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一个高性能预测模型对帕金森病认知障碍的早期识别价值:DHA模型的开发与验证
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作者 阳素琼 潘洪润 +1 位作者 王佳音 洪培昆 《福建医药杂志》 2026年第2期23-28,共6页
目的构建一个用于早期预测帕金森病(PD)患者出现认知障碍的临床风险预测模型。方法回顾性收集437例PD患者的临床资料,通过单因素及多因素logistic回归分析构建预测模型。采用受试者工作特征曲线、校准曲线和决策曲线评估模型的区分度、... 目的构建一个用于早期预测帕金森病(PD)患者出现认知障碍的临床风险预测模型。方法回顾性收集437例PD患者的临床资料,通过单因素及多因素logistic回归分析构建预测模型。采用受试者工作特征曲线、校准曲线和决策曲线评估模型的区分度、校准度和临床实用性。结果经逻辑回归单因素分析筛选变量后再采用向后似然法进行多因素分析,构建了纳入年龄、病程和高密度脂蛋白胆固醇3个因素的PD认知障碍预测模型(DHA模型)。该模型曲线下面积为0.921,灵敏度为89.60%,特异度为79.68%;校准曲线显示预测值与实测值高度一致(平均绝对误差=0.022);决策曲线证实该模型在广泛阈值范围内具有显著的临床净获益。结论本研究构建的DHA预测模型具有良好的预测效能与临床适用性,可为PD患者认知障碍的早期识别和风险分层提供有效的量化工具。 展开更多
关键词 dha预测模型 帕金森病 认知障碍
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高载量DHA藻油微胶囊的制备及理化性质分析
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作者 胡荣海 陈文荣 +2 位作者 崔绍华 方素琼 万芝力 《现代食品科技》 北大核心 2026年第1期246-254,共9页
为了改善二十二碳六烯酸(DHA)的氧化稳定性、感官风味,提高其在营养健康产品的应用价值,该研究通过分离乳清蛋白(WPI)与果胶(PEC)、阿拉伯胶(GA)、辛烯基琥珀酸酯化淀粉(OSA)的复合凝聚作用包埋DHA藻油,并系统探究不同组成的复合凝聚体... 为了改善二十二碳六烯酸(DHA)的氧化稳定性、感官风味,提高其在营养健康产品的应用价值,该研究通过分离乳清蛋白(WPI)与果胶(PEC)、阿拉伯胶(GA)、辛烯基琥珀酸酯化淀粉(OSA)的复合凝聚作用包埋DHA藻油,并系统探究不同组成的复合凝聚体对乳液理化特性,以及对相应配方微胶囊总油含量与表面油含量、贮藏稳定性、表观形貌等的影响。WPI-PEC复合凝聚体显著提升DHA藻油乳液稳定性,平均粒径为362 nm,D[3,2]和D[4,3]分别为312 nm和391 nm,并且LUMiSizer透光率指纹曲线波动小。此外,喷雾干燥制得WPI-PEC微胶囊载油量约为50%,表面油含量较低至2.59%,SEM显示样品微观结构完整。40℃贮存3月,过氧化值低于1 g/100 g,感官评分高,腥味低、风味较好。然而,GA和OSA的添加弱化WPI的乳化特性,导致乳液粒径偏大、稳定性差,微胶囊表面油含量高,微观结构不完整,贮藏稳定性差。综上,WPI-PEC复合凝聚体具有协同增效作用,制备的藻油乳液和微胶囊稳定性好、品质高,该研究为提升DHA藻油的应用价值奠定了基础。 展开更多
关键词 dha藻油 微胶囊 分离乳清蛋白 多糖 复合凝聚技术
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富含DHA油茶籽油结构脂制备的研究
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作者 晏彩凤 左宗明 +5 位作者 郦娟 钟武 张星河 殷娇娇 胡传荣 高盼 《中国粮油学报》 北大核心 2026年第2期106-112,共7页
为制备富含二十二碳六烯酸(DHA)的油茶籽油结构酯,本文探讨了3种脂肪酶(Novozym 435、Lipozyme TL IM和Lipozyme RM)在制备中的催化性能。研究发现,Lipozyme RM展现出最佳的催化效果,其DHA掺入率和含DHA甘油三酯质量分数分别达到29.94%... 为制备富含二十二碳六烯酸(DHA)的油茶籽油结构酯,本文探讨了3种脂肪酶(Novozym 435、Lipozyme TL IM和Lipozyme RM)在制备中的催化性能。研究发现,Lipozyme RM展现出最佳的催化效果,其DHA掺入率和含DHA甘油三酯质量分数分别达到29.94%和66.03%。正交实验优化表明,最优工艺参数为反应温度70℃、反应时间6 h、脂肪酶添加量质量分数8%、底物质量比1∶50,在此条件下,DHA掺入率和含DHA甘油三酯质量分数分别提升至39.03%和76.56%。与物理调配油相比,酶法酯交换产物具有更高的稳定性和品质。 展开更多
关键词 dha 油茶籽油 脂肪酶 正交实验 油脂营养强化
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Rapid determination of DHA in sturgeon caviar extracts and its correlation with bioactive efficacy
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作者 Xiaoling Tan Jiaxin Kang 《日用化学工业(中英文)》 北大核心 2026年第3期347-353,共7页
A reversed-phase high-performance liquid chromatography(HPLC)method was developed for the direct determination of docosahexaenoic acid(DHA)in sturgeon caviar extract.The assay employed n-hexane extraction combined wit... A reversed-phase high-performance liquid chromatography(HPLC)method was developed for the direct determination of docosahexaenoic acid(DHA)in sturgeon caviar extract.The assay employed n-hexane extraction combined with gradient elution(ZORBAX SB-C18 column),with data collected using a diode array detector.The content was calculated by external standard method and validated against the national standard(GB 5009.168-2016).The study also measured DPPH free radical scavenging capacity and moisture retention rate across different DHA concentration groups.The results demonstrate that the proposed method exhibits excellent linearity(r=0.9997),with recovery rates ranging from 92.1% to 101.1% and relative standard deviations(RSD)of 2.23% to 3.92%.Compared to the national standard method,the relative deviation was 0.67% to 1.68%.At specific test concentrations,the high-DHA group shows significantly higher moisture retention(100.48%),hygroscopicity(100.85%),and DPPH scavenging efficiency(57.46%)than the low-DHA group(10.33%,11.76%,and 3.71%).The RP-HPLC method developed in this study simplifies DHA detection procedures with simple reagents and reliable results,making it suitable for rapid qualitative identification and quantitative analysis of target components in caviar extract quality control.The DPPH experiment further reveals the correlation between DHA content and antioxidant efficacy in sturgeon caviar extracts,providing scientific evidence for developing functional cosmetics. 展开更多
关键词 reverse-phase high-performance liquid chromatography dha sturgeon roe extract moisturizing capacity antioxidant activity method validation
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AIGC赋能高校跨学科艺术美育DHA融创模型构建
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作者 张晶晶 谭东芳 刘璐 《文化创新比较研究》 2026年第4期9-12,共4页
以生成式人工智能为代表的新一轮科技革命,正有力推动着高校艺术美育场景向数智化方向发生深刻变革。为积极回应数智化变革的迫切需求,该研究构建DHA跨学科艺术美育融创模式。该模式以高意识审美、人机共美为导向,在AIGC技术介入下,将... 以生成式人工智能为代表的新一轮科技革命,正有力推动着高校艺术美育场景向数智化方向发生深刻变革。为积极回应数智化变革的迫切需求,该研究构建DHA跨学科艺术美育融创模式。该模式以高意识审美、人机共美为导向,在AIGC技术介入下,将数字、人文、艺术三个学科领域实现深度融合。通过主题设计、AIGC共创、融合创作以及反馈优化四个阶段,实现涵盖审美想象、人文知识、情感体验和技术表达等多个维度的高阶艺术美育升级。DHA融创模型的构建,是加速人工智能时代艺术美育数智化转型的可行路径选择,能够为推进人机协同背景下跨学科艺术美育实现高质量发展提供思路与策略。 展开更多
关键词 生成式人工智能 跨学科 艺术美育 dha融创模式 人机共美 人机协同
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Comparing trans-oral endoscopic thyroidectomy vestibular approach and trans-areolar approaches regarding postoperative infections and swallowing difficulty
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作者 Hyder Mirghani 《World Journal of Clinical Cases》 2026年第1期21-27,共7页
BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidec... BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidectomy vestibular approach and trans-areolar approaches(TAA)are the two most commonly used remote approaches.No previous meta-analysis has compared postoperative infections and swallowing difficulties among the two procedures.AIM To compared the same among patients undergoing lobectomy for unilateral thyroid carcinoma/benign thyroid nodule.METHODS We searched PubMed MEDLINE,Google Scholar,and Cochrane Library from the date of the first published article up to August 2025.The term used were transoral thyroidectomy vestibular approach,trans areolar thyroidectomy,scarless thyroidectomy,remote thyroidectomy,infections,postoperative,inflammation,dysphagia,and swallowing difficulties.We identified 130 studies,of them,30 full texts were screened and only six studies were included in the final meta-analysis.RESULTS Postoperative infections were not different between the two approaches,odd ratio=1.33,95%confidence interval:0.50-3.53,theχ2 was 1.92 and the P-value for overall effect of 0.57.Similarly,transient swallowing difficulty was not different between the two forms of surgery,with odd ratio=0.91,95%confidence interval:0.35-2.40;theχ2 was 1.32,and the P-value for overall effect of 0.85.CONCLUSION No significant statistical differences were evident between trans-oral endoscopic Mirghani H.Infections and swallowing difficulty in scarless thyroidectomy WJCC https://www.wjgnet.com 2 January 6,2026 Volume 14 Issue 1 thyroidectomy vestibular approach and trans-areolar approach regarding postoperative infection and transient swallowing difficulties.Further longer randomized trials are needed. 展开更多
关键词 Trans-oral endoscopic thyroidectomy vestibular approach Trans-areolar approaches Postoperative Infections swallowing difficulty
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Rhizopus oryzae脂肪酶@改性二氧化硅催化醇解法富集鱼油中EPA和DHA
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作者 左东杰 蒋曹奇 +3 位作者 李倩 苟兴莉 徐晓语 曹茜 《西华大学学报(自然科学版)》 2026年第2期64-73,共10页
以三甲氧基苯基硅烷(Trimethoxyphenylsilane,TMPS)和三甲氧基辛基硅烷(Trimethoxyoctylsilane,TMOS)改性的纳米SiO_(2)为载体,固定化米根霉脂肪酶(Rhizopus oryzae lipase,ROL),考察不同改性载体对固定化酶催化鱼油醇解富集二十碳五烯... 以三甲氧基苯基硅烷(Trimethoxyphenylsilane,TMPS)和三甲氧基辛基硅烷(Trimethoxyoctylsilane,TMOS)改性的纳米SiO_(2)为载体,固定化米根霉脂肪酶(Rhizopus oryzae lipase,ROL),考察不同改性载体对固定化酶催化鱼油醇解富集二十碳五烯酸(Eicosapentaenoic acid,EPA)和二十二碳六烯酸(Docosahexaenoic acid,DHA)的影响。通过测定酶活和对反应产物进行分析,对比了两种固定化酶(ROL@SiO_(2)-TMPS和ROL@SiO_(2)-TMOS)的负载效率及其对EPA和DHA的富集效果。结果表明:TMOS对SiO_(2)的疏水改性效果更佳,显著提高了酶的负载率(92.08%);在醇解反应中,ROL@SiO_(2)-TMPS对EPA的富集效果更优(2 h时EPA含量达初始的1.93倍,回收率为98.62%),而ROL@SiO_(2)-TMOS对DHA的富集效果更佳(2 h时DHA含量达初始的1.98倍,回收率98.25%),富集的EPA和DHA主要分布于甘油二酯中;同时,反应产生的副产物脂肪酸乙酯富含肉豆蔻酸、棕榈酸和棕榈油酸(三者总含量>80%),可作为生物柴油。本研究实现了EPA和DHA的高效富集与副产物的高值化利用,为鱼油资源的综合利用提供了有效途径。 展开更多
关键词 脂肪酶 二氧化硅 鱼油 二十碳五烯酸 二十二碳六烯酸
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Approach angle constrained and varying speed cooperative guidance against maneuvering targets
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作者 Xiangjun Ding Jianan Wang +1 位作者 Junhui Liu Jiayuan Shan 《Defence Technology(防务技术)》 2026年第3期56-70,共15页
This paper addresses the three-dimensional(3-D)approach angle constrained cooperative guidance problem for speed-varying missiles against maneuvering targets.First,the guidance problem is formulated in a relative refe... This paper addresses the three-dimensional(3-D)approach angle constrained cooperative guidance problem for speed-varying missiles against maneuvering targets.First,the guidance problem is formulated in a relative reference frame and a virtual control input is selected.Then,the cooperative guidance law is designed on the basis of a prediction-correction framework.The time-to-go under the baseline command is estimated by an efficient prediction method with a realistic aerodynamic model and a biased command is developed by utilizing the time-to-go predictions for synchronizing different missiles'impact times.The design of the biased command is decoupled into the individual design of its direction and magnitude.It is proved that the designed cooperative guidance law can make the time-to-go consensus error converge to zero before interception.Finally,the designed guidance law is validated through a series of numerical simulations. 展开更多
关键词 Cooperative guidance Maneuvering target Time-varying speed approach angle constraint
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Microstructure and properties of Cu-Ni-Co-Si alloy designed by cluster formula approach
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作者 Shi-fang LI Zhu XIAO +3 位作者 Xiang-peng MENG Zhou LI Yan-lin JIA Yan-bin JIANG 《Transactions of Nonferrous Metals Society of China》 2026年第3期872-886,共15页
A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was syst... A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was systematically investigated.The strengthening mechanism and electrical conductivity of the alloy were discussed in detail.The optimal thermomechanical treatment process was as follows:solid solution→80%cold rolling→(450℃,4 h)aging→50%cold rolling→(400℃,4 h)aging.The designed alloy achieved excellent comprehensive properties with a microhardness of HV 260,a yield strength of 843 MPa,a tensile strength of 884 MPa,and an electrical conductivity of 42.6%(IACS).Compared to direct aging treatment,the designed alloy subjected to multi-stage thermomechanical treatment had refined grains,high density of dislocations,and accelerated of precipitation of(Ni,Co)_(2)Si precipitates.High strength was mainly attributed to the combined effect of dislocation strengthening,work hardening and sub-grain strengthening,while good electrical conductivity was maintained through the precipitation of the large number of nanoparticles. 展开更多
关键词 Cu-Ni-Co-Si alloys cluster formula approach thermomechanical treatment MICROSTRUCTURE strengthening mechanism
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The application of multi-combinatorial approach in sensitivity improvement of lipid photoacoustic imaging
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作者 Yi Tan Dongjian Wu +4 位作者 Xiatian Wang Chengbo Liu Mingjian Sun Xiaojing Gong Zhihua Xie 《Journal of Innovative Optical Health Sciences》 2026年第1期96-109,共14页
The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-effic... The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-efficiency excitation and detection elements may improve the imaging sensitivity to a certain extent,the application of the elements is inevitably subject to various limitations in practical applications,particularly during in vivo imaging and endoscopic imaging.In this study,we propose a multi-combinatorial approach to enhance the sensitivity of lipid photoacoustic imaging.The approach involves wavelet transform processing of one-dimensional A-line signals,gradient-based denoising of two-dimensional B-scan images,and finally,threedimensional spatial weighted averaging of the data processed by the previous two steps.This method not only significantly improves the signal-to-noise ratio(SNR)in distinguished feature regions of the image by around 10 dB,but also efficiently extracts weak signals with no distinct features in the original image.After processing with this method,the images acquired under single scanning were compared with those obtained under multiple scanning.The results showed highly consistent image features,with the structural similarity index increasing from 0.2 to 0.8,confirming the accuracy and reliability of the multi-combinatorial approach. 展开更多
关键词 Multi-combinatorial approach extraction of weak signals imaging sensitivity photoacoustic lipid imaging
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Optimal pricing approaches for data markets in market-operated data exchanges
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作者 Yangming Lyu Linyi Qian +2 位作者 Zhixin Yang Jing Yao Xiaochen Zuo 《Statistical Theory and Related Fields》 2026年第1期23-45,共23页
This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data e... This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data exchanges transitioning from quasi-public to marketoriented operations.To address the complex dynamics among data exchanges,suppliers,and consumers,the authors develop a threestage Stackelberg game framework.In this model,the data exchange acts as a leader setting transaction commission rates,suppliers are intermediate leaders determining unit prices,and consumers are followers making purchasing decisions.Two pricing strategies are examined:the Independent Pricing Approach(IPA)and the novel Perfectly Competitive Pricing Approach(PCPA),which accounts for competition among data providers.Using backward induction,the study derives subgame-perfect equilibria and proves the existence and uniqueness of Stackelberg equilibria under both approaches.Extensive numerical simulations are carried out in the model,demonstrating that PCPA enhances data demander utility,encourages supplier competition,increases transaction volume,and improves the overall profitability and sustainability of data exchanges.Social welfare analysis further confirms PCPA’s superiority in promoting efficient and fair data markets. 展开更多
关键词 Data exchange data market digital economy perfectly competitive pricing approach Stackelberg game
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SSA*-PDWA:A Hierarchical Path Planning Framework with Enhanced A*Algorithm and Dynamic Window Approach for Mobile Robots
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作者 Lishu Qin Yu Gao Xinyuan Lu 《Computers, Materials & Continua》 2026年第4期2069-2094,共26页
With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper pro... With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper proposes an intelligent path planning framework based on grid map modeling.First,an improved Safe and Smooth A*(SSA*)algorithm is employed for global path planning.By incorporating obstacle expansion and cornerpoint optimization,the proposed SSA*enhances the safety and smoothness of the planned path.Then,a Partitioned Dynamic Window Approach(PDWA)is integrated for local planning,which is triggered when dynamic or sudden static obstacles appear,enabling real-time obstacle avoidance and path adjustment.A unified objective function is constructed,considering path length,safety,and smoothness comprehensively.Multiple simulation experiments are conducted on typical port grid maps.The results demonstrate that the improved SSA*significantly reduces the number of expanded nodes and computation time in static environmentswhile generating smoother and safer paths.Meanwhile,the PDWA exhibits strong real-time performance and robustness in dynamic scenarios,achieving shorter paths and lower planning times compared to other graph search algorithms.The proposedmethodmaintains stable performance across maps of different scales and various port scenarios,verifying its practicality and potential for wider application. 展开更多
关键词 Dynamic window approach improved A*algorithm dynamic path planning trajectory optimization
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Adaptive event-triggered decentralized control for nonlinear interconnected large-scale systems with actuator failures:a fully actuated system approach
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作者 Yueyao Ye Yanan Qi +2 位作者 Yiyu Feng Xiaofeng Xu Xianfu Zhang 《Control Theory and Technology》 2026年第1期82-95,共14页
This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the ... This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the design process,we transform the studied system into the form of a fully actuated system through a state transformation.Then,to address the unknown nonlinear functions and actuator fault parameters,we employ neural networks and adaptive estimation techniques,respectively.Moreover,to reduce the control cost and improve the control efficiency,we introduce event-triggered inputs into the control strategy.It is proved by the Lyapunov stability analysis that all signals of the closed-loop system are bounded and the output of system eventually converge to a bounded region.The efficacy of the control approach is ultimately demonstrated via the simulation of an actual machine feeding system. 展开更多
关键词 Nonlinear interconnected large-scale systems Fully actuated system approach Actuator failures Neural networks
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Collaborative Approaches to Poverty Reduction:Experts and o"cials from China and abroad exchange views on cooperation and sustainable development at seminar
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作者 LU JIAJUN 《ChinAfrica》 2026年第2期34-35,共2页
The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are havi... The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are having a significant impact,particularly on global poverty governance.As a platform for dialogue,exchange and technical cooperation,the 2025 International Seminar on Global Poverty Reduction Partnerships was held in Beijing on 10 December 2025. 展开更多
关键词 climate changeregional conflicts collaborative approaches China global poverty reduction OFFICIALS sustainable development goals sdgs economic recession experts
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Fast identification of γ‑emitting radionuclides based on sequential Bayesian approach
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作者 Xuan Zhang Jian-Wei Huang +5 位作者 Lin-Jian Wan Jia-Cheng Liu Xiao-Le Zhang De-Hong Li Fei Tuo Zhi-Jun Yang 《Nuclear Science and Techniques》 2026年第2期1-15,共15页
The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring suffi... The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring sufficient count accumulation for evaluation,thereby limiting response time.The sequential Bayesian approach,which utilizes prior information and considers both photon energies and interarrival times,can significantly enhance the performance of radionuclides identification.This study proposes a theoretical optimization method for the traditional sequential Bayesian approach.Each photon is processed sequentially,and the corresponding posterior probability is updated in real time using a noninformative prior from the Bayesian theory.By comparing the posterior probabilities of the background and radionuclides based on the energy variance and time interval,the type of γ-rays can be identified(background characteristic γ-rays,Compton plateaus γ-rays,or radionuclide-specific characteristic γ-rays).By integrating the information from these multiple characteristic γ-rays,the presence and type of radionuclides were determined based on the final decision function and a set threshold.Based on theoretical research,verification experiments were conducted using a LaBr_(3)(Ce)detector in both low-and natural background radiation environments with typical radionuclides(^(137)Cs,^(60)Co,and ^(133)Ba).The results show that this approach can identify ^(137)Cs in 7.9 s and 8.5 s(source dose rate contribution:approximately 6.5×10^(−3)μGy/h),^(60)Co in 8.1 s and 9.8 s(approximately 4.8×10^(−2)μGy/h),and ^(133)Ba in 4.05 s and 5.99 s(approximately 3.4×10^(−2)μGy/h)under low and natural background radiation,respectively,with a miss rate below 0.01%.This demonstrates the effectiveness of the proposed approach for fast radionuclides identification,even at low activity levels and highlights its potential for enhancing public safety in diverse radiation environments. 展开更多
关键词 Sequential Bayesian approach Fast radionuclides identification LaBr_(3)(Ce)detector Low background radiation laboratory
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Trigeminal nerve stimulation as a neuromodulatory approach for disorders of consciousness
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作者 Bandy Chen 《Neural Regeneration Research》 2026年第8期3541-3542,共2页
Disorders of consciousness(DoC),including coma,vegetative state,and minimally conscious state,present a spectrum of conditions characterized by impaired awareness and responsiveness due to severe brain injury.Conventi... Disorders of consciousness(DoC),including coma,vegetative state,and minimally conscious state,present a spectrum of conditions characterized by impaired awareness and responsiveness due to severe brain injury.Conventional interventions for DoC primarily focus on promoting conditions conducive to spontaneous neurological recovery including pharmacological treatments such as dopaminergic agents(e.g.,amantadine)and rehabilitative strategies including sensory stimulation programs and physical therapy. 展开更多
关键词 neuromodulatory approach disorders consciousness doc including physical therapy pharmacological treatments sensory stimulation programs dopaminergic agents egamantadine promoting conditions rehabilitative strategies
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A Stochastic Optimal Control for a Class of LTI Systems With a State-Dependent Wiener Process:An Algebraic Approach
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作者 Kento Fujita Daisuke Tsubakino Shiuji Hara 《IEEE/CAA Journal of Automatica Sinica》 2026年第2期489-491,共3页
Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in a... Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in an algebra,then the solution(and also the control gain in many cases)is also in the same algebra.The main result is verified by a numerical simulation. 展开更多
关键词 stochastic optimal control algebraic relationship algebraic approach state dependent Wiener process coefficient matrices stochastic algebraic Riccati equation numerical simulation stochastic algebraic riccati equationit
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微藻-桑叶复合粉对芦花鸡生产性能、蛋品质、胆固醇及DHA沉积的影响 被引量:1
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作者 彭津津 陈亚强 《中国饲料》 北大核心 2025年第2期117-120,共4页
文章旨在探讨微藻-桑叶复合粉对芦花鸡生长性能,蛋品质,胆固醇及DHA沉积的影响。试验选用400羽健康的28周龄芦花鸡,采用4×2(微藻粉×桑叶粉)完全随机试验设计分成8组,每组5个重复,每个重复10羽鸡。微藻粉按照0%、1%、3%、5%,... 文章旨在探讨微藻-桑叶复合粉对芦花鸡生长性能,蛋品质,胆固醇及DHA沉积的影响。试验选用400羽健康的28周龄芦花鸡,采用4×2(微藻粉×桑叶粉)完全随机试验设计分成8组,每组5个重复,每个重复10羽鸡。微藻粉按照0%、1%、3%、5%,桑叶粉按照2%、4%添加到基础日粮,预饲期1周,试验期4周。结果表明,复合粉对芦花鸡产蛋率、蛋均重、日均采食量、料蛋比等生产性能指标和蛋形指数、蛋白高度、蛋壳强度、蛋壳厚度等蛋品质指标均无显著影响(P> 0.05),但能显著提高蛋黄颜色和哈氏单位(P <0.05),微藻粉单、桑叶粉单独添加还是协同效应均能显著降低蛋黄胆固醇含量(P <0.05),复合粉极显著提高蛋黄DHA含量(P <0.01)。由此可见,在芦花鸡日粮中添加复合粉,能显著降低蛋黄胆固醇含量,大幅提高鸡蛋DHA沉积,为功能性鸡蛋开发提供参考。 展开更多
关键词 微藻-桑叶复合粉 芦花鸡 生长性能 蛋品质 dha沉积
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草原羊脑磷脂型DHA对小鼠生理机能的影响
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作者 包音都古荣·金花 宝鲁日 +6 位作者 和硕特麦丽斯 侯荣伦 呼格吉勒图 敖日格勒 岩松 敖日格乐 周欢敏 《中国油脂》 北大核心 2025年第3期60-67,共8页
旨在为草原羊脑磷脂型DHA(DHA-PLs)的开发利用提供科学依据,从苏尼特羊脑中萃取DHA-PLs,在确定其不携带朊病毒蛋白的基础上,选择7周龄、平均体质量为27 g的SPF级昆明雌性小白鼠30只,分为空白组(基础饲料)、鱼油组(基础饲料+鱼油)和羊脑D... 旨在为草原羊脑磷脂型DHA(DHA-PLs)的开发利用提供科学依据,从苏尼特羊脑中萃取DHA-PLs,在确定其不携带朊病毒蛋白的基础上,选择7周龄、平均体质量为27 g的SPF级昆明雌性小白鼠30只,分为空白组(基础饲料)、鱼油组(基础饲料+鱼油)和羊脑DHA-PLs组(基础饲料+羊脑DHA-PLs),考察饲喂3个月后各组小鼠体征指标、周能量排出量、粪便中粗脂肪含量和脏器指数的变化,测定其血清生化和肝功能指标,观察肠道和脏器组织形态,以揭示羊脑DHA-PLs对小鼠营养物质吸收、脏器、血脂和肝功能的影响程度。结果表明:羊脑中无朊病毒蛋白,正常朊蛋白含量最高达200 mg/g;3个月饲喂试验结束后,各组小鼠健康状况良好,平均日采食量无差异,终体质量均显著增大(p<0.05);与空白组比较,羊脑DHA-PLs组小鼠周能量排出量,粪便中粗脂肪含量,血清中甘油三酯和总胆固醇含量,以及谷草转氨酶、谷丙转氨酶水平显著降低(p<0.05),但与鱼油组无显著差异(p>0.05);各组小鼠脏器指数之间无显著差异(p>0.05),心脏、肝脏、肾脏、脾脏、胃和脑等组织均未出现病变,肠道均无损伤,空肠绒毛高度与隐窝深度比值组间无差异(p>0.05),但羊脑DHA-PLs组和鱼油组小鼠肠道分别长出14个和13个潘氏斑,而空白组未出现。综上,草原羊脑DHA-PLs能促进小鼠营养物质吸收,显著降低血脂,提高肝脏机能和肠道免疫机能,对小鼠脏器无不良影响,可以应用于食品和保健品生产中。 展开更多
关键词 草原羊脑磷脂型dha 脏器指数 血脂 肝功能 组织学分析 潘氏斑
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