An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone products.Theβ-aminoenones c...An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone products.Theβ-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions.The reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.展开更多
基金the financial support from the National Natural Science Foundation of China(Nos.21772029,32172459,21961006,22001173)The 10 Talent Plan(Shicengci)of Guizhou Province(No.[2016]5649)+4 种基金the Science and Technology Department of Guizhou Province(Nos.[2019]1020,Qiankehejichu-ZK[2021]Key033)the Program of Introducing Talents of Discipline to Universities of China(111 Program,No.D20023)at Guizhou UniversityFrontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[No.Qianjiaohe KY(2020)004]the Guizhou Province First-Class Disciplines Project(No.GNYL(2017)008)Guizhou University(China)。
文摘An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone products.Theβ-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions.The reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.
