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Galen’s place in Avicenna’s The Canon of Medicine: Respect,confirmation and criticism 被引量:2
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作者 Sajjad Sadeghi Farzaneh Ghaffari +1 位作者 Ghazaleh Heydarirad Mehdi Alizadeh 《Journal of Integrative Medicine》 SCIE CAS CSCD 2020年第1期21-25,共5页
Galen(129–199 A.D.), an ancient Greek scholar, is one of the most influential and recognized physicians and surgeons in the history of medicine. He is one of the most influential Greek scholar in Persian medicine, wh... Galen(129–199 A.D.), an ancient Greek scholar, is one of the most influential and recognized physicians and surgeons in the history of medicine. He is one of the most influential Greek scholar in Persian medicine, who has been repeatedly cited by Iranian scholars. The purpose of this article is to describe the exact position of Galen in Avicenna’s The Canon of Medicine, the most important work of Persian medicine. In The Canon of Medicine, Galen is cited about 300 times, and Avicenna always admired and praised Galen repeatedly. Galen’s ideas were important to Avicenna, but there are also many elements of Galen’s views that Avicenna challenged or criticized. For example, Avicenna diverged from Galen’s philosophical view in medicine and rejected some of Galen’s pharmaceutical opinions and Galen’s views on the physiology of pain, the physiology of pulse, the same nature of the tendons and nerves and separation of the mind and body. Although the views of Greek scholars, especially Galen, in The Canon of Medicine have been quoted abundantly, Avicenna revised the knowledge of the ancient scholars through critical thinking and relying on observation and testing, systematized the science of medicine and introduced many ideas and innovations. As such, Europeans considered Avicenna as the most prominent physician of the Islamic Golden Age. 展开更多
关键词 GALEN avicenna The Canon of MEDICINE PERSIAN MEDICINE
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Optimal fluid intake in daily diet: Avicenna's view 被引量:1
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作者 Majid Nimrouzi Vahid Tafazoli +1 位作者 Babak Daneshfard Manijhe Zare 《Journal of Integrative Medicine》 SCIE CAS CSCD 2016年第4期241-244,共4页
Adequate daily water consumption is an important factor of keeping regular homeostasis. However, the best quantity of daily water consumption for a healthy individual is not virtually stated in the literature. Despite... Adequate daily water consumption is an important factor of keeping regular homeostasis. However, the best quantity of daily water consumption for a healthy individual is not virtually stated in the literature. Despite the dearth of evidence-based recommendations, it is commonly thought that ingesting eight glasses of water a day is good for a healthy person. Avicenna had a unique viewpoint. He believed that daily water intake depended on numerous elements together with age, intercourse, body temperament, season, occupation and various internal and external elements. He also cited a few essential and usefu measures regarding proper water consumption, which have additionally been emphasized in Islamic hadiths. 展开更多
关键词 avicenna traditional Persian medicine daily water intake optimal fluid intake balance water DRINKING
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Blistering disease in viewpoint of Avicenna 被引量:1
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作者 Fatemeh Atarzadeh Majid Nimrouzi Gholamreza Amin 《Journal of Integrative Medicine》 SCIE CAS CSCD 2016年第6期412-414,共3页
1 Introduction According to traditional Persian medicine (TPM) resources, establishing a balance between quality of organs (hotness, coldness, wetness, dryness) and external factors, including the consumed food, ... 1 Introduction According to traditional Persian medicine (TPM) resources, establishing a balance between quality of organs (hotness, coldness, wetness, dryness) and external factors, including the consumed food, plays a critical role in the health status. Avicenna believed that skin is the most balanced organ in the body. His interpretation is that according to quality perspective, hotness-coldness and wetness-dryness, skin is more moderate in comparison with other organs. Traditional Persian sages (Hakim) emphasized on the role of these quadruple qualities' balance on health. They believed that every organ, based on its function. 展开更多
关键词 BLISTER traditional Persian medicine avicenna
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Digestion process and causes of indigestion based on Avicenna's view and modern medicine 被引量:1
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作者 Ali Reza Derakhshan Mahdi Yousefi +2 位作者 Sohrab Dehghan Arman Zargaran Mahmood Khodadoost 《Traditional Medicine Research》 2019年第3期140-147,共8页
The process of food digestion is one of the most important physiologic processes in human body. In this review, we are seeking the views of Avicenna, the most distinguished Persian medical scholar about digestion and ... The process of food digestion is one of the most important physiologic processes in human body. In this review, we are seeking the views of Avicenna, the most distinguished Persian medical scholar about digestion and indigestion. Avicenna’s view was based on the humoral theory. Avicenna has focused scrutiny on the process of digestion. He divided this process into four phases including gastric, hepatic, intravascular and intra-organ digestion. A defect in any of these phases can lead to disturbance in other stages. Avicenna approached the problem of indigestion through factors of diet, lifestyle and inherent structural characteristics of digestive organs. Modern medicine confirms Avicenna's opinion about the start of digestion from the mouth, the role of the stomach in digestion and the role of the liver in the metabolism of foods. Overeating or eating certain foods, snacking between meals, eating variety of different foods together, intense physical activity, sexual activity after a meal, stress and sleep insufficiency are among factors that may be linked to indigestion in modern medicine viewpoints and also have been mentioned in Avicenna's teachings. It seems rational to consider the medical approaches recommended by Avicenna for future studies in the field of digestive disorders. 展开更多
关键词 PERSIAN MEDICINE DIGESTION Indigestion MALABSORPTION avicenna
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Germination and Photosynthetic Responses to Salinity and Alkalinity in Avicenna marina Propagules 被引量:1
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作者 Abdallah Atia Ahmed Abdallah Hussain Barhoumi Zouhaier 《Phyton-International Journal of Experimental Botany》 SCIE 2022年第5期1015-1026,共12页
Avicenna marina(Forssk.)Vierh is a halophytic mangrove.The reproductive unit is green and has photosynthetic propagules.Mangroves are naturally exposed to fluctuations in some abiotic factors at the soil surface,inclu... Avicenna marina(Forssk.)Vierh is a halophytic mangrove.The reproductive unit is green and has photosynthetic propagules.Mangroves are naturally exposed to fluctuations in some abiotic factors at the soil surface,including salinity and alkalinity.The objective of this study was to determine the effects of two salts including NaCl and NaHCO_(3)on germination processes and discuss the relationships between cotyledon photosynthesis and embryo axis growth in A.marina propagules.These propagules came from Al Birk,located on the shoreline of the Saudi Red Sea.The results showed that the studied salts did not affect neither the final germination percentage nor the embryo axis growth.However,rooting and root growth were delayed by both salts at 300 mM and were strongly inhibited by 600 mM NaHCO_(3).Both NaCl and NaHCO_(3)reduced the photosynthetic activity.These two salts did not affect the other photosynthetic parameters,including stomatal conductance,net transpiration,and intercellular CO_(2).Thereafter,the reduction in net photosynthesis was not related to any limitation of stomatal conductance.The early germination phase was independent of cotyledon photosynthesis,whereas rooting and root growth may be limited by reduced photosynthesis under NaCl and NaHCO_(3). 展开更多
关键词 avicenna marina propagules cotyledons embryo growth GERMINATION photosynthesis ALKALINITY SALINITY
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Periconceptional care and offspring health at birth and long term,from the perspective of Avicenna
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作者 Mohammad Ansaripour Mohsen Naseri +4 位作者 Mohammad Mahdi Esfahani Iraj Nabipour Fatemeh Rakhshani Arman Zargaran Roya Kelishadi 《Journal of Integrative Medicine》 SCIE CAS CSCD 2019年第2期80-86,共7页
Periconceptional care such as lifestyle plays an important impact role in offspring health. The aim of the present study was to clarify the perspective of Avicenna on periconceptional care. Avicenna(980–1037 A.D.) wa... Periconceptional care such as lifestyle plays an important impact role in offspring health. The aim of the present study was to clarify the perspective of Avicenna on periconceptional care. Avicenna(980–1037 A.D.) was one of the outstanding Persian physicians, who made great contributions to the field of medical sciences, in particular, obstetrics. In advance, Avicenna's book, Canon of Medicine, was considered to find his perspectives on periconceptional care. Then, his ideas and theories were compared to the current findings by searching the keywords in main indexing systems including PubMed/MEDLINE,Scopus and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. Current investigations show that gamete quality, pregnancy outcome, and offspring health at birth and long term depend on both parents' lifestyle in pre-and periconceptional period, as well as the intrauterine environment. Avicenna believed that seminal fluid, sperm, ovum, and developing conditions in utero were influenced by the stages of food digestion and the function of some organs.On the other hand, food digestion and function of the organs also depend on each parent's lifestyle and environmental factors. He mentioned 6 principles of healthy lifestyle: exercise, nutrition, sleep and awareness, excretion of body wastes and retention of necessary materials, psychic features, as well as air and climate. Thus, a multicomponent healthy lifestyle should be considered by parents of child-bearing age in an appropriate period before and in early pregnancy as well as elimination of any disorders in parents, to give birth to more healthy offspring. 展开更多
关键词 avicenna EPIGENETIC diseases Healthy lifestyle OFFSPRING HEALTH Periconceptional CARE PERSIAN medicine
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Insights into Avicenna's knowledge of the science of orthopedics
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作者 Behnam Dalfardi Hassan Yarmohammadi Mohammad Kalantari Meibodi 《World Journal of Orthopedics》 2014年第1期67-68,共2页
The art of orthopedics traces its history back to ancient civilizations like those of the Egyptians. The evolution of this branch of medicine is indebted to investigations of many scientists, including Greek, Roman an... The art of orthopedics traces its history back to ancient civilizations like those of the Egyptians. The evolution of this branch of medicine is indebted to investigations of many scientists, including Greek, Roman and Persian scholars. The Persian physician Avicenna(980-1037 AD) is one such scientist who investigated different aspects of orthopedics. It is possible to analyze Avicenna's knowledge of orthopedics and his contributions to this branch of medicine by an examination of his epic encyclopedia of medicine, Al-Qanun fi al-Tibb(The Canon of Medicine). 展开更多
关键词 avicenna BONE FRACTURES CANON History of medicine PERSIA
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Letter to the editor regarding "Galen’s place in Avicenna’s The Canon of Medicine: Respect,confirmation and criticism"
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作者 Mostafa Araj-Khodaei Javad Ghazi-Sha’rbaf +1 位作者 Somaiyeh Taheri-Targhi Reza Mohammadinasab 《Journal of Integrative Medicine》 SCIE CAS CSCD 2020年第3期274-274,共1页
We have read the article entitled "Galen’s place in Avicenna’s The Canon of Medicine: Respect, confirmation and criticism."(online available: 15 November 2019) [1]. We want to congratulate the authors for ... We have read the article entitled "Galen’s place in Avicenna’s The Canon of Medicine: Respect, confirmation and criticism."(online available: 15 November 2019) [1]. We want to congratulate the authors for this successful review article and make some contributions.The article explains that Avicenna mentioned Galen in his famous medical book—The Cannon of Medicine, in detail. 展开更多
关键词 Galen’s PLACE in avicenna’s The CANON of Medicine LETTER to the editor regarding Respect confirmation and CRITICISM
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Rabies in medieval Persian literature – the Canon of Avicenna (980–1037 AD)
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作者 Behnam Dalfardi Mohammad Hosein Esnaashary Hassan Yarmohammadi 《Infectious Diseases of Poverty》 SCIE 2014年第1期56-61,共6页
Ibn Sina(980-1037 AD),known by his full name Abu Ali al-Hussain ibn Abdallah ibn Sina and the Latin name‘Avicenna’,was a Persian scholar who is primarily remembered for his contributions to the science of medicine.H... Ibn Sina(980-1037 AD),known by his full name Abu Ali al-Hussain ibn Abdallah ibn Sina and the Latin name‘Avicenna’,was a Persian scholar who is primarily remembered for his contributions to the science of medicine.He authored Al-Qanun fi al-Tibb(The Canon of Medicine).Sections of his work are devoted to detailed descriptions of a number of infectious illnesses,particularly rabies.Avicenna described rabies in humans and animals and explained its clinical manifestations,route of transmission,and treatment methods.In this article,our goal is to discuss Avicenna’s 11th-century points of view on rabies and compare them with modern medical knowledge. 展开更多
关键词 avicenna Canon of medicine Medieval history PERSIA Rabie
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Some aspects of the life history of Cobitis avicennae(Actinopterygii:Cypriniformes:Cobitidae)from Western Iran
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作者 Hadi Jamali Rahman Patimar +3 位作者 Vahid Daraei Nafiseh Paricheh Mohammad Farhadi Sareh Nazerian 《Journal of Coastal Life Medicine》 2016年第6期435-439,共5页
Objective:To describe the age structure,growth,reproductive characteristics and lengthweight relationship of Cobitis avicennae(C.avicennae)population inhabiting the Gamasiab River,Western Iran.Methods:C.avicennae was ... Objective:To describe the age structure,growth,reproductive characteristics and lengthweight relationship of Cobitis avicennae(C.avicennae)population inhabiting the Gamasiab River,Western Iran.Methods:C.avicennae was collected throughout the spawning season(February to July,2015)in Gamasiab River and its age,growth,and reproductive traits were investigated.Total length was measured to the nearest 1 mm,and total weight and gonad weight to the nearest 0.001 g.The age was determined using operculum.Sex was determined by examination of the gonad tissue.The number of eggs was estimated by gravimetric method.Average egg diameter was examined by measuring 30 eggs for each female with an ocular micrometer microscope.Results:The maximum age was 3 years.The specimens size ranged from 32.63 to 100.00 mm in total length,weighing from 0.22 to 5.17 g in total weight.Length-weight relationship was estimated as W=1E-05TL^(2.85)for females,W=1E-05TL^(2.83)for males and W=7E-06TL^(2.94)for the population.The growth model was isometric for males and sexes combined and negatively allometric for females.The absolute fecundity ranged between 132 and 900 eggs with a mean of 490.55 eggs.Conclusions:The life history traits described for C.avicennae from the Western Iran basin indicated a moderate life span,a moderate body weight,a short duration of spawning season,relatively high heterogeneity in egg size and low egg number.Some life history traits of C.avicennae demonstrated obvious differences compared with its closely related species,indicating that latitude and local environment conditions are important selective forces for this species. 展开更多
关键词 Cobitis avicennae Growth REPRODUCTION Gamasiab River
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Glisson’s capsule in The Avicenna’s Canon of Medicine
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作者 Sajjad Sadeghi Elnaz Dostmohammadi Mahdi Firoozi 《Hepatobiliary Surgery and Nutrition》 SCIE 2023年第5期804-805,共2页
The rich history of anatomy in Persian Medicine is evident and significant(1).In the medieval era,there were a large number of experienced Persian physicians who studied and were experts in the field of human dissecti... The rich history of anatomy in Persian Medicine is evident and significant(1).In the medieval era,there were a large number of experienced Persian physicians who studied and were experts in the field of human dissection such as Avicenna that we can see his innovations in anatomy,for example,his description of the Willis circle(2). 展开更多
关键词 Glisson’s capsule Francis Gleason avicenna The Canon of Medicine
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From the Silk Road to the Belt and Road:A History of Chinese-Iranian Medical Exchanges
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作者 Ehsan Doostmohammadi 《Chinese Medicine and Culture》 2025年第4期399-408,共10页
Since ancient times,China and Iran,two ancient civilizations with profound medical traditions,have engaged in extensive medical interactions through trade and cultural exchange channels,such as the Silk Road.The paper... Since ancient times,China and Iran,two ancient civilizations with profound medical traditions,have engaged in extensive medical interactions through trade and cultural exchange channels,such as the Silk Road.The paper first reviews the emergence of medical exchanges between the two countries during the Han dynasty,then elaborates on the in-depth development of medical exchanges from the Three Kingdoms to the eve of the Tang dynasty.Entering the Song and Yuan dynasties,the medical exchanges between the two countries became more specific,involving the translation and dissemination of medical classics,the exchanges between doctors,and the trade and cultivation of medicinal materials.The paper further examines the new opportunities and challenges presented by traditional medical exchanges between the two countries under the Belt and Road Initiative.It emphasizes the contribution of this cross-civilization medical exchange to the development of the medical systems of both sides and to human health.This article reveals its far-reaching significance by systematically examining the historical context of medical exchanges between the two countries.It provides historical references and inspiration for future in-depth cooperation between the two countries in traditional medicine. 展开更多
关键词 Silk Road The Belt and Road Sino-Iranian exchange Traditional medicine avicenna Chinese medicine Intercultural history Global health
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《阿维森纳医典》与《黄帝内经》情绪认知理论对比研究
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作者 李佳悦 宋欣阳 +3 位作者 张雪丹 徐丽莉 丁杰 王丽慧 《亚太传统医药》 2025年第4期1-5,共5页
中东传统医学典籍《阿维森纳医典》称情绪是建立在体液配属说之上。体液配属可产生情绪,而情绪也可以通过体液影响整个人体。而在《黄帝内经》代表的中医理论中,藏象学说是情志学说的基础。情志与五脏紧密相连,情志产生于五脏又可以影... 中东传统医学典籍《阿维森纳医典》称情绪是建立在体液配属说之上。体液配属可产生情绪,而情绪也可以通过体液影响整个人体。而在《黄帝内经》代表的中医理论中,藏象学说是情志学说的基础。情志与五脏紧密相连,情志产生于五脏又可以影响五脏,通过调治五脏可治疗情志病。但二者作为中国和中东的传统医学理论,都将情志转化为实质并与脏腑相联系,并认为情绪波动是很多疾病的重要诱因。总体而言,《阿维森纳医典》的情绪说和《黄帝内经》的情志学说在整体性、系统性、完整性和先进性方面各具特色,均有独到之处,值得今人学习。 展开更多
关键词 《阿维森纳医典》 《黄帝内经》 中东传统医学 中医学 情绪
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阿维森纳精神疾病理论中的哲学思想与实践
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作者 王亚萍 《自然辩证法通讯》 北大核心 2025年第3期65-72,共8页
阿维森纳对精神疾病的认识是其医学哲学思想的集中体现。他关于身体、灵魂与精气三者本质、相互关系的哲学思考,是理解其精神疾病观的理论基础。更重要的是,阿维森纳通过考察灵魂、精气、器官、呼吸等之间的运行机制、密切联系与相互作... 阿维森纳对精神疾病的认识是其医学哲学思想的集中体现。他关于身体、灵魂与精气三者本质、相互关系的哲学思考,是理解其精神疾病观的理论基础。更重要的是,阿维森纳通过考察灵魂、精气、器官、呼吸等之间的运行机制、密切联系与相互作用,阐释精神疾病病因与病程的心理性和生理性原理。阿维森纳对精神疾病具体症状、诊断与疗法的认识与实践,如对激情之爱、脑部炎症等的医学哲学分析,进一步发展出一套基于身心哲学之上的,更加准确、严谨的精神疾病医学理论体系。总之,阿维森纳对精神疾病的相关研究,有力地推动了精神疾病史研究的发展,是研究该类疾病知识发展史上必不可少的一环。 展开更多
关键词 阿维森纳 身心哲学 黑胆汁 治疗
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基于网络药理学和细胞实验探讨簕欓花椒下调HSP90AA1治疗肺腺癌的作用机制
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作者 杨航芮 陈洪 +1 位作者 黄桂琼 张岳阳 《生命的化学》 2025年第8期1594-1604,共11页
本文通过网络药理学、分子对接和细胞实验探讨簕欓花椒治疗肺腺癌的有效成分、关键作用靶点及潜在作用机制。通过文献检索及数据库筛选簕欓花椒的活性成分及肺腺癌(lung adenocarcinoma,LA)的疾病靶点,后续对作用靶点进行预测,然后构建... 本文通过网络药理学、分子对接和细胞实验探讨簕欓花椒治疗肺腺癌的有效成分、关键作用靶点及潜在作用机制。通过文献检索及数据库筛选簕欓花椒的活性成分及肺腺癌(lung adenocarcinoma,LA)的疾病靶点,后续对作用靶点进行预测,然后构建蛋白质互作(protein-protein interaction,PPI)网络,并对交集靶点进行富集分析和通路分析。最终获得簕欓花椒活性成分30个、成分靶点共598个、疾病靶点1262个、药物-疾病交集靶点189个;簕欓花椒[Zanthoxylum avicennae(Lam.)DC.]治疗LA的核心基因主要涉及热休克蛋白90-α(heat shock protein 90-alpha,HSP90AA1)、转录激活因子3(activator of transcription 3,STAT3)、丝氨酸/苏氨酸蛋白激酶B1(protein kinase B1,AKT1)、Src酪氨酸激酶(Src tyrosine kinase,SRC)、表皮生长因子受体(epidermal growth factor receptor,EGFR)、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基α(phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha,PIK3CA)等,其中主要通过滨蒿内酯(scoparone)、鹰不泊内酯醇(avicennol)、阿维森诺尔甲醚(avicennol methyl ethe)、芹黄素(apigenin)、阿诺缇胺(arnottianamide)等11个潜在活性成分作用于癌细胞中PD-L1表达和PD-1检查点通路、PI3K/AKT、EGFR酪氨酸激酶抑制剂等信号通路,发挥治疗LA的功效。在通过大量文献调研后,最终确定HSP90AA1为主要靶点,拟通过HSP90A-TCL1A-AKT通路以达到治疗LA的效果。运用AutoDock Tools软件对HSP90AA1可对接化合物进行分子对接验证。之后进行初步细胞实验验证,簕欓花椒能够显著下调靶点HSP90AA1的表达,抑制人肺腺癌细胞株A549的增殖活性。故推测其机制可能是通过抑制分子伴侣蛋白HSP90AA1来促进TCL1A(一种重要的激酶辅助因子,参与细胞内的AKT信号通路)降解,进而减少AKT的磷酸化水平,AKT的活化使得肿瘤细胞维持多种恶性表型,包括耐药性和免疫逃逸。综上,簕欓花椒可能通过下调HSP90AA1进而抑制HSP90A-TCL1A-AKT信号通路的活性,达到抑制肿瘤的生长、转移及对化疗和免疫治疗抵抗的目的。 展开更多
关键词 簕欓花椒 肺腺癌 网络药理 分子对接 HSP90AA1
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因特网上免费MEDLINE检索各站点介绍 被引量:1
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作者 王永光 赵可晓 《医院图书馆杂志》 1999年第1期18-19,共2页
关键词 医学信息 因特网 网络信息资源 免费资源 信息检索 网站 MEDLINE PUBMED Internet-Grateful-Med HealthGate avicenna BioMedlNet Medscape PhyNet
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簕欓花椒叶挥发油的GC-MS分析及抗菌抗肿瘤活性研究 被引量:26
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作者 张大帅 钟琼芯 +3 位作者 宋鑫明 刘文洁 王菁 张琼玉 《中药材》 CAS CSCD 北大核心 2012年第8期1263-1267,共5页
目的:研究簕欓花椒(Zanthoxylum avicennae)叶挥发油的化学成分及其抗菌和抗肿瘤活性。方法:用水蒸气蒸馏法从簕欓花椒叶中提取挥发油,用气相色谱-质谱联用技术对其挥发油成分进行分析。结果:从挥发油中鉴定出72种物质,占总成分的98.15%... 目的:研究簕欓花椒(Zanthoxylum avicennae)叶挥发油的化学成分及其抗菌和抗肿瘤活性。方法:用水蒸气蒸馏法从簕欓花椒叶中提取挥发油,用气相色谱-质谱联用技术对其挥发油成分进行分析。结果:从挥发油中鉴定出72种物质,占总成分的98.15%,含量较高的组分为芳樟醇(24.36%)、β-榄香烯(12.03%)、(E)-2-己烯-1-醇(11.73%)、石竹烯氧化物(10.84%)等。簕欓花椒叶挥发油对实验菌株均具有一定的抗菌活性;对四种肿瘤细胞株都具有一定的抑制活性,其中对白血病细胞K-562的抑制活性最强,IC50值为1.76μg/mL。结论:簕欓花椒挥发油具有多种活性成分,为进一步研究其药理作用提供了科学依据。 展开更多
关键词 簕欓花椒 挥发油 化学成分 抗菌活性 抗肿瘤活性
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簕欓花椒的化学成分及生物活性研究 被引量:12
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作者 郑楠楠 杨胜祥 +1 位作者 周慧 袁珂 《中草药》 CAS CSCD 北大核心 2015年第2期189-193,共5页
目的对簕欓花椒Zanthoxylum avicennae进行化学成分和生物活性研究。方法采用Diaion HP-20、MCI-Gel CHP-20、Sephadex LH-20、Toyopearl HW-40、RP18及硅胶等柱色谱法对簕欓花椒中的化学成分进行分离纯化,根据理化性质和波谱技术(1H-... 目的对簕欓花椒Zanthoxylum avicennae进行化学成分和生物活性研究。方法采用Diaion HP-20、MCI-Gel CHP-20、Sephadex LH-20、Toyopearl HW-40、RP18及硅胶等柱色谱法对簕欓花椒中的化学成分进行分离纯化,根据理化性质和波谱技术(1H-NMR、13C-NMR、HR-ESI-MS)鉴定化合物的结构,采用斜面试管法和海虾致死生物活性法测定部分化合物的抑菌活性和细胞毒活性。结果从簕欓花椒醋酸乙酯部位和正丁醇部位共分离鉴定了9个化合物,分别为二氢山柰素(1)、滨蒿内酯(2)、3-吲哚甲酸(3)、6-oxo-2(4-hydroxy-3,5-dimethoxyphenyl)-3,7-dioxabicyclo-[3.3.0]-octane(4)、辛二酸(5)、4,4-二甲基-1,7-庚二酸(6)、丁香酸甲酯(7)、β-谷甾醇(8)、前茵芋碱(9)。其中化合物2对玉米大斑病菌和大麦赤霉病菌具有较强的抗真菌活性,最低抑制浓度(MIC)值均为15.63μg/m L;化合物1-3具有一定的细胞毒活性,对海虾致死的LC50值分别为9.8、2.6、4.9μg/m L。结论除化合物9外,其他化合物均为首次从该植物中分离得到,其中化合物2具有较强的抗真菌活性,化合物1-3具有一定的细胞毒活性。 展开更多
关键词 簕欓花椒 二氢山柰素 滨蒿内酯 3-吲哚甲酸 抗真菌活性
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HPLC法测定鹰不泊中橙皮苷的含量 被引量:2
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作者 夏爱军 韦少宣 廖厚知 《解放军药学学报》 CAS 2012年第3期248-249,共2页
目的建立鹰不泊中橙皮苷的含量测定方法。方法采用HPLC法。色谱柱:VP-ODS C18(4.6 mm×150 mm,5μm);流动相:乙腈-水(25∶75);流速:1.0 ml/min;检测波长:283 nm。结果鹰不泊中橙皮苷在0.1015~1.6240μg范围内进样量与峰面积的线性... 目的建立鹰不泊中橙皮苷的含量测定方法。方法采用HPLC法。色谱柱:VP-ODS C18(4.6 mm×150 mm,5μm);流动相:乙腈-水(25∶75);流速:1.0 ml/min;检测波长:283 nm。结果鹰不泊中橙皮苷在0.1015~1.6240μg范围内进样量与峰面积的线性关系良好(r=0.9998);平均回收率为99.42%,RSD为0.76%。结论所建立的方法准确、灵敏、重复性好,可用于鹰不泊中橙皮苷的含量测定。 展开更多
关键词 鹰不泊 橙皮苷 HPLC
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促进负责任的研究,使科学研究成果服务于人民——在联合国教科文组织总部授奖典礼上的演说 被引量:4
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作者 邱仁宗 《中国医学伦理学》 2010年第2期3-7,共5页
2009年12月18日,笔者获得联合国教科文组织颁发的阿维森纳科学伦理学奖,这不仅是对本人工作的承认,也是对中国伦理学工作者们努力的认可。感谢联合国教科文组织等国际组织及外国生命伦理学工作者几十年来对中国的理解和支持。生物伦理... 2009年12月18日,笔者获得联合国教科文组织颁发的阿维森纳科学伦理学奖,这不仅是对本人工作的承认,也是对中国伦理学工作者们努力的认可。感谢联合国教科文组织等国际组织及外国生命伦理学工作者几十年来对中国的理解和支持。生物伦理学研究有"放风筝"和"骑单车"两个模型,绝不存在一种万能的伦理学理论,能解决所有伦理学问题,我们的决策不应该是单单从伦理学理论或原则直接推演的结果;对科学活动进行伦理管理是绝对必要的,生命伦理学在科学研究方面的体制化是旨在建立一个保护人类受试者的结构和框架,虽然有些科学家和决策者对伦理学仍有误解,但已取得一些成绩,还需耐心与努力;处理伦理学的国际准则与本土文化的张力问题时,唯有"协调进路"能够使我们恰当地处理文化张力,其结果是"和而不同"。 展开更多
关键词 阿维森纳科学伦理学奖 生命伦理学 科学研究 体制化 国际准则 生命伦理本土化
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