Passiflora incarnata L.,commonly known as passionflower,is traditionally cultivated as an ornamental plant but has demonstrated diverse therapeutic potential.Its pharmacological effects are attributed to bioactive com...Passiflora incarnata L.,commonly known as passionflower,is traditionally cultivated as an ornamental plant but has demonstrated diverse therapeutic potential.Its pharmacological effects are attributed to bioactive compounds such as flavonoids and alkaloids,which influence multiple biological pathways.This review aims to summarise and critically analyse recent findings on the pharmacological properties of Passiflora incarnata L.,focusing on its neuropsychiatric,antioxidant,antimicrobial,and anticancer activities.A targeted literature search was conducted in PubMed,Scopus,Web of Science,and Google Scholar for peer-reviewed publications between 2000 to 2025.Relevant articles were screened,and a more appropriate article related to the objective of the review was selected.Some classical papers are also cited as per the requirement of the topic.Passiflora incarnata L.showed multifunctional medicinal properties with various applications in neuropsychiatry,oxidative stress management,antimicrobial agent,and as an anticancer agent.The U.S.Food and Drug Administration categorizes passionflower extracts as“generally recognized as safe”.However,most evidence remains preclinical,with methodological variation limiting generalisation.Standardised formulation,robust clinical trials,and in-depth in vivo studies are essential to establish its therapeutic relevance and safety in modern medicine.展开更多
The nervous system function requires a precise but plastic neural architecture.The neuronal shape dictates how neurons interact with each other and with other cells,being the morphology of dendrites and axons the cent...The nervous system function requires a precise but plastic neural architecture.The neuronal shape dictates how neurons interact with each other and with other cells,being the morphology of dendrites and axons the central determinant of the functional properties of neurons and neural circuits.The topological and structural morphology of axons and dendrites defines and determines how synapses are conformed.The morphological diversity of axon and dendrite arborization governs the neuron’s inputs,synaptic integration,neuronal computation,signal transmission,and network circuitry,hence defining the particular connectivity and function of the different brain areas.展开更多
车型:2016年奥迪A6L,配置CYY发动机、RKW变速器。行驶里程:220548km。故障现象:中央M M I屏幕不亮,但媒体播放仍有声音,具体情况如图1所示。故障诊断:使用诊断仪对信息电子装置1(MIB)进行检测,读取到的故障码为U10E200多媒体系统显示单...车型:2016年奥迪A6L,配置CYY发动机、RKW变速器。行驶里程:220548km。故障现象:中央M M I屏幕不亮,但媒体播放仍有声音,具体情况如图1所示。故障诊断:使用诊断仪对信息电子装置1(MIB)进行检测,读取到的故障码为U10E200多媒体系统显示单元1无通信,如图2所示。展开更多
L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,...L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,其中关键词密度和贡献图谱结果显示LTA相关研究集中在茶叶类型、胁迫反应、LTA的生物活性等方面。因此,本文综述了茶叶LTA含量的影响因素,并重点阐述LTA生物活性作用机制,包括抗氧化、抗热应激、抗抑郁、调节代谢、抗癌、调节免疫、调节肠道菌群、保护神经系统、保护肝脏和保护肠道的作用机制,发现LTA主要通过调控核因子κB(Nuclear factor kappa B,NF-κB)、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、信号传导及转录激活因子(Signal transducer and activator of transcription,STAT)和丝裂原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)等信号通路发挥生物活性功能,并总结了当前LTA在食品产业中的实际应用。本文可为LTA的研究和发展提供方向,并为开发LTA功能性食品提供一定的参考。展开更多
In the words of the late Sir Colin Blakemore,neurologists have historically sought to infer brain functions in a manner akin to to king a hammer to a computeranalyzing localized anatomical lesions caused by trauma,tum...In the words of the late Sir Colin Blakemore,neurologists have historically sought to infer brain functions in a manner akin to to king a hammer to a computeranalyzing localized anatomical lesions caused by trauma,tumors,or strokes,noting deficits,and inferring what functions certain brain regions may be responsible for.This approach exemplifies a deletion heuristic,where the absence of a specific function reveals insights about the underlying structures or mechanisms responsible for it.By observing what is lost when a particular brain region is damaged,throughout the history of the field,neurologists have pieced together the intricate relationship between anatomy and function.展开更多
Spinal cord ischemia-reperfusion injury,a severe form of spinal cord damage,can lead to sensory and motor dysfunction.This injury often occurs after traumatic events,spinal cord surgeries,or thoracoabdominal aortic su...Spinal cord ischemia-reperfusion injury,a severe form of spinal cord damage,can lead to sensory and motor dysfunction.This injury often occurs after traumatic events,spinal cord surgeries,or thoracoabdominal aortic surgeries.The unpredictable nature of this condition,combined with limited treatment options,poses a significant burden on patients,their families,and society.Spinal cord ischemia-reperfusion injury leads to reduced neuronal regenerative capacity and complex pathological processes.In contrast,mitophagy is crucial for degrading damaged mitochondria,thereby supporting neuronal metabolism and energy supply.However,while moderate mitophagy can be beneficial in the context of spinal cord ischemia-reperfusion injury,excessive mitophagy may be detrimental.Therefore,this review aims to investigate the potential mechanisms and regulators of mitophagy involved in the pathological processes of spinal cord ischemia-reperfusion injury.The goal is to provide a comprehensive understanding of recent advancements in mitophagy related to spinal cord ischemia-reperfusion injury and clarify its potential clinical applications.展开更多
文摘Passiflora incarnata L.,commonly known as passionflower,is traditionally cultivated as an ornamental plant but has demonstrated diverse therapeutic potential.Its pharmacological effects are attributed to bioactive compounds such as flavonoids and alkaloids,which influence multiple biological pathways.This review aims to summarise and critically analyse recent findings on the pharmacological properties of Passiflora incarnata L.,focusing on its neuropsychiatric,antioxidant,antimicrobial,and anticancer activities.A targeted literature search was conducted in PubMed,Scopus,Web of Science,and Google Scholar for peer-reviewed publications between 2000 to 2025.Relevant articles were screened,and a more appropriate article related to the objective of the review was selected.Some classical papers are also cited as per the requirement of the topic.Passiflora incarnata L.showed multifunctional medicinal properties with various applications in neuropsychiatry,oxidative stress management,antimicrobial agent,and as an anticancer agent.The U.S.Food and Drug Administration categorizes passionflower extracts as“generally recognized as safe”.However,most evidence remains preclinical,with methodological variation limiting generalisation.Standardised formulation,robust clinical trials,and in-depth in vivo studies are essential to establish its therapeutic relevance and safety in modern medicine.
基金supported by the Wellcome Trust(grant No.103852).
文摘The nervous system function requires a precise but plastic neural architecture.The neuronal shape dictates how neurons interact with each other and with other cells,being the morphology of dendrites and axons the central determinant of the functional properties of neurons and neural circuits.The topological and structural morphology of axons and dendrites defines and determines how synapses are conformed.The morphological diversity of axon and dendrite arborization governs the neuron’s inputs,synaptic integration,neuronal computation,signal transmission,and network circuitry,hence defining the particular connectivity and function of the different brain areas.
文摘L-茶氨酸(L-Theanine,LTA)是茶叶中独特的游离氨基酸,是茶汤鲜爽味的主要来源,具有多种生物活性,属于新食品原料。本文基于Citespace和VOSviewer对Web of Science核心数据库和中国知网数据库,对2014~2024年LTA相关文献进行可视化分析,其中关键词密度和贡献图谱结果显示LTA相关研究集中在茶叶类型、胁迫反应、LTA的生物活性等方面。因此,本文综述了茶叶LTA含量的影响因素,并重点阐述LTA生物活性作用机制,包括抗氧化、抗热应激、抗抑郁、调节代谢、抗癌、调节免疫、调节肠道菌群、保护神经系统、保护肝脏和保护肠道的作用机制,发现LTA主要通过调控核因子κB(Nuclear factor kappa B,NF-κB)、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、信号传导及转录激活因子(Signal transducer and activator of transcription,STAT)和丝裂原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)等信号通路发挥生物活性功能,并总结了当前LTA在食品产业中的实际应用。本文可为LTA的研究和发展提供方向,并为开发LTA功能性食品提供一定的参考。
文摘In the words of the late Sir Colin Blakemore,neurologists have historically sought to infer brain functions in a manner akin to to king a hammer to a computeranalyzing localized anatomical lesions caused by trauma,tumors,or strokes,noting deficits,and inferring what functions certain brain regions may be responsible for.This approach exemplifies a deletion heuristic,where the absence of a specific function reveals insights about the underlying structures or mechanisms responsible for it.By observing what is lost when a particular brain region is damaged,throughout the history of the field,neurologists have pieced together the intricate relationship between anatomy and function.
基金supported by Cuiying Scientific and Technological Innovation Program of Second Hospital of Lanzhou University,Nos.CY2023-QN-B18(to YD),2020QN-16(to YZ)the Natural Science Foundation of Gansu Province,No.22JR11RA082(to YZ)Key R&D Plan of Gansu Provincial Department of Science and Technology-Social Development Projects,No.23YFFA0043(to XK).
文摘Spinal cord ischemia-reperfusion injury,a severe form of spinal cord damage,can lead to sensory and motor dysfunction.This injury often occurs after traumatic events,spinal cord surgeries,or thoracoabdominal aortic surgeries.The unpredictable nature of this condition,combined with limited treatment options,poses a significant burden on patients,their families,and society.Spinal cord ischemia-reperfusion injury leads to reduced neuronal regenerative capacity and complex pathological processes.In contrast,mitophagy is crucial for degrading damaged mitochondria,thereby supporting neuronal metabolism and energy supply.However,while moderate mitophagy can be beneficial in the context of spinal cord ischemia-reperfusion injury,excessive mitophagy may be detrimental.Therefore,this review aims to investigate the potential mechanisms and regulators of mitophagy involved in the pathological processes of spinal cord ischemia-reperfusion injury.The goal is to provide a comprehensive understanding of recent advancements in mitophagy related to spinal cord ischemia-reperfusion injury and clarify its potential clinical applications.
