The objective of this research was to assess the potential of phosphatidylcholineencapsulated resveratrol as a cosmetic ingredient.The hydrogen peroxide(H_(2)O_(2))and ultraviolet A(UVA)induced human skin fibroblasts(...The objective of this research was to assess the potential of phosphatidylcholineencapsulated resveratrol as a cosmetic ingredient.The hydrogen peroxide(H_(2)O_(2))and ultraviolet A(UVA)induced human skin fibroblasts(HSF)models of skin damage were established to compare the antioxidant and anti-wrinkle properties between phosphatidylcholine-encapsulated resveratrol and unencapsulated resveratrol.The findings reveal that encapsulating resveratrol with phosphatidylcholine not only enhances skin absorption but also significantly improves its antioxidant capabilities.In the H2O2-induced HSF injury model,phosphatidylcholine-encapsulated resveratrol demonstrates a superior ability to neutralize reactive oxygen species(ROS)generated by H2O2 compared to the resveratrol group.Further analysis indicates that this enhanced functionality is associated with increased enzymatic activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and catalase(CAT)when treated with phosphatidylcholine-encapsulated resveratrol.Additionally,in UVA-irradiated HSF cells,phosphatidylcholine-encapsulated resveratrol effectively reduces the levels of matrix metalloproteinases-1 and-3(MMP-1 and MMP-3)and increased the contents of CollagenⅠand CollagenⅢ(Col-1 and Col-3),demonstrating significant anti-wrinkle effects.These findings provide critical evaluation criteria and application references for enhancing cosmetic ingredients through phosphatidylcholine encapsulation,thereby advancing skincare formulations.展开更多
In this study, our objective was to evaluate the antioxidant, cytotoxicity and collagen synthesis activity in vitro and also to test the anti-wrinkle effect of formulated cream containing Veronica officinalis extract ...In this study, our objective was to evaluate the antioxidant, cytotoxicity and collagen synthesis activity in vitro and also to test the anti-wrinkle effect of formulated cream containing Veronica officinalis extract in vivo. Antioxidant evaluation was based on the scavenging activity of free radicles (DPPH) and procollagen type 1 protein (P1P) synthesis test was performed in fibroblast cell. Clinical anti-wrinkle activity was performed on female subjects in placebo-controlled trail. Verbascoside (an isolated compound) showed higher (IC50 value of 36.24 ± 1.81 μg/ml) free radicle inhibition activity but weaker collagen synthesis activity. The ethanolic extract showed good inhibition to DPPH free radicals and also showed a significant effect in collagen synthesis activity without cytotoxicity. In the in vivo study, treatment with the formulated cream (Scoti-Speedwell) for 56 days significantly reduced the percentage of wrinkle area and length with 18.0% and 16.05%, respectively. Overall, Veronica officinalis extract containing product (Scoti-SpeedwellTM) can be regarded as a potent anti-wrinkle agent in human skin.展开更多
This study investigates the potential of marine algae-derived polysaccharides,specifically the biological mac-romolecules fucoidan,agar,and ulvan,encapsulated in mesoporous silica nanoparticles(MSN)for cosmetic applic...This study investigates the potential of marine algae-derived polysaccharides,specifically the biological mac-romolecules fucoidan,agar,and ulvan,encapsulated in mesoporous silica nanoparticles(MSN)for cosmetic applications.Novel composite materials,MSN@Fucoidan,MSN@Agar,and MSN@Ulvan,were synthesized and characterized for their anti-tyrosinase,moisturizing,antioxidant,and anti-collagenase activities.Thermogravi-metric analysis revealed high loading capacities of these polysaccharides into MSN,as well as MSN into agar.In vitro experiments demonstrated the biocompatibility of the materials and their ability to inhibit melanin pro-duction while promoting collagen synthesis.Among them,MSN@Agar exhibited the most promising results,suggesting the potential of these composite materials for skincare formulations.This study highlights the sig-nificance of natural biopolymers and nanotechnology in developing effective and safe cosmetics targeting skin health.展开更多
文摘The objective of this research was to assess the potential of phosphatidylcholineencapsulated resveratrol as a cosmetic ingredient.The hydrogen peroxide(H_(2)O_(2))and ultraviolet A(UVA)induced human skin fibroblasts(HSF)models of skin damage were established to compare the antioxidant and anti-wrinkle properties between phosphatidylcholine-encapsulated resveratrol and unencapsulated resveratrol.The findings reveal that encapsulating resveratrol with phosphatidylcholine not only enhances skin absorption but also significantly improves its antioxidant capabilities.In the H2O2-induced HSF injury model,phosphatidylcholine-encapsulated resveratrol demonstrates a superior ability to neutralize reactive oxygen species(ROS)generated by H2O2 compared to the resveratrol group.Further analysis indicates that this enhanced functionality is associated with increased enzymatic activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and catalase(CAT)when treated with phosphatidylcholine-encapsulated resveratrol.Additionally,in UVA-irradiated HSF cells,phosphatidylcholine-encapsulated resveratrol effectively reduces the levels of matrix metalloproteinases-1 and-3(MMP-1 and MMP-3)and increased the contents of CollagenⅠand CollagenⅢ(Col-1 and Col-3),demonstrating significant anti-wrinkle effects.These findings provide critical evaluation criteria and application references for enhancing cosmetic ingredients through phosphatidylcholine encapsulation,thereby advancing skincare formulations.
文摘In this study, our objective was to evaluate the antioxidant, cytotoxicity and collagen synthesis activity in vitro and also to test the anti-wrinkle effect of formulated cream containing Veronica officinalis extract in vivo. Antioxidant evaluation was based on the scavenging activity of free radicles (DPPH) and procollagen type 1 protein (P1P) synthesis test was performed in fibroblast cell. Clinical anti-wrinkle activity was performed on female subjects in placebo-controlled trail. Verbascoside (an isolated compound) showed higher (IC50 value of 36.24 ± 1.81 μg/ml) free radicle inhibition activity but weaker collagen synthesis activity. The ethanolic extract showed good inhibition to DPPH free radicals and also showed a significant effect in collagen synthesis activity without cytotoxicity. In the in vivo study, treatment with the formulated cream (Scoti-Speedwell) for 56 days significantly reduced the percentage of wrinkle area and length with 18.0% and 16.05%, respectively. Overall, Veronica officinalis extract containing product (Scoti-SpeedwellTM) can be regarded as a potent anti-wrinkle agent in human skin.
基金support provided through grants 106-2113-M-019-003,107-2113-M-019-001,108-2113-M-019-002,109-2113-M-019-002,110-2113-M-019-006-,111-2113-M-019-003,112-2113-M-019-001-,113-2113-M-019-003-,114-2113-M-019-001-.
文摘This study investigates the potential of marine algae-derived polysaccharides,specifically the biological mac-romolecules fucoidan,agar,and ulvan,encapsulated in mesoporous silica nanoparticles(MSN)for cosmetic applications.Novel composite materials,MSN@Fucoidan,MSN@Agar,and MSN@Ulvan,were synthesized and characterized for their anti-tyrosinase,moisturizing,antioxidant,and anti-collagenase activities.Thermogravi-metric analysis revealed high loading capacities of these polysaccharides into MSN,as well as MSN into agar.In vitro experiments demonstrated the biocompatibility of the materials and their ability to inhibit melanin pro-duction while promoting collagen synthesis.Among them,MSN@Agar exhibited the most promising results,suggesting the potential of these composite materials for skincare formulations.This study highlights the sig-nificance of natural biopolymers and nanotechnology in developing effective and safe cosmetics targeting skin health.
