The unmanned aerial vehicle(UAV)-assisted mobile edge computing(MEC)has been deemed a promising solution for energy-constrained devices to run smart applications with computationintensive and latency-sensitive require...The unmanned aerial vehicle(UAV)-assisted mobile edge computing(MEC)has been deemed a promising solution for energy-constrained devices to run smart applications with computationintensive and latency-sensitive requirements,especially in some infrastructure-limited areas or some emergency scenarios.However,the multi-UAVassisted MEC network remains largely unexplored.In this paper,the dynamic trajectory optimization and computation offloading are studied in a multi-UAVassisted MEC system where multiple UAVs fly over a target area with different trajectories to serve ground users.By considering the dynamic channel condition and random task arrival and jointly optimizing UAVs'trajectories,user association,and subchannel assignment,the average long-term sum of the user energy consumption minimization problem is formulated.To address the problem involving both discrete and continuous variables,a hybrid decision deep reinforcement learning(DRL)-based intelligent energyefficient resource allocation and trajectory optimization algorithm is proposed,named HDRT algorithm,where deep Q network(DQN)and deep deterministic policy gradient(DDPG)are invoked to process discrete and continuous variables,respectively.Simulation results show that the proposed HDRT algorithm converges fast and outperforms other benchmarks in the aspect of user energy consumption and latency.展开更多
Flammable ionic liquids exhibit high conductivity and a broad electrochemical window,enabling the generation of combustible gases for combustion via electrochemical decomposition and thermal decomposition.This charact...Flammable ionic liquids exhibit high conductivity and a broad electrochemical window,enabling the generation of combustible gases for combustion via electrochemical decomposition and thermal decomposition.This characteristic holds significant implications in the realm of novel satellite propulsion.Introducing a fraction of the electrical energy into energetic ionic liquid fuels,the thermal decomposition process is facilitated by reducing the apparent activation energy required,and electrical energy can trigger the electrochemical decomposition of ionic liquids,presenting a promising approach to enhance combustion efficiency and energy release.This study applied an external voltage during the thermal decomposition of 1-ethyl-3-methylimidazole nitrate([EMIm]NO_(3)),revealing the effective alteration of the activation energy of[EMIm]NO_(3).The pyrolysis,electrochemical decomposition,and electron assisted enhancement products were identified through Thermogravimetry-Differential scanning calorimetry-Fourier transform infrared-Mass spectrometry(TG-DSC-FTIR-MS)and gas chromatography(GC)analyses,elucidating the degradation mechanism of[EMIm]NO_(3).Furthermore,an external voltage was introduced during the combustion of[EMIm]NO_(3),demonstrating the impact of voltage on the combustion process.展开更多
BACKGROUND The gold standard for colorectal polyp screening is currently colonoscopy,but the miss rate is still high and the adenoma detection rate and polyp detection rate are still low.The risk factors include the p...BACKGROUND The gold standard for colorectal polyp screening is currently colonoscopy,but the miss rate is still high and the adenoma detection rate and polyp detection rate are still low.The risk factors include the patient,operators,and the tools used.The use of artificial intelligence(AI)in colonoscopy has gained popularity by assisting endoscopists in the detection and characterization of polyps.AIM To evaluate the diagnostic performance of AI-assisted colonoscopy[computer assisted diagnosis(CAD)eye function]for colorectal polyp characterization.METHODS This study used a cross-sectional design conducted at the Gastrointestinal Endoscopy Center of Dr.Cipto Mangunkusumo Hospital in January-May 2024 on adult patients with suspected colorectal polyps.RESULTS A total of 60 patients with 100 polyps were involved in this study.Based on the results of the examination,it was found that the AI CAD eye function examination had a sensitivity of 79.17%,specificity of 75.00%,positive predictive value(PPV)of 89.06%,negative predictive value(NPV)of 58.33%,and accuracy of 78.00%.In polyps with diminutive size,sensitivity was 86.27%,specificity was 60.00%,PPV was 95.65%,NPV was 30.00%,and accuracy was 83.93%.Meanwhile,in polyps with non-diminutive size,sensitivity was 61.90%,specificity was 78.26%,PPV was 72.22%,NPV was 69.23%,and accuracy was 70.45%.In polyps on the left side of the colon,sensitivity was 78.85%,specificity was 81.25%,PPV was 93.18%,NPV was 54.17%,and accuracy was 79.41%.Meanwhile,in rightsided polyps the sensitivity was 80.00%,specificity was 66.67%,PPV was 80.00%,NPV was 66.67%,and accuracy was 75.00%.In sessile polyps the sensitivity was 81.54%,specificity was 50.00%,PPV was 91.38%,NPV was 29.41%,and accuracy was 77.33%.Meanwhile,in non-sessile polyps,the sensitivity was 57.14%,specificity was 88.89%,PPV was 66.67%,NPV was 84.21%,and accuracy was 80.00%.CONCLUSION AI CAD eye function examination had a high sensitivity value in diminutive,sessile polyps and right-sided polyps and a high specificity in non-diminutive,non-sessile polyps and left-sided polyps.展开更多
Precise control and measurement of nanoparticles using low-power optical tweezers are pivotal for advancing single-particle analysis,nanoscale sensing,and energy transport research.In this work,we present the tipassis...Precise control and measurement of nanoparticles using low-power optical tweezers are pivotal for advancing single-particle analysis,nanoscale sensing,and energy transport research.In this work,we present the tipassisted nanoparticle capture system that simultaneously achieves localized temperature probing and nanoparticle trapping,significantly lowering the required laser power input.Unlike traditional metal-tip plasmonic techniques that predominantly rely on intense electric field gradients,our approach employs a silicon nanotip under resonant laser excitation,uniquely integrating optical forces,thermophoretic forces,and interatomic interactions for stable nanoparticle confinement.This synergistic collaboration mechanism enables approximately a 42%reduction in laser power density compared to conventional bowtie nanoaperture methods.This experimental method achieved direct and simultaneous Raman-based measurements of localized thermal dynamics,providing new insights into nanoscale thermodynamics during optical trapping.Additionally,the silicon nanotip demonstrates reduced thermal transport due to its confined nanoscale geometry,aligning closely with our theoretical predictions.Our integrated strategy of efficient nanoparticle manipulation coupled with precise thermal probing not only enhances overall energy efficiency but also broadens the scope of potential applications in cutting-edge nanoscience and nanotechnology.展开更多
1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-...1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-sized particles(5-50μm)to fabricate coatings[1-3].CS has been extensively used in a variety of coating applications,such as aerospace,automotive,energy,medical,marine,and others,to provide protection against high temperatures,corrosion,erosion,oxidation,and chemicals[4,5].Nowadays,the technical interest in CS is twofold:(i)as a repair process for damaged components,and(ii)as a solid-state additive manufacturing process.Compared to other fusion-based additive manufacturing(AM)technologies,Cold Spray Additive Manufacturing(CSAM)is a new member of the AM family that can enable the fabrication of deposits without undergoing melting.The chemical composition has been largely preserved from the powder to the deposit due to the minimal oxidation.The significant advantages of CSAM over other additive manufacturing processes include a high production rate,unlimited deposition size,high flexibility,and suitability for repairing damaged parts.展开更多
BACKGROUND Acupuncture,an ancient practice,is gaining recognition as a complementary and alternative medicine,especially in assisted reproductive technology.It plays a crucial role in enhancing embryo transfer success...BACKGROUND Acupuncture,an ancient practice,is gaining recognition as a complementary and alternative medicine,especially in assisted reproductive technology.It plays a crucial role in enhancing embryo transfer success rates.Research indicates that acupuncture can improve blood flow,increase endometrial receptivity regulate pressure,and affect neuroendocrine activities in the ovaries and uterus during embryo implantation,therefore improving pregnancy outcomes.AIM To highlight recent developments related to acupuncture's influence on embryo transfer and elucidating the precise mechanisms by which acupuncture influences embryo transfer.METHODS We searched database including PubMed,Cochrane Library up to September 2024 for relevant studies and patents to evaluate the effects of acupuncture on women undergoing in vitro fertilization(IVF).The experimental design included an intervention group using needling,and a control group consisting of no needling or sham needling.The main outcome is clinical pregnancy rate(CPR),while secondary includes live birth rate(LBR)and biochemical pregnancy rate(BPR).We examined the influence of adjunctive needling on pregnancy outcomes by analyzing variations in the main outcomes.RESULTS A total of 145 randomized controlled trials involving 27748 participants were analyzed.Data revealed that the overall CPR was significantly elevated in all acupuncture cohorts compared to the control group[relative risk(RR):1.21,95%CI:1.07-1.38,P=0.01].In contrast,the aggregated LBR did not exhibit a corresponding increase,and notable statistical heterogeneity was observed among the studies.Acupuncture-assisted frozen-thawed embryo transfer enhanced the BPR(RR:1.51,95%CI:1.21-1.89,P=0.03)and improved endometrial morphology(RR:1.41,95%CI:1.13-1.75,P=0.01).Furthermore,IVF outcomes were significantly superior in the acupuncture group when acupuncture was administered during controlled ovarian hyperstimulation(RR:1.71,95%CI:1.08-2.13,95%CI:1.08-4.21,P=0.03).CONCLUSION We find that acupuncture positively influences pregnancy rates in women receiving IVF treatment.Nonetheless,there are no established guidelines for optimal acupuncture protocols.Considering the methodological limitations identified in current research,there is a need for larger,methodologically rigorous studies.展开更多
Solid-state precipitation is an effective strategy for tuning the mechanical and functional properties of ad-vanced alloys.Structure design and modification necessitate good knowledge of the kinetic evolution of preci...Solid-state precipitation is an effective strategy for tuning the mechanical and functional properties of ad-vanced alloys.Structure design and modification necessitate good knowledge of the kinetic evolution of precipitates during fabrication,which is strongly correlated with defect concentration.For Fe-Ga alloys,giant magnetostriction can be induced by the precipitation of the nanoscale tetragonal L60 phase.By introducing quenched-in vacancies,we significantly enhance the magnetostriction of the aged Fe81Ga19 polycrystalline alloys to~305 ppm,which is close to the level of single crystals.Although vacancies were found to facilitate the generation of the L60 phase,their impact on the precipitation mechanism and kinetics has yet to be revealed.This study combined transmission electron microscopy(TEM)and time-resolved small-angle neutron scattering(SANS)to investigate the precipitation of the L60 phase during the isothermal aging at 350 and 400℃,respectively.The evolution of L60 nanophase in morphology and number density in as-cast(AC)and liquid nitrogen quenched(LN)Fe81Ga19 alloys with aging time were quantitatively compared.Interestingly,the nucleation of the L60 phase proceeds progressively in AC while suddenly in LN specimens,indicating the homogenous to heterogeneous mechanism switching in-duced by concentrated vacancies.Moreover,excess vacancies can change the shape of nanoprecipitates and significantly accelerate the growth and coarsening kinetics.The magnetostrictive coefficient is opti-mized when the size(long-axis)of L60 precipitates lies between 100 and 110Åwith a number density between 3.2-4.3×10-7Å-3.Insight from this study validates the feasibility of achieving high magnetoe-lastic properties through precise manipulation of the nanostructure.展开更多
Mg-Li alloys hold significant potential for applications in aerospace,automotive manufacturing,military weaponry,and biomedical implants,due to their excellent recyclability,high specific strength,biocompatibility,and...Mg-Li alloys hold significant potential for applications in aerospace,automotive manufacturing,military weaponry,and biomedical implants,due to their excellent recyclability,high specific strength,biocompatibility,and superior electromagnetic shielding properties.However,their poor corrosion resistance and high susceptibility to environmentally assisted cracking(EAC)significantly limit broader application.In recent years,growing attention has been directed toward understanding the corrosion and EAC behavior of Mg-Li alloys,as localized corrosion areas and hydrogen generated during the corrosion process can serve as crack initiation points and promote crack propagation.A comprehensive understanding of these mechanisms is essential for enhancing the reliability and performance of Mg-Li alloys in practical environments.This paper presents a detailed review of corrosion and EAC in Mg-Li alloys,focusing on corrosion behavior,crack initiation and propagation mechanisms,and the key factors influencing these processes.It summarizes recent advances in alloying,heat treatment,mechanical processing,microstructural control,environmental influences,mechanical loading,and surface treatments.In addition,the paper explores future research directions,highlights emerging trends,and proposes strategies to improve the durability and service performance of Mg-Li alloys.展开更多
Dear Editor,Radical cystectomy(RC)remains the standard treatment for muscle-invasive bladder cancer[1].However,urinary diversion after RC can lead to a range of postoperative complications,including parastomal hernia,...Dear Editor,Radical cystectomy(RC)remains the standard treatment for muscle-invasive bladder cancer[1].However,urinary diversion after RC can lead to a range of postoperative complications,including parastomal hernia,incontinence,urinary retention,recurrent urinary tract infections,and metabolic disorders,significantly impacting patients'quality of life[2].Partial cystectomy(PC)is a bladdersparing alternative for patients who cannot accept RC and has been utilized in managing muscle-invasive bladder cancer since the last century.However,the application of PC has always been a subject of controversy in clinical practice due to the high recurrence rate.In a matched case-control analysis conducted by Knoedler et al.[3],38%of the patients experienced intravesical tumor recurrence,and 19%of the patients ultimately underwent RC.Another study in the Memorial Sloan-Kettering Cancer Center showed that 22 of 58 patients who received PC experienced superficial or advanced recurrence[4].展开更多
Dear Editor,Robotic-assisted laparoscopic varicocelectomy(RALV)has been recently described in the pediatric field[1].Although the learning curve of surgical procedures is flattened by a robotic approach[2],complicatio...Dear Editor,Robotic-assisted laparoscopic varicocelectomy(RALV)has been recently described in the pediatric field[1].Although the learning curve of surgical procedures is flattened by a robotic approach[2],complications may occur especially at the beginning of experience.We herein describe an unexpected severe case of parietal blood dripping in a boy who underwent RALV.The study was approved by the institutional review board of Federico Il University Hospital in Naples,Italy(approval number:Fll/2024-PL149).All procedures performed were in accordance with the ethical standards of the institution and/or national research committee.The written informed consent was obtained by his parents to agree the treatment and publish this paper.展开更多
In tissue engineering(TE),tissue-inducing scaffolds are a promising solution for organ and tissue repair owing to their ability to attract stem cells in vivo,thereby inducing endogenous tissue regeneration through top...In tissue engineering(TE),tissue-inducing scaffolds are a promising solution for organ and tissue repair owing to their ability to attract stem cells in vivo,thereby inducing endogenous tissue regeneration through topological cues.An ideal TE scaffold should possess biomimetic cross-scale structures,similar to that of natural extracellular matrices,at the nano-to macro-scale level.Although freeform fabrication of TE scaffolds can be achieved through 3D printing,this method is limited in simultaneously building multiscale structures.To address this challenge,low-temperature fields were adopted in the traditional fabrication processes,such as casting and 3D printing.Ice crystals grow during scaffold fabrication and act as a template to control the nano-and micro-structures.These microstructures can be optimized by adjusting various parameters,such as the direction and magnitude of the low-temperature field.By preserving the macro-features fabricated using traditional methods,additional micro-structures with smaller scales can be incorporated simultaneously,realizing cross-scale structures that provide a better mimic of natural organs and tissues.In this paper,we present a state-of-the-art review of three low-temperature-field-assisted fabrication methods—freeze casting,cryogenic3D printing,and freeze spinning.Fundamental working principles,fabrication setups,processes,and examples of biomedical applications are introduced.The challenges and outlook for low-temperature-assisted fabrication are also discussed.展开更多
In this paper,we propose a sub-6GHz channel assisted hybrid beamforming(HBF)for mmWave system under both line-of-sight(LOS)and non-line-of-sight(NLOS)scenarios without mmWave channel estimation.Meanwhile,we resort to ...In this paper,we propose a sub-6GHz channel assisted hybrid beamforming(HBF)for mmWave system under both line-of-sight(LOS)and non-line-of-sight(NLOS)scenarios without mmWave channel estimation.Meanwhile,we resort to the selfsupervised approach to eliminate the need for labels,thus avoiding the accompanied high cost of data collection and annotation.We first construct the dense connection network(DCnet)with three modules:the feature extraction module for extracting channel characteristic from a large amount of channel data,the feature fusion module for combining multidimensional features,and the prediction module for generating the HBF matrices.Next,we establish a lightweight network architecture,named as LDnet,to reduce the number of model parameters and computational complexity.The proposed sub-6GHz assisted approach eliminates mmWave pilot resources compared to the method using mmWave channel information directly.The simulation results indicate that the proposed DCnet and LDnet can achieve the spectral efficiency that is superior to the traditional orthogonal matching pursuit(OMP)algorithm by 13.66% and 10.44% under LOS scenarios and by 32.35% and 27.75% under NLOS scenarios,respectively.Moreover,the LDnet achieves 98.52% reduction in the number of model parameters and 22.93% reduction in computational complexity compared to DCnet.展开更多
The electrically assisted(EA)deformation process has received considerable attention in recent years,ac-companied by research on current-induced deformation mechanisms.However,there are still challenges in eliminating...The electrically assisted(EA)deformation process has received considerable attention in recent years,ac-companied by research on current-induced deformation mechanisms.However,there are still challenges in eliminating thermal effects,which have prevented a comprehensive understanding of the underlying current-induced mechanisms.Opting for a single crystal(SC)in research provides advantages in decou-pling the nonthermal effect of electric current at smaller scales and eliminating the complex interactions that exist in polycrystalline materials.Therefore,the innovation of this work lies in decoupling the non-thermal effect of electric current and conducting a comprehensive analysis of anisotropic deformation and mechanisms within a Ni-based SC with different crystallographic axes and various current directions dur-ing electrically assisted tensile simulation.A significant tension axis direction in the SC during EA tension was induced by the combination of a higher current direction factor(|cosθ|)and a dimensionless factor for the current density(|J^(α)/J_(0)^(α)|)along the[100]axis.The stress drop within the SC due to the nonthermal effect of electric current generally increased with increasing current direction.This was attributed to the increased dislocation density differences and decreased temperature.The increased stress anisotropy of the SC at a current direction of 45°was attributed to fewer activated(111)slip systems and the pinning effect of more dislocations within these systems.This study advances our understanding of the thermal and nonthermal effects of electric current and offers valuable insights for the informed application of EA deformations in industrial and aerospace settings with SC superalloys.展开更多
Reproductive medicine has been transformed by assisted reproductive technologies(ART),providing multiple options for infertile couples to conceive biological offspring.The medical and legal frameworks,governing the pr...Reproductive medicine has been transformed by assisted reproductive technologies(ART),providing multiple options for infertile couples to conceive biological offspring.The medical and legal frameworks,governing the practice of embryologists in ART,focus on the ethical and safe handling of gametes and embryos.Embryologists play a crucial role in the success of ART procedures,requiring technical expertise and a thorough understanding of legal and ethical considerations.The importance of quality control,safety protocols,and sterility in ART laboratories is essential to ensure optimal embryo development and patient well-being.The legal responsibilities of an embryologist under the Assisted Reproductive Technology(Regulation)Act,2021 in India are required.This review emphasizes the importance of record-keeping,patient confidentiality,informed consent,and adherence to legal and ethical standards to minimize the risk of malpractice claims.Overall,this narrative review provides a detailed overview of the medical,legal,and ethical frameworks governing embryologists'practice in ART,underscoring the significance of responsible and ethical conduct in this rapidly advancing field.展开更多
SiC-reinforced aluminum matrix(SiCp/Al)composite is widely utilized in the aerospace,automotive,and electronics industries due to the combination of ceramic hardness and metal toughness.However,the significant dispari...SiC-reinforced aluminum matrix(SiCp/Al)composite is widely utilized in the aerospace,automotive,and electronics industries due to the combination of ceramic hardness and metal toughness.However,the significant disparity in properties between SiC particles and the aluminum matrix results in severe tool wear and diminished surface quality during conventional machining.This study proposes an environmentally friendly and clean dry electrical discharge assisted grinding process as an efficient and low-damage machining method for SiCp/Al.An experimental platform was set up to study the impact of grinding and discharge process parameters on surface quality.The study compared the chip formation mechanism and surface quality between dry electrical discharge assisted grinding and conventional grinding,revealing relationships between surface roughness,grinding force,grinding temperature,and related parameters.The results indicate that the proposed grinding method leads to smaller chip sizes,lower grinding forces and temperatures,and an average reduction of 19.2%in surface roughness compared to conventional grinding.The axial,tangential,and normal grinding forces were reduced by roughly 10.5%,37.8%,and 23.0%,respectively.The optimized process parameters were determined to be N=2500 r/min,vf=30 mm/min,a=10μm,E=15 V,f=5000 Hz,dc=80%,resulting in a surface roughness of 0.161μm.展开更多
The rapidly evolving environment of assisted reproductive technology(ART)requires consideration of how new innovations are reshaping clinical practice as much as research.In particular,there are three key areas that,w...The rapidly evolving environment of assisted reproductive technology(ART)requires consideration of how new innovations are reshaping clinical practice as much as research.In particular,there are three key areas that,while full of promise,also present significant challenges:the use of artificial intelligence(AI)in embryo selection,the impact of personalized medicine on ART success rates,and the ethical considerations of genetic screening of embryos[1].This letter is meant to provoke further discussion and highlight the need for harmonized global guidelines as these advances continue to reshape the reproductive medicine environment.展开更多
Sperm-structure-integrating nanodecorated microrobots have shown promise in medicine delivery and infertility treatment.A variety of spermbots use cutting-edge nanomaterials and 3D printing technology to enhance their...Sperm-structure-integrating nanodecorated microrobots have shown promise in medicine delivery and infertility treatment.A variety of spermbots use cutting-edge nanomaterials and 3D printing technology to enhance their functioning,such as biomimetic sperms and flagellate microorganisms.The success rates of assisted reproductive technology techniques like in vitro fertilisation(IVF)and intracytoplasmic sperm injection(ICSI)may increase as a result of these developments.Furthermore,the incorporation of artificial intelligence(AI)into spermbots has the potential to optimize reproductive therapies by reducing inherited illnesses through genetic screening and editing.However,before the widespread implementation of spermbots in clinical practice,several critical aspects must be addressed.Thorough investigations into biocompatibility,ethical considerations,and long-term safety are necessary to ensure that these technologies are safe and effective for in vivo applications.展开更多
Intestinal autotransplantation(IATx)allows for radical resection to be performed on selected patients with superior mesenteric artery(SMA)involvement.However,the complexity of IATx is a major consideration.This surgic...Intestinal autotransplantation(IATx)allows for radical resection to be performed on selected patients with superior mesenteric artery(SMA)involvement.However,the complexity of IATx is a major consideration.This surgical technique requires a simpler approach,shorter operative time and lower perioperative risk.Our group has successfully pioneered a semi-ex vivo IATx approach for patients with locally advanced pancreatic cancer with the SMA,superior mesenteric vein(SMV),and jejunal artery(JA)branch involvement.The present report illustrates how this operation was carried out.At a follow-up of up to 8 months,there were no signs of tumor recurrence.展开更多
Current research on the fabrication of rolled composite plates primarily focuses on processing and bonding mechanisms.Compared with hot-rolling technology,the electrically assisted rolling process has demonstrated exc...Current research on the fabrication of rolled composite plates primarily focuses on processing and bonding mechanisms.Compared with hot-rolling technology,the electrically assisted rolling process has demonstrated excellent performance in interfacial bonding effects.However,the influence of different current loading modes on the interfacial recombination process of composite panels varies significantly.In this study,low-frequency electrically assisted rolling was used in the first pass to pre-bond a composite plate at a low reduction rate of 15%.High-frequency electrically assisted rolling was used during the second pass,and Al/Mg alloy composite plates were obtained.The interfacial microstructure and mechanical properties of the composite plate were coordinated regulation by designing the rolling reduction rate.The results showed the interfacial morphology of the alternating distribution of the melt-diffusion layer,diffusion layer,and the formation of a new Al/Mg bonding interface.At the melt-diffusion interface,the irregular intermetallic compounds(IMCs)and the new Al/Mg bonding interface were alternately distributed,and the IMCs contained theα-Mg,Mg17Al12,and Mg2Al3 phases.In addition,an extremely high shear strength of 78.26 MPa was achieved.Adhesion of the Mg alloy matrix was observed on the fracture surface of the Al alloy side.The high shear strength was mainly attributed to the formation of a unique interfacial structure and the appearance of a melt-diffusion layer.Compared to the diffusion-reduction interface,the regular rectangular IMCs and the new Al/Mg bonding interface were alternately distributed,and the IMCs consisted of the Mg17Al12 and Mg2Al3 phases.The shear test results showed that the shear strength of the interface reached 68.69 MPa,and a regular distribution of the Mg alloy matrix with dimples and the Al alloy matrix with a necking zone was observed on the fracture surface of the Al side.Tensile strength test results revealed a maximum value of 316.86 MPa for the Al/Mg alloy composite plate.The tensile and interfacial bonding strengths can be synchronously enhanced by coordinating the regulation of the interfacial structure.This study proposes a new electrically assisted rolling technology that is useful for the fabrication of composite plates with excellent mechanical properties.展开更多
BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is contraindicated for patients with cavernous transformation of the portal vein(CTPV)due to high surgery-related mortality risk.However,surgically assiste...BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is contraindicated for patients with cavernous transformation of the portal vein(CTPV)due to high surgery-related mortality risk.However,surgically assisted TIPS(SATIPS)can significantly reduce the risk.AIM To evaluate the clinical efficacy of SATIPS,this study was conducted.METHODS One hundred and seven patients with CTPV and esophagogastric variceal bleeding were recruited from January 2023 to December 2024.The patients were recruited from three different hospitals.Overall,54 patients received SATIPS treatment(SATIPS group),while 53 patients did not receive SATIPS and underwent prophylactic endoscopic sclerosing ligation(control group).Subsequently,survival rates,incidence rates of gastrointestinal bleeding,incidence of hepatic encephalopathy rate,and the incidence of liver failure after treatment in both groups at 3 and 6 months were observed.RESULTS The survival rates for the SATIPS and control groups were 94.4%and 92.5%at 3 months(P value=0.72)and 94.4%and 73.6%at 6 months(P value=0.0051)respectively.The incidence of liver failure was 3.7%and 9.4%at 3 months(P value=0.26)and 3.7%and18.9%at 6 months(P value=0.016);the incidence of gastrointestinal bleeding was 5.6%and 37.7%at 3 months(P value<0.001)and 9.3%and 47.2%(P value<0.001)at 6 months;and the incidence of hepatic encephalopathy was 3.7%and 17.0%at 3 months(P value=0.026)and 7.4%and 26.4%at 6 months(P value=0.026)respectively.CONCLUSION For patients with CTPV,there were no optimal treatment.Regarding long-term efficacy,SATIPS can significantly reduce the rate of rebleeding,hepatic encephalopathy and liver failure,and is associated with better survival.展开更多
基金supported by National Natural Science Foundation of China(No.62471254)National Natural Science Foundation of China(No.92367302)。
文摘The unmanned aerial vehicle(UAV)-assisted mobile edge computing(MEC)has been deemed a promising solution for energy-constrained devices to run smart applications with computationintensive and latency-sensitive requirements,especially in some infrastructure-limited areas or some emergency scenarios.However,the multi-UAVassisted MEC network remains largely unexplored.In this paper,the dynamic trajectory optimization and computation offloading are studied in a multi-UAVassisted MEC system where multiple UAVs fly over a target area with different trajectories to serve ground users.By considering the dynamic channel condition and random task arrival and jointly optimizing UAVs'trajectories,user association,and subchannel assignment,the average long-term sum of the user energy consumption minimization problem is formulated.To address the problem involving both discrete and continuous variables,a hybrid decision deep reinforcement learning(DRL)-based intelligent energyefficient resource allocation and trajectory optimization algorithm is proposed,named HDRT algorithm,where deep Q network(DQN)and deep deterministic policy gradient(DDPG)are invoked to process discrete and continuous variables,respectively.Simulation results show that the proposed HDRT algorithm converges fast and outperforms other benchmarks in the aspect of user energy consumption and latency.
基金supported by the National Natural Science Foundation of China(Grant No.52206165)。
文摘Flammable ionic liquids exhibit high conductivity and a broad electrochemical window,enabling the generation of combustible gases for combustion via electrochemical decomposition and thermal decomposition.This characteristic holds significant implications in the realm of novel satellite propulsion.Introducing a fraction of the electrical energy into energetic ionic liquid fuels,the thermal decomposition process is facilitated by reducing the apparent activation energy required,and electrical energy can trigger the electrochemical decomposition of ionic liquids,presenting a promising approach to enhance combustion efficiency and energy release.This study applied an external voltage during the thermal decomposition of 1-ethyl-3-methylimidazole nitrate([EMIm]NO_(3)),revealing the effective alteration of the activation energy of[EMIm]NO_(3).The pyrolysis,electrochemical decomposition,and electron assisted enhancement products were identified through Thermogravimetry-Differential scanning calorimetry-Fourier transform infrared-Mass spectrometry(TG-DSC-FTIR-MS)and gas chromatography(GC)analyses,elucidating the degradation mechanism of[EMIm]NO_(3).Furthermore,an external voltage was introduced during the combustion of[EMIm]NO_(3),demonstrating the impact of voltage on the combustion process.
文摘BACKGROUND The gold standard for colorectal polyp screening is currently colonoscopy,but the miss rate is still high and the adenoma detection rate and polyp detection rate are still low.The risk factors include the patient,operators,and the tools used.The use of artificial intelligence(AI)in colonoscopy has gained popularity by assisting endoscopists in the detection and characterization of polyps.AIM To evaluate the diagnostic performance of AI-assisted colonoscopy[computer assisted diagnosis(CAD)eye function]for colorectal polyp characterization.METHODS This study used a cross-sectional design conducted at the Gastrointestinal Endoscopy Center of Dr.Cipto Mangunkusumo Hospital in January-May 2024 on adult patients with suspected colorectal polyps.RESULTS A total of 60 patients with 100 polyps were involved in this study.Based on the results of the examination,it was found that the AI CAD eye function examination had a sensitivity of 79.17%,specificity of 75.00%,positive predictive value(PPV)of 89.06%,negative predictive value(NPV)of 58.33%,and accuracy of 78.00%.In polyps with diminutive size,sensitivity was 86.27%,specificity was 60.00%,PPV was 95.65%,NPV was 30.00%,and accuracy was 83.93%.Meanwhile,in polyps with non-diminutive size,sensitivity was 61.90%,specificity was 78.26%,PPV was 72.22%,NPV was 69.23%,and accuracy was 70.45%.In polyps on the left side of the colon,sensitivity was 78.85%,specificity was 81.25%,PPV was 93.18%,NPV was 54.17%,and accuracy was 79.41%.Meanwhile,in rightsided polyps the sensitivity was 80.00%,specificity was 66.67%,PPV was 80.00%,NPV was 66.67%,and accuracy was 75.00%.In sessile polyps the sensitivity was 81.54%,specificity was 50.00%,PPV was 91.38%,NPV was 29.41%,and accuracy was 77.33%.Meanwhile,in non-sessile polyps,the sensitivity was 57.14%,specificity was 88.89%,PPV was 66.67%,NPV was 84.21%,and accuracy was 80.00%.CONCLUSION AI CAD eye function examination had a high sensitivity value in diminutive,sessile polyps and right-sided polyps and a high specificity in non-diminutive,non-sessile polyps and left-sided polyps.
基金supported by the National Natural Science Foundation of China(Grant No.52206107)the National Key R&D Program of China(Grant No.2023YFE0120200)。
文摘Precise control and measurement of nanoparticles using low-power optical tweezers are pivotal for advancing single-particle analysis,nanoscale sensing,and energy transport research.In this work,we present the tipassisted nanoparticle capture system that simultaneously achieves localized temperature probing and nanoparticle trapping,significantly lowering the required laser power input.Unlike traditional metal-tip plasmonic techniques that predominantly rely on intense electric field gradients,our approach employs a silicon nanotip under resonant laser excitation,uniquely integrating optical forces,thermophoretic forces,and interatomic interactions for stable nanoparticle confinement.This synergistic collaboration mechanism enables approximately a 42%reduction in laser power density compared to conventional bowtie nanoaperture methods.This experimental method achieved direct and simultaneous Raman-based measurements of localized thermal dynamics,providing new insights into nanoscale thermodynamics during optical trapping.Additionally,the silicon nanotip demonstrates reduced thermal transport due to its confined nanoscale geometry,aligning closely with our theoretical predictions.Our integrated strategy of efficient nanoparticle manipulation coupled with precise thermal probing not only enhances overall energy efficiency but also broadens the scope of potential applications in cutting-edge nanoscience and nanotechnology.
基金supported by the National Natural Science Foundation of China(No.52061135101 and 52001078)the German Research Foundation(DFG,No.448318292)+3 种基金the Technology Innovation Guidance Special Foundation of Shaanxi Province(No.2023GXLH-085)the Fundamental Research Funds for the Central Universities(No.D5000240161)the Project of Key areas of innovation team in Shaanxi Province(No.2024RS-CXTD-20)The author Yingchun Xie thanks the support from the National Key R&D Program(No.2023YFE0108000).
文摘1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-sized particles(5-50μm)to fabricate coatings[1-3].CS has been extensively used in a variety of coating applications,such as aerospace,automotive,energy,medical,marine,and others,to provide protection against high temperatures,corrosion,erosion,oxidation,and chemicals[4,5].Nowadays,the technical interest in CS is twofold:(i)as a repair process for damaged components,and(ii)as a solid-state additive manufacturing process.Compared to other fusion-based additive manufacturing(AM)technologies,Cold Spray Additive Manufacturing(CSAM)is a new member of the AM family that can enable the fabrication of deposits without undergoing melting.The chemical composition has been largely preserved from the powder to the deposit due to the minimal oxidation.The significant advantages of CSAM over other additive manufacturing processes include a high production rate,unlimited deposition size,high flexibility,and suitability for repairing damaged parts.
基金Supported by Funding from the Jiangsu Provincial Science and Technology Plan Special Foundation,No.BE2022712The Special Research Project on The Development Plan of Traditional Chinese Medicine Technology in Jiangsu Province,No.ZT202120.
文摘BACKGROUND Acupuncture,an ancient practice,is gaining recognition as a complementary and alternative medicine,especially in assisted reproductive technology.It plays a crucial role in enhancing embryo transfer success rates.Research indicates that acupuncture can improve blood flow,increase endometrial receptivity regulate pressure,and affect neuroendocrine activities in the ovaries and uterus during embryo implantation,therefore improving pregnancy outcomes.AIM To highlight recent developments related to acupuncture's influence on embryo transfer and elucidating the precise mechanisms by which acupuncture influences embryo transfer.METHODS We searched database including PubMed,Cochrane Library up to September 2024 for relevant studies and patents to evaluate the effects of acupuncture on women undergoing in vitro fertilization(IVF).The experimental design included an intervention group using needling,and a control group consisting of no needling or sham needling.The main outcome is clinical pregnancy rate(CPR),while secondary includes live birth rate(LBR)and biochemical pregnancy rate(BPR).We examined the influence of adjunctive needling on pregnancy outcomes by analyzing variations in the main outcomes.RESULTS A total of 145 randomized controlled trials involving 27748 participants were analyzed.Data revealed that the overall CPR was significantly elevated in all acupuncture cohorts compared to the control group[relative risk(RR):1.21,95%CI:1.07-1.38,P=0.01].In contrast,the aggregated LBR did not exhibit a corresponding increase,and notable statistical heterogeneity was observed among the studies.Acupuncture-assisted frozen-thawed embryo transfer enhanced the BPR(RR:1.51,95%CI:1.21-1.89,P=0.03)and improved endometrial morphology(RR:1.41,95%CI:1.13-1.75,P=0.01).Furthermore,IVF outcomes were significantly superior in the acupuncture group when acupuncture was administered during controlled ovarian hyperstimulation(RR:1.71,95%CI:1.08-2.13,95%CI:1.08-4.21,P=0.03).CONCLUSION We find that acupuncture positively influences pregnancy rates in women receiving IVF treatment.Nonetheless,there are no established guidelines for optimal acupuncture protocols.Considering the methodological limitations identified in current research,there is a need for larger,methodologically rigorous studies.
基金supported by the National Natural Science Foundation of China(Grant No.12275154)the Guangdong Basic and Applied Basic Research Foundation,China(Project No.2021B1515140028)+1 种基金the Youth Innovation Promotion Association,CAS(No.2020010)the National Key Research and Development Program of China,grant number(Nos.2021YFA1600701 and 2021YFB3501201).
文摘Solid-state precipitation is an effective strategy for tuning the mechanical and functional properties of ad-vanced alloys.Structure design and modification necessitate good knowledge of the kinetic evolution of precipitates during fabrication,which is strongly correlated with defect concentration.For Fe-Ga alloys,giant magnetostriction can be induced by the precipitation of the nanoscale tetragonal L60 phase.By introducing quenched-in vacancies,we significantly enhance the magnetostriction of the aged Fe81Ga19 polycrystalline alloys to~305 ppm,which is close to the level of single crystals.Although vacancies were found to facilitate the generation of the L60 phase,their impact on the precipitation mechanism and kinetics has yet to be revealed.This study combined transmission electron microscopy(TEM)and time-resolved small-angle neutron scattering(SANS)to investigate the precipitation of the L60 phase during the isothermal aging at 350 and 400℃,respectively.The evolution of L60 nanophase in morphology and number density in as-cast(AC)and liquid nitrogen quenched(LN)Fe81Ga19 alloys with aging time were quantitatively compared.Interestingly,the nucleation of the L60 phase proceeds progressively in AC while suddenly in LN specimens,indicating the homogenous to heterogeneous mechanism switching in-duced by concentrated vacancies.Moreover,excess vacancies can change the shape of nanoprecipitates and significantly accelerate the growth and coarsening kinetics.The magnetostrictive coefficient is opti-mized when the size(long-axis)of L60 precipitates lies between 100 and 110Åwith a number density between 3.2-4.3×10-7Å-3.Insight from this study validates the feasibility of achieving high magnetoe-lastic properties through precise manipulation of the nanostructure.
基金supported by the National Natural Science Foundation of China Projects under Grant(nos.52301112,52331004,U21A2049,and 51871211)Guangdong Basic and Applied Basic Research Foundation(Grant no.2024A1515030065)+4 种基金Basic and Applied Basic Research Project of Guangzhou(Grant no.2024A04J6299)LiaoNing Revitalization Talents Program(XLYC1907062,and XLYC2403026)Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(RC231178)the Fundamental Research Funds for the Central Universities(N25GFY002)the Innovation Fund of Institute of Metal Research(IMR),Chinese Academy of Sciences(CAS).
文摘Mg-Li alloys hold significant potential for applications in aerospace,automotive manufacturing,military weaponry,and biomedical implants,due to their excellent recyclability,high specific strength,biocompatibility,and superior electromagnetic shielding properties.However,their poor corrosion resistance and high susceptibility to environmentally assisted cracking(EAC)significantly limit broader application.In recent years,growing attention has been directed toward understanding the corrosion and EAC behavior of Mg-Li alloys,as localized corrosion areas and hydrogen generated during the corrosion process can serve as crack initiation points and promote crack propagation.A comprehensive understanding of these mechanisms is essential for enhancing the reliability and performance of Mg-Li alloys in practical environments.This paper presents a detailed review of corrosion and EAC in Mg-Li alloys,focusing on corrosion behavior,crack initiation and propagation mechanisms,and the key factors influencing these processes.It summarizes recent advances in alloying,heat treatment,mechanical processing,microstructural control,environmental influences,mechanical loading,and surface treatments.In addition,the paper explores future research directions,highlights emerging trends,and proposes strategies to improve the durability and service performance of Mg-Li alloys.
基金supported by Natural Science Foundation of Hubei Province(ZRMS2020002466 to Liu Z).
文摘Dear Editor,Radical cystectomy(RC)remains the standard treatment for muscle-invasive bladder cancer[1].However,urinary diversion after RC can lead to a range of postoperative complications,including parastomal hernia,incontinence,urinary retention,recurrent urinary tract infections,and metabolic disorders,significantly impacting patients'quality of life[2].Partial cystectomy(PC)is a bladdersparing alternative for patients who cannot accept RC and has been utilized in managing muscle-invasive bladder cancer since the last century.However,the application of PC has always been a subject of controversy in clinical practice due to the high recurrence rate.In a matched case-control analysis conducted by Knoedler et al.[3],38%of the patients experienced intravesical tumor recurrence,and 19%of the patients ultimately underwent RC.Another study in the Memorial Sloan-Kettering Cancer Center showed that 22 of 58 patients who received PC experienced superficial or advanced recurrence[4].
文摘Dear Editor,Robotic-assisted laparoscopic varicocelectomy(RALV)has been recently described in the pediatric field[1].Although the learning curve of surgical procedures is flattened by a robotic approach[2],complications may occur especially at the beginning of experience.We herein describe an unexpected severe case of parietal blood dripping in a boy who underwent RALV.The study was approved by the institutional review board of Federico Il University Hospital in Naples,Italy(approval number:Fll/2024-PL149).All procedures performed were in accordance with the ethical standards of the institution and/or national research committee.The written informed consent was obtained by his parents to agree the treatment and publish this paper.
基金National Natural Science Foundation Council of China(Grant No.52305359)Hubei Provincial Natural Science Foundation of China(Grant No.2023AFB141)National Medical Products Administration Key Laboratory for Dental Materials(PKUSS20240401)。
文摘In tissue engineering(TE),tissue-inducing scaffolds are a promising solution for organ and tissue repair owing to their ability to attract stem cells in vivo,thereby inducing endogenous tissue regeneration through topological cues.An ideal TE scaffold should possess biomimetic cross-scale structures,similar to that of natural extracellular matrices,at the nano-to macro-scale level.Although freeform fabrication of TE scaffolds can be achieved through 3D printing,this method is limited in simultaneously building multiscale structures.To address this challenge,low-temperature fields were adopted in the traditional fabrication processes,such as casting and 3D printing.Ice crystals grow during scaffold fabrication and act as a template to control the nano-and micro-structures.These microstructures can be optimized by adjusting various parameters,such as the direction and magnitude of the low-temperature field.By preserving the macro-features fabricated using traditional methods,additional micro-structures with smaller scales can be incorporated simultaneously,realizing cross-scale structures that provide a better mimic of natural organs and tissues.In this paper,we present a state-of-the-art review of three low-temperature-field-assisted fabrication methods—freeze casting,cryogenic3D printing,and freeze spinning.Fundamental working principles,fabrication setups,processes,and examples of biomedical applications are introduced.The challenges and outlook for low-temperature-assisted fabrication are also discussed.
基金supported in part by the National Natural Science Foundation of China under Grants 62325107,62341107,62261160650,and U23A20272in part by the Beijing Natural Science Foundation under Grant L222002.
文摘In this paper,we propose a sub-6GHz channel assisted hybrid beamforming(HBF)for mmWave system under both line-of-sight(LOS)and non-line-of-sight(NLOS)scenarios without mmWave channel estimation.Meanwhile,we resort to the selfsupervised approach to eliminate the need for labels,thus avoiding the accompanied high cost of data collection and annotation.We first construct the dense connection network(DCnet)with three modules:the feature extraction module for extracting channel characteristic from a large amount of channel data,the feature fusion module for combining multidimensional features,and the prediction module for generating the HBF matrices.Next,we establish a lightweight network architecture,named as LDnet,to reduce the number of model parameters and computational complexity.The proposed sub-6GHz assisted approach eliminates mmWave pilot resources compared to the method using mmWave channel information directly.The simulation results indicate that the proposed DCnet and LDnet can achieve the spectral efficiency that is superior to the traditional orthogonal matching pursuit(OMP)algorithm by 13.66% and 10.44% under LOS scenarios and by 32.35% and 27.75% under NLOS scenarios,respectively.Moreover,the LDnet achieves 98.52% reduction in the number of model parameters and 22.93% reduction in computational complexity compared to DCnet.
基金National Science Fund for Distinguished Young Scholars(No.52225505)the National Sci-ence and Technology Major Project(No.J2019-VII-0014-0154)+1 种基金the National Natural Science Foundation of China(No.52005412)the Tianjin Natural Science Foundation of China-Multi-input key projects(No.22JCZDJC00650)for financial supports given to this research.
文摘The electrically assisted(EA)deformation process has received considerable attention in recent years,ac-companied by research on current-induced deformation mechanisms.However,there are still challenges in eliminating thermal effects,which have prevented a comprehensive understanding of the underlying current-induced mechanisms.Opting for a single crystal(SC)in research provides advantages in decou-pling the nonthermal effect of electric current at smaller scales and eliminating the complex interactions that exist in polycrystalline materials.Therefore,the innovation of this work lies in decoupling the non-thermal effect of electric current and conducting a comprehensive analysis of anisotropic deformation and mechanisms within a Ni-based SC with different crystallographic axes and various current directions dur-ing electrically assisted tensile simulation.A significant tension axis direction in the SC during EA tension was induced by the combination of a higher current direction factor(|cosθ|)and a dimensionless factor for the current density(|J^(α)/J_(0)^(α)|)along the[100]axis.The stress drop within the SC due to the nonthermal effect of electric current generally increased with increasing current direction.This was attributed to the increased dislocation density differences and decreased temperature.The increased stress anisotropy of the SC at a current direction of 45°was attributed to fewer activated(111)slip systems and the pinning effect of more dislocations within these systems.This study advances our understanding of the thermal and nonthermal effects of electric current and offers valuable insights for the informed application of EA deformations in industrial and aerospace settings with SC superalloys.
文摘Reproductive medicine has been transformed by assisted reproductive technologies(ART),providing multiple options for infertile couples to conceive biological offspring.The medical and legal frameworks,governing the practice of embryologists in ART,focus on the ethical and safe handling of gametes and embryos.Embryologists play a crucial role in the success of ART procedures,requiring technical expertise and a thorough understanding of legal and ethical considerations.The importance of quality control,safety protocols,and sterility in ART laboratories is essential to ensure optimal embryo development and patient well-being.The legal responsibilities of an embryologist under the Assisted Reproductive Technology(Regulation)Act,2021 in India are required.This review emphasizes the importance of record-keeping,patient confidentiality,informed consent,and adherence to legal and ethical standards to minimize the risk of malpractice claims.Overall,this narrative review provides a detailed overview of the medical,legal,and ethical frameworks governing embryologists'practice in ART,underscoring the significance of responsible and ethical conduct in this rapidly advancing field.
基金Supported by National Natural Science Foundation of China(Grant Nos.52475480,51805334)Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2023A1515030249,2023A1515110059)Shenzhen Science and Technology Program(Grant No.GJHZ20220913144212023).
文摘SiC-reinforced aluminum matrix(SiCp/Al)composite is widely utilized in the aerospace,automotive,and electronics industries due to the combination of ceramic hardness and metal toughness.However,the significant disparity in properties between SiC particles and the aluminum matrix results in severe tool wear and diminished surface quality during conventional machining.This study proposes an environmentally friendly and clean dry electrical discharge assisted grinding process as an efficient and low-damage machining method for SiCp/Al.An experimental platform was set up to study the impact of grinding and discharge process parameters on surface quality.The study compared the chip formation mechanism and surface quality between dry electrical discharge assisted grinding and conventional grinding,revealing relationships between surface roughness,grinding force,grinding temperature,and related parameters.The results indicate that the proposed grinding method leads to smaller chip sizes,lower grinding forces and temperatures,and an average reduction of 19.2%in surface roughness compared to conventional grinding.The axial,tangential,and normal grinding forces were reduced by roughly 10.5%,37.8%,and 23.0%,respectively.The optimized process parameters were determined to be N=2500 r/min,vf=30 mm/min,a=10μm,E=15 V,f=5000 Hz,dc=80%,resulting in a surface roughness of 0.161μm.
文摘The rapidly evolving environment of assisted reproductive technology(ART)requires consideration of how new innovations are reshaping clinical practice as much as research.In particular,there are three key areas that,while full of promise,also present significant challenges:the use of artificial intelligence(AI)in embryo selection,the impact of personalized medicine on ART success rates,and the ethical considerations of genetic screening of embryos[1].This letter is meant to provoke further discussion and highlight the need for harmonized global guidelines as these advances continue to reshape the reproductive medicine environment.
文摘Sperm-structure-integrating nanodecorated microrobots have shown promise in medicine delivery and infertility treatment.A variety of spermbots use cutting-edge nanomaterials and 3D printing technology to enhance their functioning,such as biomimetic sperms and flagellate microorganisms.The success rates of assisted reproductive technology techniques like in vitro fertilisation(IVF)and intracytoplasmic sperm injection(ICSI)may increase as a result of these developments.Furthermore,the incorporation of artificial intelligence(AI)into spermbots has the potential to optimize reproductive therapies by reducing inherited illnesses through genetic screening and editing.However,before the widespread implementation of spermbots in clinical practice,several critical aspects must be addressed.Thorough investigations into biocompatibility,ethical considerations,and long-term safety are necessary to ensure that these technologies are safe and effective for in vivo applications.
基金supported by grants from the National Natural Science Foundation of China(82373189)the Science and Technology Department of Sichuan Province(2021YFS0375 and2022YFS0596)。
文摘Intestinal autotransplantation(IATx)allows for radical resection to be performed on selected patients with superior mesenteric artery(SMA)involvement.However,the complexity of IATx is a major consideration.This surgical technique requires a simpler approach,shorter operative time and lower perioperative risk.Our group has successfully pioneered a semi-ex vivo IATx approach for patients with locally advanced pancreatic cancer with the SMA,superior mesenteric vein(SMV),and jejunal artery(JA)branch involvement.The present report illustrates how this operation was carried out.At a follow-up of up to 8 months,there were no signs of tumor recurrence.
基金Supported by National Natural Science Foundation of China(Grant Nos.52075360,52275360,51805359).
文摘Current research on the fabrication of rolled composite plates primarily focuses on processing and bonding mechanisms.Compared with hot-rolling technology,the electrically assisted rolling process has demonstrated excellent performance in interfacial bonding effects.However,the influence of different current loading modes on the interfacial recombination process of composite panels varies significantly.In this study,low-frequency electrically assisted rolling was used in the first pass to pre-bond a composite plate at a low reduction rate of 15%.High-frequency electrically assisted rolling was used during the second pass,and Al/Mg alloy composite plates were obtained.The interfacial microstructure and mechanical properties of the composite plate were coordinated regulation by designing the rolling reduction rate.The results showed the interfacial morphology of the alternating distribution of the melt-diffusion layer,diffusion layer,and the formation of a new Al/Mg bonding interface.At the melt-diffusion interface,the irregular intermetallic compounds(IMCs)and the new Al/Mg bonding interface were alternately distributed,and the IMCs contained theα-Mg,Mg17Al12,and Mg2Al3 phases.In addition,an extremely high shear strength of 78.26 MPa was achieved.Adhesion of the Mg alloy matrix was observed on the fracture surface of the Al alloy side.The high shear strength was mainly attributed to the formation of a unique interfacial structure and the appearance of a melt-diffusion layer.Compared to the diffusion-reduction interface,the regular rectangular IMCs and the new Al/Mg bonding interface were alternately distributed,and the IMCs consisted of the Mg17Al12 and Mg2Al3 phases.The shear test results showed that the shear strength of the interface reached 68.69 MPa,and a regular distribution of the Mg alloy matrix with dimples and the Al alloy matrix with a necking zone was observed on the fracture surface of the Al side.Tensile strength test results revealed a maximum value of 316.86 MPa for the Al/Mg alloy composite plate.The tensile and interfacial bonding strengths can be synchronously enhanced by coordinating the regulation of the interfacial structure.This study proposes a new electrically assisted rolling technology that is useful for the fabrication of composite plates with excellent mechanical properties.
文摘BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is contraindicated for patients with cavernous transformation of the portal vein(CTPV)due to high surgery-related mortality risk.However,surgically assisted TIPS(SATIPS)can significantly reduce the risk.AIM To evaluate the clinical efficacy of SATIPS,this study was conducted.METHODS One hundred and seven patients with CTPV and esophagogastric variceal bleeding were recruited from January 2023 to December 2024.The patients were recruited from three different hospitals.Overall,54 patients received SATIPS treatment(SATIPS group),while 53 patients did not receive SATIPS and underwent prophylactic endoscopic sclerosing ligation(control group).Subsequently,survival rates,incidence rates of gastrointestinal bleeding,incidence of hepatic encephalopathy rate,and the incidence of liver failure after treatment in both groups at 3 and 6 months were observed.RESULTS The survival rates for the SATIPS and control groups were 94.4%and 92.5%at 3 months(P value=0.72)and 94.4%and 73.6%at 6 months(P value=0.0051)respectively.The incidence of liver failure was 3.7%and 9.4%at 3 months(P value=0.26)and 3.7%and18.9%at 6 months(P value=0.016);the incidence of gastrointestinal bleeding was 5.6%and 37.7%at 3 months(P value<0.001)and 9.3%and 47.2%(P value<0.001)at 6 months;and the incidence of hepatic encephalopathy was 3.7%and 17.0%at 3 months(P value=0.026)and 7.4%and 26.4%at 6 months(P value=0.026)respectively.CONCLUSION For patients with CTPV,there were no optimal treatment.Regarding long-term efficacy,SATIPS can significantly reduce the rate of rebleeding,hepatic encephalopathy and liver failure,and is associated with better survival.
