Fast and precise diagnostic techniques are required for the treatment of many disorders.Biosensors are one of the diagnostic devices that are applicable in biological and medical sciences.Biosensors could be utilized ...Fast and precise diagnostic techniques are required for the treatment of many disorders.Biosensors are one of the diagnostic devices that are applicable in biological and medical sciences.Biosensors could be utilized to recognize biological molecules with high sensitivity.Biosensors are consisted of different components and have different types.Each type of biosensor is used in a particular field according to its specific features.Nanobodies are a novel class of antibodies with small size,high affinity,and specificity to their target.The unique properties of nanobodies make them appropriate tools for diagnostic applications.In this paper,we review biosensors,and their features and roles in medicine.Antibody/nanobody-based biosensors are also specifically discussed.展开更多
In a recent study published in Cell,Hansen et al.applied antibodybased spatial proteomics and advanced confocal imaging to build a comprehensive single-organelle-resolution proteome atlas of the human primary cilium f...In a recent study published in Cell,Hansen et al.applied antibodybased spatial proteomics and advanced confocal imaging to build a comprehensive single-organelle-resolution proteome atlas of the human primary cilium from three cell types-hTERTRPE1 cells from the embryonic retina,RPTEC/TERT1 cells from the epithelial kidney proximal tubules,and the mesenchymal,multipotent,stromal ASC52telo cells-,identifying 715 proteins and revealing marked cell-type and single-cilium variability.1 This work demonstrates that primary cilia are highly customizable signaling hubs whose proteomic diversity provides a robust framework for understanding cilia-dependent signaling and uncovering the molecular basis of ciliopathies.展开更多
基金Pasteur Institute of Iran for supporting the current article
文摘Fast and precise diagnostic techniques are required for the treatment of many disorders.Biosensors are one of the diagnostic devices that are applicable in biological and medical sciences.Biosensors could be utilized to recognize biological molecules with high sensitivity.Biosensors are consisted of different components and have different types.Each type of biosensor is used in a particular field according to its specific features.Nanobodies are a novel class of antibodies with small size,high affinity,and specificity to their target.The unique properties of nanobodies make them appropriate tools for diagnostic applications.In this paper,we review biosensors,and their features and roles in medicine.Antibody/nanobody-based biosensors are also specifically discussed.
基金supported by grants from Agencia Nacional de Investigación y Desarrollo(ANID),Fondo de Financiamiento de Centros de Investigación enÁreas Prioritarias(FONDAPgrants 15130011 and 1523A0008 to S.L.and M.C.)+2 种基金Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT grants 1240443 to S.L.,and 1220392&1260122 to M.C.)supported by grants from the Key R&D Program of Jiangxi Province(20232BCD44008,HLY)the Jiangxi Province Thousand Talents Project(jxsq2023101002,H.L.).
文摘In a recent study published in Cell,Hansen et al.applied antibodybased spatial proteomics and advanced confocal imaging to build a comprehensive single-organelle-resolution proteome atlas of the human primary cilium from three cell types-hTERTRPE1 cells from the embryonic retina,RPTEC/TERT1 cells from the epithelial kidney proximal tubules,and the mesenchymal,multipotent,stromal ASC52telo cells-,identifying 715 proteins and revealing marked cell-type and single-cilium variability.1 This work demonstrates that primary cilia are highly customizable signaling hubs whose proteomic diversity provides a robust framework for understanding cilia-dependent signaling and uncovering the molecular basis of ciliopathies.
