The recent article by Jiang et al published in World Journal of Gastroenterology reports substantial bidirectional associations between gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone ...The recent article by Jiang et al published in World Journal of Gastroenterology reports substantial bidirectional associations between gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone disease(KSD),based on multicenter cross-sectional studies and a systematic review with meta-analysis.While the findings have the potential to significantly impact clinical and pre-ventive strategies,several methodological issues merit closer examination.This letter critiques key aspects of the study,including sample population hetero-geneity,potential confounding variables,and the reliance on cross-sectional data that may limit causal inferences.We also discuss the generalizability of these results to broader populations given the study's focus on the Chinese demogra-phic.By addressing these concerns,we suggest a more nuanced interpretation of the associations between GSD,NAFLD,and KSD,advocating for longitudinal studies to validate these findings and enhance their applicability in global health contexts.展开更多
It is known that long non-coding RNAs(lncRNAs)play vital roles in biological processes and contribute to the progression,development,and treatment of various diseases.Obviously,understanding associations between disea...It is known that long non-coding RNAs(lncRNAs)play vital roles in biological processes and contribute to the progression,development,and treatment of various diseases.Obviously,understanding associations between diseases and lncRNAs significantly enhances our ability to interpret disease mechanisms.Nevertheless,the process of determining lncRNA-disease associations is costly,labor-intensive,and time-consuming.Hence,it is expected to foster computational strategies to uncover lncRNA-disease relationships for further verification to save time and resources.In this study,a collaborative filtering and graph attention network-based LncRNA-Disease Association(CFGANLDA)method was nominated to expose potential lncRNA-disease associations.First,it takes into account the advantages of using biological information from multiple sources.Next,it uses a collaborative filtering technique in order to address the sparse data problem.It also employs a graph attention network to reinforce both linear and non-linear features of the associations to advance prediction performance.The computational results indicate that CFGANLDA gains better prediction performance compared to other state-of-the-art approaches.The CFGANLDA’s area under the receiver operating characteristic curve(AUC)metric is 0.9835,whereas its area under the precision-recall curve(AUPR)metric is 0.9822.Statistical analysis using 10-fold cross-validation experiments proves that these metrics are significant.Furthermore,three case studies on prostate,liver,and stomach cancers attest to the validity of CFGANLDA performance.As a result,CFGANLDA method proves to be a valued tool for lncRNA-disease association prediction.展开更多
Learning from demonstration is widely regarded as a promising paradigm for robots to acquire diverse skills.Other than the artificial learning from observation-action pairs for machines,humans can learn to imitate in ...Learning from demonstration is widely regarded as a promising paradigm for robots to acquire diverse skills.Other than the artificial learning from observation-action pairs for machines,humans can learn to imitate in a more versatile and effective manner:acquiring skills through mere“observation”.Video to Command task is widely perceived as a promising approach for task-based learning,which yet faces two key challenges:(1)High redundancy and low frame rate of fine-grained action sequences make it difficult to manipulate objects robustly and accurately.(2)Video to Command models often prioritize accuracy and richness of output commands over physical capabilities,leading to impractical or unsafe instructions for robots.This article presents a novel Video to Command framework that employs multiple data associations and physical constraints.First,we introduce an object-level appearancecontrasting multiple data association strategy to effectively associate manipulated objects in visually complex environments,capturing dynamic changes in video content.Then,we propose a multi-task Video to Command model that utilizes object-level video content changes to compile expert demonstrations into manipulation commands.Finally,a multi-task hybrid loss function is proposed to train a Video to Command model that adheres to the constraints of the physical world and manipulation tasks.Our method achieved over 10%on BLEU_N,METEOR,ROUGE_L,and CIDEr compared to the up-to-date methods.The dual-arm robot prototype was established to demonstrate the whole process of learning from an expert demonstration of multiple skills and then executing the tasks by a robot.展开更多
CircRNAs,widely found throughout the human bodies,play a crucial role in regulating various biological processes and are closely linked to complex human diseases.Investigating potential associations between circRNAs a...CircRNAs,widely found throughout the human bodies,play a crucial role in regulating various biological processes and are closely linked to complex human diseases.Investigating potential associations between circRNAs and diseases can enhance our understanding of diseases and provide new strategies and tools for early diagnosis,treatment,and disease prevention.However,existing models have limitations in accurately capturing similarities,handling the sparse and noise attributes of association networks,and fully leveraging bioinformatical aspects from multiple viewpoints.To address these issues,this study introduces a new non-negative matrix factorization-based framework called NMFMSN.First,we incorporate circRNA sequence data and disease semantic information to compute circRNA and disease similarity,respectively.Given the sparse known associations between circRNAs and diseases,we reconstruct the network to complete more associations by imputing missing links based on neighboring circRNA and disease interactions.Finally,we integrate these two similarity networks into a non-negative matrix factorization framework to identify potential circRNA-disease associations.Upon conducting 5-fold cross-validation and leave-one-out cross-validation,the AUC values for NMFMSN reach 0.9712 and 0.9768,respectively,outperforming the currently most advanced models.Case studies on lung cancer and hepatocellular carcinoma show that NMFMSN is a good way to predict new associations between circRNAs and diseases.展开更多
Secure interaction and interoperability between two or more administrative domains is a major concern. The IRBAC 2000 model accomplishes secure interaction and interoperability by flexibly dynamic inter-domain role tr...Secure interaction and interoperability between two or more administrative domains is a major concern. The IRBAC 2000 model accomplishes secure interaction and interoperability by flexibly dynamic inter-domain role translations. Associations are the key element of the IRBAC 2000 model, which have a great impact on security and efficiency of dynamic role translations. Therefore, it is a crucial problem how to manage the associations in the IRBAC 2000 model. There are two cases under which some matters will emerge. One is where conflicting associations may result in a security hazard. Another is where redundant associations may reduce the efficiency of dynamic role translations and increase the difficulty of management of associations. The formal definitions on conflicting associations and redundant associations are given, and the methods are discusses to judge whether there are conflicting associations or redundant associations in IRBAC 2000 model. The protective mechanism is presented, which utilizes prerequisite conditions to prevent conflicting or redundant associations from appearing in IRBAC 2000 model.展开更多
BACKGROUND Primary sclerosing cholangitis(PSC)associated inflammatory bowel disease(IBD)is a unique form of IBD(PSC-IBD)with distinct clinical and histologic features from ulcerative colitis(UC)and Crohn disease(CD).I...BACKGROUND Primary sclerosing cholangitis(PSC)associated inflammatory bowel disease(IBD)is a unique form of IBD(PSC-IBD)with distinct clinical and histologic features from ulcerative colitis(UC)and Crohn disease(CD).In patients with PSC and IBD,the severity of the two disease processes may depend on each other.AIM To study the histologic and clinical features of PSC patients with and without IBD.METHODS We assessed specimens from patients with UC(n=28),CD(n=10),PSC and UC(PSC-UC;n=26);PSC and CD(PSC-CD;n=6);and PSC and no IBD(PSC-no IBD;n=4)between years 1999-2013.PSC-IBD patients were matched to IBD patients without PSC by age and colitis duration.Clinical data including age,gender,age at IBD and PSC diagnoses,IBD duration,treatment,follow-up,orthotopic liver transplantation(OLT)were noted.RESULTS PSC-UC patients had more isolated right-sided disease(P=0.03),and less active inflammation in left colon,rectum(P=0.03 and P=0.0006),and overall(P=0.0005)compared to UC.They required less steroids(P=0.01)and fewer colectomies(P=0.03)than UC patients.The PSC-CD patients had more ileitis and less rectal involvement compared to PSC-UC and CD.No PSC-CD patients required OLT compared to 38%of PSC-UC(P=0.1).PSC-IBD(PSC-UC and PSCCD)patients with OLT had severe disease in the left colon and rectum(P=0.04).CONCLUSION PSC-UC represents a distinct form of IBD.The different disease phenotype in PSC-IBD patients with OLT may support liver-gut axis interaction,however warrants clinical attention and further research.展开更多
AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of pat...AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations.展开更多
The five chemical associations of heavy metals have been extracted continuously using the Tessier extracting method. Results show that Cu, Pb, Fe, Zn and Cr in the sediments are mainly distributed in residual fraction...The five chemical associations of heavy metals have been extracted continuously using the Tessier extracting method. Results show that Cu, Pb, Fe, Zn and Cr in the sediments are mainly distributed in residual fraction, while the major chemical association of Mn is carbonates. Carbonate heavy metals are converted into Fe-Mn oxides in autumn. And in the low tidal flat, after carbonates have changed into ionic heavy metals, some of the elements are transported to the overlying water. Cu, Pb, Fe and Mn have good correlations with each other, and Zn, Cr also show their similarity of chemical behavior in the sediments.展开更多
Colorectal cancer(CRC)is a common cancer with high morbidity and mortality rates.Its occurrence and development are determined by many factors,including genetics,the environment,lifestyle,and so on.The occurrence of C...Colorectal cancer(CRC)is a common cancer with high morbidity and mortality rates.Its occurrence and development are determined by many factors,including genetics,the environment,lifestyle,and so on.The occurrence of CRC is often accompanied by changes in the intestinal microenvironment.Numerous studies have focused on the association between dietary patterns,dietary components,and CRC now.This article reviews five different dietary patterns:the Western diet,the Mediterranean diet,the ketogenic diet,the Dietary Approaches to Stop Hypertension diet,and fasting,and themechanistic associations between their food components and CRC.The finding can provide a reference for further studies on the association between different dietary patterns and CRC and will help clinicians formulate reasonable and feasible dietary interventions.展开更多
As a volunteer organization,NGO plays an important role nowadays for its unique social functions.In recent years,Chinese Young Volunteers Associations have made great progress,but compared with the EU countries,there ...As a volunteer organization,NGO plays an important role nowadays for its unique social functions.In recent years,Chinese Young Volunteers Associations have made great progress,but compared with the EU countries,there is still a significant gap.This paper in cludes the result of the comparative researches on two aspects: Volunteer associations;Training systems.From the result,a relatively compre hensive reference can be provided for the development of the Chinese Youth Volunteers Associations.展开更多
Biodiversity,large trees,and environmental conditions such as climate and soil have important effects on forest carbon stocks.However,recent studies in temperate forests suggest that the relative importance of these f...Biodiversity,large trees,and environmental conditions such as climate and soil have important effects on forest carbon stocks.However,recent studies in temperate forests suggest that the relative importance of these factors depends on tree mycorrhizal associations,whereby large-tree effects may be driven by ectomycorrhizal(EM)trees,diversity effects may be driven by arbuscular mycorrhizal(AM)trees,and environment effects may depend on differential climate and soil preferences of AM and EM trees.To test this hypothesis,we used forest-inventory data consisting of over 80,000 trees from 631 temperate-forest plots(30 m×30 m)across Northeast China to examine how biodiversity(species diversity and ecological uniqueness),large trees(top 1%of tree diameters),and environmental factors(climate and soil nutrients)differently regulate aboveground carbon stocks of AM trees,EM trees,and AM and EM trees combined(i.e.total aboveground carbon stock).We found that large trees had a positive effect on both AM and EM tree carbon stocks.However,biodiversity and environmental factors had opposite effects on AM vs.EM tree carbon stocks.Specifically,the two components of biodiversity had positive effects on AM tree carbon stocks,but negative effects on EM tree carbon stocks.Environmental heterogeneity(mean annual temperature and soil nutrients)also exhibited contrasting effects on AM and EM tree carbon stocks.Consequently,for the total carbon stock,the positive large-tree effect far surpasses the diversity and environment effect.This is mainly because when integrating AM and EM tree carbon stock into total carbon stock,the opposite diversity-effect(also environment-effect)on AM vs.EM tree carbon stock counteracts each other while the consistent positive large-tree effect on AM and EM tree carbon stock is amplified.In summary,this study emphasized a mycorrhizal viewpoint to better understand the determinants of overarching aboveground carbon profile across regional forests.展开更多
Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized treatment.We present a well-designed ...Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized treatment.We present a well-designed radiogenomic framework image–gene–gene set(IMAGGS),which detects multi-way associations in BC subtypes by integrating radiomic and genomic features.Our dataset consists of 721 patients,each of whom has 12 ultrasound(US)images captured from different angles and gene mutation data.To better characterize tumor traits,12 multi-angle US images are fused using two distinct strategies.Then,we analyze complex many-to-many associations between phenotypic and genotypic features using a machine learning algorithm,deviating from the prevalent one-to-one relationship pattern observed in previous studies.Key radiomic and genomic features are screened using these associations.In addition,gene set enrichment analysis is performed to investigate the joint effects of gene sets and delve deeper into the biological functions of BC subtypes.We further validate the feasibility of IMAGGS in a glioblastoma multiforme dataset to demonstrate the scalability of IMAGGS across different modalities and diseases.Taken together,IMAGGS provides a comprehensive characterization for diseases by associating imaging,genes,and gene sets,paving the way for biological interpretation of radiomics and development of targeted therapy.展开更多
The structural diversity of different tree-crop associations were studied at Gachabari Sal forest area of Madhupur Garh on Buffer and Peripheral Zone during 2006. The total density, basal area of trees in the Buffer a...The structural diversity of different tree-crop associations were studied at Gachabari Sal forest area of Madhupur Garh on Buffer and Peripheral Zone during 2006. The total density, basal area of trees in the Buffer and Peripheral Zone were 155.5 trees·hm^(-2), 795.4 trees·hm^(-2) and 3.9 m2·hm-2, 5.8 m^2·hm^(-2), respectively. No regeneration and natural trees were found in Peripheral Zone and the Zone is totally occupied by exotic species where the Buffer Zone comprised of both natural and exotic trees. The Peripheral Zone belonged to younger and smaller trees whereas the Buffer Zone belonged to mixture of smaller, taller, younger and mature trees simultaneously. For the practicing of different agroforestry systems both Zones have lost their original characters of Sal forest.展开更多
The original version of this article unfortunately contained three mistakes. （1） The spelling of the [A. Nishad＇] name was incorrect. The corrected spelling is given below.
Microbial communities play key roles in the marine ecosystem. Despite a few studies on marine microbial communities in deep straits, ecological associations among microbial communities in the sediments of shallow stra...Microbial communities play key roles in the marine ecosystem. Despite a few studies on marine microbial communities in deep straits, ecological associations among microbial communities in the sediments of shallow straits have not been fully investigated. The Bohai Strait in northern China(average depth less than 20 m) separates the Bohai Sea from the Yellow Sea and has organic-rich sediments. In this study, in the summer of 2014, six stations across the strait were selected to explore the taxonomic composition of microbial communities and their ecological associations. The four most abundant classes were Gammaproteobacteria, Deltaproteobacteria, Bacilli and Flavobacteriia. Temperature, total carbon, depth, nitrate, fishery breeding and cold water masses influenced the microbial communities, as suggested by representational dif ference and composition analyses. Network analysis of microbial associations revealed that key families included Flavobacteriaceae, Pirellulaceae and Piscirickettsiaceae. Our findings suggest that the families with high phylogenetic diversity are key populations in the microbial association network that ensure the stability of microbial ecosystems. Our study contributes to a better understanding of microbial ecology in complex hydrological environments.展开更多
We report the results of our search for planet candidates in open clusters and young stellar associations based on the Transiting Exoplanet Survey Satellite(TESS) Objects of Interest Catalog.We find one confirmed plan...We report the results of our search for planet candidates in open clusters and young stellar associations based on the Transiting Exoplanet Survey Satellite(TESS) Objects of Interest Catalog.We find one confirmed planet,one promising candidate,one brown dwarf and three unverified planet candidates in a sample of 1229 open clusters from the second Gaia data release.We discuss individual planet-star systems based on their basic parameters,membership probability and the observation notes from the ExoFOP-TESS website.We also find ten planet candidates(P> 95%) in young stellar associations by using the BANYAN ∑ Multivariate Bayesian Algorithm.Among the ten candidates,five are known planetary systems.We estimate the rotation periods of the host stars using the TESS light curves and estimate their ages based on gyrochronology.Two candidates with periodic variations are likely to be young planets,but their exact memberships to young stellar associations remain unknown.展开更多
Mesocosms experiments were used to study the influence of associations of hydrocarbon oxidizing microorganisms on the microbial cenosis and oil destruction in soil. The introduction of active oil oxidizing microorgani...Mesocosms experiments were used to study the influence of associations of hydrocarbon oxidizing microorganisms on the microbial cenosis and oil destruction in soil. The introduction of active oil oxidizing microorganisms associations into the soil purify of soil from oil to 59.8% - 63.8% after 2 months with 5% oil content and with 10% to 49.2% - 55.6%. As a result of oil destruction there was enlarging of the number of all investigated groups of microorganisms.展开更多
Purpose: To evaluate the associations for vaginal dose points of vaginal stricture in image-guided brachytherapy. Materials and Methods: Twenty-six patients of locally advanced cervical cancer were treated with Image-...Purpose: To evaluate the associations for vaginal dose points of vaginal stricture in image-guided brachytherapy. Materials and Methods: Twenty-six patients of locally advanced cervical cancer were treated with Image-Guided Brachytherapy (IGBT) with the dose at least 7 Gy per fraction to the D90 of High-Risk Clinical Target Volume (HR-CTV). The vaginal dose points of recommendations of the American Brachytherapy Society (ABS) were added into the plan and cumulative dose to these points was evaluated in Equivalent Dose of 2 Gy (EQD2) concepts. Results: The mean doses to right vaginal dose point (VR), left vaginal dose point (VL) and average dose of VR/VL ((VR + VL)/2) were 101.5 Gy, 98.2 Gy and 99.8 Gy in EQD2 concepts, respectively. Volume-based planning significantly reduced the cumulative dose in EQD2 concepts at vaginal points. At the median follow-up time of 22 months, grade-2 vaginal stricture was observed in two patients. The incidences of vaginal stricture were not differed between the cumulative dose to vaginal dose points in EQD2 concepts of ≤90 Gy versus >90 Gy (P = 1.000) and ≤100 Gy versus >100 Gy (P = 0.815). Conclusion: No association for cumulative vaginal doses and events of vaginal stricture was found.展开更多
基金Supported by The National Natural Science Foundation of China,No.82074508Fujian Provincial Natural Science Foundation,No.2023J011627+2 种基金Fujian Provincial Health and Wellness Science and Technology Plan Project,No.2023CXB003Xiamen City Support for the Development of Traditional Chinese Medicine Special TCM Scientific Research Project,No.XWZY-2023-0603The Seventh Batch of National Famous Old Traditional Chinese Medicine Experts Experience Heritage Construction Program of National Administration of TCM,No.76(2022).
文摘The recent article by Jiang et al published in World Journal of Gastroenterology reports substantial bidirectional associations between gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone disease(KSD),based on multicenter cross-sectional studies and a systematic review with meta-analysis.While the findings have the potential to significantly impact clinical and pre-ventive strategies,several methodological issues merit closer examination.This letter critiques key aspects of the study,including sample population hetero-geneity,potential confounding variables,and the reliance on cross-sectional data that may limit causal inferences.We also discuss the generalizability of these results to broader populations given the study's focus on the Chinese demogra-phic.By addressing these concerns,we suggest a more nuanced interpretation of the associations between GSD,NAFLD,and KSD,advocating for longitudinal studies to validate these findings and enhance their applicability in global health contexts.
基金supported by the Vietnam Ministry of Education and Training under project code B2023-SPH-14。
文摘It is known that long non-coding RNAs(lncRNAs)play vital roles in biological processes and contribute to the progression,development,and treatment of various diseases.Obviously,understanding associations between diseases and lncRNAs significantly enhances our ability to interpret disease mechanisms.Nevertheless,the process of determining lncRNA-disease associations is costly,labor-intensive,and time-consuming.Hence,it is expected to foster computational strategies to uncover lncRNA-disease relationships for further verification to save time and resources.In this study,a collaborative filtering and graph attention network-based LncRNA-Disease Association(CFGANLDA)method was nominated to expose potential lncRNA-disease associations.First,it takes into account the advantages of using biological information from multiple sources.Next,it uses a collaborative filtering technique in order to address the sparse data problem.It also employs a graph attention network to reinforce both linear and non-linear features of the associations to advance prediction performance.The computational results indicate that CFGANLDA gains better prediction performance compared to other state-of-the-art approaches.The CFGANLDA’s area under the receiver operating characteristic curve(AUC)metric is 0.9835,whereas its area under the precision-recall curve(AUPR)metric is 0.9822.Statistical analysis using 10-fold cross-validation experiments proves that these metrics are significant.Furthermore,three case studies on prostate,liver,and stomach cancers attest to the validity of CFGANLDA performance.As a result,CFGANLDA method proves to be a valued tool for lncRNA-disease association prediction.
基金Supported by Zhejiang Provincial Key Research and Development Program(Grant No.2021C04015)。
文摘Learning from demonstration is widely regarded as a promising paradigm for robots to acquire diverse skills.Other than the artificial learning from observation-action pairs for machines,humans can learn to imitate in a more versatile and effective manner:acquiring skills through mere“observation”.Video to Command task is widely perceived as a promising approach for task-based learning,which yet faces two key challenges:(1)High redundancy and low frame rate of fine-grained action sequences make it difficult to manipulate objects robustly and accurately.(2)Video to Command models often prioritize accuracy and richness of output commands over physical capabilities,leading to impractical or unsafe instructions for robots.This article presents a novel Video to Command framework that employs multiple data associations and physical constraints.First,we introduce an object-level appearancecontrasting multiple data association strategy to effectively associate manipulated objects in visually complex environments,capturing dynamic changes in video content.Then,we propose a multi-task Video to Command model that utilizes object-level video content changes to compile expert demonstrations into manipulation commands.Finally,a multi-task hybrid loss function is proposed to train a Video to Command model that adheres to the constraints of the physical world and manipulation tasks.Our method achieved over 10%on BLEU_N,METEOR,ROUGE_L,and CIDEr compared to the up-to-date methods.The dual-arm robot prototype was established to demonstrate the whole process of learning from an expert demonstration of multiple skills and then executing the tasks by a robot.
基金the Gansu Province Industrial Support Plan(No.2023CYZC-25)Natural Science Foundation of Gansu Province(No.23JRRA770)the National Natural Science Foundation of China(No.62162040)。
文摘CircRNAs,widely found throughout the human bodies,play a crucial role in regulating various biological processes and are closely linked to complex human diseases.Investigating potential associations between circRNAs and diseases can enhance our understanding of diseases and provide new strategies and tools for early diagnosis,treatment,and disease prevention.However,existing models have limitations in accurately capturing similarities,handling the sparse and noise attributes of association networks,and fully leveraging bioinformatical aspects from multiple viewpoints.To address these issues,this study introduces a new non-negative matrix factorization-based framework called NMFMSN.First,we incorporate circRNA sequence data and disease semantic information to compute circRNA and disease similarity,respectively.Given the sparse known associations between circRNAs and diseases,we reconstruct the network to complete more associations by imputing missing links based on neighboring circRNA and disease interactions.Finally,we integrate these two similarity networks into a non-negative matrix factorization framework to identify potential circRNA-disease associations.Upon conducting 5-fold cross-validation and leave-one-out cross-validation,the AUC values for NMFMSN reach 0.9712 and 0.9768,respectively,outperforming the currently most advanced models.Case studies on lung cancer and hepatocellular carcinoma show that NMFMSN is a good way to predict new associations between circRNAs and diseases.
基金Supported bythe Scientific Research Foundation ofHunan Provincial Education Department (03C500)
文摘Secure interaction and interoperability between two or more administrative domains is a major concern. The IRBAC 2000 model accomplishes secure interaction and interoperability by flexibly dynamic inter-domain role translations. Associations are the key element of the IRBAC 2000 model, which have a great impact on security and efficiency of dynamic role translations. Therefore, it is a crucial problem how to manage the associations in the IRBAC 2000 model. There are two cases under which some matters will emerge. One is where conflicting associations may result in a security hazard. Another is where redundant associations may reduce the efficiency of dynamic role translations and increase the difficulty of management of associations. The formal definitions on conflicting associations and redundant associations are given, and the methods are discusses to judge whether there are conflicting associations or redundant associations in IRBAC 2000 model. The protective mechanism is presented, which utilizes prerequisite conditions to prevent conflicting or redundant associations from appearing in IRBAC 2000 model.
文摘BACKGROUND Primary sclerosing cholangitis(PSC)associated inflammatory bowel disease(IBD)is a unique form of IBD(PSC-IBD)with distinct clinical and histologic features from ulcerative colitis(UC)and Crohn disease(CD).In patients with PSC and IBD,the severity of the two disease processes may depend on each other.AIM To study the histologic and clinical features of PSC patients with and without IBD.METHODS We assessed specimens from patients with UC(n=28),CD(n=10),PSC and UC(PSC-UC;n=26);PSC and CD(PSC-CD;n=6);and PSC and no IBD(PSC-no IBD;n=4)between years 1999-2013.PSC-IBD patients were matched to IBD patients without PSC by age and colitis duration.Clinical data including age,gender,age at IBD and PSC diagnoses,IBD duration,treatment,follow-up,orthotopic liver transplantation(OLT)were noted.RESULTS PSC-UC patients had more isolated right-sided disease(P=0.03),and less active inflammation in left colon,rectum(P=0.03 and P=0.0006),and overall(P=0.0005)compared to UC.They required less steroids(P=0.01)and fewer colectomies(P=0.03)than UC patients.The PSC-CD patients had more ileitis and less rectal involvement compared to PSC-UC and CD.No PSC-CD patients required OLT compared to 38%of PSC-UC(P=0.1).PSC-IBD(PSC-UC and PSCCD)patients with OLT had severe disease in the left colon and rectum(P=0.04).CONCLUSION PSC-UC represents a distinct form of IBD.The different disease phenotype in PSC-IBD patients with OLT may support liver-gut axis interaction,however warrants clinical attention and further research.
文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations.
基金This work is supported by the National Natural Science Focal Projects Foundation of China(Grant No.40131020)the National Natural Science Foundation of China(Grant No.49833030)+2 种基金the Venus Program Foundation for Young Scientists of Shanghai(Grant No.97QA14023)its Tracking Program(Grant No.01QMH1406)the Dawn Program of Shanghai Ecucational Development Foundation.
文摘The five chemical associations of heavy metals have been extracted continuously using the Tessier extracting method. Results show that Cu, Pb, Fe, Zn and Cr in the sediments are mainly distributed in residual fraction, while the major chemical association of Mn is carbonates. Carbonate heavy metals are converted into Fe-Mn oxides in autumn. And in the low tidal flat, after carbonates have changed into ionic heavy metals, some of the elements are transported to the overlying water. Cu, Pb, Fe and Mn have good correlations with each other, and Zn, Cr also show their similarity of chemical behavior in the sediments.
文摘Colorectal cancer(CRC)is a common cancer with high morbidity and mortality rates.Its occurrence and development are determined by many factors,including genetics,the environment,lifestyle,and so on.The occurrence of CRC is often accompanied by changes in the intestinal microenvironment.Numerous studies have focused on the association between dietary patterns,dietary components,and CRC now.This article reviews five different dietary patterns:the Western diet,the Mediterranean diet,the ketogenic diet,the Dietary Approaches to Stop Hypertension diet,and fasting,and themechanistic associations between their food components and CRC.The finding can provide a reference for further studies on the association between different dietary patterns and CRC and will help clinicians formulate reasonable and feasible dietary interventions.
文摘As a volunteer organization,NGO plays an important role nowadays for its unique social functions.In recent years,Chinese Young Volunteers Associations have made great progress,but compared with the EU countries,there is still a significant gap.This paper in cludes the result of the comparative researches on two aspects: Volunteer associations;Training systems.From the result,a relatively compre hensive reference can be provided for the development of the Chinese Youth Volunteers Associations.
基金supported by the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(Grant ZDBS-LY-DQC019)the National Key Research and Development Program of China(2023YFE0124300)+4 种基金the National Natural Science Foundation of China(32301344)Major Program of Institute of Applied EcologyChinese Academy of Sciences(IAEMP202201)supported by grants from the U.S.National Science Foundation(DEB 2240431)the Seeding Projects for Enabling Excellence and Distinction(SPEED)Program at Washington University in St.Louis。
文摘Biodiversity,large trees,and environmental conditions such as climate and soil have important effects on forest carbon stocks.However,recent studies in temperate forests suggest that the relative importance of these factors depends on tree mycorrhizal associations,whereby large-tree effects may be driven by ectomycorrhizal(EM)trees,diversity effects may be driven by arbuscular mycorrhizal(AM)trees,and environment effects may depend on differential climate and soil preferences of AM and EM trees.To test this hypothesis,we used forest-inventory data consisting of over 80,000 trees from 631 temperate-forest plots(30 m×30 m)across Northeast China to examine how biodiversity(species diversity and ecological uniqueness),large trees(top 1%of tree diameters),and environmental factors(climate and soil nutrients)differently regulate aboveground carbon stocks of AM trees,EM trees,and AM and EM trees combined(i.e.total aboveground carbon stock).We found that large trees had a positive effect on both AM and EM tree carbon stocks.However,biodiversity and environmental factors had opposite effects on AM vs.EM tree carbon stocks.Specifically,the two components of biodiversity had positive effects on AM tree carbon stocks,but negative effects on EM tree carbon stocks.Environmental heterogeneity(mean annual temperature and soil nutrients)also exhibited contrasting effects on AM and EM tree carbon stocks.Consequently,for the total carbon stock,the positive large-tree effect far surpasses the diversity and environment effect.This is mainly because when integrating AM and EM tree carbon stock into total carbon stock,the opposite diversity-effect(also environment-effect)on AM vs.EM tree carbon stock counteracts each other while the consistent positive large-tree effect on AM and EM tree carbon stock is amplified.In summary,this study emphasized a mycorrhizal viewpoint to better understand the determinants of overarching aboveground carbon profile across regional forests.
基金supported by the National Natural Science Foundation of China(81830058,82071945,91959207,92159301,and 82302212)the Science and Technology Commission of Shanghai Municipality(22ZR1404800)。
文摘Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized treatment.We present a well-designed radiogenomic framework image–gene–gene set(IMAGGS),which detects multi-way associations in BC subtypes by integrating radiomic and genomic features.Our dataset consists of 721 patients,each of whom has 12 ultrasound(US)images captured from different angles and gene mutation data.To better characterize tumor traits,12 multi-angle US images are fused using two distinct strategies.Then,we analyze complex many-to-many associations between phenotypic and genotypic features using a machine learning algorithm,deviating from the prevalent one-to-one relationship pattern observed in previous studies.Key radiomic and genomic features are screened using these associations.In addition,gene set enrichment analysis is performed to investigate the joint effects of gene sets and delve deeper into the biological functions of BC subtypes.We further validate the feasibility of IMAGGS in a glioblastoma multiforme dataset to demonstrate the scalability of IMAGGS across different modalities and diseases.Taken together,IMAGGS provides a comprehensive characterization for diseases by associating imaging,genes,and gene sets,paving the way for biological interpretation of radiomics and development of targeted therapy.
文摘The structural diversity of different tree-crop associations were studied at Gachabari Sal forest area of Madhupur Garh on Buffer and Peripheral Zone during 2006. The total density, basal area of trees in the Buffer and Peripheral Zone were 155.5 trees·hm^(-2), 795.4 trees·hm^(-2) and 3.9 m2·hm-2, 5.8 m^2·hm^(-2), respectively. No regeneration and natural trees were found in Peripheral Zone and the Zone is totally occupied by exotic species where the Buffer Zone comprised of both natural and exotic trees. The Peripheral Zone belonged to younger and smaller trees whereas the Buffer Zone belonged to mixture of smaller, taller, younger and mature trees simultaneously. For the practicing of different agroforestry systems both Zones have lost their original characters of Sal forest.
文摘The original version of this article unfortunately contained three mistakes. （1） The spelling of the [A. Nishad＇] name was incorrect. The corrected spelling is given below.
基金Supported by the Strategic Priority Research Program of Chinese Academic of Sciences(No.XDA1102040303)the National Basic Research Program of China(973 Program)(No.2015CB453300)
文摘Microbial communities play key roles in the marine ecosystem. Despite a few studies on marine microbial communities in deep straits, ecological associations among microbial communities in the sediments of shallow straits have not been fully investigated. The Bohai Strait in northern China(average depth less than 20 m) separates the Bohai Sea from the Yellow Sea and has organic-rich sediments. In this study, in the summer of 2014, six stations across the strait were selected to explore the taxonomic composition of microbial communities and their ecological associations. The four most abundant classes were Gammaproteobacteria, Deltaproteobacteria, Bacilli and Flavobacteriia. Temperature, total carbon, depth, nitrate, fishery breeding and cold water masses influenced the microbial communities, as suggested by representational dif ference and composition analyses. Network analysis of microbial associations revealed that key families included Flavobacteriaceae, Pirellulaceae and Piscirickettsiaceae. Our findings suggest that the families with high phylogenetic diversity are key populations in the microbial association network that ensure the stability of microbial ecosystems. Our study contributes to a better understanding of microbial ecology in complex hydrological environments.
基金partly supported by the National Science Foundation of China (Grant No. 12133005)。
文摘We report the results of our search for planet candidates in open clusters and young stellar associations based on the Transiting Exoplanet Survey Satellite(TESS) Objects of Interest Catalog.We find one confirmed planet,one promising candidate,one brown dwarf and three unverified planet candidates in a sample of 1229 open clusters from the second Gaia data release.We discuss individual planet-star systems based on their basic parameters,membership probability and the observation notes from the ExoFOP-TESS website.We also find ten planet candidates(P> 95%) in young stellar associations by using the BANYAN ∑ Multivariate Bayesian Algorithm.Among the ten candidates,five are known planetary systems.We estimate the rotation periods of the host stars using the TESS light curves and estimate their ages based on gyrochronology.Two candidates with periodic variations are likely to be young planets,but their exact memberships to young stellar associations remain unknown.
文摘Mesocosms experiments were used to study the influence of associations of hydrocarbon oxidizing microorganisms on the microbial cenosis and oil destruction in soil. The introduction of active oil oxidizing microorganisms associations into the soil purify of soil from oil to 59.8% - 63.8% after 2 months with 5% oil content and with 10% to 49.2% - 55.6%. As a result of oil destruction there was enlarging of the number of all investigated groups of microorganisms.
文摘Purpose: To evaluate the associations for vaginal dose points of vaginal stricture in image-guided brachytherapy. Materials and Methods: Twenty-six patients of locally advanced cervical cancer were treated with Image-Guided Brachytherapy (IGBT) with the dose at least 7 Gy per fraction to the D90 of High-Risk Clinical Target Volume (HR-CTV). The vaginal dose points of recommendations of the American Brachytherapy Society (ABS) were added into the plan and cumulative dose to these points was evaluated in Equivalent Dose of 2 Gy (EQD2) concepts. Results: The mean doses to right vaginal dose point (VR), left vaginal dose point (VL) and average dose of VR/VL ((VR + VL)/2) were 101.5 Gy, 98.2 Gy and 99.8 Gy in EQD2 concepts, respectively. Volume-based planning significantly reduced the cumulative dose in EQD2 concepts at vaginal points. At the median follow-up time of 22 months, grade-2 vaginal stricture was observed in two patients. The incidences of vaginal stricture were not differed between the cumulative dose to vaginal dose points in EQD2 concepts of ≤90 Gy versus >90 Gy (P = 1.000) and ≤100 Gy versus >100 Gy (P = 0.815). Conclusion: No association for cumulative vaginal doses and events of vaginal stricture was found.
