A case of the absorption of corona virus disease 2019(COVID-19)promoted by professor Xu ZOU’s acupuncture technique for"benefiting kidney and strengthening anti-pathogenic qi"is introduced.A female patient ...A case of the absorption of corona virus disease 2019(COVID-19)promoted by professor Xu ZOU’s acupuncture technique for"benefiting kidney and strengthening anti-pathogenic qi"is introduced.A female patient suffered from COVID-19,64 years old,had been treated with acupuncture and Chinese herb granules for 10 days on the base of the oral administration of moxifloxacin.In the re-examination,the chest CT image indicated that the absorption of COVID-19 was obvious as compared with before,the nucleic acid test of novel corona virus was negative and the patient narrated no obvious discomfort.Acupuncture therapy plays its active adjuvant effect in the whole process of the treatment of COVID-19.展开更多
The damage caused by rice damping-off diseasecould be controlled efficiently by planting vig-orous seedlings. By adjusting the environ-ment, immunization of rice nursery (IRN)could raise seedlings with well developed ...The damage caused by rice damping-off diseasecould be controlled efficiently by planting vig-orous seedlings. By adjusting the environ-ment, immunization of rice nursery (IRN)could raise seedlings with well developed rootsand high physiological activity. These展开更多
Keratinocytes,located in the outer part of human skin,are the main epidermal cell type and play an essential role in skins defense against infection.Besides creating a physical barrier between the environment and the ...Keratinocytes,located in the outer part of human skin,are the main epidermal cell type and play an essential role in skins defense against infection.Besides creating a physical barrier between the environment and the internal body,keratinocytes exert powerful immune function in anti-pathogen infection in the skin.At the recognition stage,pattern recognition receptors(PRRs)expressed by keratinocytes sense pathogen-associated molecular patterns(PAMPs)existing in pathogens.Toll like receptors(TLRs)are the most important PRRs in keratinocytes.Other PRRs such as dectin-1 and nucleotide-binding oligomerization domain(NOD)-like receptors(NLRs)are also found to participate in this process.Activated PRRs enhance the secretion of cytokines,chemokines and the production of antimicrobial peptides(AMPs).Proinflammatory cytokines tumor necrosis factor-α,interleukin(IL)-1α,IL-6,IL-1βand IL-18,chemokines(C-X-Cmotif)ligand(CXCL)1,CXCL2,CCL20,CCL2 and IL-8,AMPs human β-defensin(HBD)2,HBD3 and LL37 are the main molecules expressed in this procedure.Thymic stromal lymphopoietin(TSLP),IL-36γ,IL-17 family member IL-17C and anti-inflammatory cytokine IL-10 can also be secreted.Some molecules produced by keratinocytes such as ribonuclease 5 and 7,S100 proteins own antimicrobial properties.Keratinocytes defense responses can be regulated by internal and external factors.This review summarizes recent advances on the innate immune function of keratinocytes against infection,promoting the finding of a new direction for avoiding severe skin infection as well as the potential treatment of keratinocyte-associated inflammatory dermatosis.展开更多
基金Xu ZOU studio of famous Chinese medicine physicianGuangdong province+1 种基金Pneumonia emergency research project of the prevention and treatment of COVID-19 with traditional Chinese medicinethe State Administration of Traditional Chinese Medicine。
文摘A case of the absorption of corona virus disease 2019(COVID-19)promoted by professor Xu ZOU’s acupuncture technique for"benefiting kidney and strengthening anti-pathogenic qi"is introduced.A female patient suffered from COVID-19,64 years old,had been treated with acupuncture and Chinese herb granules for 10 days on the base of the oral administration of moxifloxacin.In the re-examination,the chest CT image indicated that the absorption of COVID-19 was obvious as compared with before,the nucleic acid test of novel corona virus was negative and the patient narrated no obvious discomfort.Acupuncture therapy plays its active adjuvant effect in the whole process of the treatment of COVID-19.
文摘The damage caused by rice damping-off diseasecould be controlled efficiently by planting vig-orous seedlings. By adjusting the environ-ment, immunization of rice nursery (IRN)could raise seedlings with well developed rootsand high physiological activity. These
基金This work was supported by the CAMS Innovation Fund for Medical Science(No.2017-I2M-1-017)the National Natural Science Foundation of China(No.81773338)the Nanjing Incubation Program for National Clinical Research Center(No.2019060001).
文摘Keratinocytes,located in the outer part of human skin,are the main epidermal cell type and play an essential role in skins defense against infection.Besides creating a physical barrier between the environment and the internal body,keratinocytes exert powerful immune function in anti-pathogen infection in the skin.At the recognition stage,pattern recognition receptors(PRRs)expressed by keratinocytes sense pathogen-associated molecular patterns(PAMPs)existing in pathogens.Toll like receptors(TLRs)are the most important PRRs in keratinocytes.Other PRRs such as dectin-1 and nucleotide-binding oligomerization domain(NOD)-like receptors(NLRs)are also found to participate in this process.Activated PRRs enhance the secretion of cytokines,chemokines and the production of antimicrobial peptides(AMPs).Proinflammatory cytokines tumor necrosis factor-α,interleukin(IL)-1α,IL-6,IL-1βand IL-18,chemokines(C-X-Cmotif)ligand(CXCL)1,CXCL2,CCL20,CCL2 and IL-8,AMPs human β-defensin(HBD)2,HBD3 and LL37 are the main molecules expressed in this procedure.Thymic stromal lymphopoietin(TSLP),IL-36γ,IL-17 family member IL-17C and anti-inflammatory cytokine IL-10 can also be secreted.Some molecules produced by keratinocytes such as ribonuclease 5 and 7,S100 proteins own antimicrobial properties.Keratinocytes defense responses can be regulated by internal and external factors.This review summarizes recent advances on the innate immune function of keratinocytes against infection,promoting the finding of a new direction for avoiding severe skin infection as well as the potential treatment of keratinocyte-associated inflammatory dermatosis.
