Human longevity has increased dramatically during the past century.More than 20%of the 9 billion population of the world will exceed the age of 60 in 2050.Since the last three decades,some interventions and many precl...Human longevity has increased dramatically during the past century.More than 20%of the 9 billion population of the world will exceed the age of 60 in 2050.Since the last three decades,some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast,flies,rodents to nonhuman primates.The interventions are classified into two groups:lifestyle modifications and pharmacological/genetic manipulations.Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan.Thus,all genes in the pathways are potential antiaging targets.Currently,many antiaging compounds target the calorie-restriction mimetic,autophagy induction,and putative enhancement of cell regeneration,epige-netic modulation of gene activity such as inhibition of histone deacetylases and DNA methyltransferases,are under development.It appears evident that the exploration of new targets for these antiaging agents based on biogeron-tological research provides an incredible opportunity for the healthcare and pharmaceutical industries.The present review focus on the properties of slow aging and healthy life span extension of natural products from various biologi-cal resources,endogenous substances,drugs,and synthetic compounds,as well as the mechanisms of targets for antiaging evaluation.These bioactive compounds that could benefit healthy aging and the potential role of life span extension are discussed.展开更多
Low molecular weight peptide (LMWP) was prepared from clam Paphia undulate and its antiaging effect on D-galactose-induced acute aging in rats, aged Kunming mice, ultraviolet-exposed rats, and thermally injured rats w...Low molecular weight peptide (LMWP) was prepared from clam Paphia undulate and its antiaging effect on D-galactose-induced acute aging in rats, aged Kunming mice, ultraviolet-exposed rats, and thermally injured rats was investigated. P. undulate flesh was homogenized and digested using papain under optimal conditions, then subjected to Sephadex G-25 chromatography to isolate the LMWP. Administration of LMWP significantly reversed D-galactose-induced oxidative stress by increasing the activities of glutathione peroxidase (GPx) and catalase (CAT), and by decreasing the level of malondialdehyde (MDA). This process was accompanied by increased collagen synthesis. The LMWP prevented photoaging and promoted dermis recovery and remission of elastic fiber hyperplasia. Furthermore, treatment with the LMWP helped to regenerate elastic fibers and the collagen network, increased superoxide dismutase (SOD) in the serum and significantly decreased MDA. Thermal scald-induced inflammation and edema were also relieved by the LWMP, while wound healing in skin was promoted. These results suggest that the LMWP from P. undulate could serve as a new antiaging substance in cosmetics.展开更多
Cosmeceuticals are cosmetic products claimed to have medicinal or drug-like benefits.The term was created in 1990s from cosme(tics)and(pharma)ceuticals.These products are marketed as cosmetics but formulated with biol...Cosmeceuticals are cosmetic products claimed to have medicinal or drug-like benefits.The term was created in 1990s from cosme(tics)and(pharma)ceuticals.These products are marketed as cosmetics but formulated with biologically active ingredients to promote them to have the benefits beyond the traditional moisturizer.Cosmeceuticals,however,are not recognized under any categories of the Food,Drug,and Cosmetic Act.In consideration on rice,it is the most widely consumed staple food for large parts of the world’s human population,especially in Asia,as the source of nutrition and caloric intake.展开更多
Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and ...Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and traditional Chinese medicine(TCM).In this review,we summarize the current state of antiaging research related to both modern medicine and TCM and provide suggestions for further research.Various theories related to the aging process have been proposed,including the free radical theory,mitochondrial DNA damage theory,telomere theory,cross-linking theory,and intestinal flora theory,and a number of antiaging chemical treatments have been developed using modern medicine.These theories and achievements have resulted in major advancements in antiaging research.TCM is based on practical experience and has a long history with unique advantages in antiaging research.Some antiaging practices such as moderate diet consumption,acupuncture,Tai Chi(a traditional Chinese martial art that can relax the nerves to slow down the aging process),and Wuqin Xi(a traditional Chinese exercise to strengthen the body)have been adopted to maintain health.Several TCMs and prescriptions,particularly those related to medicine food homology,have been used in antiaging treatment,and their antiaging properties have been demonstrated to be effective based on pharmacological experiments and clinical applications.展开更多
The skin’s primary function is to protect the body against a spectrum of environmental stressors, including mechanical insults, microorganisms, chemicals, and allergens. Located in the outermost layers, the primary s...The skin’s primary function is to protect the body against a spectrum of environmental stressors, including mechanical insults, microorganisms, chemicals, and allergens. Located in the outermost layers, the primary structures and components responsible for the skin’s barrier function are susceptible to environmental variables, dermatological conditions, and the aging process. The ensuing alterations to structure, composition, and organizational attributes of the epidermal barrier can impact its integrity and functionality. The aim of this study was to assess the effect of a novel complex composed of a ceramide, energizing peptide, and Camu Camu extract (SUPCERAT<sup>TM</sup> complex) on specific markers of epidermal barrier integrity, as well as epidermal and dermal function. All the experiments were conducted on fresh human abdominal skin explants. Intradermal production of hyaluronic acid, epidermal claudin-1, and ceramide synthase 3 expressions, as well as epidermal lipids content were assessed using specific fluorescent stainings on ex vivo skin after the application of the complex or placebo. Additionally, dermal elastase and collagenase activities were assessed using in tubo enzymatic assays. Lastly, the effect of a cosmetic cream containing SUPCERAT<sup>TM</sup> complex was assessed using subjective Global Aesthetic Improvement Scale (GAIS) in a small cohort of patients after 60 days of use. The application of the SUPCERAT<sup>TM</sup> complex on ex vivo skin led to significant increase in dermal hyaluronic acid content and epidermal activity of claudin-1, ceramide synthase 3 and epidermal ceramide content. Furthermore, in tubo enzymatic assays demonstrated inhibition of both dermal elastase and collagenase activities. In addition, the patient-reported results indicated significant improvements in skin quality and appearance. .展开更多
Aging is one of the causes of cognitive dysfunction,which seriously affects people's quality of life.Unsaponifiable matter(USM)has antioxidant potential,but the molecular mechanisms that ameliorate aging and cogni...Aging is one of the causes of cognitive dysfunction,which seriously affects people's quality of life.Unsaponifiable matter(USM)has antioxidant potential,but the molecular mechanisms that ameliorate aging and cognitive dysfunction are unknown.In this study,we used a galactose-induced brain aging mouse model and systematically analyzed the mechanism of USM in delaying aging in mice by detecting changes in serum and brain by metabolomics and transcriptomics.USM was compared with the model group,and non-targeted metabolomics identified 68(15 up-regulated,53 down-regulated)differentially metabolites,and transcriptomics identified 303 differentially expressed genes(228 up-regulated,75 down-regulated).Combined multi-omics analyses showed that USM maintains normal brain function by regulating glycolytic processes,the tricarboxylic acid cycle(TCA),tryptophan metabolism,pyrimidine metabolism,the alanine,aspartate,and glutamate metabolism,and p38 mitogen-activated protein kinase(p38 MAPK)pathway.Meanwhile,USM increased neurotransmitter release from GABAergic synapses and cholinergic synapses by regulating synaptic vesicle cycling.In summary,USM increased energy metabolism and enhanced brain nerve signaling in the mouse brain,thereby delaying brain aging.This investigation offers novel perspectives into the molecular mechanism of USM to mitigate brain aging.展开更多
Have you found an antiaging solution?It has been a subject of interest in many studies.Even if there is no treatment on the market that can prove an effective method to slow human aging,research shows that the consump...Have you found an antiaging solution?It has been a subject of interest in many studies.Even if there is no treatment on the market that can prove an effective method to slow human aging,research shows that the consumption of low calories and a balanced diet can help to boost our immune system.展开更多
Pterostilbene is gaining recognition as a promising ingredient in skincare for its anti-aging benefits.This study assessed the clinical effectiveness of a 0.1%pterostilbene-containing skincare emulsion against a contr...Pterostilbene is gaining recognition as a promising ingredient in skincare for its anti-aging benefits.This study assessed the clinical effectiveness of a 0.1%pterostilbene-containing skincare emulsion against a control emulsion over 28 days with 31 participants.A double-blind,split-face design was used,comparing the left and right sides of the face and preand post-treatment conditions.Efficacy was measured using advanced tools,including the Skin Elasticity Tester CutometerR dual MPA580,the facial imaging and analysis system VISIAR-CR,the skin microstructure 3D imaging system PRIMOSCR,and the in vivo two-photon microscopy imaging system SUPERVISION-780,along with subjects’selfassessment after 14 and 28 days of continual use.Results demonstrated that the 0.1%pterostilbene emulsion significantly enhanced skin elasticity R2 and firmness F4,reduced the area and volume of forehead and undern-eye wrinkles,decreased the percentage of Crow’s feet wrinkles area,improved the aging index ELCOR,and increased the thickness of the epidermis layer,collagen intensity,elastic fiber fluorescence,and the standardized area of the epidermal-dermal junction(DEJ).Compared to the control emulsion,the pterostilbene emulsion showed statistically significant(p<0.05)improvements in these metrics,as well as aging index SAIID and skin pore size.All subjects expressed higher satisfaction with the pterostilbene emulsion,highlighting its superior skincare benefits.The findings emphasize the potent anti-aging efficacy of pterostilbene,reinforcing its value as an active ingredient in cosmetics formulations.展开更多
[ Objective ] The research aimed to develop anti-aging masks with aqueous extracts of Ganoderma lucidum and to study the clinical efficacy on the delaying of skin aging. [Method] The anti-aging efficacy of the aqueous...[ Objective ] The research aimed to develop anti-aging masks with aqueous extracts of Ganoderma lucidum and to study the clinical efficacy on the delaying of skin aging. [Method] The anti-aging efficacy of the aqueous extract of C.anoderrna luciclum was evaluated by sensory evaluation, safety evaluation, instrumental measurements, etc. [ Result] The results of sensory evaluation showed that after continuous application of the test materials for 12 weeks, the skin dryness, elasticity, surface sheen, fine wrinkles and smoothness were well improved, and the improvement rates were 9l. 17%, 91.17% , 94.12% , 11.76% and 91.18% , respectively. The measurement results by specialized instrument showed that the skin hydration on the target site increased continuously with the prolonging of the using time. Significant differences existed between each time point after using the products and the time before using. There was no signiScant difference existed in elasticity index 112 and R5 compared with before using. [Result] Clinical data showed that the active ingredients in aqueous extract of Ganoderma lucidum had a certain effect on the delaying of skin aging.展开更多
In the context of global ageing,the prevalence of neurodegenerative diseases and dementia,such as Alzheimer's disease(AD),is increasing.However,the current symptomatic and disease-modifying therapies have achieved...In the context of global ageing,the prevalence of neurodegenerative diseases and dementia,such as Alzheimer's disease(AD),is increasing.However,the current symptomatic and disease-modifying therapies have achieved limited benefits for neurodegenerative diseases in clinical settings.Halting the progress of neurodegeneration and cognitive decline or even improving impaired cognition and function are the clinically meaningful goals of treatments for neurodegenerative diseases.Ageing is the primary risk factor for neurodegenerative diseases and their associated comorbidities,such as vascular pathologies,in elderly individuals.Thus,we aim to elucidate the role of ageing in neurodegenerative diseases from the perspective of a complex system,in which the brain is the core and peripheral organs and tissues form a holistic network to support brain functions.During ageing,the progressive deterioration of the structure and function of the entire body hampers its active and adaptive responses to various stimuli,thereby rendering individuals more vulnerable to neurodegenerative diseases.Consequently,we propose that the prevention and treatment of neurodegenerative diseases should be grounded in holistic antiageing and rejuvenation means complemented by interventions targeting disease-specific pathogenic events.This integrated approach is a promising strategy to effectively prevent,pause or slow down the progression of neurodegenerative diseases.展开更多
Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which pro...Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which provides valuable references for the in-depth study of overall aging.According to the Qi-collateral theory in traditional Chinese medicine,essence is the origin of life;Qi is the driving force of life;and spirit is the embodiment of life.This theory interprets key scientific issues such as the formation of life,the driving force of life,the function of Zang-Fu organs,and the spirit and consciousness.Furthermore,it reveals the key mechanism of aging.That is,the deficiency of kidney essence is the root of aging;the loss of vitality is the key of aging;and the depletion of body and spirit is the manifestation of aging.Based on the experience of medical practitioners in the past dynasties,such as nourishing essence,black food tonifying the kidney,and supplementing essence with flesh-blood products,the treatment method of invigorating kidney and supplementing essence,harmonizing Yin and Yang,reinforcing the vitality,and nourishing the body and spirit was proposed.Furthermore,an innovative Chinese patent medicine,Bazi Bushen capsules,is developed,which exerts the antiaging effect by replenishing Qi,invigorating the spirit,and nourishing the body and spirit.Pharmacological and clinical studies have confirmed that this preparation has antiaging effects and are effective in the prevention and treatment of age-related diseases.Experimental studies have shown that Bazi Bushen capsules can delay the overall aging,reduce the DNAmethylation and extend the healthy life of naturally aging mice,mitigate the age-related cognitive dysfunction,improve neurological function,maintain redox homeostasis and telomere integrity,and inhibit apoptosis.Moreover,Bazi Bushen capsules can increase the dermal thickness and the collagen fiber and elastic fiber content to prevent skin aging.In addition,Bazi Bushen capsules can correct the lipid metabolism disorders and ameliorate multisystem age-related diseases such as osteoporosis in surgically induced menopausal rats.This article discusses the pathogenesis,treatment,and prescription of aging and the antiaging theory,aiming to provide a basis for delaying aging and preventing related diseases.展开更多
基金funding from the National Natural Science Foundation of China (Grant numbers 21961142008,22177138).
文摘Human longevity has increased dramatically during the past century.More than 20%of the 9 billion population of the world will exceed the age of 60 in 2050.Since the last three decades,some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast,flies,rodents to nonhuman primates.The interventions are classified into two groups:lifestyle modifications and pharmacological/genetic manipulations.Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan.Thus,all genes in the pathways are potential antiaging targets.Currently,many antiaging compounds target the calorie-restriction mimetic,autophagy induction,and putative enhancement of cell regeneration,epige-netic modulation of gene activity such as inhibition of histone deacetylases and DNA methyltransferases,are under development.It appears evident that the exploration of new targets for these antiaging agents based on biogeron-tological research provides an incredible opportunity for the healthcare and pharmaceutical industries.The present review focus on the properties of slow aging and healthy life span extension of natural products from various biologi-cal resources,endogenous substances,drugs,and synthetic compounds,as well as the mechanisms of targets for antiaging evaluation.These bioactive compounds that could benefit healthy aging and the potential role of life span extension are discussed.
基金Supported by the Knowledge Innovation Program of Chinese Academy of Sciences(No.KZCX2-EW-Q214)the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences(Nos.2011A090100008,2009B091300018,2010B090300027)the Marine Fisheries Technology Promotion Special Program of Guangdong Province,China(No.A2009009-035(a))
文摘Low molecular weight peptide (LMWP) was prepared from clam Paphia undulate and its antiaging effect on D-galactose-induced acute aging in rats, aged Kunming mice, ultraviolet-exposed rats, and thermally injured rats was investigated. P. undulate flesh was homogenized and digested using papain under optimal conditions, then subjected to Sephadex G-25 chromatography to isolate the LMWP. Administration of LMWP significantly reversed D-galactose-induced oxidative stress by increasing the activities of glutathione peroxidase (GPx) and catalase (CAT), and by decreasing the level of malondialdehyde (MDA). This process was accompanied by increased collagen synthesis. The LMWP prevented photoaging and promoted dermis recovery and remission of elastic fiber hyperplasia. Furthermore, treatment with the LMWP helped to regenerate elastic fibers and the collagen network, increased superoxide dismutase (SOD) in the serum and significantly decreased MDA. Thermal scald-induced inflammation and edema were also relieved by the LWMP, while wound healing in skin was promoted. These results suggest that the LMWP from P. undulate could serve as a new antiaging substance in cosmetics.
文摘Cosmeceuticals are cosmetic products claimed to have medicinal or drug-like benefits.The term was created in 1990s from cosme(tics)and(pharma)ceuticals.These products are marketed as cosmetics but formulated with biologically active ingredients to promote them to have the benefits beyond the traditional moisturizer.Cosmeceuticals,however,are not recognized under any categories of the Food,Drug,and Cosmetic Act.In consideration on rice,it is the most widely consumed staple food for large parts of the world’s human population,especially in Asia,as the source of nutrition and caloric intake.
基金the Innovation Team of Shanxi University of Chinese Medicine(2018TD-014).
文摘Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and traditional Chinese medicine(TCM).In this review,we summarize the current state of antiaging research related to both modern medicine and TCM and provide suggestions for further research.Various theories related to the aging process have been proposed,including the free radical theory,mitochondrial DNA damage theory,telomere theory,cross-linking theory,and intestinal flora theory,and a number of antiaging chemical treatments have been developed using modern medicine.These theories and achievements have resulted in major advancements in antiaging research.TCM is based on practical experience and has a long history with unique advantages in antiaging research.Some antiaging practices such as moderate diet consumption,acupuncture,Tai Chi(a traditional Chinese martial art that can relax the nerves to slow down the aging process),and Wuqin Xi(a traditional Chinese exercise to strengthen the body)have been adopted to maintain health.Several TCMs and prescriptions,particularly those related to medicine food homology,have been used in antiaging treatment,and their antiaging properties have been demonstrated to be effective based on pharmacological experiments and clinical applications.
文摘The skin’s primary function is to protect the body against a spectrum of environmental stressors, including mechanical insults, microorganisms, chemicals, and allergens. Located in the outermost layers, the primary structures and components responsible for the skin’s barrier function are susceptible to environmental variables, dermatological conditions, and the aging process. The ensuing alterations to structure, composition, and organizational attributes of the epidermal barrier can impact its integrity and functionality. The aim of this study was to assess the effect of a novel complex composed of a ceramide, energizing peptide, and Camu Camu extract (SUPCERAT<sup>TM</sup> complex) on specific markers of epidermal barrier integrity, as well as epidermal and dermal function. All the experiments were conducted on fresh human abdominal skin explants. Intradermal production of hyaluronic acid, epidermal claudin-1, and ceramide synthase 3 expressions, as well as epidermal lipids content were assessed using specific fluorescent stainings on ex vivo skin after the application of the complex or placebo. Additionally, dermal elastase and collagenase activities were assessed using in tubo enzymatic assays. Lastly, the effect of a cosmetic cream containing SUPCERAT<sup>TM</sup> complex was assessed using subjective Global Aesthetic Improvement Scale (GAIS) in a small cohort of patients after 60 days of use. The application of the SUPCERAT<sup>TM</sup> complex on ex vivo skin led to significant increase in dermal hyaluronic acid content and epidermal activity of claudin-1, ceramide synthase 3 and epidermal ceramide content. Furthermore, in tubo enzymatic assays demonstrated inhibition of both dermal elastase and collagenase activities. In addition, the patient-reported results indicated significant improvements in skin quality and appearance. .
基金supported by the National Key Research and Development Program(2022YFD1600402).
文摘Aging is one of the causes of cognitive dysfunction,which seriously affects people's quality of life.Unsaponifiable matter(USM)has antioxidant potential,but the molecular mechanisms that ameliorate aging and cognitive dysfunction are unknown.In this study,we used a galactose-induced brain aging mouse model and systematically analyzed the mechanism of USM in delaying aging in mice by detecting changes in serum and brain by metabolomics and transcriptomics.USM was compared with the model group,and non-targeted metabolomics identified 68(15 up-regulated,53 down-regulated)differentially metabolites,and transcriptomics identified 303 differentially expressed genes(228 up-regulated,75 down-regulated).Combined multi-omics analyses showed that USM maintains normal brain function by regulating glycolytic processes,the tricarboxylic acid cycle(TCA),tryptophan metabolism,pyrimidine metabolism,the alanine,aspartate,and glutamate metabolism,and p38 mitogen-activated protein kinase(p38 MAPK)pathway.Meanwhile,USM increased neurotransmitter release from GABAergic synapses and cholinergic synapses by regulating synaptic vesicle cycling.In summary,USM increased energy metabolism and enhanced brain nerve signaling in the mouse brain,thereby delaying brain aging.This investigation offers novel perspectives into the molecular mechanism of USM to mitigate brain aging.
文摘Have you found an antiaging solution?It has been a subject of interest in many studies.Even if there is no treatment on the market that can prove an effective method to slow human aging,research shows that the consumption of low calories and a balanced diet can help to boost our immune system.
文摘Pterostilbene is gaining recognition as a promising ingredient in skincare for its anti-aging benefits.This study assessed the clinical effectiveness of a 0.1%pterostilbene-containing skincare emulsion against a control emulsion over 28 days with 31 participants.A double-blind,split-face design was used,comparing the left and right sides of the face and preand post-treatment conditions.Efficacy was measured using advanced tools,including the Skin Elasticity Tester CutometerR dual MPA580,the facial imaging and analysis system VISIAR-CR,the skin microstructure 3D imaging system PRIMOSCR,and the in vivo two-photon microscopy imaging system SUPERVISION-780,along with subjects’selfassessment after 14 and 28 days of continual use.Results demonstrated that the 0.1%pterostilbene emulsion significantly enhanced skin elasticity R2 and firmness F4,reduced the area and volume of forehead and undern-eye wrinkles,decreased the percentage of Crow’s feet wrinkles area,improved the aging index ELCOR,and increased the thickness of the epidermis layer,collagen intensity,elastic fiber fluorescence,and the standardized area of the epidermal-dermal junction(DEJ).Compared to the control emulsion,the pterostilbene emulsion showed statistically significant(p<0.05)improvements in these metrics,as well as aging index SAIID and skin pore size.All subjects expressed higher satisfaction with the pterostilbene emulsion,highlighting its superior skincare benefits.The findings emphasize the potent anti-aging efficacy of pterostilbene,reinforcing its value as an active ingredient in cosmetics formulations.
基金Supported by Comprehensive Strategic Cooperation Project of Chinese Academy of Sciences in Guangdong Province(2011B090300075)Guangzhou Special Project with Benefaction for People(2014Y2-00130)Fund Project of Transformation of Agricultural Science and Technology Achievements(2013GB2E000360)
文摘[ Objective ] The research aimed to develop anti-aging masks with aqueous extracts of Ganoderma lucidum and to study the clinical efficacy on the delaying of skin aging. [Method] The anti-aging efficacy of the aqueous extract of C.anoderrna luciclum was evaluated by sensory evaluation, safety evaluation, instrumental measurements, etc. [ Result] The results of sensory evaluation showed that after continuous application of the test materials for 12 weeks, the skin dryness, elasticity, surface sheen, fine wrinkles and smoothness were well improved, and the improvement rates were 9l. 17%, 91.17% , 94.12% , 11.76% and 91.18% , respectively. The measurement results by specialized instrument showed that the skin hydration on the target site increased continuously with the prolonging of the using time. Significant differences existed between each time point after using the products and the time before using. There was no signiScant difference existed in elasticity index 112 and R5 compared with before using. [Result] Clinical data showed that the active ingredients in aqueous extract of Ganoderma lucidum had a certain effect on the delaying of skin aging.
基金supported by the National Key Research and Development Program Foundation of China(2023YFC3605400)Natural Science Foundation of China(92249305,82171418).
文摘In the context of global ageing,the prevalence of neurodegenerative diseases and dementia,such as Alzheimer's disease(AD),is increasing.However,the current symptomatic and disease-modifying therapies have achieved limited benefits for neurodegenerative diseases in clinical settings.Halting the progress of neurodegeneration and cognitive decline or even improving impaired cognition and function are the clinically meaningful goals of treatments for neurodegenerative diseases.Ageing is the primary risk factor for neurodegenerative diseases and their associated comorbidities,such as vascular pathologies,in elderly individuals.Thus,we aim to elucidate the role of ageing in neurodegenerative diseases from the perspective of a complex system,in which the brain is the core and peripheral organs and tissues form a holistic network to support brain functions.During ageing,the progressive deterioration of the structure and function of the entire body hampers its active and adaptive responses to various stimuli,thereby rendering individuals more vulnerable to neurodegenerative diseases.Consequently,we propose that the prevention and treatment of neurodegenerative diseases should be grounded in holistic antiageing and rejuvenation means complemented by interventions targeting disease-specific pathogenic events.This integrated approach is a promising strategy to effectively prevent,pause or slow down the progression of neurodegenerative diseases.
基金This study was supported by the Strategic Consulting Project of the Chinese Academy of Engineering-Strategic Research on Anti-aging Effects of Traditional Chinese Medicine(2022-XY-45)the Natural Science Foundation of Hebei Province of China(no.H2022106065)+1 种基金the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(no.2023172)the Scientific Research Project of Traditional Chinese Medicine Administration of Hebei Province(no.2023391).
文摘Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which provides valuable references for the in-depth study of overall aging.According to the Qi-collateral theory in traditional Chinese medicine,essence is the origin of life;Qi is the driving force of life;and spirit is the embodiment of life.This theory interprets key scientific issues such as the formation of life,the driving force of life,the function of Zang-Fu organs,and the spirit and consciousness.Furthermore,it reveals the key mechanism of aging.That is,the deficiency of kidney essence is the root of aging;the loss of vitality is the key of aging;and the depletion of body and spirit is the manifestation of aging.Based on the experience of medical practitioners in the past dynasties,such as nourishing essence,black food tonifying the kidney,and supplementing essence with flesh-blood products,the treatment method of invigorating kidney and supplementing essence,harmonizing Yin and Yang,reinforcing the vitality,and nourishing the body and spirit was proposed.Furthermore,an innovative Chinese patent medicine,Bazi Bushen capsules,is developed,which exerts the antiaging effect by replenishing Qi,invigorating the spirit,and nourishing the body and spirit.Pharmacological and clinical studies have confirmed that this preparation has antiaging effects and are effective in the prevention and treatment of age-related diseases.Experimental studies have shown that Bazi Bushen capsules can delay the overall aging,reduce the DNAmethylation and extend the healthy life of naturally aging mice,mitigate the age-related cognitive dysfunction,improve neurological function,maintain redox homeostasis and telomere integrity,and inhibit apoptosis.Moreover,Bazi Bushen capsules can increase the dermal thickness and the collagen fiber and elastic fiber content to prevent skin aging.In addition,Bazi Bushen capsules can correct the lipid metabolism disorders and ameliorate multisystem age-related diseases such as osteoporosis in surgically induced menopausal rats.This article discusses the pathogenesis,treatment,and prescription of aging and the antiaging theory,aiming to provide a basis for delaying aging and preventing related diseases.
