Corn peptides(CP) were prepared from zein via proteolysis by means of a type of alkaline protease, Alcalase, at 50 ℃ and pH 8.0. The anti oxidative activity of the hydrolysate was examined. It was found that the...Corn peptides(CP) were prepared from zein via proteolysis by means of a type of alkaline protease, Alcalase, at 50 ℃ and pH 8.0. The anti oxidative activity of the hydrolysate was examined. It was found that the anti oxidative activity reached the maximum at the fourth hour of the hydrolysis and then decreased. The effect of the enzyme dosage on the solubility of corn protein, the dependence of hydrolysis time on the degree of the hydrolysis(DH) and molecular weight distribution were examined respectively. 30% DH was controlled on the basis of anti oxidative activity. The hydrolysate was fractionated on a Sephadex G 15 column. The anti oxidative activities were examined for all the fractions. The main fraction for anti oxidative activity was collected and characterized by the methods of amino acid analysis, the measurement of average chain length and etc .. The main M W distribution of the main fraction was 300-600 Daltons. The anti oxidative properties of the small peptides in vitro were studied. It was found that they could inhibit the auto oxidation of pyrogallol and the oxidation of hemoglobin. The hemolysis degree of erythrocyte caused by hydroxyl free radicals was decreased greatly, indicating a protective effect of the anti oxidative peptides on the cell membrane damage of erythrocyte.展开更多
Objective: Study blood vessel injury and gene expression indicating vascular endothelial cell apoptosis induced by mannitol with and without administration of anti-oxidative vitamins. Methods: Healthy rabbits were ran...Objective: Study blood vessel injury and gene expression indicating vascular endothelial cell apoptosis induced by mannitol with and without administration of anti-oxidative vitamins. Methods: Healthy rabbits were randomly divided into four groups. Mannitol was injected into the vein of the rabbit ear in each animal. Pre-treatment prior to mannitol injection was per- formed with normal saline (group B), vitamin C (group C) and vitamin E (group D). Blood vessel injury was assessed under electron and light microscopy. In a second experiment, cell culture specimen of human umbilical vein endothelial cells were treated with mannitol. Pre-treatment was done with normal saline (sample B), vitamin C (sample C) and vitamin E (sample D). Total RNA was extracted with the original single step procedure, followed by hybridisation and analysis of gene expression. Results: In the animal experiment, serious blood vessel injury was seen in group A and group B. Group D showed light injury only, and normal tissue without pathological changes was seen in group C. Of all 330 apoptosis-related genes analysed in human cell culture specimen, no significant difference was seen after pre-treatment with normal saline, compared with the gene chip without pre-treatment. On the gene chip pre-treated with vitamin C, 45 apoptosis genes were down-regulated and 34 anti-apoptosis genes were up-regulated. Pre-treatment with vitamin E resulted in the down-regulation of 3 apoptosis genes. Conclusion: Vitamin C can protect vascular endothelial cells from mannitol-induced injury.展开更多
Objective To investigate the pretreatment effects of Rhodiola rosea （R. rosea） extract on cognitive dysfunction, oxidative stress in hippocampus and hippocampal neuron injury in a rat model of Alzheimer＇s disease ...Objective To investigate the pretreatment effects of Rhodiola rosea （R. rosea） extract on cognitive dysfunction, oxidative stress in hippocampus and hippocampal neuron injury in a rat model of Alzheimer＇s disease （AD）. Methods Male Sprague-Dawley rats were pretreated with R. rosea extract at doses of 1.5, 3.0, and 6.0 g/kg for 3 weeks, followed by bilateral intracerebroventricular injection with streptozotocin （1.5 mg/kg） on days 1 and 3. Behavioral alterations were monitored after 2 weeks from the lesion using Morris water maze task. Three weeks after the lesion, the rats were sacrificed for measuring the malondialdehyde （MDA）, glutathione reductase （GR） and reduced glutathione （GSH） levels in hippocampus and histopathology of hippocampal neurons. Results The MDA level was significantly increased while the GR and GSH levels were significantly decreased with striking impairments in spatial learning and memory and severe damage to hippocampal neurons in the model rat induced by intracerebroventricular injection of streptozotocin. These abnormalities were significantly improved by pretreatment with R. rosea extract （3.0 g/kg）. Conclusion R. rosea extract can protect rats against cognitive deficits, neuronal injury and oxidative stress induced by intracerebroventricular injection of streptozotocin, and may be used as a potential agent in treatment of neurodegenerative diseases such as AD.展开更多
The aim of this study was to compare the effects of waterbome copper （Cu） and cadmium （Cd） on survival, anti-oxida- tive response, lipid peroxidation and metal accumulation in abalone Haliotis discus hannai. Exper...The aim of this study was to compare the effects of waterbome copper （Cu） and cadmium （Cd） on survival, anti-oxida- tive response, lipid peroxidation and metal accumulation in abalone Haliotis discus hannai. Experimental animals （initial weight： 7.49 g±0.01 g） were exposed to graded concentrations of waterborne Cu （0.02, 0.04, 0.06, 0.08 mg L-1） or Cd （0.025, 0.05, 0.25, 0.5 mgL-1） for 28 days, respectively. Activities of the anti-oxidative enzymes （catalase, CAT; superoxide dismutase, SOD; glutathione peroxidases, GPx; glutathione S-transferase, GST）, contents of the reduced glutathione （GSH） and malondiadehyde （MDA） in the hepatopancreas, and metal accumulation in hepatopancreas and muscles were analyzed after 0, 1, 3, 6, 10, 15, 21, 28 days of metal exposure, respectively. Results showed that 0.04 mg L-1, 0.06 mg L-1 and 0.08 mgL-1 Cu caused 100% death of abalone on the 21st, 10th and 6th day, respectively. However, no dead abalone was found during the 28-day waterborne Cd exposure at all experimental concentrations. Generally, activities of SOD and GST in hepatopancreas under all Cu concentrations followed a decrease trend as the exposure time prolonged. However, these activities were firstly increased and then decreased to the control level and increased again during Cd exposure. Activities of CAT in all Cu exposure treatments were higher than those in the control. These activities were firstly increased and then decreased to the control level and increased again during Cd exposure. Contents of MDA in hepatopancreas in all Cu treatments significantly increased first and then decreased to the control level. However, the MDA contents in hepatopan- creas were not significantly changed during the 28-day Cd exposure. The metals accumulation in both hepatopancreas and muscles of abalone significantly increased with the increase of waterborne metals concentration and exposure time. These results indicated that H. discus hannai has a positive anti-oxidative defense against Cu or Cd. In conclusion, anti-oxidative mechanism in abalone to resist waterborne Cu did not follow the same pattern as that for waterborne Cd.展开更多
Objective To study the antidiabetic and anti-oxidative effects of honokiol （Hon） in Magnolia officinalis and its underlying molecular mechanism in diabetic rats induced by high-fat diet （HFD） and streptozotocin （...Objective To study the antidiabetic and anti-oxidative effects of honokiol （Hon） in Magnolia officinalis and its underlying molecular mechanism in diabetic rats induced by high-fat diet （HFD） and streptozotocin （STZ）. Methods After ig administration with Hon [25, 50, and 100 mg/（kg.d）] to diabetic rats for consecutive 10 weeks, the levels of blood glucose （BG）, oral glucose tolerance （OGT）, blood lipids including total cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol （HDL-C）, and low density lipoprotein-cholesterol （LDL-C）, hepatic oxidative stress including the activities of superoxide dismutase （SOD）, catalase （CAT）, glutathione peroxidase （GSH-Px）, methane dicarboxylic aldehyde （MDA）, and cytochrome P4502E1 （CYP2E1） in diabetic rats were measured. Results Compared to the diabetic control rats, ig administration of Hon resulted in significant decrease in BC, TC, TG, and LDL-C levels in serum, as well as hepatic CYP2E] activity and MDA content in diabetic rats, whereas the level of OGT and activities of hepatic CAT, SOD, and CSH-Px in diabetic rats were significantly increased. Conclusion Hon could alleviate hyperglycemia, hyperlipemia, hepatic oxidative damage, and insulin resistance in diabetic rats by inhibiting hepatic CYP2E1 activity.展开更多
There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ische...There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondi-adehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These ifndings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.展开更多
Lignosus rhinocerus is a highly valued medicinal mushroom traditionally consumed by the indigenous communities of Southeast Asia as treatment for numerous ailments,some of which are linked to its antioxidative activit...Lignosus rhinocerus is a highly valued medicinal mushroom traditionally consumed by the indigenous communities of Southeast Asia as treatment for numerous ailments,some of which are linked to its antioxidative activities.While the antioxidative capacity of L.rhinocerus has been established in vitro,lack of translational studies are available on the effect of L.rhinocerus in the pathogenesis of diseases driven by high oxidative stress.This study aims to investigate the in vivo antioxidative effects of cultivated Lignosus rhinocerus(TM02®)sclerotia in a multifaceted in vivo model of oxidative stress,induced by chronic hyperglycemia associated with diabetes.A type 2 diabetes mellitus(T2DM)rodent model was generated using a high-fat diet in combination with low dose streptozotocin after which TM02®cultivar,at a dose of 200 mg/kg,was administered orally for 14 days.Diabetic rats treated with TM02®cultivar had decreased plasma AGEs concentration,complemented with improved mitochondrial respiratory function associated with elevated cardiac and skeletal muscle ATP concentrations in both diabetic and non diabetic rats.Interestingly,TM02®cultivar-treated rats have improved glycemic control,with the potential ability to induce insulin secretion.Our findings revealed that TM02®exhibits antioxidative effects to potentially alleviate diabetes-related complications associated with AGEs accumulation,with significant effects in enhancing mitochondrial function and energy production.展开更多
A 240-day feeding trial was conducted to investigate the effects of dietary vitamin C on growth performance,anti-oxidative response,and fatty acid composition of juvenile abalone Haliotis discus hannai Ino(initial bod...A 240-day feeding trial was conducted to investigate the effects of dietary vitamin C on growth performance,anti-oxidative response,and fatty acid composition of juvenile abalone Haliotis discus hannai Ino(initial body weight:0.93±0.00 g).Three semi-purified experimental diets were formulated containing 0.00,94.52,and 9649.58 mg/kg of vitamin C supplied as L-ascorbyl-2-monophosphate.The results show that there was no significant difference in weight gain ratio,daily increment in shell length,and survival rate among the three treatments.Adding dietary vitamin C(9649.58 mg/kg)significantly increased the activities of superoxide dismutase(SOD),glutathine peroxidase(GPX),glitathione-S-transferase(GST),glutathione reductase(GR),alkaline phosphatase(AKP),and lysozyme in viscera(P<0.05).In muscle,activities of phenoloxidase,catalase,SOD,GST,GR,and AKP were increased in the treatment with 9649.58 mg/kg of dietary vitamin C(P<0.05).The highest concentrations of ascorbic acid in viscera and muscle were found in the group with 9649.58 mg/kg of dietary vitamin C(P<0.05).The contents of crude protein and crude lipid in the soft body were significantly increased in the 9649.58 mg/kg group(P<0.05).Dietary vitamin C supplementation significantly decreased the contents of saturated fatty acids(14:0,16:0,and 18:0),and increased the composition of 18:2n-6 and 22:6n-3 in the soft body of abalone(P<0.05).Therefore,although there were no significant effects on the growth performance,dietary vitamin C supplementation improved the anti-oxidation and immune responses,increased specific unsaturated fatty acid(i.e.,16:1,18:1n-7,18:1n-9,18:2n-6 and 22:6n-3),and decreased specific saturated fatty acid(i.e.,14:0,16:0 and 18:0)contents in the soft body of abalone.展开更多
Objective To explore the effects of a potential anti-oxidative plant,Erigeron multiradiatus(Asteraceae) ,plant materials from naturally distributed high-altitude populations at different stages of life cycle were coll...Objective To explore the effects of a potential anti-oxidative plant,Erigeron multiradiatus(Asteraceae) ,plant materials from naturally distributed high-altitude populations at different stages of life cycle were collected.Methods Fifteen extracts obtained from the Ganzi region(Sichuan,China) were studied to assess their radical-scavenging ability on 1,1-diphenyl-2-picrylhydrazyl radicals and reducing power ability.Moreover,considering that anti-oxidants and free radical scavengers can also exert protective effect on endothelial cells from oxidative injury,these extracts were also evaluated for their anti-oxidative activity against cellular injury in the cultured human endothelial cell line(ECV304) induced by hydrogen peroxide(H2O2) .Results All the extracts had radical-scavenging and/or reducing power ability,and the most active extract was found during flowering whereas the lowest appeared during vegetative growth period.The accumulation of anti-oxidative compounds was found to be affected by the altitude of growth environment.Total flavonoid content assay was also performed to support this outcome.Furthermore,these extracts also exhibited different effects on attenuating H2O2-induced cytotoxicity and inhibiting lipid peroxidation and LDH leakage from endothelial cells.Conclusion E.multiradiatus may be an important natural anti-oxidant and this property may contribute to verifying the utilization of this plant in Tibet folk medicine.展开更多
The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF...The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF)argon plasma,and the temperatures were measured using a DPV-2000 monitor.A model combining the electromagnetism,thermal flow,and heat transfer characteristics of powder during in-flight heating in argon plasma was proposed.The melting processes of CeO_(2)powders of different diameters,with and without thermal resistance effect,were investigated.Results show that the heating process of CeO_(2)powder particles consists of three main stages,one of which is relevant to a dimensionless parameter known as the Biot number.When the Biot value≥0.1,thermal resistance increases significantly,especially for the larger powders.The predicted temperature of the particles at the outlet(1800–2880 K)is in good agreement with the experimental result.展开更多
Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electro...Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.展开更多
The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,rem...The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,remove toxins,clear heat,and alleviate wind-heat syndromes.It also has hepatoprotective,anti-inflammatory,antiviral,antibacterial,anticancer,antioxidant,antiaging,and anti-obesity effects,as well as potential therapeutic effects on Alzheimer’s disease and diabetic nephropathy.It is used to treat scrofula,mastitis,wind-heat common cold,and other ailments.The review summarizes the chemical constituents and pharmacological effects of F.suspensa,aiming to provide a scientific foundation for its future development,research,and clinical utilization.展开更多
Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based met...Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.展开更多
Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which...Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which has a Curie temperature of~290 K and an in-plane easy magnetization axis.Magnetotransport measurements show a positive magnetoresistance(MR)below 50 K,which becomes negative at higher temperatures.An intrinsic anomalous Hall conductivity of 114 S·cm^(-1)is observed in MgMn_(6)Sn_(6) single crystals,consistent with ab initio calculations.Moreover,theoretical predictions indicate that shifting the Fermi level(EF)upward by~70 meV could enhance the AHE to~528 S·cm^(-1).These results position MgMn_(6)Sn_(6) as a promising and tunable platform for exploring topological magnetism and related electronic phenomena.展开更多
Fe_(3)Sn_(2),a ferromagnetic metal with a kagome lattice,serves as an ideal platform for exploring topological electronic states and Berry curvature due to its unique band structure.However,systematic reports on the t...Fe_(3)Sn_(2),a ferromagnetic metal with a kagome lattice,serves as an ideal platform for exploring topological electronic states and Berry curvature due to its unique band structure.However,systematic reports on the transport properties of Fe_(3)Sn_(2)nanosheets remain scarce.We present temperature-dependent transport property measurements of Fe_(3)Sn_(2)nanosheets synthesized via chemical vapor deposition on Si/SiO_(2)substrates.The samples exhibit a robust anomalous Hall effect from 40 K to 300 K,along with a magnetoresistance sign reversal at 40 K at high magnetic fields,indicating a spin reorientation from in-plane to out-of-plane.Notably,a sharp crossover in the dominant transport contribution from electrons to holes near 200 K is observed,accompanied by distinct anomalous Hall behaviors in the two regimes,indicating a temperature-induced Lifshitz transition within the multi-band system.This divergence is potentially linked to a topological reconstruction of the Fermi surface across the transition.Our findings highlight the tunability of topological transport in two-dimensional kagome magnets and provide new insights into the interplay between band topology,dimensionality and magnetic order.展开更多
The effect of adding hydroxycinnamic acids(caffeic acid,sinapic acid,p-coumaric acid and chlorogenic acid)in Cabernet Sauvignon dry red wine before and after fermentation was investigated,taking into account the color...The effect of adding hydroxycinnamic acids(caffeic acid,sinapic acid,p-coumaric acid and chlorogenic acid)in Cabernet Sauvignon dry red wine before and after fermentation was investigated,taking into account the color parameters,anthocyanin content,and overall polyphenol levels in the wine samples.The copigmentation effect of malvidin-3-Oglucoside and sinapic acid was further explored in model solution and through theoretical calculations.The results indicated that the addition of hydroxycinnamic acids significantly enhanced the wine's color with sinapic acid(before the fermentation)showing the most pronounced color protection effect.Compared to control samples,the addition of hydroxycinnamic acids resulted in a 36%increase in total phenolic content and a 28% increase in total anthocyanin content.Thermodynamic analysis revealed that the interaction between sinapic acid and malvidin-3-O-glucoside was spontaneous and exothermic.Theoretical studies identified hydrogen bonding(HB)and dispersion forces as the main primary stabilizing forces,with the carboxyl group of sinapic acid playing a critical role while the anthocyanin backbone also influenced the interaction.展开更多
Iron and steel industry is one of the main sources of air pollution emissions in China.The sintering process is an important link in the blast furnace ironmaking process,but it is also accompanied by a large number of...Iron and steel industry is one of the main sources of air pollution emissions in China.The sintering process is an important link in the blast furnace ironmaking process,but it is also accompanied by a large number of pollutants.Under the background of ultra-low emissions,iron and steel enterprises urgently need to upgrade their existing processes to address the existing process in practical application problems.In this study,a steel group in Gansu Province was taken as an example.By comparing and analyzing the pollutant emission characteristics before and after the ultra-low emission retrofit,the collaborative control effect of the combined process on SO_(2),NO_(x),particulate matter,and dioxins after the new retrofit was systematically evaluated.The results show that after the retrofit,the concentrations of particulate matter,SO_(2) and NO_(x) have dropped to near-zero levels,and the dioxin removal efficiency has reached 98.87%,with all indicators being better than the national ultra-low emission standards.The study confirms that the optimal combination of multi-pollutant collaborative treatment technologies is the key to achieving efficient emission reduction,among which selective catalytic reduction technology has a particularly significant synergistic removal effect on NO_(x) and dioxins.This study provides an important technical reference and practical basis for the ultra-low emission retrofit of the steel industry,and has important guiding significance for promoting the green retrofit of the industry.Its ultra-low emission retrofit is of great significance for achieving green and low-carbon development.展开更多
Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative patho...Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.展开更多
[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based ...[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based on the demonstration construction project of the ecological ditch-constructed wetland system in the Hetao Irrigation District,an experimental study was conducted from July to September 2023 to investigate the interception and purification effects of ecological ditches,constructed wetlands,and the combined ecological ditch-constructed wetland system on farmland drainage pollutants.Key water quality parameters measured included total nitrogen(TN)concentration and total phosphorus(TP)concentration.[Results]Different treatment modes of ecological ditches and constructed wetlands have a certain removal effect on nitrogen and phosphorus pollutants in water bodies.The ecological ditches treated with Astragalus laxmannii,Melilotus officinalis,Medicago sativa,bio-ball substrate,and bio-sheet substrate showed reduction efficiencies for TN and TP of 21.09% and 23.84%,12.06% and 26.67%,20.08% and 34.15%,23.65% and 20.56%,and 19.92% and 25.83%,respectively.The emergent plant area showed reduction efficiencies of 24.28%for TN and 17.89%for TP,while the submerged plant area achieved a reduction efficiency of 10.21%for both TN and TP.Among the different treatment modes,the ecological ditch with M.sativa performed better in TP removal,whereas the bio-ball substrate treatment mode showed higher effectiveness in TN removal.In addition,the emergent plant area exhibited better TP removal performance,while the submerged plant area was more effective in TN removal.The combined system of ecological ditch and constructed wetland achieved removal rates of 37.55% for TN and 11.47% for TP.It effectively facilitates the step-by-step interception and adsorption purification of pollutants,thereby showing significant removal and purification effects on nitrogen and phosphorus contaminants.This contributes to mitigating agricultural non-point source pollution.[Conclusions]The combined ecological ditch-constructed wetland system serves dual functions of agricultural drainage and pollutant interception and purification.It reduces the pollution load of farmland drainage on receiving water bodies to some extent and mitigates agricultural non-point source pollution.Therefore,it is a relatively suitable technology for managing agricultural non-point source pollution in the Hetao Irrigation District.展开更多
Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continu...Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.展开更多
基金Supported by the Science and Technology Comm ission of Jinlin Province(No. 94 35 4 6 - 3)
文摘Corn peptides(CP) were prepared from zein via proteolysis by means of a type of alkaline protease, Alcalase, at 50 ℃ and pH 8.0. The anti oxidative activity of the hydrolysate was examined. It was found that the anti oxidative activity reached the maximum at the fourth hour of the hydrolysis and then decreased. The effect of the enzyme dosage on the solubility of corn protein, the dependence of hydrolysis time on the degree of the hydrolysis(DH) and molecular weight distribution were examined respectively. 30% DH was controlled on the basis of anti oxidative activity. The hydrolysate was fractionated on a Sephadex G 15 column. The anti oxidative activities were examined for all the fractions. The main fraction for anti oxidative activity was collected and characterized by the methods of amino acid analysis, the measurement of average chain length and etc .. The main M W distribution of the main fraction was 300-600 Daltons. The anti oxidative properties of the small peptides in vitro were studied. It was found that they could inhibit the auto oxidation of pyrogallol and the oxidation of hemoglobin. The hemolysis degree of erythrocyte caused by hydroxyl free radicals was decreased greatly, indicating a protective effect of the anti oxidative peptides on the cell membrane damage of erythrocyte.
文摘Objective: Study blood vessel injury and gene expression indicating vascular endothelial cell apoptosis induced by mannitol with and without administration of anti-oxidative vitamins. Methods: Healthy rabbits were randomly divided into four groups. Mannitol was injected into the vein of the rabbit ear in each animal. Pre-treatment prior to mannitol injection was per- formed with normal saline (group B), vitamin C (group C) and vitamin E (group D). Blood vessel injury was assessed under electron and light microscopy. In a second experiment, cell culture specimen of human umbilical vein endothelial cells were treated with mannitol. Pre-treatment was done with normal saline (sample B), vitamin C (sample C) and vitamin E (sample D). Total RNA was extracted with the original single step procedure, followed by hybridisation and analysis of gene expression. Results: In the animal experiment, serious blood vessel injury was seen in group A and group B. Group D showed light injury only, and normal tissue without pathological changes was seen in group C. Of all 330 apoptosis-related genes analysed in human cell culture specimen, no significant difference was seen after pre-treatment with normal saline, compared with the gene chip without pre-treatment. On the gene chip pre-treated with vitamin C, 45 apoptosis genes were down-regulated and 34 anti-apoptosis genes were up-regulated. Pre-treatment with vitamin E resulted in the down-regulation of 3 apoptosis genes. Conclusion: Vitamin C can protect vascular endothelial cells from mannitol-induced injury.
文摘Objective To investigate the pretreatment effects of Rhodiola rosea （R. rosea） extract on cognitive dysfunction, oxidative stress in hippocampus and hippocampal neuron injury in a rat model of Alzheimer＇s disease （AD）. Methods Male Sprague-Dawley rats were pretreated with R. rosea extract at doses of 1.5, 3.0, and 6.0 g/kg for 3 weeks, followed by bilateral intracerebroventricular injection with streptozotocin （1.5 mg/kg） on days 1 and 3. Behavioral alterations were monitored after 2 weeks from the lesion using Morris water maze task. Three weeks after the lesion, the rats were sacrificed for measuring the malondialdehyde （MDA）, glutathione reductase （GR） and reduced glutathione （GSH） levels in hippocampus and histopathology of hippocampal neurons. Results The MDA level was significantly increased while the GR and GSH levels were significantly decreased with striking impairments in spatial learning and memory and severe damage to hippocampal neurons in the model rat induced by intracerebroventricular injection of streptozotocin. These abnormalities were significantly improved by pretreatment with R. rosea extract （3.0 g/kg）. Conclusion R. rosea extract can protect rats against cognitive deficits, neuronal injury and oxidative stress induced by intracerebroventricular injection of streptozotocin, and may be used as a potential agent in treatment of neurodegenerative diseases such as AD.
基金financially supported by grant from the National Natural Science Foundation of China (No. 30972262)
文摘The aim of this study was to compare the effects of waterbome copper （Cu） and cadmium （Cd） on survival, anti-oxida- tive response, lipid peroxidation and metal accumulation in abalone Haliotis discus hannai. Experimental animals （initial weight： 7.49 g±0.01 g） were exposed to graded concentrations of waterborne Cu （0.02, 0.04, 0.06, 0.08 mg L-1） or Cd （0.025, 0.05, 0.25, 0.5 mgL-1） for 28 days, respectively. Activities of the anti-oxidative enzymes （catalase, CAT; superoxide dismutase, SOD; glutathione peroxidases, GPx; glutathione S-transferase, GST）, contents of the reduced glutathione （GSH） and malondiadehyde （MDA） in the hepatopancreas, and metal accumulation in hepatopancreas and muscles were analyzed after 0, 1, 3, 6, 10, 15, 21, 28 days of metal exposure, respectively. Results showed that 0.04 mg L-1, 0.06 mg L-1 and 0.08 mgL-1 Cu caused 100% death of abalone on the 21st, 10th and 6th day, respectively. However, no dead abalone was found during the 28-day waterborne Cd exposure at all experimental concentrations. Generally, activities of SOD and GST in hepatopancreas under all Cu concentrations followed a decrease trend as the exposure time prolonged. However, these activities were firstly increased and then decreased to the control level and increased again during Cd exposure. Activities of CAT in all Cu exposure treatments were higher than those in the control. These activities were firstly increased and then decreased to the control level and increased again during Cd exposure. Contents of MDA in hepatopancreas in all Cu treatments significantly increased first and then decreased to the control level. However, the MDA contents in hepatopan- creas were not significantly changed during the 28-day Cd exposure. The metals accumulation in both hepatopancreas and muscles of abalone significantly increased with the increase of waterborne metals concentration and exposure time. These results indicated that H. discus hannai has a positive anti-oxidative defense against Cu or Cd. In conclusion, anti-oxidative mechanism in abalone to resist waterborne Cu did not follow the same pattern as that for waterborne Cd.
文摘Objective To study the antidiabetic and anti-oxidative effects of honokiol （Hon） in Magnolia officinalis and its underlying molecular mechanism in diabetic rats induced by high-fat diet （HFD） and streptozotocin （STZ）. Methods After ig administration with Hon [25, 50, and 100 mg/（kg.d）] to diabetic rats for consecutive 10 weeks, the levels of blood glucose （BG）, oral glucose tolerance （OGT）, blood lipids including total cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol （HDL-C）, and low density lipoprotein-cholesterol （LDL-C）, hepatic oxidative stress including the activities of superoxide dismutase （SOD）, catalase （CAT）, glutathione peroxidase （GSH-Px）, methane dicarboxylic aldehyde （MDA）, and cytochrome P4502E1 （CYP2E1） in diabetic rats were measured. Results Compared to the diabetic control rats, ig administration of Hon resulted in significant decrease in BC, TC, TG, and LDL-C levels in serum, as well as hepatic CYP2E] activity and MDA content in diabetic rats, whereas the level of OGT and activities of hepatic CAT, SOD, and CSH-Px in diabetic rats were significantly increased. Conclusion Hon could alleviate hyperglycemia, hyperlipemia, hepatic oxidative damage, and insulin resistance in diabetic rats by inhibiting hepatic CYP2E1 activity.
文摘There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondi-adehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These ifndings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.
基金acknowledge(1)Ministry of Higher Education(MOHE),Malaysia[FRGS/1/2020/STG02/UM/02/1,Fundamental Research Grant Scheme(FRGS)]2)Universiti Malaya for the UMRG grant RP034 B,C-17AFR and(3)postgraduate scholarship granted to Chee-Sum A.Yap by LiGNO Research Initiative,LiGNO Biotech Sdn Bhd.
文摘Lignosus rhinocerus is a highly valued medicinal mushroom traditionally consumed by the indigenous communities of Southeast Asia as treatment for numerous ailments,some of which are linked to its antioxidative activities.While the antioxidative capacity of L.rhinocerus has been established in vitro,lack of translational studies are available on the effect of L.rhinocerus in the pathogenesis of diseases driven by high oxidative stress.This study aims to investigate the in vivo antioxidative effects of cultivated Lignosus rhinocerus(TM02®)sclerotia in a multifaceted in vivo model of oxidative stress,induced by chronic hyperglycemia associated with diabetes.A type 2 diabetes mellitus(T2DM)rodent model was generated using a high-fat diet in combination with low dose streptozotocin after which TM02®cultivar,at a dose of 200 mg/kg,was administered orally for 14 days.Diabetic rats treated with TM02®cultivar had decreased plasma AGEs concentration,complemented with improved mitochondrial respiratory function associated with elevated cardiac and skeletal muscle ATP concentrations in both diabetic and non diabetic rats.Interestingly,TM02®cultivar-treated rats have improved glycemic control,with the potential ability to induce insulin secretion.Our findings revealed that TM02®exhibits antioxidative effects to potentially alleviate diabetes-related complications associated with AGEs accumulation,with significant effects in enhancing mitochondrial function and energy production.
基金Supported by the National Key R&D Program of China(No.2018YFD0900400)the Earmarked Fund for Modern Agro-industry Technology Research System(No.CARS-49)。
文摘A 240-day feeding trial was conducted to investigate the effects of dietary vitamin C on growth performance,anti-oxidative response,and fatty acid composition of juvenile abalone Haliotis discus hannai Ino(initial body weight:0.93±0.00 g).Three semi-purified experimental diets were formulated containing 0.00,94.52,and 9649.58 mg/kg of vitamin C supplied as L-ascorbyl-2-monophosphate.The results show that there was no significant difference in weight gain ratio,daily increment in shell length,and survival rate among the three treatments.Adding dietary vitamin C(9649.58 mg/kg)significantly increased the activities of superoxide dismutase(SOD),glutathine peroxidase(GPX),glitathione-S-transferase(GST),glutathione reductase(GR),alkaline phosphatase(AKP),and lysozyme in viscera(P<0.05).In muscle,activities of phenoloxidase,catalase,SOD,GST,GR,and AKP were increased in the treatment with 9649.58 mg/kg of dietary vitamin C(P<0.05).The highest concentrations of ascorbic acid in viscera and muscle were found in the group with 9649.58 mg/kg of dietary vitamin C(P<0.05).The contents of crude protein and crude lipid in the soft body were significantly increased in the 9649.58 mg/kg group(P<0.05).Dietary vitamin C supplementation significantly decreased the contents of saturated fatty acids(14:0,16:0,and 18:0),and increased the composition of 18:2n-6 and 22:6n-3 in the soft body of abalone(P<0.05).Therefore,although there were no significant effects on the growth performance,dietary vitamin C supplementation improved the anti-oxidation and immune responses,increased specific unsaturated fatty acid(i.e.,16:1,18:1n-7,18:1n-9,18:2n-6 and 22:6n-3),and decreased specific saturated fatty acid(i.e.,14:0,16:0 and 18:0)contents in the soft body of abalone.
基金Applied Fundamental Research Scheme of the Bureau of Science and Technology of Sichuan Province,China(2009JY0017)the Fundamental Research Funds for the Central Universities,Southwest University for Nationalities(09NZYZJ01)
文摘Objective To explore the effects of a potential anti-oxidative plant,Erigeron multiradiatus(Asteraceae) ,plant materials from naturally distributed high-altitude populations at different stages of life cycle were collected.Methods Fifteen extracts obtained from the Ganzi region(Sichuan,China) were studied to assess their radical-scavenging ability on 1,1-diphenyl-2-picrylhydrazyl radicals and reducing power ability.Moreover,considering that anti-oxidants and free radical scavengers can also exert protective effect on endothelial cells from oxidative injury,these extracts were also evaluated for their anti-oxidative activity against cellular injury in the cultured human endothelial cell line(ECV304) induced by hydrogen peroxide(H2O2) .Results All the extracts had radical-scavenging and/or reducing power ability,and the most active extract was found during flowering whereas the lowest appeared during vegetative growth period.The accumulation of anti-oxidative compounds was found to be affected by the altitude of growth environment.Total flavonoid content assay was also performed to support this outcome.Furthermore,these extracts also exhibited different effects on attenuating H2O2-induced cytotoxicity and inhibiting lipid peroxidation and LDH leakage from endothelial cells.Conclusion E.multiradiatus may be an important natural anti-oxidant and this property may contribute to verifying the utilization of this plant in Tibet folk medicine.
基金National Natural Science Foundation of China(11875039)Shanxi Scholarship Council of China(2023-033)+2 种基金Fundamental Research Program of Shanxi Province(202303021221071)China Baowu Low Carbon Metallurgical Innovation Foundation(2022)2023 Anhui Major Industrial Innovation Plan Project。
文摘The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF)argon plasma,and the temperatures were measured using a DPV-2000 monitor.A model combining the electromagnetism,thermal flow,and heat transfer characteristics of powder during in-flight heating in argon plasma was proposed.The melting processes of CeO_(2)powders of different diameters,with and without thermal resistance effect,were investigated.Results show that the heating process of CeO_(2)powder particles consists of three main stages,one of which is relevant to a dimensionless parameter known as the Biot number.When the Biot value≥0.1,thermal resistance increases significantly,especially for the larger powders.The predicted temperature of the particles at the outlet(1800–2880 K)is in good agreement with the experimental result.
基金supported by the National Natural Science Foundation of China(No.62464010)Spring City Plan-Special Program for Young Talents(K202005007)+2 种基金Yunnan Talents Support Plan for Young Talents(XDYC-QNRC-2022-0482)Yunnan Local Colleges Applied Basic Research Projects(202101BA070001-138)Frontier Research Team of Kunming University 2023.
文摘Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.
文摘The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,remove toxins,clear heat,and alleviate wind-heat syndromes.It also has hepatoprotective,anti-inflammatory,antiviral,antibacterial,anticancer,antioxidant,antiaging,and anti-obesity effects,as well as potential therapeutic effects on Alzheimer’s disease and diabetic nephropathy.It is used to treat scrofula,mastitis,wind-heat common cold,and other ailments.The review summarizes the chemical constituents and pharmacological effects of F.suspensa,aiming to provide a scientific foundation for its future development,research,and clinical utilization.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT)(No.RS-2022-00143178)the Ministry of Education(MOE)(Nos.2022R1A6A3A13053896 and 2022R1F1A1074616),Republic of Korea.
文摘Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.
基金Project supported by the National Natural Science Foundation of China(Grant No.12204347)National Key Research and Development Program of China(Grant No.2022YFA1402600)the Fund from Beijing National Laboratory for Condensed Matter Physics(Grant No.2023BNLCMPKF011)。
文摘Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which has a Curie temperature of~290 K and an in-plane easy magnetization axis.Magnetotransport measurements show a positive magnetoresistance(MR)below 50 K,which becomes negative at higher temperatures.An intrinsic anomalous Hall conductivity of 114 S·cm^(-1)is observed in MgMn_(6)Sn_(6) single crystals,consistent with ab initio calculations.Moreover,theoretical predictions indicate that shifting the Fermi level(EF)upward by~70 meV could enhance the AHE to~528 S·cm^(-1).These results position MgMn_(6)Sn_(6) as a promising and tunable platform for exploring topological magnetism and related electronic phenomena.
基金Project supported by the National Key Research and Development Program of China(Grant Nos.2022YFA1403503,2022YFA1602802,2023YFA1607400,and 2024YFA1613200)Beijing Natural Science Foundation(Grant No.JQ23022)supported by the Synergetic Extreme Condition User Facility and the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302600)。
文摘Fe_(3)Sn_(2),a ferromagnetic metal with a kagome lattice,serves as an ideal platform for exploring topological electronic states and Berry curvature due to its unique band structure.However,systematic reports on the transport properties of Fe_(3)Sn_(2)nanosheets remain scarce.We present temperature-dependent transport property measurements of Fe_(3)Sn_(2)nanosheets synthesized via chemical vapor deposition on Si/SiO_(2)substrates.The samples exhibit a robust anomalous Hall effect from 40 K to 300 K,along with a magnetoresistance sign reversal at 40 K at high magnetic fields,indicating a spin reorientation from in-plane to out-of-plane.Notably,a sharp crossover in the dominant transport contribution from electrons to holes near 200 K is observed,accompanied by distinct anomalous Hall behaviors in the two regimes,indicating a temperature-induced Lifshitz transition within the multi-band system.This divergence is potentially linked to a topological reconstruction of the Fermi surface across the transition.Our findings highlight the tunability of topological transport in two-dimensional kagome magnets and provide new insights into the interplay between band topology,dimensionality and magnetic order.
基金supported by the Key R&D Program of Shaanxi Province,China(2024NC-YBXM-146)the Xi’an Agricultural Technology Research and Development Project,China(24NYGG0048)+1 种基金the Key R&D Program of Xianyang,China(L2024-ZDYF-ZDYF-NY-0028)the National Foreign Expert Project of China(G2023172002L)。
文摘The effect of adding hydroxycinnamic acids(caffeic acid,sinapic acid,p-coumaric acid and chlorogenic acid)in Cabernet Sauvignon dry red wine before and after fermentation was investigated,taking into account the color parameters,anthocyanin content,and overall polyphenol levels in the wine samples.The copigmentation effect of malvidin-3-Oglucoside and sinapic acid was further explored in model solution and through theoretical calculations.The results indicated that the addition of hydroxycinnamic acids significantly enhanced the wine's color with sinapic acid(before the fermentation)showing the most pronounced color protection effect.Compared to control samples,the addition of hydroxycinnamic acids resulted in a 36%increase in total phenolic content and a 28% increase in total anthocyanin content.Thermodynamic analysis revealed that the interaction between sinapic acid and malvidin-3-O-glucoside was spontaneous and exothermic.Theoretical studies identified hydrogen bonding(HB)and dispersion forces as the main primary stabilizing forces,with the carboxyl group of sinapic acid playing a critical role while the anthocyanin backbone also influenced the interaction.
基金supported by the Key Research and Development Program of Gansu Province(22YF7FA070)the National Natural Science Foundation of China(22406076,22466026)the Basic Research Project of Yunnan Province(202301BE070001-017,202401CF070139,202401AS070085)。
文摘Iron and steel industry is one of the main sources of air pollution emissions in China.The sintering process is an important link in the blast furnace ironmaking process,but it is also accompanied by a large number of pollutants.Under the background of ultra-low emissions,iron and steel enterprises urgently need to upgrade their existing processes to address the existing process in practical application problems.In this study,a steel group in Gansu Province was taken as an example.By comparing and analyzing the pollutant emission characteristics before and after the ultra-low emission retrofit,the collaborative control effect of the combined process on SO_(2),NO_(x),particulate matter,and dioxins after the new retrofit was systematically evaluated.The results show that after the retrofit,the concentrations of particulate matter,SO_(2) and NO_(x) have dropped to near-zero levels,and the dioxin removal efficiency has reached 98.87%,with all indicators being better than the national ultra-low emission standards.The study confirms that the optimal combination of multi-pollutant collaborative treatment technologies is the key to achieving efficient emission reduction,among which selective catalytic reduction technology has a particularly significant synergistic removal effect on NO_(x) and dioxins.This study provides an important technical reference and practical basis for the ultra-low emission retrofit of the steel industry,and has important guiding significance for promoting the green retrofit of the industry.Its ultra-low emission retrofit is of great significance for achieving green and low-carbon development.
基金supported by the National Natural Science Foundation of China(No.32170121).
文摘Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.
基金Supported by Special Fund Project for the Transformation of Scientific and Technological Achievements in Inner Mongolia Autonomous Region(2021CG0013)Bayannur City Science and Technology Plan Project(K202014)+1 种基金Inner Mongolia Autonomous Region Science and Technology Plan Project(2022YFHH0088)Research Special Project of the Education Department of Inner Mongolia Autonomous Region(STAQZX202320).
文摘[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based on the demonstration construction project of the ecological ditch-constructed wetland system in the Hetao Irrigation District,an experimental study was conducted from July to September 2023 to investigate the interception and purification effects of ecological ditches,constructed wetlands,and the combined ecological ditch-constructed wetland system on farmland drainage pollutants.Key water quality parameters measured included total nitrogen(TN)concentration and total phosphorus(TP)concentration.[Results]Different treatment modes of ecological ditches and constructed wetlands have a certain removal effect on nitrogen and phosphorus pollutants in water bodies.The ecological ditches treated with Astragalus laxmannii,Melilotus officinalis,Medicago sativa,bio-ball substrate,and bio-sheet substrate showed reduction efficiencies for TN and TP of 21.09% and 23.84%,12.06% and 26.67%,20.08% and 34.15%,23.65% and 20.56%,and 19.92% and 25.83%,respectively.The emergent plant area showed reduction efficiencies of 24.28%for TN and 17.89%for TP,while the submerged plant area achieved a reduction efficiency of 10.21%for both TN and TP.Among the different treatment modes,the ecological ditch with M.sativa performed better in TP removal,whereas the bio-ball substrate treatment mode showed higher effectiveness in TN removal.In addition,the emergent plant area exhibited better TP removal performance,while the submerged plant area was more effective in TN removal.The combined system of ecological ditch and constructed wetland achieved removal rates of 37.55% for TN and 11.47% for TP.It effectively facilitates the step-by-step interception and adsorption purification of pollutants,thereby showing significant removal and purification effects on nitrogen and phosphorus contaminants.This contributes to mitigating agricultural non-point source pollution.[Conclusions]The combined ecological ditch-constructed wetland system serves dual functions of agricultural drainage and pollutant interception and purification.It reduces the pollution load of farmland drainage on receiving water bodies to some extent and mitigates agricultural non-point source pollution.Therefore,it is a relatively suitable technology for managing agricultural non-point source pollution in the Hetao Irrigation District.
基金supported by the National Natural Science Foundation of China(Nos.82003977,82274134 and 82274139)the National Key Research and Development Plan(No.2017YFC1702200)+1 种基金the Key Research and Development Program of Zhejiang Province(No.2020C04020)the Science and Technology Program of Zhejiang Province(No.2025C02183).
文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.
