Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza...Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.展开更多
Pyrazinamide(PZA)is a key first-line drug recognized for the treatment of Tuberculosis,exhibiting superior anti-tuberculosis activity against Mycobacterium tuberculosis.The global demand for PZA is growing rapidly,rea...Pyrazinamide(PZA)is a key first-line drug recognized for the treatment of Tuberculosis,exhibiting superior anti-tuberculosis activity against Mycobacterium tuberculosis.The global demand for PZA is growing rapidly,reaching$1.3 billion in 2016 and exceeding$2.0 billion to date.For the conventional production of PZA,methods including 2-pyrazinecarboxylate ammonolysis[1],pyrazine amine reduction[2],hydration of 2-pyrazinecarbonitrile[3]and 2-pyrazinecarboxylic acid reduction[4]have been developed.展开更多
文摘Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.
基金supported by the National Key R&D Program of China(2023YFA1507204)the National Natural Science Foundation of China(22475074,22225109,and 22171139)+4 种基金the Guangdong Provincial Key Laboratory of Carbon Dioxide Resource Utilization(2024B1212010011)the Natural Science Foundation of Guangdong Province(2023B1515020076)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX24_1808)Major Research plan of the National Natural Science Foundation of China(92461310)Double Thousand Talents Plan of Jiangxi Province(jxsq2023102003).
文摘Pyrazinamide(PZA)is a key first-line drug recognized for the treatment of Tuberculosis,exhibiting superior anti-tuberculosis activity against Mycobacterium tuberculosis.The global demand for PZA is growing rapidly,reaching$1.3 billion in 2016 and exceeding$2.0 billion to date.For the conventional production of PZA,methods including 2-pyrazinecarboxylate ammonolysis[1],pyrazine amine reduction[2],hydration of 2-pyrazinecarbonitrile[3]and 2-pyrazinecarboxylic acid reduction[4]have been developed.
