Social defeat stress(SDS)plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression.Sleep is generally considered to involve recovery of the brain from prior experience during wakefuln...Social defeat stress(SDS)plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression.Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS.However,the effect of acute SDS on sleep/wake behavior in mice varies between studies.In addition,whether sleep changes in response to stress contribute to anxiety is not well established.Here,we first investigated the effects of acute SDS on sleep/wake states in the active period in mice.Our results showed that total sleep time(time in rapid eyemovement[REM]and non-REM[NREM]sleep)increased in the active period after acute SDS.NREM sleep increased mainly during the first 3 h after SDS,while REM sleep increased at a later time.Then,we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute SDS.Mice deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state,while in mice with ad libitum sleep the anxiety rapidly faded away.Altogether,our findings suggest an anxiolytic effect of NREM sleep,and indicate a potential therapeutic strategy for anxiety.展开更多
A recent study published in Neuron by Tiwari et al.identified the critical role of 5-HT2A receptor in ventral hippocampal parvalbumin(PV)interneurons(INs)in mediating the acute anxiolytic effects of the serotonergic p...A recent study published in Neuron by Tiwari et al.identified the critical role of 5-HT2A receptor in ventral hippocampal parvalbumin(PV)interneurons(INs)in mediating the acute anxiolytic effects of the serotonergic psychedelic 2,5-dimethoxy-4-iodoamphetamine(DOI).This study not only advances psychedelic neuropharmacology but also provides a robust framework for developing novel rapid-acting therapeutics for anxiety disorders[1].展开更多
基金This work was supported by the National Key Research and Development Program of China(2016YFA0501000 and 2016YFC1306700)the National Natural Science Foundation of China(31970939,81527901,81821091,31771167,31571090,and 31490592)+2 种基金the Science and Technology Planning Project of Guangdong Province of China(2018B030331001)the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041)and Fundamental Research Funds for the Central Universities,China(2017FZA7003).
文摘Social defeat stress(SDS)plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression.Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS.However,the effect of acute SDS on sleep/wake behavior in mice varies between studies.In addition,whether sleep changes in response to stress contribute to anxiety is not well established.Here,we first investigated the effects of acute SDS on sleep/wake states in the active period in mice.Our results showed that total sleep time(time in rapid eyemovement[REM]and non-REM[NREM]sleep)increased in the active period after acute SDS.NREM sleep increased mainly during the first 3 h after SDS,while REM sleep increased at a later time.Then,we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute SDS.Mice deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state,while in mice with ad libitum sleep the anxiety rapidly faded away.Altogether,our findings suggest an anxiolytic effect of NREM sleep,and indicate a potential therapeutic strategy for anxiety.
基金supported by the National Natural Science Foundation of China(82204353).
文摘A recent study published in Neuron by Tiwari et al.identified the critical role of 5-HT2A receptor in ventral hippocampal parvalbumin(PV)interneurons(INs)in mediating the acute anxiolytic effects of the serotonergic psychedelic 2,5-dimethoxy-4-iodoamphetamine(DOI).This study not only advances psychedelic neuropharmacology but also provides a robust framework for developing novel rapid-acting therapeutics for anxiety disorders[1].
