Two new tirucallane triterpenoids,2a-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid(1)and(23E)-2a-hydroxytirucalla-7,23,25-triene-3-one(2),along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,2...Two new tirucallane triterpenoids,2a-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid(1)and(23E)-2a-hydroxytirucalla-7,23,25-triene-3-one(2),along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione(3),were isolated from the leaves and twigs of Aphanamixis grandifolia.Their structures were elucidated by extensive NMR and MS data,and compound 3 was further confirmed by X-ray crystal diffraction analysis.Antimicrobial activities and insecticidal activities of these three compounds were also evaluated.Compound 1 showed good antimicrobial activity against Staphylococcus aureus with the MIC value of 1.56μg/mL,while compounds 1 and 2 showed insecticidal activity at 100 ppm,with the corrected mortality 79.1%and 60.6%,respectively.展开更多
A new limonoid named rohituka-15 1, with a known limonoid dregeana-1 2, was isolated from the seed of Aphanamixis polystachya (Meliaceae). The 13C NMR data assignment of dregeana-1 2 and the structural elucidation of...A new limonoid named rohituka-15 1, with a known limonoid dregeana-1 2, was isolated from the seed of Aphanamixis polystachya (Meliaceae). The 13C NMR data assignment of dregeana-1 2 and the structural elucidation of the new compound 1 were based on spectral analysis including 1H-1H COSY, HMQC and HMBC experiments.展开更多
Aphamines A-C(1-3),three pairs of acyclic diterpene dimer enantiomers with an unprecedent ploymerization pattern,were discovered from Aphanamixis polystachya by NMR-guided isolation and chiral resolution.The elucidati...Aphamines A-C(1-3),three pairs of acyclic diterpene dimer enantiomers with an unprecedent ploymerization pattern,were discovered from Aphanamixis polystachya by NMR-guided isolation and chiral resolution.The elucidation of their novel carbon skeletons was achieved based on spectroscopic analysis,exciton chirality,and calculated electronic circular dichroism(ECD).Plausible Claisen rearrangement,5-exo-trig cyclization,and reduction reactions may play important roles in the polymeric biosynthesis pathway.Compounds 1 and 3 showed inhibitory effects on nitric oxide(NO)production(IC_(50):6.71-15.36μmol/L)and reduced the expression of iNOS in LPS-induced RAW 264.7 macrophages.展开更多
Two new tirucallane-type triterpenoids, 3a,24β＇,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene （I） and 3a-acetoxy-21fl-methoxy-24,25,26,27-tetranortirucall-7-ene-23（21）-lactone （2）, were isolated from the...Two new tirucallane-type triterpenoids, 3a,24β＇,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene （I） and 3a-acetoxy-21fl-methoxy-24,25,26,27-tetranortirucall-7-ene-23（21）-lactone （2）, were isolated from the stem barks ofAphanamixis grandifblia, and their structures were elucidated on the basis of spectroscopic data analysis includ- ing ID, 2D NMR, IR, and ESI-MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI-H460 and HeLa cell lines.展开更多
Four new limonoids, named aphanagranins A-D （1-4）, were isolated from the fruits ofAphanamixis grandi- folia. The new structures were determined by spectroscopic methods especially 1D and 2D NMR analysis, Aphana- gr...Four new limonoids, named aphanagranins A-D （1-4）, were isolated from the fruits ofAphanamixis grandi- folia. The new structures were determined by spectroscopic methods especially 1D and 2D NMR analysis, Aphana- granin A （1） possessed a rare four membered oxygen heterocyclic ring and its absolute configurations were deter- mined on the basis of the signal crystal X-ray diffraction analysis. Furthermore, compounds 1 and 2 showed weak activity toward brine shrimp （Artemia salina）.展开更多
Current study aims to investigate the allelopathic potential of the differentparts (leaf, bark, stem, twig and root) of three oil-enrich plant species ofBangladesh viz., Jatropha curcus, Ricinus communis and Aphanamix...Current study aims to investigate the allelopathic potential of the differentparts (leaf, bark, stem, twig and root) of three oil-enrich plant species ofBangladesh viz., Jatropha curcus, Ricinus communis and Aphanamixispolystachya. The aqueous extract of those plant parts were diluted intofour different concentrations viz., 1:5, 1:10, 1:15, 1:20 (w/v) and testedagainst the seedling growth of jute, rice, wheat, radish, tomato, mungbeanand mustard under control laboratory condition. A control (distilled waterwithout extract) was also maintained in every cases and the bioassayexperiment was replicated thrice. The results of this research showed thatthe shoot and root growth inhibition of rice, wheat, jute, tomato, radish,mungbean and mustard by leaf, bark, stem, twig and root extracts of J.curcus, R. communis and A. polystachya varied significantly. Compareto the shoot growth, the root growth of the test species inhibited moreexcept J. curcus. The leaf and root have higher allelopathic potential thanany other parts of the studied plants. Finally, it can be concluded here thatJ. curcus plant extracts has higher allelopathic potential than other twoplants R. communis and A. polystachya. Therefore, J. curcus can be usedas a candidate plant for isolation and identification of allelopathic substancesfor the development of new natural herbicides.展开更多
基金This work was financially supported by grants from the National Basic Research Program of China(973 Program,2009CB522300 and 2009CB940900)National Natural Science Funding of China(31170332)the Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).
文摘Two new tirucallane triterpenoids,2a-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid(1)and(23E)-2a-hydroxytirucalla-7,23,25-triene-3-one(2),along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione(3),were isolated from the leaves and twigs of Aphanamixis grandifolia.Their structures were elucidated by extensive NMR and MS data,and compound 3 was further confirmed by X-ray crystal diffraction analysis.Antimicrobial activities and insecticidal activities of these three compounds were also evaluated.Compound 1 showed good antimicrobial activity against Staphylococcus aureus with the MIC value of 1.56μg/mL,while compounds 1 and 2 showed insecticidal activity at 100 ppm,with the corrected mortality 79.1%and 60.6%,respectively.
文摘A new limonoid named rohituka-15 1, with a known limonoid dregeana-1 2, was isolated from the seed of Aphanamixis polystachya (Meliaceae). The 13C NMR data assignment of dregeana-1 2 and the structural elucidation of the new compound 1 were based on spectral analysis including 1H-1H COSY, HMQC and HMBC experiments.
基金Financial support for this study is from the National Natural Science Foundation of China(No.31470416)the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63)+2 种基金the"Double First-Class"University Project,China(No.CPU2018GY08)the 111 Project from Ministry of Education ofChina and the State Administration of Foreign Export Affairs of China(No.B18056)the National New Drug Innovation Major Project(No.2018ZX09711-001-007)。
文摘Aphamines A-C(1-3),three pairs of acyclic diterpene dimer enantiomers with an unprecedent ploymerization pattern,were discovered from Aphanamixis polystachya by NMR-guided isolation and chiral resolution.The elucidation of their novel carbon skeletons was achieved based on spectroscopic analysis,exciton chirality,and calculated electronic circular dichroism(ECD).Plausible Claisen rearrangement,5-exo-trig cyclization,and reduction reactions may play important roles in the polymeric biosynthesis pathway.Compounds 1 and 3 showed inhibitory effects on nitric oxide(NO)production(IC_(50):6.71-15.36μmol/L)and reduced the expression of iNOS in LPS-induced RAW 264.7 macrophages.
文摘Two new tirucallane-type triterpenoids, 3a,24β＇,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene （I） and 3a-acetoxy-21fl-methoxy-24,25,26,27-tetranortirucall-7-ene-23（21）-lactone （2）, were isolated from the stem barks ofAphanamixis grandifblia, and their structures were elucidated on the basis of spectroscopic data analysis includ- ing ID, 2D NMR, IR, and ESI-MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI-H460 and HeLa cell lines.
文摘Four new limonoids, named aphanagranins A-D （1-4）, were isolated from the fruits ofAphanamixis grandi- folia. The new structures were determined by spectroscopic methods especially 1D and 2D NMR analysis, Aphana- granin A （1） possessed a rare four membered oxygen heterocyclic ring and its absolute configurations were deter- mined on the basis of the signal crystal X-ray diffraction analysis. Furthermore, compounds 1 and 2 showed weak activity toward brine shrimp （Artemia salina）.
文摘Current study aims to investigate the allelopathic potential of the differentparts (leaf, bark, stem, twig and root) of three oil-enrich plant species ofBangladesh viz., Jatropha curcus, Ricinus communis and Aphanamixispolystachya. The aqueous extract of those plant parts were diluted intofour different concentrations viz., 1:5, 1:10, 1:15, 1:20 (w/v) and testedagainst the seedling growth of jute, rice, wheat, radish, tomato, mungbeanand mustard under control laboratory condition. A control (distilled waterwithout extract) was also maintained in every cases and the bioassayexperiment was replicated thrice. The results of this research showed thatthe shoot and root growth inhibition of rice, wheat, jute, tomato, radish,mungbean and mustard by leaf, bark, stem, twig and root extracts of J.curcus, R. communis and A. polystachya varied significantly. Compareto the shoot growth, the root growth of the test species inhibited moreexcept J. curcus. The leaf and root have higher allelopathic potential thanany other parts of the studied plants. Finally, it can be concluded here thatJ. curcus plant extracts has higher allelopathic potential than other twoplants R. communis and A. polystachya. Therefore, J. curcus can be usedas a candidate plant for isolation and identification of allelopathic substancesfor the development of new natural herbicides.
