Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic ...Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied.In this investigation,we established mouse models of depression using aversive stimuli including exposure to fox urine,air puff and foot shock and physical restraint.Concurrently,we administered 5 mg/kg per day Lycium barbarum polysaccharide-glycoprotein to each mouse intragastrically for the 28 days.Our results showed that long-term exposure to aversive stimuli significantly enhanced depressive-like behavior evaluated by the sucrose preference test and the forced swimming test and increased anxietylike behaviors evaluated using the open field test.In addition,aversive stimuli-induced depressed mice exhibited aberrant neuronal activity in the lateral habenula.Importantly,concurrent Lycium barbarum polysaccharide-glycoprotein treatment significantly reduced these changes.These findings suggest that Lycium barbarum polysaccharide-glycoprotein is a potential preventative intervention for depression and may act by preventing aberrant neuronal activity and microglial activation in the lateral habenula.The study was approved by the Jinan University Institutional Animal Care and Use Committee(approval No.20170301003)on March 1,2017.展开更多
Clinical studies have suggested that internal and/or external aversive cues may produce a negative affective-motivational component whereby maladaptive responses(plasticity)of dural afferent neurons are initiated cont...Clinical studies have suggested that internal and/or external aversive cues may produce a negative affective-motivational component whereby maladaptive responses(plasticity)of dural afferent neurons are initiated contributing to migraine chronification.However,pathophysiological processes and neural circuitry involved in aversion(unpleasantness)-producing migraine chronification are still evolving.An interdisciplinary team conducted this narrative review aimed at reviewing neuronal plasticity for developing migraine chronicity and its relevant neurocircuits and providing the most cutting-edge information on neuronal mechanisms involved in the processing of affective aspects of pain and the role of unpleasantness evoked by internal and/or external cues in facilitating the chronification process of migraine headache.Thus,information presented in this review promotes the understanding of the pathophysiology of chronic migraine and contribution of unpleasantness(aversion)to migraine chronification.We hope that it will bring clinicians’attention to how the maladaptive neuroplasticity of the emotion brain in the aversive environment produces a significant impact on the chronification of migraine headache,which will in turn lead to new therapeutic strategies for this type of pain.展开更多
Stress has been considered as a major risk factor for depressive disorders,triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits.Among various regions across...Stress has been considered as a major risk factor for depressive disorders,triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits.Among various regions across the brain,the lateral habenula(LHb)serves as a critical hub for processing aversive information during the dynamic process of stress accumulation,thus having been implicated in the pathogenesis of depression.LHb neurons integrate aversive valence conveyed by distinct upstream inputs,many of which selectively innervate the medial part(LHbM)or lateral part(LHbL)of LHb.LHb subregions also separately assign aversive valence via dissociable projections to the downstream targets in the midbrain which provides feedback loops.Despite these strides,the spatiotemporal dynamics of LHb-centric neural circuits remain elusive during the progression of depression-like state under stress.In this review,we attempt to describe a framework in which LHb orchestrates aversive valence via the input-output specific neuronal architecture.Notably,a physiological form of Hebbian plasticity in LHb under multiple stressors has been unveiled to incubate neuronal hyperactivity in an input-specific manner,which causally encodes chronic stress experience and drives depression onset.Collectively,the recent progress and future efforts in elucidating LHb circuits shed light on early interventions and circuit-specific antidepressant therapies.展开更多
Aim:Extinction of aversive memories associated with drug withdrawal has been proposed as a therapeutic strategy for the treatment of drug addiction.However,the mechanisms underlying extinction of such memory are poorl...Aim:Extinction of aversive memories associated with drug withdrawal has been proposed as a therapeutic strategy for the treatment of drug addiction.However,the mechanisms underlying extinction of such memory are poorly understood.This study was,therefore,undertaken to investigate the role of Rho GTPase Rac1-mediated GABAAR endocytosis in the vmPFC in extinction of aversive memories associated with drug withdrawal.Methods:conditioned place aversion(CPA)was used as a model for measurement of the aversive memories of opiate withdrawal.Extinction experiments were performed as described in our previous study(Wang et al.,2012).Results:we found that extinction of CPA required activation of Rac1 in the vmPFC in a brain-derived neurotrophic factor(BDNF)-dependent manner,which triggers actin polymerization via Pak1-cofilin signaling pathway,leading to synaptic localization of activity-regulated cytoskeleton-associated protein(Arc)in the vmPFC.The synaptic Arc further determines GABAA receptor(GABAAR)endocytosis that is necessary and sufficient for vmPFC long-term potentiation and CPA extinction.Thus,extinction of an aversive memory associated with drug withdrawal is intriguingly controlled by Rac1-dependent GABAAR endocytosis in the vmPFC,thereby suggesting therapeutic targets to promote extinction of the unwanted memory.Conclusion:BDNF dependent Rac1 GTPase activation in the vmPFC contributes to aversive memory extinction by Arc-mediated GABAA receptor endocytosis.展开更多
The biogenic amine octopamine(OA,invertebrate counterpart of nora-drenaline)plays critical roles in the regulation of olfactory behavior.Historically,OA has been thought to mediate appetitive but not aversive learning...The biogenic amine octopamine(OA,invertebrate counterpart of nora-drenaline)plays critical roles in the regulation of olfactory behavior.Historically,OA has been thought to mediate appetitive but not aversive learning in honeybees,fruit flies(Drosophila),and crickets.However,this viewpoint has recently been challenged because OA activity through aβ-adrenergic-like receptor drives both appetitive and aversive learn-ing.Here,we explored the roles of OA neurons in olfactory learning and memory retrieval in Bactrocera dorsalis.We trained flies to associate an orange odor with a sucrose reward or to associate methyl eugenol,a male lure,with N,N-diethyl-3-methyl benzoyl amide(DEET)punishment.We then treated flies with OA receptor antagonists before appetitive or aversive conditioning and a memory retention test.Injection of OA receptor antagonist mianserin or epinastine into the abdomen of flies led to impaired of appetitive learning and memory retention with a sucrose reward,while aversive learning and memory reten-tion with DEET punishment remained intact.Our results suggest that the OA signaling participates in appetitive but not aversive learning and memory retrieval in B.dorsalis through OA receptors.展开更多
The Ventral Tegmental Area(VTA)is a midbrain structure known to integrate aversive and rewarding stimuli,but little is known about the role of VTA glutamatergic(VGluT2)neurons in these functions.Direct activation of V...The Ventral Tegmental Area(VTA)is a midbrain structure known to integrate aversive and rewarding stimuli,but little is known about the role of VTA glutamatergic(VGluT2)neurons in these functions.Direct activation of VGluT2 soma evokes rewarding behaviors,while activation of their downstream projections evokes aversive behaviors.To facilitate our understanding of these conflicting properties,we recorded calcium signals from VTAVGluT2+neurons using fiber photometry in VGluT2-cre mice to investigate how this population was recruited by aversive and rewarding stimulation,both during unconditioned and conditioned protocols.Our results revealed that,as a population,VTAVGluT2+neurons responded similarly to unconditioned-aversive and unconditioned-rewarding stimulation.During aversive and rewarding conditioning,the CS-evoked responses gradually increased across trials whilst the US-evoked response remained stable.Retrieval 24 h after conditioning,during which mice received only CS presentation,resulted in VTAVGluT2+neurons strongly responding to CS presentation and to the expected-US but only for aversive conditioning.To help understand these differences based on VTAVGluT2+neuronal networks,the inputs and outputs of VTAVGluT2+neurons were investigated using Cholera Toxin B(CTB)and rabies virus.Based on our results,we propose that the divergent VTAVGluT2+neuronal responses to aversion and reward conditioning may be partly due to the existence of VTAVGluT2+subpopulations that are characterized by their connectivity.展开更多
The valuation of financial derivatives often assumes risk neutrality with respect to the risk-neutral martingale measure,which prevents arbitrage opportunities.However,casual traders may still incur substantial losses...The valuation of financial derivatives often assumes risk neutrality with respect to the risk-neutral martingale measure,which prevents arbitrage opportunities.However,casual traders may still incur substantial losses when trading at this risk-neutral price,especially when the price has to be paid now and the payoff is only realized in the future.This study proposes a new valuation framework that provides risksensitive investors with an additional safeguard.The proposed framework embraces a worst-case perspective while exploiting the underlier’s stochastic process,representing a combination of robust optimization and stochastic programming.Notably,it aims to mitigate losses in the likelier scenarios of the underlying asset’s prices.When the underlier’s returns are independent and lognormally but not necessarily identically distributed,our approach for pricing variance and volatility swaps could be greatly simplified,benefit from parallel computing,and be solved by a two-dimensional grid search.We further derive a closed-form solution in some special stationary cases and provide experimental results to highlight the effect of risk aversion on fending off sizable trading losses.展开更多
We construct a model to examine the time-varying ambiguity of investors.When ambiguity occurs concerning recent news,long(short)position investors who are averse to ambiguity reduce(increase)their holdings,resulting i...We construct a model to examine the time-varying ambiguity of investors.When ambiguity occurs concerning recent news,long(short)position investors who are averse to ambiguity reduce(increase)their holdings,resulting in price drops(rises).We empirically analyze how the“two sessions,”a significant event with high policy ambiguity in China,affect the financial market.Our findings suggest that institutional investors mainly sell their holdings between 15 and 5 days before the meetings.Furthermore,the delay in the“two sessions”in 2020 suggests that these selloffs are driven by ambiguity aversion rather than new information.展开更多
In the process of daily psychological counseling,it is found that more and more school-age children have a dislike for learning,and the rate is increasing year by year.They are unclear about the purpose of learning,lo...In the process of daily psychological counseling,it is found that more and more school-age children have a dislike for learning,and the rate is increasing year by year.They are unclear about the purpose of learning,lose interest in class,do not listen carefully,cannot complete homework independently,and even skip school.This case analyzes the mechanism of a 7-year-old primary school student's aversion to learning and analyzes and discusses this behavior.展开更多
Objective To investigate whether environmental cues associated with different properties of morphine could regulate the extracellular levels of glutamate and y-aminobutyric acid （GABA） in the hippocampal ventral sub...Objective To investigate whether environmental cues associated with different properties of morphine could regulate the extracellular levels of glutamate and y-aminobutyric acid （GABA） in the hippocampal ventral subiculum, which play a critical role in the reinstatement of drug-seeking behavior induced by environmental cues. Methods Conditioning place preference （CPP） and conditioning place aversion （CPA） models were used to establish environment associated with rewarding and aversive properties of morphine respectively. Microdialysis and high performance liquid chromatography were used to measure the extracelluar level of glutamate and GABA in the ventral subiculum under these environmental cues. Results Exposure to the environmental cues associated with rewarding properties of morphine resulted in a decrease （approximately 11%） of extracellular level of GABA in ventral subiculum, and exposure to the environmental cues associated with aversive properties of morphine resulted in an increase （approximately 230%） of extracellular level of glutamate in ventral subiculum. Conclusion Environmental cues associated with different properties of morphine modulate the release of distinct neurotransmitters in the hippocampal ventral subiculum possibly through different neural circuit.展开更多
Recent advances in the study of affective-cognitive regulation of aggressive behavior suggest positive correlations between poor executive capacities (ECF) and negative reactivity. If the global assumption is correct ...Recent advances in the study of affective-cognitive regulation of aggressive behavior suggest positive correlations between poor executive capacities (ECF) and negative reactivity. If the global assumption is correct what are the likely implications of predicted relation? The central issue in present research is to verify this assumption and examine how situational characteristics can alter executive performance in adults experiencing Civil War (Syrians students living in their country or in a host country) and adults experiencing peaceful life (French students) to explore some of the consequences of those modifications for aggressive and anxious tendencies. Precisely, we expect the positive correlations between poor executive performances and high dispositional as well situational aggressive and anxious tendencies, specifically for adults exposed to warfare. In order to assess executive capacities and dispositional as well as situational aggressive and anxious tendencies, during one pilot and two comparative studies [pilot study: N = 60 female French students;first comparative study: N = 60 French and N = 60 Syrian students of both sexes (50%);second comparative study: N = 60 Syrian students of both sexes (50%) living in France] right-handed French/Arabic-speakers participants complete twice, before and after completion executive tasks (standard neuropsychological tests) under different experimental conditions (Aversive/Neutral condition), a series of aggression and anxiety questionnaires. The results provide evidence of a dispositional relationship between poor executive functioning and negative reactivity, and extend it to situational level. For all participants, it shows that increases in impulsiveness (negative emotionality and aggressive choices) due to an aversive noise (80 db) are concomitant with an inability to focus individuals’ attention on ongoing tasks, specifically in those living directly or indirectly stressful life-event.展开更多
Pain consists of sensory-discriminative and emotional-affective components.The anterior cingulate cortex(ACC)is a critical brain area in mediating the affective pain.However,the molecular mechanisms involved remain la...Pain consists of sensory-discriminative and emotional-affective components.The anterior cingulate cortex(ACC)is a critical brain area in mediating the affective pain.However,the molecular mechanisms involved remain largely unknown.Our recent study indicated that C-X-C motif chemokine 13(CXCL13)and its sole receptor CXCR5 are involved in sensory sensitization in the spinal cord after spinal nerve ligation(SNL).Whether CXCL13/CXCR5 signaling in the ACC contributes to the pathogenesis of pain-related aversion remains unknown.Here,we showed that SNL increased the CXCL13 level and CXCR5 expression in the ACC after SNL.Knockdown of CXCR5 by microinjection of Cxcr5 shRNA into the ACC did not affect SNL-induced mechanical allodynia but effectively alleviated neuropathic painrelated place avoidance behavior.Furthermore,electrophysiological recording from layer Ⅱ-Ⅲ neurons in the ACC showed that SNL increased the frequency and amplitude of spontaneous excitatory postsynaptic currents(sEPSCs),decreased the EPSC paired-pulse ratio,and increased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor/N-methyl-D-aspartate receptor ratio,indicating enhanced glutamatergic synaptic transmission.Finally,superfusion of CXCL13 onto ACC slices increased the frequency and amplitude of spontaneous EPSCs.Pre-injection of Cxcr5 shRNA into the ACC reduced the increase in glutamatergic synaptic transmis sion induced by SNL.Collectively,these results suggest that CXCL13/CXCR5 signaling in the ACC is involved in neuropathic pain-related aversion via synaptic potentiation.展开更多
The traditional newsvendor model assumes that a decision-maker is risk-neutral. However, in actuality, a decisionmaker's order behavior is often influenced by waste-averse preference and stockout-averse preference...The traditional newsvendor model assumes that a decision-maker is risk-neutral. However, in actuality, a decisionmaker's order behavior is often influenced by waste-averse preference and stockout-averse preference. We extend the newsvendor model with consideration of averse preferences to investigate how the decision results of the previous period impact the order behavior of the current period, and design an inventory decision-making behavior experiment. Results from the study demonstrate that the order behavior of both a group and an individual exhibits a demand chasing phenomenon, and the former is more significant. Through the interval estimation of the decision maker's order quantity, by the maximum likelihood method we find that the stockout-averse preference has an effect on the decision-making when the prior period is insufficient, causing the current period order quantity larger than the expected profit-maximizing order quantity. In a similar way, waste-averse preference has an effect on decision-making when the prior period is surplus, resulting in the current period order quantity smaller than the expected profit-maximizing order quantity. Finally, we investigate the formation mechanism of demand chasing phenomenon from the perspective of the averse preferences, and propose that this phenomenon is a decision maker's cognitive reaction to stochastic demand environment.展开更多
The nucleus accumbens shell(NAcSh) plays an important role in reward and aversion. Traditionally, NAc dopamine receptor 2-expressing(D2) neurons are assumed to function in aversion. However, this has been challenged b...The nucleus accumbens shell(NAcSh) plays an important role in reward and aversion. Traditionally, NAc dopamine receptor 2-expressing(D2) neurons are assumed to function in aversion. However, this has been challenged by recent reports which attribute positive motivational roles to D2 neurons. Using optogenetics and multiple behavioral tasks, we found that activation of D2 neurons in the dorsomedial NAcSh drives preference and increases the motivation for rewards, whereas activation of ventral NAcSh D2 neurons induces aversion. Stimulation of D2 neurons in the ventromedial NAcSh increases movement speed and stimulation of D2 neurons in the ventrolateral NAc Sh decreases movement speed. Combining retrograde tracing and in situ hybridization, we demonstrated that glutamatergic and GABAergic neurons in the ventral pallidum receive inputs differentially from the dorsomedial and ventral NAcSh. All together, these findings shed light on the controversy regarding the function of NAcSh D2 neurons, and provide new insights into understanding the heterogeneity of the NAcSh.展开更多
Understanding the factors behind apple farmers’willingness to pass on the management of their farms to their descendants is crucial to the continuity of apple production.Due to the high specificity of the human capit...Understanding the factors behind apple farmers’willingness to pass on the management of their farms to their descendants is crucial to the continuity of apple production.Due to the high specificity of the human capital,physical assets,land assets,and geographical location in apple production,this study used a binary logistic regression and a mediating effect model to explore the impact of asset specificity on farmers’intergenerational succession willingness of apple management(FISWAM)and to examine the mediating effects of loss aversion in the impact of asset specificity on the FISWAM.The results showed that about 18.68%of the respondents expressed willingness to transfer their apple business between generations,and the FISWAM was generally weak.In addition to the negative impact of geographical location specificity(GLS),human capital specificity(HCS),physical assets specificity(PAS),and land assets specificity(LAS)can enhance the FISWAM.Loss aversion plays a partial mediating role in the impact of PAS,LAS,and GLS on the FISWAM.展开更多
We consider a distribution system with one supplier and two retailers. For the two retailers, they face different demand and are both risk averse. We study a single period model which the supplier has ample goods and ...We consider a distribution system with one supplier and two retailers. For the two retailers, they face different demand and are both risk averse. We study a single period model which the supplier has ample goods and the retailers order goods separately. Market search is measured as the fraction of customers who unsatisfied with their ＂local＂ retailer due to stock-out, and search for the goods at the other retailer before leaving the system. We investigate how the retailers game for order quantity in a Conditional Value-at-Risk framework and study how risk averse degree, market search level, holding cost and backorder cost influence the optimal order strategies. Furthermore, we use uniform distribution to illustrate these results and obtain Nash equilibrium of order strategies.展开更多
Objective:To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase(TK)expression and activity.Methods:To test this,we ...Objective:To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase(TK)expression and activity.Methods:To test this,we separated 50 rats into five groups that were either fed a standard chow diet(controls)or a high-fat diet(experimental groups HO,HI,H2,and H3).HO group animals received no additional dietary supplementation,while H1 group animals were administered 100 mg/kg body weight(BW)thiamine,100 mg/kg BW riboflavin,and 250 mg/kg BW niacin each day,and group H2 animals received daily doses of 100 mg/kg BW pyridoxine,100 mg/kg BW cobalamin,and 5 mg/kg BW folate.Animals in the H3 group received the B vitamin regimens administered to both H1 and H2 each day.Results:Over time,group HO exhibited greater increases in BW and fat mass relative to other groups.When spatial and memory capabilities in these animals were evaluated via conditioned taste aversion(CTA)and Morris Water Maze(MWM),we found B vitamin treatment was associated with significant improvements relative to untreated HO controls.Similarly,B vitamin supplementation was associated with elevated TK expression in erythrocytes and hypothalamus of treated animals relative to those in HO(P<0.05).Conclusion:Together,these findings suggest B vitamin can modulate hypothalamic TK activity to reduce the severity of cognitive deficits in a rat model of obesity.As such,B vitamin supplementation may be a beneficial method for reducing cognitive dysfunction in clinical settings associated with high-fat diets.展开更多
Consider a risk-averse newsvendor who has an option to purchase the units that are short at an emergency purchase price after demand is realized. We use the conditional value-at-risk （CVaR） as the risk measure. The ...Consider a risk-averse newsvendor who has an option to purchase the units that are short at an emergency purchase price after demand is realized. We use the conditional value-at-risk （CVaR） as the risk measure. The aim of the study is to investigate the optimal ordering decision in such a setting under CVaR only and mean-CVaR criterions. For each case, we derive the closed-form optimal solution and perform comparative statics to show the monotonicity properties and other characteristics of the optimal decisions. We also compare our results with those of risk-neutral newsvendor.展开更多
Under the S-shaped utility of loss aversion,this paper considers the bequest motivation of pension plan participants,random salary income before retirement and the substitution rate between receiving pension benefits ...Under the S-shaped utility of loss aversion,this paper considers the bequest motivation of pension plan participants,random salary income before retirement and the substitution rate between receiving pension benefits after retirement and wages before retirement,and studies the optimal investment strategy of defined contribution(DC)pension.Assuming that pension funds can invest in a financial market consisting of three assets(risk-free asset cash,rolling bonds and stocks),inflation is considered by discount.Under the S-shaped utility,the Lagrange method is used to find the terminal optimal surplus of pensions in retirement,so as to find the terminal optimal wealth,and then the martingale method is used to find the optimal wealth process and investment strategy.Finally,a sensitivity analysis is carried out on the the influence of bequest motivation and loss aversion on the optimal investment strategy of DC pension.展开更多
Itch is an unpleasant sensation that urges people and animals to scratch.Neuroimaging studies on itch have yielded extensive correlations with diverse cortical and subcortical regions,including the insular lobe.Howeve...Itch is an unpleasant sensation that urges people and animals to scratch.Neuroimaging studies on itch have yielded extensive correlations with diverse cortical and subcortical regions,including the insular lobe.However,the role and functional specificity of the insular cortex(IC)and its subdivisions in itch mediation remains unclear.Here,we demonstrated by immunohistochemistry and fiber photometry tests,that neurons in both the anterior insular cortex(AIC)and the posterior insular cortex(PIC)are activated during acute itch processes.Pharmacogenetic experiments revealed that nonselective inhibition of global AIC neurons,or selective inhibition of the activity of glutaminergic neurons in the AIC,reduced the scratching behaviors induced by intradermal injection of 5-hydroxytryptamine(5-HT),but not those induced by compound 48/80.However,both nonselective inhibition of global PIC neurons and selective inhibition of glutaminergic neurons in the PIC failed to affect the itching-scratching behaviors induced by either 5-HT or compound 48/80.In addition,pharmacogenetic inhibition of AIC glutaminergic neurons effectively blocked itch-associated conditioned place aversion behavior,and inhibition of AIC glutaminergic neurons projecting to the prelimbic cortex significantly suppressed 5-HT-evoked scratching.These findings provide preliminary evidence that the AIC is involved,at least partially via aversive emotion mediation,in the regulation of 5-HT-,but not compound 48/80-induced itch.展开更多
基金supported by the National Natural Science Foundation of China,Nos.31900825(to SL),31922030(to CRR),31771170(to CRR)Science and Technology Program of Guangdong Province of China,No.2018B030334001(to CRR)+3 种基金Science and Techology of Guangzhou of China,No.202007030012(to CRR)Guangdong Special Support Program of China,No.2017TQ04R173(to CRR)Pearl River S&T Nova Program of Guangzhou Province of China,No.201806010198(to CRR)Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory of China,No.2018GZR110102002(to KFS)。
文摘Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied.In this investigation,we established mouse models of depression using aversive stimuli including exposure to fox urine,air puff and foot shock and physical restraint.Concurrently,we administered 5 mg/kg per day Lycium barbarum polysaccharide-glycoprotein to each mouse intragastrically for the 28 days.Our results showed that long-term exposure to aversive stimuli significantly enhanced depressive-like behavior evaluated by the sucrose preference test and the forced swimming test and increased anxietylike behaviors evaluated using the open field test.In addition,aversive stimuli-induced depressed mice exhibited aberrant neuronal activity in the lateral habenula.Importantly,concurrent Lycium barbarum polysaccharide-glycoprotein treatment significantly reduced these changes.These findings suggest that Lycium barbarum polysaccharide-glycoprotein is a potential preventative intervention for depression and may act by preventing aberrant neuronal activity and microglial activation in the lateral habenula.The study was approved by the Jinan University Institutional Animal Care and Use Committee(approval No.20170301003)on March 1,2017.
基金Supported by The Science and Technology Department of Yibin,No.2016YZY004.
文摘Clinical studies have suggested that internal and/or external aversive cues may produce a negative affective-motivational component whereby maladaptive responses(plasticity)of dural afferent neurons are initiated contributing to migraine chronification.However,pathophysiological processes and neural circuitry involved in aversion(unpleasantness)-producing migraine chronification are still evolving.An interdisciplinary team conducted this narrative review aimed at reviewing neuronal plasticity for developing migraine chronicity and its relevant neurocircuits and providing the most cutting-edge information on neuronal mechanisms involved in the processing of affective aspects of pain and the role of unpleasantness evoked by internal and/or external cues in facilitating the chronification process of migraine headache.Thus,information presented in this review promotes the understanding of the pathophysiology of chronic migraine and contribution of unpleasantness(aversion)to migraine chronification.We hope that it will bring clinicians’attention to how the maladaptive neuroplasticity of the emotion brain in the aversive environment produces a significant impact on the chronification of migraine headache,which will in turn lead to new therapeutic strategies for this type of pain.
基金supported by the STI2030-Major Projects(No.2022ZD0211700)the National Natural Science Foundation of China(Nos.32371057,31922031,32071017,81971309,32170980,82201707,and 82200562)+6 种基金the Zhejiang Provincial Natural Science Foundation of China(No.LDQ24C090001)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2023PT310-01)the CAS Youth Interdisciplinary Team(No.JCTD2022-11)the China Postdoctoral Science Foundation(No.BX20230319)the Guangdong Basic and Applied Basic Research Foundation(Nos.2022B1515020012 and 2021A1515110121)the Science and Technology Planning Project of Guangdong Province(No.2023B1212060018)the Shenzhen Fundamental Research Program(Nos.JCYJ20210324123212035,RCYX20200714114644167,ZDSYS20220606100801003,JCYJ20210324122809025,and JCYJ20230807110315031),China。
文摘Stress has been considered as a major risk factor for depressive disorders,triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits.Among various regions across the brain,the lateral habenula(LHb)serves as a critical hub for processing aversive information during the dynamic process of stress accumulation,thus having been implicated in the pathogenesis of depression.LHb neurons integrate aversive valence conveyed by distinct upstream inputs,many of which selectively innervate the medial part(LHbM)or lateral part(LHbL)of LHb.LHb subregions also separately assign aversive valence via dissociable projections to the downstream targets in the midbrain which provides feedback loops.Despite these strides,the spatiotemporal dynamics of LHb-centric neural circuits remain elusive during the progression of depression-like state under stress.In this review,we attempt to describe a framework in which LHb orchestrates aversive valence via the input-output specific neuronal architecture.Notably,a physiological form of Hebbian plasticity in LHb under multiple stressors has been unveiled to incubate neuronal hyperactivity in an input-specific manner,which causally encodes chronic stress experience and drives depression onset.Collectively,the recent progress and future efforts in elucidating LHb circuits shed light on early interventions and circuit-specific antidepressant therapies.
文摘Aim:Extinction of aversive memories associated with drug withdrawal has been proposed as a therapeutic strategy for the treatment of drug addiction.However,the mechanisms underlying extinction of such memory are poorly understood.This study was,therefore,undertaken to investigate the role of Rho GTPase Rac1-mediated GABAAR endocytosis in the vmPFC in extinction of aversive memories associated with drug withdrawal.Methods:conditioned place aversion(CPA)was used as a model for measurement of the aversive memories of opiate withdrawal.Extinction experiments were performed as described in our previous study(Wang et al.,2012).Results:we found that extinction of CPA required activation of Rac1 in the vmPFC in a brain-derived neurotrophic factor(BDNF)-dependent manner,which triggers actin polymerization via Pak1-cofilin signaling pathway,leading to synaptic localization of activity-regulated cytoskeleton-associated protein(Arc)in the vmPFC.The synaptic Arc further determines GABAA receptor(GABAAR)endocytosis that is necessary and sufficient for vmPFC long-term potentiation and CPA extinction.Thus,extinction of an aversive memory associated with drug withdrawal is intriguingly controlled by Rac1-dependent GABAAR endocytosis in the vmPFC,thereby suggesting therapeutic targets to promote extinction of the unwanted memory.Conclusion:BDNF dependent Rac1 GTPase activation in the vmPFC contributes to aversive memory extinction by Arc-mediated GABAA receptor endocytosis.
基金funded by the National Natural Science Foundation of China(32072486,31971424,and 31572314).
文摘The biogenic amine octopamine(OA,invertebrate counterpart of nora-drenaline)plays critical roles in the regulation of olfactory behavior.Historically,OA has been thought to mediate appetitive but not aversive learning in honeybees,fruit flies(Drosophila),and crickets.However,this viewpoint has recently been challenged because OA activity through aβ-adrenergic-like receptor drives both appetitive and aversive learn-ing.Here,we explored the roles of OA neurons in olfactory learning and memory retrieval in Bactrocera dorsalis.We trained flies to associate an orange odor with a sucrose reward or to associate methyl eugenol,a male lure,with N,N-diethyl-3-methyl benzoyl amide(DEET)punishment.We then treated flies with OA receptor antagonists before appetitive or aversive conditioning and a memory retention test.Injection of OA receptor antagonist mianserin or epinastine into the abdomen of flies led to impaired of appetitive learning and memory retention with a sucrose reward,while aversive learning and memory reten-tion with DEET punishment remained intact.Our results suggest that the OA signaling participates in appetitive but not aversive learning and memory retrieval in B.dorsalis through OA receptors.
基金supported by the National Natural Science Foundation of China,China(31630031,81425010,31471109,31671116,and 31500861)International Partnership Program of Chinese Academy of Sciences,China(172644KYS820170004)+7 种基金Helmholtz-CAS Joint Research Grant(GJHZ1508)Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,China(2017B030301017)Shenzhen Governmental Grants,China(JCYJ20160429190927063,KQJSCX20160301144002,JCYJ20170413164535041,JCYJ20150401150223647,JCYJ20160429185854999,JSGG20160429190521240)Research Instrument Development Project of the Chinese Academy of Sciences,China(YJKYYQ20170064)Youth Innovation Promotion Association of Chinese Academy of Sciences(2017413)Shenzhen Municipal Funding,China(GJHZ20160229200136090)Shenzhen Discipline Construction Project for Neurobiology,China(DRCSM[2016]1379)Ten Thousand Talent Program,Guangdong Special Support Program,China and Science and Technology Planning Project of Guangdong Province,China(2018B030331001)
文摘The Ventral Tegmental Area(VTA)is a midbrain structure known to integrate aversive and rewarding stimuli,but little is known about the role of VTA glutamatergic(VGluT2)neurons in these functions.Direct activation of VGluT2 soma evokes rewarding behaviors,while activation of their downstream projections evokes aversive behaviors.To facilitate our understanding of these conflicting properties,we recorded calcium signals from VTAVGluT2+neurons using fiber photometry in VGluT2-cre mice to investigate how this population was recruited by aversive and rewarding stimulation,both during unconditioned and conditioned protocols.Our results revealed that,as a population,VTAVGluT2+neurons responded similarly to unconditioned-aversive and unconditioned-rewarding stimulation.During aversive and rewarding conditioning,the CS-evoked responses gradually increased across trials whilst the US-evoked response remained stable.Retrieval 24 h after conditioning,during which mice received only CS presentation,resulted in VTAVGluT2+neurons strongly responding to CS presentation and to the expected-US but only for aversive conditioning.To help understand these differences based on VTAVGluT2+neuronal networks,the inputs and outputs of VTAVGluT2+neurons were investigated using Cholera Toxin B(CTB)and rabies virus.Based on our results,we propose that the divergent VTAVGluT2+neuronal responses to aversion and reward conditioning may be partly due to the existence of VTAVGluT2+subpopulations that are characterized by their connectivity.
基金supported by the Ministry of Education,Singapore,under its Academic Research Fund Tier 2 Grant MOE-T2EP20222-0003.
文摘The valuation of financial derivatives often assumes risk neutrality with respect to the risk-neutral martingale measure,which prevents arbitrage opportunities.However,casual traders may still incur substantial losses when trading at this risk-neutral price,especially when the price has to be paid now and the payoff is only realized in the future.This study proposes a new valuation framework that provides risksensitive investors with an additional safeguard.The proposed framework embraces a worst-case perspective while exploiting the underlier’s stochastic process,representing a combination of robust optimization and stochastic programming.Notably,it aims to mitigate losses in the likelier scenarios of the underlying asset’s prices.When the underlier’s returns are independent and lognormally but not necessarily identically distributed,our approach for pricing variance and volatility swaps could be greatly simplified,benefit from parallel computing,and be solved by a two-dimensional grid search.We further derive a closed-form solution in some special stationary cases and provide experimental results to highlight the effect of risk aversion on fending off sizable trading losses.
基金National Natural Science Foundation of China(Grant No.71771006)Science and Technology Support Plan of Guizhou(Grant No.2023–221).
文摘We construct a model to examine the time-varying ambiguity of investors.When ambiguity occurs concerning recent news,long(short)position investors who are averse to ambiguity reduce(increase)their holdings,resulting in price drops(rises).We empirically analyze how the“two sessions,”a significant event with high policy ambiguity in China,affect the financial market.Our findings suggest that institutional investors mainly sell their holdings between 15 and 5 days before the meetings.Furthermore,the delay in the“two sessions”in 2020 suggests that these selloffs are driven by ambiguity aversion rather than new information.
文摘In the process of daily psychological counseling,it is found that more and more school-age children have a dislike for learning,and the rate is increasing year by year.They are unclear about the purpose of learning,lose interest in class,do not listen carefully,cannot complete homework independently,and even skip school.This case analyzes the mechanism of a 7-year-old primary school student's aversion to learning and analyzes and discusses this behavior.
基金supported by the National Natural Science Foundation of China(No.30230130 and No.30400129)the Ministry of Science and Technology of China(No.2003CB515405,No.2005CB522406)+1 种基金the Program for Changjiang Scholars and Innovative Research Team of Ministry of Education of ChinaShanghai Municipal Commission for Science and Technology(No.06JC14008).
文摘Objective To investigate whether environmental cues associated with different properties of morphine could regulate the extracellular levels of glutamate and y-aminobutyric acid （GABA） in the hippocampal ventral subiculum, which play a critical role in the reinstatement of drug-seeking behavior induced by environmental cues. Methods Conditioning place preference （CPP） and conditioning place aversion （CPA） models were used to establish environment associated with rewarding and aversive properties of morphine respectively. Microdialysis and high performance liquid chromatography were used to measure the extracelluar level of glutamate and GABA in the ventral subiculum under these environmental cues. Results Exposure to the environmental cues associated with rewarding properties of morphine resulted in a decrease （approximately 11%） of extracellular level of GABA in ventral subiculum, and exposure to the environmental cues associated with aversive properties of morphine resulted in an increase （approximately 230%） of extracellular level of glutamate in ventral subiculum. Conclusion Environmental cues associated with different properties of morphine modulate the release of distinct neurotransmitters in the hippocampal ventral subiculum possibly through different neural circuit.
文摘Recent advances in the study of affective-cognitive regulation of aggressive behavior suggest positive correlations between poor executive capacities (ECF) and negative reactivity. If the global assumption is correct what are the likely implications of predicted relation? The central issue in present research is to verify this assumption and examine how situational characteristics can alter executive performance in adults experiencing Civil War (Syrians students living in their country or in a host country) and adults experiencing peaceful life (French students) to explore some of the consequences of those modifications for aggressive and anxious tendencies. Precisely, we expect the positive correlations between poor executive performances and high dispositional as well situational aggressive and anxious tendencies, specifically for adults exposed to warfare. In order to assess executive capacities and dispositional as well as situational aggressive and anxious tendencies, during one pilot and two comparative studies [pilot study: N = 60 female French students;first comparative study: N = 60 French and N = 60 Syrian students of both sexes (50%);second comparative study: N = 60 Syrian students of both sexes (50%) living in France] right-handed French/Arabic-speakers participants complete twice, before and after completion executive tasks (standard neuropsychological tests) under different experimental conditions (Aversive/Neutral condition), a series of aggression and anxiety questionnaires. The results provide evidence of a dispositional relationship between poor executive functioning and negative reactivity, and extend it to situational level. For all participants, it shows that increases in impulsiveness (negative emotionality and aggressive choices) due to an aversive noise (80 db) are concomitant with an inability to focus individuals’ attention on ongoing tasks, specifically in those living directly or indirectly stressful life-event.
基金supported by grants from the National Natural Science Foundation of China (31671091 and 81771197)the Natural Science Foundation of Jiangsu Province, China (BK20171255)the Science and Technology Planning Project of Nantong Municipality, China (MS12017023-9)
文摘Pain consists of sensory-discriminative and emotional-affective components.The anterior cingulate cortex(ACC)is a critical brain area in mediating the affective pain.However,the molecular mechanisms involved remain largely unknown.Our recent study indicated that C-X-C motif chemokine 13(CXCL13)and its sole receptor CXCR5 are involved in sensory sensitization in the spinal cord after spinal nerve ligation(SNL).Whether CXCL13/CXCR5 signaling in the ACC contributes to the pathogenesis of pain-related aversion remains unknown.Here,we showed that SNL increased the CXCL13 level and CXCR5 expression in the ACC after SNL.Knockdown of CXCR5 by microinjection of Cxcr5 shRNA into the ACC did not affect SNL-induced mechanical allodynia but effectively alleviated neuropathic painrelated place avoidance behavior.Furthermore,electrophysiological recording from layer Ⅱ-Ⅲ neurons in the ACC showed that SNL increased the frequency and amplitude of spontaneous excitatory postsynaptic currents(sEPSCs),decreased the EPSC paired-pulse ratio,and increased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor/N-methyl-D-aspartate receptor ratio,indicating enhanced glutamatergic synaptic transmission.Finally,superfusion of CXCL13 onto ACC slices increased the frequency and amplitude of spontaneous EPSCs.Pre-injection of Cxcr5 shRNA into the ACC reduced the increase in glutamatergic synaptic transmis sion induced by SNL.Collectively,these results suggest that CXCL13/CXCR5 signaling in the ACC is involved in neuropathic pain-related aversion via synaptic potentiation.
基金Funded by the Fundamental Research Funds for the Central Universities of China(No.26816WTD23)Key Projects of Scientific Research and Development Plan,Chengdu Railway Bureau,China(No.CX1716)Sichuan Science and Technology Project,China(Title:Safety operation behavior mechanism of rail transit dispatcher taking the Chengdu metro as an example)
文摘The traditional newsvendor model assumes that a decision-maker is risk-neutral. However, in actuality, a decisionmaker's order behavior is often influenced by waste-averse preference and stockout-averse preference. We extend the newsvendor model with consideration of averse preferences to investigate how the decision results of the previous period impact the order behavior of the current period, and design an inventory decision-making behavior experiment. Results from the study demonstrate that the order behavior of both a group and an individual exhibits a demand chasing phenomenon, and the former is more significant. Through the interval estimation of the decision maker's order quantity, by the maximum likelihood method we find that the stockout-averse preference has an effect on the decision-making when the prior period is insufficient, causing the current period order quantity larger than the expected profit-maximizing order quantity. In a similar way, waste-averse preference has an effect on decision-making when the prior period is surplus, resulting in the current period order quantity smaller than the expected profit-maximizing order quantity. Finally, we investigate the formation mechanism of demand chasing phenomenon from the perspective of the averse preferences, and propose that this phenomenon is a decision maker's cognitive reaction to stochastic demand environment.
基金supported by National Science Foundation of China grants 31571095 and 91332122a Key Scientific Technological Innovation Research project from the Ministry of Education+1 种基金a grant from Insitute Guo Qiang at Tsinghua Universityfunding from the Beijing Program on the Study of Functional Chips and Related Core Technologies of Brain-inspired Computing Systems。
文摘The nucleus accumbens shell(NAcSh) plays an important role in reward and aversion. Traditionally, NAc dopamine receptor 2-expressing(D2) neurons are assumed to function in aversion. However, this has been challenged by recent reports which attribute positive motivational roles to D2 neurons. Using optogenetics and multiple behavioral tasks, we found that activation of D2 neurons in the dorsomedial NAcSh drives preference and increases the motivation for rewards, whereas activation of ventral NAcSh D2 neurons induces aversion. Stimulation of D2 neurons in the ventromedial NAcSh increases movement speed and stimulation of D2 neurons in the ventrolateral NAc Sh decreases movement speed. Combining retrograde tracing and in situ hybridization, we demonstrated that glutamatergic and GABAergic neurons in the ventral pallidum receive inputs differentially from the dorsomedial and ventral NAcSh. All together, these findings shed light on the controversy regarding the function of NAcSh D2 neurons, and provide new insights into understanding the heterogeneity of the NAcSh.
基金supported by the National Natural Science Foundation of China(71573211)the Humanities and Social Sciences Youth Foundation+1 种基金Ministry of Education of China(22YJC790164)the earmarked fund for China Agriculture Research System(CARS-28)。
文摘Understanding the factors behind apple farmers’willingness to pass on the management of their farms to their descendants is crucial to the continuity of apple production.Due to the high specificity of the human capital,physical assets,land assets,and geographical location in apple production,this study used a binary logistic regression and a mediating effect model to explore the impact of asset specificity on farmers’intergenerational succession willingness of apple management(FISWAM)and to examine the mediating effects of loss aversion in the impact of asset specificity on the FISWAM.The results showed that about 18.68%of the respondents expressed willingness to transfer their apple business between generations,and the FISWAM was generally weak.In addition to the negative impact of geographical location specificity(GLS),human capital specificity(HCS),physical assets specificity(PAS),and land assets specificity(LAS)can enhance the FISWAM.Loss aversion plays a partial mediating role in the impact of PAS,LAS,and GLS on the FISWAM.
基金Supported by the National Natural Science Foundation of China (70471034, A0324666)
文摘We consider a distribution system with one supplier and two retailers. For the two retailers, they face different demand and are both risk averse. We study a single period model which the supplier has ample goods and the retailers order goods separately. Market search is measured as the fraction of customers who unsatisfied with their ＂local＂ retailer due to stock-out, and search for the goods at the other retailer before leaving the system. We investigate how the retailers game for order quantity in a Conditional Value-at-Risk framework and study how risk averse degree, market search level, holding cost and backorder cost influence the optimal order strategies. Furthermore, we use uniform distribution to illustrate these results and obtain Nash equilibrium of order strategies.
基金supported by a grant from Medical Scientific Research Foundation of Guangdong Province,China(No.A2018282).
文摘Objective:To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase(TK)expression and activity.Methods:To test this,we separated 50 rats into five groups that were either fed a standard chow diet(controls)or a high-fat diet(experimental groups HO,HI,H2,and H3).HO group animals received no additional dietary supplementation,while H1 group animals were administered 100 mg/kg body weight(BW)thiamine,100 mg/kg BW riboflavin,and 250 mg/kg BW niacin each day,and group H2 animals received daily doses of 100 mg/kg BW pyridoxine,100 mg/kg BW cobalamin,and 5 mg/kg BW folate.Animals in the H3 group received the B vitamin regimens administered to both H1 and H2 each day.Results:Over time,group HO exhibited greater increases in BW and fat mass relative to other groups.When spatial and memory capabilities in these animals were evaluated via conditioned taste aversion(CTA)and Morris Water Maze(MWM),we found B vitamin treatment was associated with significant improvements relative to untreated HO controls.Similarly,B vitamin supplementation was associated with elevated TK expression in erythrocytes and hypothalamus of treated animals relative to those in HO(P<0.05).Conclusion:Together,these findings suggest B vitamin can modulate hypothalamic TK activity to reduce the severity of cognitive deficits in a rat model of obesity.As such,B vitamin supplementation may be a beneficial method for reducing cognitive dysfunction in clinical settings associated with high-fat diets.
基金Supported by the Social Science Foundation of the Ministry of Education of China (07JA630015)
文摘Consider a risk-averse newsvendor who has an option to purchase the units that are short at an emergency purchase price after demand is realized. We use the conditional value-at-risk （CVaR） as the risk measure. The aim of the study is to investigate the optimal ordering decision in such a setting under CVaR only and mean-CVaR criterions. For each case, we derive the closed-form optimal solution and perform comparative statics to show the monotonicity properties and other characteristics of the optimal decisions. We also compare our results with those of risk-neutral newsvendor.
基金Supported by the National Social Science Foundation of China(20BTJ048)Anhui University Humanities and Social Science Research Major Project(SK2021ZD0043)
文摘Under the S-shaped utility of loss aversion,this paper considers the bequest motivation of pension plan participants,random salary income before retirement and the substitution rate between receiving pension benefits after retirement and wages before retirement,and studies the optimal investment strategy of defined contribution(DC)pension.Assuming that pension funds can invest in a financial market consisting of three assets(risk-free asset cash,rolling bonds and stocks),inflation is considered by discount.Under the S-shaped utility,the Lagrange method is used to find the terminal optimal surplus of pensions in retirement,so as to find the terminal optimal wealth,and then the martingale method is used to find the optimal wealth process and investment strategy.Finally,a sensitivity analysis is carried out on the the influence of bequest motivation and loss aversion on the optimal investment strategy of DC pension.
基金supported by the National Natural Science Foundation of China(82271542)the Natural Science Foundation of Chongqing(cstc2020jcyj-msxm X0391 and cstc2019jcyj-msxm X0269)the Chongqing Medical Scientific Research Project(Joint project of Chongqing Health Commission and Science and Technology Bureau)(2023ZDXM001).
文摘Itch is an unpleasant sensation that urges people and animals to scratch.Neuroimaging studies on itch have yielded extensive correlations with diverse cortical and subcortical regions,including the insular lobe.However,the role and functional specificity of the insular cortex(IC)and its subdivisions in itch mediation remains unclear.Here,we demonstrated by immunohistochemistry and fiber photometry tests,that neurons in both the anterior insular cortex(AIC)and the posterior insular cortex(PIC)are activated during acute itch processes.Pharmacogenetic experiments revealed that nonselective inhibition of global AIC neurons,or selective inhibition of the activity of glutaminergic neurons in the AIC,reduced the scratching behaviors induced by intradermal injection of 5-hydroxytryptamine(5-HT),but not those induced by compound 48/80.However,both nonselective inhibition of global PIC neurons and selective inhibition of glutaminergic neurons in the PIC failed to affect the itching-scratching behaviors induced by either 5-HT or compound 48/80.In addition,pharmacogenetic inhibition of AIC glutaminergic neurons effectively blocked itch-associated conditioned place aversion behavior,and inhibition of AIC glutaminergic neurons projecting to the prelimbic cortex significantly suppressed 5-HT-evoked scratching.These findings provide preliminary evidence that the AIC is involved,at least partially via aversive emotion mediation,in the regulation of 5-HT-,but not compound 48/80-induced itch.
