Secondary trauma, resulting in undesirable injury and bleeding during wound dressing treatment, which will cause the treatment of chronic wounds ineffective. The medical cotton gauzes often bring strong adhesion due t...Secondary trauma, resulting in undesirable injury and bleeding during wound dressing treatment, which will cause the treatment of chronic wounds ineffective. The medical cotton gauzes often bring strong adhesion due to the exudates absorbed and clots formed. Conversely, the easily detachable wound dressings neglect the wound seepage management, rendering them ineffective in facing the complexities of chronic wounds. To address this challenge, we propose a novel draining anti-adhesion dressings(DAD) by constructing the hydrophilic microchannels array on the superhydrophobic dressing. The superhydrophobic areas facilitate stable wound fiuid repellence leading to achieve the anti-adhesion(18.7% detachment energy of cotton) and the microchannel array ensures the transportation of excess exudates(>92%) by the capillary force. Notably, our dressing demonstrates a significant healing-promoting in a chronic wound model in rats. The development of such dressings holds promise for advancing wound care practices and addressing the unique challenges posed by chronic wounds, offering a valuable solution for improved clinical outcomes.展开更多
Adhesion of leukocytes to endothelium plays an important role in inflammation-associated diseases.Our previous studies showed that multivalent lactosides were able to inhibit this process.Using 2-azide-l,3-propandiol ...Adhesion of leukocytes to endothelium plays an important role in inflammation-associated diseases.Our previous studies showed that multivalent lactosides were able to inhibit this process.Using 2-azide-l,3-propandiol and glutamic acid as spacers,we synthesized divalent lactoside An-2 and tetravalent lactoside Gu-4 by means of convergent method.These two compounds displayed high anti-adhesive activity and showed therapeutic effect in rats with severe burn shock.In addition, investigation of the anti-adhesion biological mechanism using labeled compounds YAn-2 and YGu-4 demonstrated that the target of multivalent lactosides was CD11b,theβ2 integrin subunit,on the surface of leukocytes.In this paper,the synthesis of these two new multivalent lactosides as well as their fluorescein-labeled and biotin-labeled compounds is reported.展开更多
Surgical electrodes are frequently associated with disadvantages such as high surface adhesion and severe thermal damage to adjacent normal tissues,which threaten operation quality and patient safety.In this study,by ...Surgical electrodes are frequently associated with disadvantages such as high surface adhesion and severe thermal damage to adjacent normal tissues,which threaten operation quality and patient safety.In this study,by mimicking the micromorphology and bio-anti-adhesion of shark skin,we proposed a strategy that utilized nanoscale aluminium oxide(Al_(2)O_(3))films deposited on bioinspired shark skin(BSS)microstructures to design a composite surface(Al_(2)O_(3)@BSS)and integrated it into both flat sides of the surgical electrodes.Micro/nano-manufacturing of the Al_(2)O_(3)@BSS surface was sequentially accomplished using nanosecond laser texturing,atomic layer deposition,and low-temperature annealing,endowing it with excellent blood-repellent properties.Visualisation experiments revealed that the tensile stress gradient of the blood coagulum with increasing thickness under a thermal field prompted it to separate from the Al_(2)O_(3)@BSS surface,resulting in anti-adhesion.Furthermore,it was observed for the first time that Al_(2)O_(3) films could transiently excite discharge along a dielectric surface(DADS)to ablate tissues while suppressing Joule heat,thereby minimising thermal damage.A combination of ex vivo tissue and living mouse experiments demonstrated that the Al_(2)O_(3)@BSS electrodes exhibited optimal comprehensive performance in terms of anti-adhesion,damage minimisation,and drag reduction.In addition,the Al_(2)O_(3)@BSS electrodes possessed remarkable antibacterial efficacy against E.coli and S.aureus.The proposed strategy can meet the extreme application requirements of surgical electrodes to improve operation quality and offer valuable insights for future studies.展开更多
基金funding support by the National Nature Science Foundation of China (Nos. 22275028, 22325201, 52103136 and 22205033)the Shenzhen Science and Technology Program (No. JCYJ20210324142210027)+2 种基金the Sichuan Outstanding Young Scholars Foundation (No. 2021JDJQ0013)the Sichuan Science and Technology Program (No. 2023JDRC0081)the Fundamental Research Funds for the Central Universities (Nos. ZYGX2021YGCX009 and ZYGX2021YGLH207)。
文摘Secondary trauma, resulting in undesirable injury and bleeding during wound dressing treatment, which will cause the treatment of chronic wounds ineffective. The medical cotton gauzes often bring strong adhesion due to the exudates absorbed and clots formed. Conversely, the easily detachable wound dressings neglect the wound seepage management, rendering them ineffective in facing the complexities of chronic wounds. To address this challenge, we propose a novel draining anti-adhesion dressings(DAD) by constructing the hydrophilic microchannels array on the superhydrophobic dressing. The superhydrophobic areas facilitate stable wound fiuid repellence leading to achieve the anti-adhesion(18.7% detachment energy of cotton) and the microchannel array ensures the transportation of excess exudates(>92%) by the capillary force. Notably, our dressing demonstrates a significant healing-promoting in a chronic wound model in rats. The development of such dressings holds promise for advancing wound care practices and addressing the unique challenges posed by chronic wounds, offering a valuable solution for improved clinical outcomes.
基金National Natural Science Foundation of China (Grant No 90713004)Ministry of Science and Technology of China(Grant No.2009ZX09103044.2009ZX09301-010)
文摘Adhesion of leukocytes to endothelium plays an important role in inflammation-associated diseases.Our previous studies showed that multivalent lactosides were able to inhibit this process.Using 2-azide-l,3-propandiol and glutamic acid as spacers,we synthesized divalent lactoside An-2 and tetravalent lactoside Gu-4 by means of convergent method.These two compounds displayed high anti-adhesive activity and showed therapeutic effect in rats with severe burn shock.In addition, investigation of the anti-adhesion biological mechanism using labeled compounds YAn-2 and YGu-4 demonstrated that the target of multivalent lactosides was CD11b,theβ2 integrin subunit,on the surface of leukocytes.In this paper,the synthesis of these two new multivalent lactosides as well as their fluorescein-labeled and biotin-labeled compounds is reported.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52275425,52405473,and 52405472)the Natural Science Foundation of Guangdong Province(Grant No.2024A1515010993)。
文摘Surgical electrodes are frequently associated with disadvantages such as high surface adhesion and severe thermal damage to adjacent normal tissues,which threaten operation quality and patient safety.In this study,by mimicking the micromorphology and bio-anti-adhesion of shark skin,we proposed a strategy that utilized nanoscale aluminium oxide(Al_(2)O_(3))films deposited on bioinspired shark skin(BSS)microstructures to design a composite surface(Al_(2)O_(3)@BSS)and integrated it into both flat sides of the surgical electrodes.Micro/nano-manufacturing of the Al_(2)O_(3)@BSS surface was sequentially accomplished using nanosecond laser texturing,atomic layer deposition,and low-temperature annealing,endowing it with excellent blood-repellent properties.Visualisation experiments revealed that the tensile stress gradient of the blood coagulum with increasing thickness under a thermal field prompted it to separate from the Al_(2)O_(3)@BSS surface,resulting in anti-adhesion.Furthermore,it was observed for the first time that Al_(2)O_(3) films could transiently excite discharge along a dielectric surface(DADS)to ablate tissues while suppressing Joule heat,thereby minimising thermal damage.A combination of ex vivo tissue and living mouse experiments demonstrated that the Al_(2)O_(3)@BSS electrodes exhibited optimal comprehensive performance in terms of anti-adhesion,damage minimisation,and drag reduction.In addition,the Al_(2)O_(3)@BSS electrodes possessed remarkable antibacterial efficacy against E.coli and S.aureus.The proposed strategy can meet the extreme application requirements of surgical electrodes to improve operation quality and offer valuable insights for future studies.
