离散型生产线具有多品种、变批量、混线生产的特征,导致多项制造资源存在逻辑共用的情况。制造资源的动态可重构技术使APS(Advanced Planning and Scheduling,高级计划排程)能够快速响应生产任务、现场扰动等变化量并及时对计划调度作...离散型生产线具有多品种、变批量、混线生产的特征,导致多项制造资源存在逻辑共用的情况。制造资源的动态可重构技术使APS(Advanced Planning and Scheduling,高级计划排程)能够快速响应生产任务、现场扰动等变化量并及时对计划调度作出调整,同时为工艺重构、资源布局优化提供数据支持,从而实现制造资源全局配置最优化。主要介绍了动态可重构生产线基本架构,对滚动排程、资源二次映射、资源同一性/延续性等APS动态可重构技术进行了详细分析,选择具有动态搜索半径的果蝇优化算法进行排程,验证了APS动态可重构技术在离散型生产线实际生产中的有效性。展开更多
Background:Cisplatin(DDP)has been used in the treatment of various human cancers.However,DDP alone lacks efficacy in treating triple-negative breast cancer(TNBC),and its clinical application is often hampered by side ...Background:Cisplatin(DDP)has been used in the treatment of various human cancers.However,DDP alone lacks efficacy in treating triple-negative breast cancer(TNBC),and its clinical application is often hampered by side effects.Astragalus polysaccharide(APS)is one of the active components extracted from Astragalus membranaceus and has gained attention for its various biological properties.This research is aimed to evaluate the effectiveness of a combination of APS and DDP on TNBC and explore the potential mechanisms.Methods:The efficacy and mechanisms of single or combined treatment were evaluated using Cell Counting Kit-8(CCK8)assay,Annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)staining,wound healing assay,trans-well invasion/migration assay,hematoxylin-eosin(HE)staining,immunohistochemical(IHC)staining,Western Blot(WB)analysis,and fluorescence-activated cell sorting(FACS).An orthotopic model of TNBC was used to assess the in vivo treatment efficacy of single or combination treatment.Results:APS significantly enhanced the anti-proliferative,anti-migratory,and anti-invasive effects of DDP on TNBC cells.The combination of APS and DDP downregulated anti-apoptotic genes(Bcl2 and Bcl-xL)while upregulating pro-apoptotic genes(Puma,Cle-Caspase3,Cle-PARP),leading to enhanced apoptosis.This combination treatment increased E-cadherin levels,decreased Vimentin,Snail,Slug,and Twist levels,and effectively suppressed epithelial-mesenchymal transition(EMT)-associated cell invasion.In the orthotopic model of TNBC,a synergistic reduction in tumor growth was observed in mice treated with APS and DDP.Additionally,the combination of APS and DDP induced the infiltration of CD8+T lymphocytes into the tumor immune microenvironment.Conclusion:The combination of APS and DDP exhibits more potent tumor inhibition and anti-tumor immunity than either agent alone,representing a novel approach to enhance therapeutic efficacy without increasing the side effects of DDP.展开更多
1 Aims and scope Advances in Polar Science(APS)is an international,English-language,peer-reviewed journal that publishes scientific research results concerning the Arctic and Antarctic regions across a broad range of ...1 Aims and scope Advances in Polar Science(APS)is an international,English-language,peer-reviewed journal that publishes scientific research results concerning the Arctic and Antarctic regions across a broad range of disciplines.It is sponsored by the Polar Research Institute of China.APS is a true open-access journal,with no publication fees and all articles are freely accessible as soon as they are released.展开更多
From its founding in 1990 as Antarctic Research(English version)to the autumn issue in 2025(this issue),Advances in Polar Science(APS)has published a total of 100 issues,marking the beginning of a new stage in its dev...From its founding in 1990 as Antarctic Research(English version)to the autumn issue in 2025(this issue),Advances in Polar Science(APS)has published a total of 100 issues,marking the beginning of a new stage in its development.The year 2025 is a significant milestone for both global polar research and APS.APS was endorsed by the Asian Forum for Polar Sciences(AFoPS)and initiated cooperation during the 2025 AFoPS annual general meeting in India.APS will support AFoPS in planning and organizing special issues in various fields of polar science and in supporting early-career researchers from Asia in publishing their work.展开更多
文摘离散型生产线具有多品种、变批量、混线生产的特征,导致多项制造资源存在逻辑共用的情况。制造资源的动态可重构技术使APS(Advanced Planning and Scheduling,高级计划排程)能够快速响应生产任务、现场扰动等变化量并及时对计划调度作出调整,同时为工艺重构、资源布局优化提供数据支持,从而实现制造资源全局配置最优化。主要介绍了动态可重构生产线基本架构,对滚动排程、资源二次映射、资源同一性/延续性等APS动态可重构技术进行了详细分析,选择具有动态搜索半径的果蝇优化算法进行排程,验证了APS动态可重构技术在离散型生产线实际生产中的有效性。
基金the Xuzhou Science and Technology Bureau,No.KC23186,Jiangsu Provincial Key Laboratory of New Drug Research and Clinical Pharmacy Project(No.XZSYSKF2023013)Key Medical Disciplines of Jiangsu Province’s 14th Five-Year Plan(ZDXK202237).
文摘Background:Cisplatin(DDP)has been used in the treatment of various human cancers.However,DDP alone lacks efficacy in treating triple-negative breast cancer(TNBC),and its clinical application is often hampered by side effects.Astragalus polysaccharide(APS)is one of the active components extracted from Astragalus membranaceus and has gained attention for its various biological properties.This research is aimed to evaluate the effectiveness of a combination of APS and DDP on TNBC and explore the potential mechanisms.Methods:The efficacy and mechanisms of single or combined treatment were evaluated using Cell Counting Kit-8(CCK8)assay,Annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)staining,wound healing assay,trans-well invasion/migration assay,hematoxylin-eosin(HE)staining,immunohistochemical(IHC)staining,Western Blot(WB)analysis,and fluorescence-activated cell sorting(FACS).An orthotopic model of TNBC was used to assess the in vivo treatment efficacy of single or combination treatment.Results:APS significantly enhanced the anti-proliferative,anti-migratory,and anti-invasive effects of DDP on TNBC cells.The combination of APS and DDP downregulated anti-apoptotic genes(Bcl2 and Bcl-xL)while upregulating pro-apoptotic genes(Puma,Cle-Caspase3,Cle-PARP),leading to enhanced apoptosis.This combination treatment increased E-cadherin levels,decreased Vimentin,Snail,Slug,and Twist levels,and effectively suppressed epithelial-mesenchymal transition(EMT)-associated cell invasion.In the orthotopic model of TNBC,a synergistic reduction in tumor growth was observed in mice treated with APS and DDP.Additionally,the combination of APS and DDP induced the infiltration of CD8+T lymphocytes into the tumor immune microenvironment.Conclusion:The combination of APS and DDP exhibits more potent tumor inhibition and anti-tumor immunity than either agent alone,representing a novel approach to enhance therapeutic efficacy without increasing the side effects of DDP.
文摘1 Aims and scope Advances in Polar Science(APS)is an international,English-language,peer-reviewed journal that publishes scientific research results concerning the Arctic and Antarctic regions across a broad range of disciplines.It is sponsored by the Polar Research Institute of China.APS is a true open-access journal,with no publication fees and all articles are freely accessible as soon as they are released.
文摘From its founding in 1990 as Antarctic Research(English version)to the autumn issue in 2025(this issue),Advances in Polar Science(APS)has published a total of 100 issues,marking the beginning of a new stage in its development.The year 2025 is a significant milestone for both global polar research and APS.APS was endorsed by the Asian Forum for Polar Sciences(AFoPS)and initiated cooperation during the 2025 AFoPS annual general meeting in India.APS will support AFoPS in planning and organizing special issues in various fields of polar science and in supporting early-career researchers from Asia in publishing their work.
