<b><span style="font-family:Verdana;">The objective of our study</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;&qu...<b><span style="font-family:Verdana;">The objective of our study</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;"> was to investigate the association between the Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-АR gene and body mass index (BMI) in patients with bronchial asthma (BA) with regard to the age of onset. </span><b><span style="font-family:Verdana;">Materials and methods</span></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;"> 553 patients were examined. The control group consisted of 95 apparently healthy individuals. The patients were divided into 2 groups depending on the age of BA onset: 282 patients with late onset (Group I) and 271 patients with early onset (Group II). Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-АR gene (rs1042713) was determined using polymerase chain reaction-</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">restriction fragment length polymorphism analysis. Statistical analysis of obtained results was performed using SPSS–17 program. </span><b><span style="font-family:Verdana;">Results</span></b></span><b><span style="font-family:Verdana;">:</span><span style="font-family:;" "=""> </span></b><span style="font-family:;" "=""><span style="font-family:Verdana;">There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-AR gene depending on BMI (</span><i><span style="font-family:Verdana;">χ</span></i><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 5.74;р = 0.22), and no association was found with obesity risks disregarding the age of BA onset. The study on the frequency of genotypes for this polymorphism with regard to the age of asthma onset and BMI found statistically significant differences between early-onset (</span><i><span style="font-family:Verdana;">χ</span></i><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 11.27;p = 0.02) and late-onset (</span><i><span style="font-family:Verdana;">χ</span></i><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 10.66;p = 0.03) asthma. It was found that the risk of obesity in Group I patients was 1.57 times higher in the additive model and 2.67 times higher—in the recessive model of inheritance. In patients with late-onset asthma, Gly16 allele in the recessive model of inheritance was found to have a protective role against obesity. </span><b><span style="font-family:Verdana;">Conclusions</span></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;"> There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-AR gene with regard to BMI, and no association was found with obesity risks in BA patients disregarding the age of BA onset. The risk of obesity in patients with early-onset asthma was 1.6 times higher in the additive model and 2.7 times higher—in the recessive model of inheritance.</span></span>展开更多
文摘<b><span style="font-family:Verdana;">The objective of our study</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;"> was to investigate the association between the Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-АR gene and body mass index (BMI) in patients with bronchial asthma (BA) with regard to the age of onset. </span><b><span style="font-family:Verdana;">Materials and methods</span></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;"> 553 patients were examined. The control group consisted of 95 apparently healthy individuals. The patients were divided into 2 groups depending on the age of BA onset: 282 patients with late onset (Group I) and 271 patients with early onset (Group II). Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-АR gene (rs1042713) was determined using polymerase chain reaction-</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">restriction fragment length polymorphism analysis. Statistical analysis of obtained results was performed using SPSS–17 program. </span><b><span style="font-family:Verdana;">Results</span></b></span><b><span style="font-family:Verdana;">:</span><span style="font-family:;" "=""> </span></b><span style="font-family:;" "=""><span style="font-family:Verdana;">There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-AR gene depending on BMI (</span><i><span style="font-family:Verdana;">χ</span></i><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 5.74;р = 0.22), and no association was found with obesity risks disregarding the age of BA onset. The study on the frequency of genotypes for this polymorphism with regard to the age of asthma onset and BMI found statistically significant differences between early-onset (</span><i><span style="font-family:Verdana;">χ</span></i><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 11.27;p = 0.02) and late-onset (</span><i><span style="font-family:Verdana;">χ</span></i><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> = 10.66;p = 0.03) asthma. It was found that the risk of obesity in Group I patients was 1.57 times higher in the additive model and 2.67 times higher—in the recessive model of inheritance. In patients with late-onset asthma, Gly16 allele in the recessive model of inheritance was found to have a protective role against obesity. </span><b><span style="font-family:Verdana;">Conclusions</span></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;"> There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the </span><i><span style="font-family:Verdana;">β</span></i><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">-AR gene with regard to BMI, and no association was found with obesity risks in BA patients disregarding the age of BA onset. The risk of obesity in patients with early-onset asthma was 1.6 times higher in the additive model and 2.7 times higher—in the recessive model of inheritance.</span></span>
