This thesis aims at investigating what the discourse patterns are in the asking-for-leave notes written by Chinese students and native English speakers respectively and what excuses are given by Chinese students and n...This thesis aims at investigating what the discourse patterns are in the asking-for-leave notes written by Chinese students and native English speakers respectively and what excuses are given by Chinese students and native English speakers.Role play and retrospective interview were employed as research methords.The results show that the Chinese students all use an inductive pattern,while all native English speakers write the note in a deductive way.Besides,the excuses presented by the two kinds of subjects are different due to their different cultural background.展开更多
A: Hello, B. What’s the hurry?B: Well. we have a meeting And I’m afraid I’ll be late, Do youhave the time?A: It’s ten minuter to three.B: Good gracious. Then I’m early. And I thought I was
Mr King lives in a village.He has a piece of farm and he works hard on it.He is very busy and has little time to travel.This autumn he picked a lot of apples in his garden.He sold them in the town and got much money,s...Mr King lives in a village.He has a piece of farm and he works hard on it.He is very busy and has little time to travel.This autumn he picked a lot of apples in his garden.He sold them in the town and got much money,so he was going to travel in London.His wife asked him to take her there.He agreed with her and a few days later they took a train and left for the capital.They visited some places of interest,parks and zoos.Mrs King bought nice clothes for her family and they had a good time there.But one evening the woman felt unwell.Her husband had to take her to ahopital.But he didn’t know where the hospital was.He stopped a man and asked,“Excuseme,sir,which is the way to the hospital,please?”But the man didn’t know English.Mr King said sorry to him and had to ask others.He saw a few young men come out of a pub.He came up to them and asked them the way.They all drank too much.One of them said,“You’d better lie in the middle of the street and soon they will take you to the hospital.展开更多
That old standby conversation opener between strangers may not cut it inBeijing right now. "Lovely weather we’re having,"is possibly the last opening line local residents would want
随着新课程改革的不断深入,课堂正以崭新的面貌出现在我们面前。课堂已由"以知识为中心"的知识性教学转化为"以人为本"的发展性教学,课堂生成很难与教师原有的教学设计完全吻合。当学生在课堂上的生成与教师预设的...随着新课程改革的不断深入,课堂正以崭新的面貌出现在我们面前。课堂已由"以知识为中心"的知识性教学转化为"以人为本"的发展性教学,课堂生成很难与教师原有的教学设计完全吻合。当学生在课堂上的生成与教师预设的思维轨道不一致时,教师应随机应变及时调整教学设计,因势利导,以达到教学相长的目的。下面笔者谈谈在执教六年级时的一次课堂教学经历。【课堂实录】这是《牛津小学英语》六年级下册Unit3《Asking the way》第二课时。展开更多
Background:Apoptosis signal-regulating kinase 1(ASK1)is a MAP3K kinase in the MAPK signaling pathway activated by stressors and triggers downstream biological effects such as inflammation and apoptosis;therefore,inhib...Background:Apoptosis signal-regulating kinase 1(ASK1)is a MAP3K kinase in the MAPK signaling pathway activated by stressors and triggers downstream biological effects such as inflammation and apoptosis;therefore,inhibition of ASK1 kinase ac-tivity can protect cells from pathological injury.In this study,we designed and synthe-sized a novel selective ASK1 inhibitor,CS17919,and investigated its pharmacological effects in various animal models of metabolic injury.Methods:First,we validated the ability of CS17919 to inhibit ASK1 in vitro and then tested the safety profile of CS17919 in cell lines compared with Selonsertib(GS-4997),a phase III ASK1 inhibitor.We then conducted pharmacokinetic(PK)studies in mice.Finally,we tested the in vivo efficacy of CS17919 in murine models of chronic kidney disease(CKD)and non-alcoholic steatohepatitis(NASH).Results:Compared to GS-4997,CS17919 demonstrated comparable inhibition of ASK1 in vitro,exhibited lower toxicity,and provided greater protection in palmitic acid-treated LO2 cells.CS17919 also showed pronounced pharmacokinetic prop-erties such as a high plasma concentration.In the unilateral ureteral obstruction model(UUO),CS17919 and GS-4997 preserved kidney function and showed a non-significant tendency to alleviate kidney fibrosis.In the diabetic kidney disease(DKD)model,CS17919 significantly improved serum creatinine and glomerular sclerosis.In the NASH model,the combination of CS17919 and a THRβagonist(CS27109)was found to significantly improve liver inflammation and substantially reduced liver fibrosis.Conclusions:CS17919 showed cell protective,anti-inflammatory,and antifibrotic ef-fects in vitro and in vivo,suggesting its therapeutic potential for metabolic-related kidney and liver diseases.展开更多
探讨科学传播以何“出圈”,不仅是对科学传播现实困境的回应,也是响应国家提升全民科学素养的战略所需。研究引入迷因理论,对“Ask Me Anything”迷因这一科学传播“出圈”案例展开分析。研究发现,“Ask Me Anything”作为一种网络迷因...探讨科学传播以何“出圈”,不仅是对科学传播现实困境的回应,也是响应国家提升全民科学素养的战略所需。研究引入迷因理论,对“Ask Me Anything”迷因这一科学传播“出圈”案例展开分析。研究发现,“Ask Me Anything”作为一种网络迷因,其科学传播的“出圈”立足于易模仿且稳定的符号基础,科学家示范效应与魅力驱动,参与且可见的对话机制,以及平台算法与流量运营的合力助推。在此基础上,研究为新媒体环境下科学传播的“出圈”提出相应实践策略。展开更多
文摘This thesis aims at investigating what the discourse patterns are in the asking-for-leave notes written by Chinese students and native English speakers respectively and what excuses are given by Chinese students and native English speakers.Role play and retrospective interview were employed as research methords.The results show that the Chinese students all use an inductive pattern,while all native English speakers write the note in a deductive way.Besides,the excuses presented by the two kinds of subjects are different due to their different cultural background.
文摘A: Hello, B. What’s the hurry?B: Well. we have a meeting And I’m afraid I’ll be late, Do youhave the time?A: It’s ten minuter to three.B: Good gracious. Then I’m early. And I thought I was
文摘Mr King lives in a village.He has a piece of farm and he works hard on it.He is very busy and has little time to travel.This autumn he picked a lot of apples in his garden.He sold them in the town and got much money,so he was going to travel in London.His wife asked him to take her there.He agreed with her and a few days later they took a train and left for the capital.They visited some places of interest,parks and zoos.Mrs King bought nice clothes for her family and they had a good time there.But one evening the woman felt unwell.Her husband had to take her to ahopital.But he didn’t know where the hospital was.He stopped a man and asked,“Excuseme,sir,which is the way to the hospital,please?”But the man didn’t know English.Mr King said sorry to him and had to ask others.He saw a few young men come out of a pub.He came up to them and asked them the way.They all drank too much.One of them said,“You’d better lie in the middle of the street and soon they will take you to the hospital.
文摘That old standby conversation opener between strangers may not cut it inBeijing right now. "Lovely weather we’re having,"is possibly the last opening line local residents would want
文摘随着新课程改革的不断深入,课堂正以崭新的面貌出现在我们面前。课堂已由"以知识为中心"的知识性教学转化为"以人为本"的发展性教学,课堂生成很难与教师原有的教学设计完全吻合。当学生在课堂上的生成与教师预设的思维轨道不一致时,教师应随机应变及时调整教学设计,因势利导,以达到教学相长的目的。下面笔者谈谈在执教六年级时的一次课堂教学经历。【课堂实录】这是《牛津小学英语》六年级下册Unit3《Asking the way》第二课时。
文摘Background:Apoptosis signal-regulating kinase 1(ASK1)is a MAP3K kinase in the MAPK signaling pathway activated by stressors and triggers downstream biological effects such as inflammation and apoptosis;therefore,inhibition of ASK1 kinase ac-tivity can protect cells from pathological injury.In this study,we designed and synthe-sized a novel selective ASK1 inhibitor,CS17919,and investigated its pharmacological effects in various animal models of metabolic injury.Methods:First,we validated the ability of CS17919 to inhibit ASK1 in vitro and then tested the safety profile of CS17919 in cell lines compared with Selonsertib(GS-4997),a phase III ASK1 inhibitor.We then conducted pharmacokinetic(PK)studies in mice.Finally,we tested the in vivo efficacy of CS17919 in murine models of chronic kidney disease(CKD)and non-alcoholic steatohepatitis(NASH).Results:Compared to GS-4997,CS17919 demonstrated comparable inhibition of ASK1 in vitro,exhibited lower toxicity,and provided greater protection in palmitic acid-treated LO2 cells.CS17919 also showed pronounced pharmacokinetic prop-erties such as a high plasma concentration.In the unilateral ureteral obstruction model(UUO),CS17919 and GS-4997 preserved kidney function and showed a non-significant tendency to alleviate kidney fibrosis.In the diabetic kidney disease(DKD)model,CS17919 significantly improved serum creatinine and glomerular sclerosis.In the NASH model,the combination of CS17919 and a THRβagonist(CS27109)was found to significantly improve liver inflammation and substantially reduced liver fibrosis.Conclusions:CS17919 showed cell protective,anti-inflammatory,and antifibrotic ef-fects in vitro and in vivo,suggesting its therapeutic potential for metabolic-related kidney and liver diseases.
文摘探讨科学传播以何“出圈”,不仅是对科学传播现实困境的回应,也是响应国家提升全民科学素养的战略所需。研究引入迷因理论,对“Ask Me Anything”迷因这一科学传播“出圈”案例展开分析。研究发现,“Ask Me Anything”作为一种网络迷因,其科学传播的“出圈”立足于易模仿且稳定的符号基础,科学家示范效应与魅力驱动,参与且可见的对话机制,以及平台算法与流量运营的合力助推。在此基础上,研究为新媒体环境下科学传播的“出圈”提出相应实践策略。
