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Seismic responses and shattering cumulative effects of bedding parallel stepped rock slope:Model test and numerical simulation 被引量:1
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作者 Chunlei Xin Fei Yang +2 位作者 Wenkai Feng Zhao Wang Wenhui Li 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第4期2009-2030,共22页
Bedding parallel stepped rock slopes exist widely in nature and are used in slope engineering.They are characterized by complex topography and geological structure and are vulnerable to shattering under strong earthqu... Bedding parallel stepped rock slopes exist widely in nature and are used in slope engineering.They are characterized by complex topography and geological structure and are vulnerable to shattering under strong earthquakes.However,no previous studies have assessed the mechanisms underlying seismic failure in rock slopes.In this study,large-scale shaking table tests and numerical simulations were conducted to delineate the seismic failure mechanism in terms of acceleration,displacement,and earth pressure responses combined with shattering failure phenomena.The results reveal that acceleration response mutations usually occur within weak interlayers owing to their inferior performance,and these mutations may transform into potential sliding surfaces,thereby intensifying the nonlinear seismic response characteristics.Cumulative permanent displacements at the internal corners of the berms can induce quasi-rigid displacements at the external corners,leading to greater permanent displacements at the internal corners.Therefore,the internal corners are identified as the most susceptible parts of the slope.In addition,the concept of baseline offset was utilized to explain the mechanism of earth pressure responses,and the result indicates that residual earth pressures at the internal corners play a dominant role in causing deformation or shattering damage.Four evolutionary deformation phases characterize the processes of seismic responses and shattering failure of the bedding parallel stepped rock slope,i.e.the formation of tensile cracks at the internal corners of the berm,expansion of tensile cracks and bedding surface dislocation,development of vertical tensile cracks at the rear edge,and rock mass slipping leading to slope instability.Overall,this study provides a scientific basis for the seismic design of engineering slopes and offers valuable insights for further studies on preventing seismic disasters in bedding parallel stepped rock slopes. 展开更多
关键词 Rock slope stability Shaking table test Numerical simulation Permanent displacement Acceleration amplification factor
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Design of insulation support system of 120 keV positive ion source accelerator
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作者 Wen DENG Yahong XIE +5 位作者 Yuming GU Yunfei JIANG Longbin LIU Fang WANG Jianglong WEI Chundong HU 《Plasma Science and Technology》 2025年第1期128-133,共6页
In order to support the physical research on the EAST tokamak,a new positive ion source with designed beam energy of 120 keV was proposed to be developed.Accelerator structure is one of the key components of the ion s... In order to support the physical research on the EAST tokamak,a new positive ion source with designed beam energy of 120 keV was proposed to be developed.Accelerator structure is one of the key components of the ion source.Through the finite element analysis method,the electrostatic analyses of insulators and grid plates were carried out,the material and structure parameters of insulators were determined.The maximum electric field around each insulator is about 4 kV/mm,and the maximum electric field between grids is about 14 kV/mm,which can meet the 120 keV withstand voltage holding.The insulation system for the positive ion source accelerator with 120 keV is designed,and the connection and basic parameters of insulators and support flanges are analyzed and determined. 展开更多
关键词 positive ion source accelerator insulation support system electrostatic simulation
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Compact RF linear accelerator for electron beam irradiation applications at PBP-CMU Electron Linac Laboratory
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作者 Monchai Jitvisate Pittaya Apiwattanakul +3 位作者 Noppadol Kangrang Jatuporn Saisut Chitrlada Thongbai Sakhorn Rimjaem 《Nuclear Science and Techniques》 2025年第4期45-58,共14页
A 4 MeV RF linear accelerator for electron beam irradiation applications has been developed at the PBP-CMU Electron Linac Laboratory,Thailand.The system has been reengineered using a decommissioned medical linear acce... A 4 MeV RF linear accelerator for electron beam irradiation applications has been developed at the PBP-CMU Electron Linac Laboratory,Thailand.The system has been reengineered using a decommissioned medical linear accelerator.The main components include a thermionic DC electron gun,an RF linear accelerator,a beam diagnostic chamber,and a beam exit window for electron beam irradiation.Therefore,reengineering must be performed based on the characteristics of the electron beam and its dynamics throughout the system.In this study,the electron beam current density emitted from the cathode was calculated based on the thermionic emission theory,and the result was used to produce the electron beam distribution in the gun using CST Studio Suite^(■)software.The properties of the electron beam and its acceleration in the linear accelerator and downstream diagnostic section were studied using the ASTRA electron beam dynamics simulation code,with the aim of producing an electron beam with an average energy of 4 MeV at the linear accelerator exit.The transverse beam profile and electron deposition dose in the ambient environment were calculated using Geant4 Monte Carlo simulation software to estimate the beam performance for the irradiation experiments.The parameters studied can be used as guidelines for machine operation and future experimental plans. 展开更多
关键词 Thermionic electron gun RF linear accelerator Electron dynamics simulation Monte Carlo simulation Electron beam irradiation Electron beam processing Deposition dose
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高速公路平行式加速车道渐变段长度计算模型对比研究
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作者 邵长桥 张东宇 《重庆交通大学学报(自然科学版)》 北大核心 2026年第1期1-6,14,共7页
平行式加速车道渐变段对保障高速公路合流区运行效率与安全具有关键作用,现有渐变段长度计算模型因考虑因素不同,导致结果差异显著。基于此,对比研究了多种平行式加速车道渐变段长度计算模型。基于实测数据与国内外文献,给出了不同模型... 平行式加速车道渐变段对保障高速公路合流区运行效率与安全具有关键作用,现有渐变段长度计算模型因考虑因素不同,导致结果差异显著。基于此,对比研究了多种平行式加速车道渐变段长度计算模型。基于实测数据与国内外文献,给出了不同模型理论计算结果;并以合流车辆平均运行速度及与主线车辆交通冲突数为指标,运用VISSIM仿真分析各模型所对应渐变段长度的合理性。研究结果表明:渐变率模型对应的车辆平均速度最高,横移换道模型的交通冲突数最少,换道行驶距离模型在平均速度与交通冲突数方面均表现最优;最终建议,在主线设计速度为120、100、80 km/h时,平行式加速车道渐变段长度分别取150、130、115 m。 展开更多
关键词 道路工程 高速公路合流区 平行式加速车道 渐变段长度 VISSIM仿真
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MONTE CARLO SIMULATION OF RADIATION FIELD OPTIMIZATION FOR MEDICAL LINAC 被引量:2
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作者 赵洪斌 张新 +2 位作者 包尚联 黄斐增 李泉凤 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2010年第1期7-12,共6页
A method for designing an X-ray flatness filter for medical electron linac is developed. It is used in the optimization process in the electron beam radiation system. Monte Carlo simulation method is used and two exam... A method for designing an X-ray flatness filter for medical electron linac is developed. It is used in the optimization process in the electron beam radiation system. Monte Carlo simulation method is used and two examples of real radiation system optimization processes for China-made medical electron linac are provided: 15 MV X- ray system of BJ-20 linac, and 12 MeV electron system of BJ-14. Results are verified by using the traditional method. 展开更多
关键词 linear accelerators computer simulation and Monte Carlo methods radiation system optimization flatness filter design
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Arrhenius relationship and two-step scheme in AF hyperdynamics simulation of diffusion of Mg/Zn interface 被引量:1
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作者 吴永全 陆秀明 沈通 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第2期508-516,共9页
The accelerating factor (AF) method is a simple and appropriate way to investigate the atomic long-time deep diffusion at solid-solid interface. In the framework of AF hyperdynamics (HD) simulation, the relationsh... The accelerating factor (AF) method is a simple and appropriate way to investigate the atomic long-time deep diffusion at solid-solid interface. In the framework of AF hyperdynamics (HD) simulation, the relationship between the diffusion coefficient along the direction of z-axis which is normal to the Mg/Zn interface and temperature was investigated, and the AF's impact on the diffusion constant (D0) and activation energy (Q^*) was studied. Then, two steps were taken to simulate the atomic diffusion process and the formation of new phases: one for acceleration and the other for equilibration. The results show that: the Arrhenius equation works well for the description of Dz with different accelerating factors; the AF has no effect on the diffusion constant Do in the case of no phase transition; and the relationship between Q* and Q conforms to Q^*=Q/A. Then, the new Arrhenius equation for AFHD is successfully constructed as Dz=Doexp[-Q/(ART)]. Meanwhile, the authentic equilibrium conformations at any dynamic moment can only be reproduced by the equilibration simulation of the HD-simulated configurations. Key words: accelerating factor method; Arrhenius equation; two-steps scheme; Mg/Zn interface; hyperdynamic simulation 展开更多
关键词 accelerating factor method Arrhenius equation two-steps scheme Mg/Zn interface hyperdynamic simulation
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Aptix硬件仿真器
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作者 石广源 胡子阳 +1 位作者 宁润涛 王福君 《辽宁大学学报(自然科学版)》 CAS 2005年第4期350-352,共3页
随着设计复杂程度的增加,RTL级仿真验证时间大幅度增加,已经成为设计的瓶颈.使用硬件仿真器可以加快仿真速度,提高仿真效率,是设计百万门以上电路的不可或缺的工具.
关键词 aptix 硬件仿真器
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PIC simulation of plasma properties in the discharge channel of a pulsed plasma thruster with flared electrodes 被引量:3
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作者 Qi LIU Lei YANG +2 位作者 Yuping HUANG Xu ZHAO Zaiping ZHENG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2019年第7期45-53,共9页
Plasma in the discharge channel of a pulsed plasma thruster(PPT) with flared electrodes is simulated by a self-developed two-dimensional code. The fully particle-in-cell method with Monte Carlo collision is employed t... Plasma in the discharge channel of a pulsed plasma thruster(PPT) with flared electrodes is simulated by a self-developed two-dimensional code. The fully particle-in-cell method with Monte Carlo collision is employed to model the particle movement and collisions and investigate the plasma properties and acceleration process. Temporal and spatial variations of the electron density distribution and the ion velocity between electrodes are calculated and analyzed in detail.The computational results of the electron number density, which is in the order of 1023 m-3,show good agreements with experimental results of a PPT named ADD SIMP-LEX. The ion velocity distributions along the center line of the channel lead to a comprehensive understanding of ions accelerated by electromagnetic field. The electron distributions of PPT with discharge voltages varying from 1300 to 2000 V are compared. The diffusion of electrons presents strong dependency on discharge voltage and implies higher degree of ionization for higher voltage. 展开更多
关键词 PULSED plasma THRUSTER DISCHARGE channel PIC simulation electron density distribution ion ACCELERATION
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Design of a 200-MHz continuous-wave radio frequency quadrupole accelerator for boron neutron capture therapy 被引量:2
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作者 Zhi-Chao Gao Liang Lu +3 位作者 Chao-Chao Xing Lei Yang Tao He Xue-Ying Zhang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2021年第3期1-10,共10页
A high-intensity continuous-wave(CW) radio frequency quadrupole(RFQ) accelerator is designed for boron neutron capture therapy.The transmission efficiency of a 20-mA proton beam accelerated from 30 keV to 2.5 MeV can ... A high-intensity continuous-wave(CW) radio frequency quadrupole(RFQ) accelerator is designed for boron neutron capture therapy.The transmission efficiency of a 20-mA proton beam accelerated from 30 keV to 2.5 MeV can reach 98.7% at an operating frequency of 200 MHz.The beam dynamics have a good tolerance to errors.By comparing the high-frequency parameters of quadrilateral and octagonal RFQ cross sections,the quadrilateral structure of the four-vane cavity is selected owing to its multiple advantages,such as a smaller cross section at the same frequency and easy processing.In addition,tuners and undercuts are designed to tune the frequency of the cavity and achieve a flat electric field distribution along the cavity.In this paper,the beam dynamic simulation and electromagnetic design are presented in detail. 展开更多
关键词 RFQ accelerator BNCT Dynamic simulation Electromagnetic design
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Two Improvements on Numerical Simulation of 2-DOF Vortex-Induced Vibration with Low Mass Ratio 被引量:1
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作者 KANG Zhuang NI Wen-chi +1 位作者 ZHANG Xu SUN Li-ping 《China Ocean Engineering》 SCIE EI CSCD 2017年第6期764-772,共9页
Till now, there have been lots of researches on numerical simulation of vortex-induced vibration. Acceptable results have been obtained for fixed cylinders with low Reynolds number. However, for responses of 2-DOF vor... Till now, there have been lots of researches on numerical simulation of vortex-induced vibration. Acceptable results have been obtained for fixed cylinders with low Reynolds number. However, for responses of 2-DOF vortex-induced vibration with low mass ratio, the accuracy is not satisfactory, especially for the maximum amplitudes. In Jauvtis and Williamson's work, the maximum amplitude of the cylinder with low mass ratio m*=2.6 can reach as large as 1.5D to be called as the "super-upper branch", but from current literatures, few simulation results can achieve such value, even fail to capture the upper branch. Besides, it is found that the amplitude decays too fast in the lower branch with the RANS-based turbulence model. The reason is likely to be the defects of the turbulence model itself in the prediction of unsteady separated flows as well as the unreasonable setting of the numerical simulation parameters. Aiming at above issues, a modified turbulence model is proposed in this paper, and the effect of the acceleration of flow field on the response of vortex-induced vibration is studied based on OpenFOAM. By analyzing the responses of amplitude, phase and trajectory, frequency and vortex mode, it is proved that the vortex-induced vibration can be predicted accurately with the modified turbulence model under appropriate flow field acceleration. 展开更多
关键词 2-DOF vortex-induced vibration numerical simulation modified turbulence model ACCELERATION
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QUICK ASSESSMENT METHODOLOGY FOR RELIABILITY OF SOLDER JOINTS IN BALL GRID ARRAY(BGA)ASSEMBLY——PART Ⅱ:RELIABILITY EXPERIMENT AND NUMERICAL SIMULATION 被引量:1
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作者 史训清 John HL Pang +2 位作者 杨前进 王志平 聂景旭 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2002年第4期356-367,共12页
In the present study,a facility,i.e.,a mechanical deflection system (MDS),was established and applied to assess the long-term reliability of the solder joints in plastic ball grid array (BGA) assembly.It was found tha... In the present study,a facility,i.e.,a mechanical deflection system (MDS),was established and applied to assess the long-term reliability of the solder joints in plastic ball grid array (BGA) assembly.It was found that the MDS not only quickly assesses the long-term reliability of solder joints within days,but can also mimic similar failure mechanisms in accelerated thermal cycling (ATC) tests. Based on the MDS and ATC reliability experiments,the acceleration factors (AF) were obtained for different reliability testing conditions.Furthermore,by using the creep constitutive relation and fatigue life model developed in part I,a numerical approach was established for the purpose of virtual life prediction of solder joints. The simulation results were found to be in good agreement with the test results from the MDS.As a result,a new reliability assessment methodology was established as an alternative to ATC for the evaluation of long-term reliability of plastic BGA assembly. 展开更多
关键词 long-term reliability plastic BGA assembly MDS reliability experiment FE numerical simulation acceleration factor
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Exhaustive review of acceleration strategies for Monte Carlo simulations in photon transit 被引量:1
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作者 Louzhe Xu Zijie Zhu Ting Li 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第5期5-21,共17页
Monte Carlo simulation techniques have become the quintessence and a pivotal nexus of inquiry in the realm of simulating photon movement within biological fabrics.Through the stochastic sampling of tissue archetypes d... Monte Carlo simulation techniques have become the quintessence and a pivotal nexus of inquiry in the realm of simulating photon movement within biological fabrics.Through the stochastic sampling of tissue archetypes delineated by explicit optical characteristics,Monte Carlo simulations possess the theoretical capacity to render unparalleled accuracy in the depiction of exceedingly intricate phenomena.Nonetheless,the quintessential challenge associated with Monte Carlo simulation methodologies resides in their extended computational duration,which significantly impedes the refinement of their precision.Consequently,this discourse is specifically dedicated to exploring innovations in strategies and technologies aimed at expediting Monte Carlo simulations.It delves into the foundational concepts of various acceleration tactics,evaluates these strategies concerning their speed,accuracy,and practicality,and amalgamates a comprehensive overview and critique of acceleration methodologies for Monte Carlo simulations.Ultimately,the discourse envisages prospective trajectories for the employment of Monte Carlo techniques within the domain of tissue optics. 展开更多
关键词 Medical optics photon transport simulation Monte Carlo simulation ACCELERATION
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Numerical simulation of chorus-driving acceleration of relativistic electrons at extremely low L-shell during geomagnetic storms 被引量:1
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作者 Zhen-Xia Zhang Ruo-Xian Zhou +3 位作者 Man Hua Xin-Qiao Li Bin-Bin Ni Ju-Tao Yang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第10期711-718,共8页
During 2018 major geomagnetic storm,relativistic electron enhancements in extremely low L-shell regions(reaching L∼3)have been reported based on observations of ZH-1 and Van Allen probes satellites,and the storm is h... During 2018 major geomagnetic storm,relativistic electron enhancements in extremely low L-shell regions(reaching L∼3)have been reported based on observations of ZH-1 and Van Allen probes satellites,and the storm is highly likely to be accelerated by strong whistler-mode waves occurring near very low L-shell regions where the plasmapause was suppressed.It is very interesting to observe the intense chorus-accelerated electrons locating in such low L-shells and filling into the slot region.In this paper,we further perform numerical simulation by solving the two-dimensional Fokker-Planck equation based on the bounce-averaged diffusion rates.Numerical results demonstrate the evolution processes of the chorus-driven electron flux and confirm the flux enhancement in low pitch angle ranges(20◦-50◦)after the wave-particle interaction for tens of hours.The simulation result is consistent with the observation of potential butterfly pitch angle distributions of relativistic electrons from both ZH-1 and Van Allen probes. 展开更多
关键词 chorus acceleration extremely low L-shell numerical simulation ZH-1 satellite Van Allen probes
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Numerical Simulations of the Equations of Particle Motion in the Gas Flow 被引量:1
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作者 Kelong Zheng Liuxiang Zhang Haiyan Chen 《Open Journal of Applied Sciences》 2013年第1期21-26,共6页
Under the assumption of considering the gravity and without gravity, two different acceleration models to describe particle’ motion in the gas flow are formulated, respectively. The corresponding numerical simulation... Under the assumption of considering the gravity and without gravity, two different acceleration models to describe particle’ motion in the gas flow are formulated, respectively. The corresponding numerical simulations of these models do not only show the trend of the velocity of the particle in different density and particle diameter sizes, but also the relationship between the maximum particle velocity and its diameter size. 展开更多
关键词 NUMERICAL simulation PARTICLE Motion ACCELERATION JET GRINDING
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All-Atom Direct Folding Simulation for Proteins Using the Accelerated Molecular Dynamics in Implicit Solvent Model 被引量:1
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作者 李宗超 段莉莉 +1 位作者 冯国强 张庆刚 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第11期169-172,共4页
We report the results of protein folding (219M, C34, N36, 2KES, 2KHK) by the method of accelerated molecular dynamics (aMD) at room temperature with the implicit solvent model. Starting from the linear structures,... We report the results of protein folding (219M, C34, N36, 2KES, 2KHK) by the method of accelerated molecular dynamics (aMD) at room temperature with the implicit solvent model. Starting from the linear structures, these proteins successfully fold to the native structure in a lO0-ns aMD simulation. In contrast, they are failed under the traditional MD simulation in the same simulation time. Then we find that the lowest root mean square deviations of helix structures from the native structures are 0.36 A, 0.63 A, 0.52 A, 1.1 A and 0.78 A. What is more, native contacts, cluster and free energy analyses show that the results of the aMD method are in accordance with the experiment very well. All analyses show that the aMD can accelerate the simulation process, thus we may apply it to the field of computer aided drug designs. 展开更多
关键词 KES MD KHK All-Atom Direct Folding simulation for Proteins Using the Accelerated Molecular Dynamics in Implicit Solvent Model
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Energy and long-term hygrothermal performance of building enclosures based on dynamic environmental simulation test 被引量:1
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作者 Shi Xing 《Engineering Sciences》 EI 2010年第1期92-96,共5页
Dynamic environmental testing is an effective means to study the energy and long-term hygrothermal performance of building enclosures. Southeast University is designing and building a large-scale dynamic environment s... Dynamic environmental testing is an effective means to study the energy and long-term hygrothermal performance of building enclosures. Southeast University is designing and building a large-scale dynamic environment simulation testing facility. It can simuhaneously and dynamically simulate temperature, relative humidity, infrared solar radiation, UV radiation, and precipitation. A transformation is needed to predict the energy and long-term hygrothermal performance of building enclosures under real service conditions using data obtained from accelerated tests. 展开更多
关键词 environmental simulation hygrothermal performance long-term performance heat box environmental acceleration
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Simulations of Stimulated Raman Scattering in Low-Density Plasmas
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作者 曹莉华 常铁强 +1 位作者 刘占军 郑春阳 《Plasma Science and Technology》 SCIE EI CAS CSCD 2007年第4期422-426,共5页
Stimulated Raman particle-in-cell (PIC) simulations scattering (SRS) in a low-density The backward stimulated Raman plasma slab is investigated by scattering (B-SRS) dominates initially and erodes the head of th... Stimulated Raman particle-in-cell (PIC) simulations scattering (SRS) in a low-density The backward stimulated Raman plasma slab is investigated by scattering (B-SRS) dominates initially and erodes the head of the pump wave, while the forward stimulated Raman scattering (F-SRS) subsequently develops and is located at the rear part of the slab. Two-stage electron acceleration may be more efficient due to the coexistence of these two instabilities. The B-SRS plasma wave with low phase velocities can accelerate the background electrons which may be further boosted to higher energies by the F-SRS plasma wave with high phase velocities. The simulations show that the peaks of the main components in both the frequency and wave number spectra occur at the positions estimated from the phase-matching conditions. 展开更多
关键词 stimulated Raman scattering PIC simulation electron acceleration
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Simulation-based Optimal Design of α-β-γ-δ Filter 被引量:1
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作者 Chun-Mu Wu Paul P. Lin +1 位作者 Zhen-Yu Han Shu-Rong Li 《International Journal of Automation and computing》 EI 2010年第2期247-253,共7页
The existing third-order tracker known as α-β-γ-δ filter has been used for target tracking and predicting for years. The filter can track the target's position and velocity, but not the acceleration. To extend it... The existing third-order tracker known as α-β-γ-δ filter has been used for target tracking and predicting for years. The filter can track the target's position and velocity, but not the acceleration. To extend its capability, a new fourth-order target tracker called α-β-γ-δ filter is proposed. The main objective of this study was to find the optimal set of filter parameters that leads to minimum position tracking errors. The tracking errors between using the α-β-γ-δ filter and the α-β-γ-δ filter are compared. As a result, the new filter exhibits significant improvement in position tracking accuracy over the existing third-order filter, but at the expense of computational time in search of the optimal filter. To reduce the computational time, a simulation-based optimization technique via Taguchi method is introduced. 展开更多
关键词 Filter design simulation-based optimization Taguchi methods position tracking velocity tracking acceleration tracking.
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Implementation of a Particle Accelerator Beam Dynamics Code on Multi-Node GPUs
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作者 Zhicong Liu Ji Qiang 《Journal of Software Engineering and Applications》 2019年第9期321-338,共18页
Particle accelerators play an important role in a wide range of scientific discoveries and industrial applications. The self-consistent multi-particle simulation based on the particle-in-cell (PIC) method has been use... Particle accelerators play an important role in a wide range of scientific discoveries and industrial applications. The self-consistent multi-particle simulation based on the particle-in-cell (PIC) method has been used to study charged particle beam dynamics inside those accelerators. However, the PIC simulation is time-consuming and needs to use modern parallel computers for high-resolution applications. In this paper, we implemented a parallel beam dynamics PIC code on multi-node hybrid architecture computers with multiple Graphics Processing Units (GPUs). We used two methods to parallelize the PIC code on multiple GPUs and observed that the replication method is a better choice for moderate problem size and current computer hardware while the domain decomposition method might be a better choice for large problem size and more advanced computer hardware that allows direct communications among multiple GPUs. Using the multi-node hybrid architectures at Oak Ridge Leadership Computing Facility (OLCF), the optimized GPU PIC code achieves a reasonable parallel performance and scales up to 64 GPUs with 16 million particles. 展开更多
关键词 PARTICLE accelerator PARTICLE-IN-CELL GPU Parallel BEAM Dynamics simulation
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Study on the Amyloid Aβ42 with Accelerated Molecular Dynamics Simulations
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作者 Kai-Fang Huang Shu-Heng Dong +2 位作者 Su-Su Zhong Hao Li Li-Li Duan 《Communications in Theoretical Physics》 SCIE CAS CSCD 2019年第9期1121-1126,共6页
One major cause of Alzheimer’s disease(AD) is evidently due to the aggregation and deposition of amyloidβ peptides(Aβ) in the brain tissue of the patient. Preventing misfolding and self-aggregation of Aβ protein c... One major cause of Alzheimer’s disease(AD) is evidently due to the aggregation and deposition of amyloidβ peptides(Aβ) in the brain tissue of the patient. Preventing misfolding and self-aggregation of Aβ protein can reduce the formation of highly toxic polymer, which is important for the treatment of AD. Among them, the α-helix consisting of42 residues(Aβ42) is the main component of senile plaques in AD. In this paper, 500 ns accelerated molecular dynamics are performed at different temperatures(300 K, 350 K, 400 K, 450 K) to study of the effect of temperature-induced conformation changes of Aβ42 protein during the unfolding process respectively. 展开更多
关键词 Amyloid protein Alzheimer’s disease accelerated molecular dynamics simulation protein folding
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