Three pairs of enantiomeric phthalide dimers,including two new ones,angesicolides A(1)and B(2),and a new phthalide monomer(3),were obtained from the rhizomes of Angelica sinensis.Their structures were established thro...Three pairs of enantiomeric phthalide dimers,including two new ones,angesicolides A(1)and B(2),and a new phthalide monomer(3),were obtained from the rhizomes of Angelica sinensis.Their structures were established through spectroscopic methods,quantum calculations,and chiral HPLC analysis.Compounds 1 and 2 were[2+2]and[4+2]cycloadducts of phthalide monomers,and their hypothetical biogenetic origin was proposed.Compounds 2,(+)-2,(-)-2,4,(+)-4,and(-)-4 exhibited significant inhibitory activity against NO production with IC_(50) values range from 1.23 to 5.55 μM.展开更多
基金financially supported by National Key R&D Program of China(2022YFF1100301)Major Science and Technology Project of Henan Province(231100310200)Yunnan Province Science and Technology Department(202305AH340005).
文摘Three pairs of enantiomeric phthalide dimers,including two new ones,angesicolides A(1)and B(2),and a new phthalide monomer(3),were obtained from the rhizomes of Angelica sinensis.Their structures were established through spectroscopic methods,quantum calculations,and chiral HPLC analysis.Compounds 1 and 2 were[2+2]and[4+2]cycloadducts of phthalide monomers,and their hypothetical biogenetic origin was proposed.Compounds 2,(+)-2,(-)-2,4,(+)-4,and(-)-4 exhibited significant inhibitory activity against NO production with IC_(50) values range from 1.23 to 5.55 μM.
