent inspection robot path planning scheme based on an improved A^(*)algorithm.The inspection robot utilizes multiple sensors to monitor key parameters of the fans,such as vibration,noise,and bearing temperature,and upload the data to the monitoring center.The robot’s inspection path employs the improved A^(*)algorithm,incorporating obstacle penalty terms,path reconstruction,and smoothing optimization techniques,thereby achieving optimal path planning for the inspection robot in complex environments.Simulation results demonstrate that the improved A^(*)algorithm significantly outperforms the traditional A^(*)algorithm in terms of total path distance,smoothness,and detour rate,effectively improving the execution efficiency of inspection tasks. 展开更多
关键词 Power plant fans Inspection robot Path planning Improved A^(*)algorithm
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Rapid pathologic grading-based diagnosis of esophageal squamous cell carcinoma via Raman spectroscopy and a deep learning algorithm 被引量:1
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作者 Xin-Ying Yu Jian Chen +2 位作者 Lian-Yu Li Feng-En Chen Qiang He 《World Journal of Gastroenterology》 2025年第14期32-46,共15页
BACKGROUND Esophageal squamous cell carcinoma is a major histological subtype of esophageal cancer.Many molecular genetic changes are associated with its occurrence.Raman spectroscopy has become a new method for the e... BACKGROUND Esophageal squamous cell carcinoma is a major histological subtype of esophageal cancer.Many molecular genetic changes are associated with its occurrence.Raman spectroscopy has become a new method for the early diagnosis of tumors because it can reflect the structures of substances and their changes at the molecular level.AIM To detect alterations in Raman spectral information across different stages of esophageal neoplasia.METHODS Different grades of esophageal lesions were collected,and a total of 360 groups of Raman spectrum data were collected.A 1D-transformer network model was proposed to handle the task of classifying the spectral data of esophageal squamous cell carcinoma.In addition,a deep learning model was applied to visualize the Raman spectral data and interpret their molecular characteristics.RESULTS A comparison among Raman spectral data with different pathological grades and a visual analysis revealed that the Raman peaks with significant differences were concentrated mainly at 1095 cm^(-1)(DNA,symmetric PO,and stretching vibration),1132 cm^(-1)(cytochrome c),1171 cm^(-1)(acetoacetate),1216 cm^(-1)(amide III),and 1315 cm^(-1)(glycerol).A comparison among the training results of different models revealed that the 1Dtransformer network performed best.A 93.30%accuracy value,a 96.65%specificity value,a 93.30%sensitivity value,and a 93.17%F1 score were achieved.CONCLUSION Raman spectroscopy revealed significantly different waveforms for the different stages of esophageal neoplasia.The combination of Raman spectroscopy and deep learning methods could significantly improve the accuracy of classification. 展开更多
关键词 Raman spectroscopy Esophageal neoplasia Early diagnosis Deep learning algorithm Rapid pathologic grading
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An Algorithm for Cloud-based Web Service Combination Optimization Through Plant Growth Simulation
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作者 Li Qiang Qin Huawei +1 位作者 Qiao Bingqin Wu Ruifang 《系统仿真学报》 北大核心 2025年第2期462-473,共12页
In order to improve the efficiency of cloud-based web services,an improved plant growth simulation algorithm scheduling model.This model first used mathematical methods to describe the relationships between cloud-base... In order to improve the efficiency of cloud-based web services,an improved plant growth simulation algorithm scheduling model.This model first used mathematical methods to describe the relationships between cloud-based web services and the constraints of system resources.Then,a light-induced plant growth simulation algorithm was established.The performance of the algorithm was compared through several plant types,and the best plant model was selected as the setting for the system.Experimental results show that when the number of test cloud-based web services reaches 2048,the model being 2.14 times faster than PSO,2.8 times faster than the ant colony algorithm,2.9 times faster than the bee colony algorithm,and a remarkable 8.38 times faster than the genetic algorithm. 展开更多
关键词 cloud-based service scheduling algorithm resource constraint load optimization cloud computing plant growth simulation algorithm
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基于最佳滑移率估计的汽车EMB防抱死控制
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作者 潘公宇 熊浩东 《郑州大学学报(工学版)》 北大核心 2026年第1期58-65,共8页
为了解决传统的逻辑门限式ABS控制方法存在无法充分利用路面利用附着系数以及滑移率波动较大的问题,提出了一种基于最佳滑移率估计的汽车EMB防抱死控制策略。首先,建立轮胎滑移率与路面利用附着系数之间的非线性模型;其次,通过一种分段... 为了解决传统的逻辑门限式ABS控制方法存在无法充分利用路面利用附着系数以及滑移率波动较大的问题,提出了一种基于最佳滑移率估计的汽车EMB防抱死控制策略。首先,建立轮胎滑移率与路面利用附着系数之间的非线性模型;其次,通过一种分段式的估计算法来快速准确地跟踪最佳滑移率;最后,基于最佳滑移率的估计结果,设计了积分滑模控制器,通过精确调节EMB制动力矩和电机制动力矩,使前后轮的滑移率维持在各自的最佳滑移率,保证车辆在不同路面条件下的最佳制动距离。仿真结果表明:所采用的估计算法都能够快速准确识别当前路面的最佳滑移率,估计出的最佳滑移率在稳态时与实际的最佳滑移率的最大误差不超过3%,且积分滑模控制器可以精确控制滑移率保持在最佳滑移率附近,与CarSim内置的ABS控制策略相比,单一路面工况制动总时间缩短了10.8%,制动总距离减少了15.8%,对接路面工况制动总时间缩短了18.0%,制动总距离减少了22.2%。 展开更多
关键词 最佳滑移率 电子机械制动 AbS 估计算法 积分滑模控制
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Improved algorithm of multi-mainlobe interference suppression under uncorrelated and coherent conditions 被引量:1
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作者 CAI Miaohong CHENG Qiang +1 位作者 MENG Jinli ZHAO Dehua 《Journal of Southeast University(English Edition)》 2025年第1期84-90,共7页
A new method based on the iterative adaptive algorithm(IAA)and blocking matrix preprocessing(BMP)is proposed to study the suppression of multi-mainlobe interference.The algorithm is applied to precisely estimate the s... A new method based on the iterative adaptive algorithm(IAA)and blocking matrix preprocessing(BMP)is proposed to study the suppression of multi-mainlobe interference.The algorithm is applied to precisely estimate the spatial spectrum and the directions of arrival(DOA)of interferences to overcome the drawbacks associated with conventional adaptive beamforming(ABF)methods.The mainlobe interferences are identified by calculating the correlation coefficients between direction steering vectors(SVs)and rejected by the BMP pretreatment.Then,IAA is subsequently employed to reconstruct a sidelobe interference-plus-noise covariance matrix for the preferable ABF and residual interference suppression.Simulation results demonstrate the excellence of the proposed method over normal methods based on BMP and eigen-projection matrix perprocessing(EMP)under both uncorrelated and coherent circumstances. 展开更多
关键词 mainlobe interference suppression adaptive beamforming spatial spectral estimation iterative adaptive algorithm blocking matrix preprocessing
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Intelligent sequential multi-impulse collision avoidance method for non-cooperative spacecraft based on an improved search tree algorithm 被引量:1
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作者 Xuyang CAO Xin NING +4 位作者 Zheng WANG Suyi LIU Fei CHENG Wenlong LI Xiaobin LIAN 《Chinese Journal of Aeronautics》 2025年第4期378-393,共16页
The problem of collision avoidance for non-cooperative targets has received significant attention from researchers in recent years.Non-cooperative targets exhibit uncertain states and unpredictable behaviors,making co... The problem of collision avoidance for non-cooperative targets has received significant attention from researchers in recent years.Non-cooperative targets exhibit uncertain states and unpredictable behaviors,making collision avoidance significantly more challenging than that for space debris.Much existing research focuses on the continuous thrust model,whereas the impulsive maneuver model is more appropriate for long-duration and long-distance avoidance missions.Additionally,it is important to minimize the impact on the original mission while avoiding noncooperative targets.On the other hand,the existing avoidance algorithms are computationally complex and time-consuming especially with the limited computing capability of the on-board computer,posing challenges for practical engineering applications.To conquer these difficulties,this paper makes the following key contributions:(A)a turn-based(sequential decision-making)limited-area impulsive collision avoidance model considering the time delay of precision orbit determination is established for the first time;(B)a novel Selection Probability Learning Adaptive Search-depth Search Tree(SPL-ASST)algorithm is proposed for non-cooperative target avoidance,which improves the decision-making efficiency by introducing an adaptive-search-depth mechanism and a neural network into the traditional Monte Carlo Tree Search(MCTS).Numerical simulations confirm the effectiveness and efficiency of the proposed method. 展开更多
关键词 Non-cooperative target Collision avoidance Limited motion area Impulsive maneuver model Search tree algorithm Neural networks
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复发难治性弥漫大B细胞淋巴瘤靶向免疫治疗的研究进展
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作者 李春梅 张清媛 《现代肿瘤医学》 2026年第1期152-158,共7页
在非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)中,弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的发生率最高,其异质性明显。利妥昔单抗的出现极大改善了患者的预后及生存,其联合CHOP成为经典一线治疗方案,50%~70%患... 在非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)中,弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的发生率最高,其异质性明显。利妥昔单抗的出现极大改善了患者的预后及生存,其联合CHOP成为经典一线治疗方案,50%~70%患者可治愈,但仍有30%~50%因耐药等原因反应差或在缓解后复发。复发难治DLBCL,尤其是无法自体造血干细胞移植或移植后复发病人的治疗是目前亟待解决的问题。随着对靶向免疫治疗研究的不断深入,许多药物不断进入临床应用或正在开发中,该文主要就单克隆抗体、双特异性抗体、抗体药物偶联物、选择性核出口蛋白抑制剂、嵌合抗原受体T细胞、程序性死亡受体/配体1抑制剂等药物作一简要综述。 展开更多
关键词 弥漫大b细胞淋巴瘤 复发 难治 靶向治疗 免疫治疗
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An Iterated Greedy Algorithm with Memory and Learning Mechanisms for the Distributed Permutation Flow Shop Scheduling Problem
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作者 Binhui Wang Hongfeng Wang 《Computers, Materials & Continua》 SCIE EI 2025年第1期371-388,共18页
The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because o... The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because of its straightforward,single-solution evolution framework.However,a potential draw-back of IGA is the lack of utilization of historical information,which could lead to an imbalance between exploration and exploitation,especially in large-scale DPFSPs.As a consequence,this paper develops an IGA with memory and learning mechanisms(MLIGA)to efficiently solve the DPFSP targeted at the mini-malmakespan.InMLIGA,we incorporate a memory mechanism to make a more informed selection of the initial solution at each stage of the search,by extending,reconstructing,and reinforcing the information from previous solutions.In addition,we design a twolayer cooperative reinforcement learning approach to intelligently determine the key parameters of IGA and the operations of the memory mechanism.Meanwhile,to ensure that the experience generated by each perturbation operator is fully learned and to reduce the prior parameters of MLIGA,a probability curve-based acceptance criterion is proposed by combining a cube root function with custom rules.At last,a discrete adaptive learning rate is employed to enhance the stability of the memory and learningmechanisms.Complete ablation experiments are utilized to verify the effectiveness of the memory mechanism,and the results show that this mechanism is capable of improving the performance of IGA to a large extent.Furthermore,through comparative experiments involving MLIGA and five state-of-the-art algorithms on 720 benchmarks,we have discovered that MLI-GA demonstrates significant potential for solving large-scale DPFSPs.This indicates that MLIGA is well-suited for real-world distributed flow shop scheduling. 展开更多
关键词 Distributed permutation flow shop scheduling MAKESPAN iterated greedy algorithm memory mechanism cooperative reinforcement learning
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