Earthquakes are predominantly associated with tectonically active regions,yet the rising frequency of seismic events globally has raised concerns about the role of industrial activities,such as fluid injection,convent...Earthquakes are predominantly associated with tectonically active regions,yet the rising frequency of seismic events globally has raised concerns about the role of industrial activities,such as fluid injection,conventional oil-gas,mining,and reservoir impoundment,in triggering significant earthquakes.While natural processes like tectonic stress changes,fluid migration,and surface loading are critical in earthquake nucleation,human-induced seismicity is becoming increasingly recognized.The Atatürk Dam,Türkiye's largest clay-core rockfill dam,situated near the East Anatolian Fault System,Adyaman Fault Zone,and Bozova Fault,offers a compelling case to explore the interplay between tectonic and anthropogenic seismicity.This study presents the first trenching studies along the Bozova Fault,revealing evidence of surface ruptures and localized seismicity linked to reservoir impoundment and conventional oil and gas.Temporal and spatial analyses suggest that reservoir-induced mechanisms,including pore pressure diffusion and stress redistribution,significantly influence seismicity,recurrence interval,alongside dominant tectonic forces.By integrating trenching investigations,seismic analyses,and stress inversion techniques,this research highlights the critical role of anthropogenic factors in modulating seismic hazards.The findings emphasize the importance of paleoseismological and geophysical studies for distinguishing induced seismicity from natural tectonic activity,thereby contributing to improved seismic hazard assessment and mitigation strategies in tectonically active,reservoir-influenced regions.展开更多
MIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage.Dynamic cytoskeletal changes accompany phagocytosis.However,whether and how these changes are...MIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage.Dynamic cytoskeletal changes accompany phagocytosis.However,whether and how these changes are associated with microglia/macrophage-mediated erythrophagocytosis remain unclear.In this study,we investigated the function of acetylatedα-tubulin,a stabilized microtubule form,in microglia/macrophage erythrophagocytosis after intracerebral hemorrhage both in vitro and in vivo.We first assessed the function of acetylatedα-tubulin in erythrophagocytosis using primary DiO GFP-labeled red blood cells co-cultured with the BV2 microglia or RAW264.7 macrophage cell lines.Acetylatedα-tubulin expression was significantly decreased in BV2 and RAW264.7 cells during erythrophagocytosis.Moreover,silencingα-tubulin acetyltransferase 1(ATAT1),a newly discoveredα-tubulin acetyltransferase,decreased Ac-α-tub levels and enhanced the erythrophagocytosis by BV2 and RAW264.7 cells.Consistent with these findings,in ATAT1-/-mice,we observed increased ionized calcium binding adapter molecule 1(Iba1)and Perls-positive microglia/macrophage phagocytes of red blood cells in peri-hematoma and reduced hematoma volume in mice with intracerebral hemorrhage.Additionally,knocking out ATAT1 alleviated neuronal apoptosis and pro-inflammatory cytokines and increased anti-inflammatory cytokines around the hematoma,ultimately improving neurological recovery of mice after intracerebral hemorrhage.These findings suggest that ATAT1 deficiency accelerates erythrophagocytosis by microglia/macrophages and hematoma absorption after intracerebral hemorrhage.These results provide novel insights into the mechanisms of hematoma clearance and suggest ATAT1 as a potential target for the treatment of intracerebral hemorrhage.展开更多
Effects of annealing temperature( T a) and annealing time( t a) on the liquid liquid transition and transition intensity of atactic poly(methyl methacrylate) were studied by means of differential scanning calorimetry....Effects of annealing temperature( T a) and annealing time( t a) on the liquid liquid transition and transition intensity of atactic poly(methyl methacrylate) were studied by means of differential scanning calorimetry. With the increase of T a from 393 to 443 K, T ll shifted to higher temperature with the decrease in transition intensity, on the contrary, when T a was over 443 K, T ll declined and transition intensity increased. When T a kept constant with the increase of t a, T ll and transition intensity varied as the results described above. Moreover, the variation extent of T ll and transition intensity increased with the increase of T a, in other words, the time needed reaching the maximum extent of variation of the two parameters was decreased with the increase of T a. The dependence of T ll and transition intensity on annealing conditions may be explained by the formation of local ordered structure, i.e . stereocomplex, during the annealing process by means of Van der Waals forces between isotacitic and syndiotactic segments of the same or different chains of atactic poly(methyl methacrylate).展开更多
详细阐释了对流有效位能(convective available potential energy,CAPE)的本质;提出了CAPE新的计算公式;简要介绍了与CAPE计算有关的物理过程和一些新的物理量。结合实例,用新的公式和目前通用的公式,对CAPE和对流抑制能量(convective i...详细阐释了对流有效位能(convective available potential energy,CAPE)的本质;提出了CAPE新的计算公式;简要介绍了与CAPE计算有关的物理过程和一些新的物理量。结合实例,用新的公式和目前通用的公式,对CAPE和对流抑制能量(convective inhibition,CIN)分三种情形进行对比计算:1)可逆湿绝热过程;2)假绝热过程;3)等假相当位温过程。计算结果表明,假绝热过程比可逆湿绝热过程CAPE新算法明显偏高、CIN明显偏低;MICAPS默认方法与等假相当位温过程计算结果大体相近。展开更多
文摘Earthquakes are predominantly associated with tectonically active regions,yet the rising frequency of seismic events globally has raised concerns about the role of industrial activities,such as fluid injection,conventional oil-gas,mining,and reservoir impoundment,in triggering significant earthquakes.While natural processes like tectonic stress changes,fluid migration,and surface loading are critical in earthquake nucleation,human-induced seismicity is becoming increasingly recognized.The Atatürk Dam,Türkiye's largest clay-core rockfill dam,situated near the East Anatolian Fault System,Adyaman Fault Zone,and Bozova Fault,offers a compelling case to explore the interplay between tectonic and anthropogenic seismicity.This study presents the first trenching studies along the Bozova Fault,revealing evidence of surface ruptures and localized seismicity linked to reservoir impoundment and conventional oil and gas.Temporal and spatial analyses suggest that reservoir-induced mechanisms,including pore pressure diffusion and stress redistribution,significantly influence seismicity,recurrence interval,alongside dominant tectonic forces.By integrating trenching investigations,seismic analyses,and stress inversion techniques,this research highlights the critical role of anthropogenic factors in modulating seismic hazards.The findings emphasize the importance of paleoseismological and geophysical studies for distinguishing induced seismicity from natural tectonic activity,thereby contributing to improved seismic hazard assessment and mitigation strategies in tectonically active,reservoir-influenced regions.
基金supported by Science and Technology Innovation Enhancement Project of Army Medical University(to LX).
文摘MIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage.Dynamic cytoskeletal changes accompany phagocytosis.However,whether and how these changes are associated with microglia/macrophage-mediated erythrophagocytosis remain unclear.In this study,we investigated the function of acetylatedα-tubulin,a stabilized microtubule form,in microglia/macrophage erythrophagocytosis after intracerebral hemorrhage both in vitro and in vivo.We first assessed the function of acetylatedα-tubulin in erythrophagocytosis using primary DiO GFP-labeled red blood cells co-cultured with the BV2 microglia or RAW264.7 macrophage cell lines.Acetylatedα-tubulin expression was significantly decreased in BV2 and RAW264.7 cells during erythrophagocytosis.Moreover,silencingα-tubulin acetyltransferase 1(ATAT1),a newly discoveredα-tubulin acetyltransferase,decreased Ac-α-tub levels and enhanced the erythrophagocytosis by BV2 and RAW264.7 cells.Consistent with these findings,in ATAT1-/-mice,we observed increased ionized calcium binding adapter molecule 1(Iba1)and Perls-positive microglia/macrophage phagocytes of red blood cells in peri-hematoma and reduced hematoma volume in mice with intracerebral hemorrhage.Additionally,knocking out ATAT1 alleviated neuronal apoptosis and pro-inflammatory cytokines and increased anti-inflammatory cytokines around the hematoma,ultimately improving neurological recovery of mice after intracerebral hemorrhage.These findings suggest that ATAT1 deficiency accelerates erythrophagocytosis by microglia/macrophages and hematoma absorption after intracerebral hemorrhage.These results provide novel insights into the mechanisms of hematoma clearance and suggest ATAT1 as a potential target for the treatment of intracerebral hemorrhage.
文摘Effects of annealing temperature( T a) and annealing time( t a) on the liquid liquid transition and transition intensity of atactic poly(methyl methacrylate) were studied by means of differential scanning calorimetry. With the increase of T a from 393 to 443 K, T ll shifted to higher temperature with the decrease in transition intensity, on the contrary, when T a was over 443 K, T ll declined and transition intensity increased. When T a kept constant with the increase of t a, T ll and transition intensity varied as the results described above. Moreover, the variation extent of T ll and transition intensity increased with the increase of T a, in other words, the time needed reaching the maximum extent of variation of the two parameters was decreased with the increase of T a. The dependence of T ll and transition intensity on annealing conditions may be explained by the formation of local ordered structure, i.e . stereocomplex, during the annealing process by means of Van der Waals forces between isotacitic and syndiotactic segments of the same or different chains of atactic poly(methyl methacrylate).
文摘详细阐释了对流有效位能(convective available potential energy,CAPE)的本质;提出了CAPE新的计算公式;简要介绍了与CAPE计算有关的物理过程和一些新的物理量。结合实例,用新的公式和目前通用的公式,对CAPE和对流抑制能量(convective inhibition,CIN)分三种情形进行对比计算:1)可逆湿绝热过程;2)假绝热过程;3)等假相当位温过程。计算结果表明,假绝热过程比可逆湿绝热过程CAPE新算法明显偏高、CIN明显偏低;MICAPS默认方法与等假相当位温过程计算结果大体相近。
