1.Discipline origins In 1984,“analytical pharmacology”was firstly used in the paper entitled“The future of analytical pharmacologyda personal view”by Dr.J.S.Cridland,director of a clinical pharmacological laborato...1.Discipline origins In 1984,“analytical pharmacology”was firstly used in the paper entitled“The future of analytical pharmacologyda personal view”by Dr.J.S.Cridland,director of a clinical pharmacological laboratory at Department of Pharmacology,University of Cape Town.He proposed“Analytical pharmacology is at present usually a tool of clinical pharmacology”,which is mainly used for therapeutic drug monitoring,analysis of clinical pharmacokinetics,and toxicological screening to provide a basis for reasonable medication and clinical dose adjustment[1].In 1984,W.J.Black,Director of Wellcome Research Laboratories,was offered a personal Chair at King's College Hospital School of Medicine and Dentistry,part of King's College London.He chose“Analytical Pharmacology”as a title for the Chair[2].展开更多
The focus of green analytical chemistry(GAC)is to minimize the negative impacts of analytical procedures on human safety,human health,and the environment.Several factors,such as the reagents used,sample collection,sam...The focus of green analytical chemistry(GAC)is to minimize the negative impacts of analytical procedures on human safety,human health,and the environment.Several factors,such as the reagents used,sample collection,sample processing,instruments,energy consumed,and the quantities of hazardous materials and waste generated during analytical procedures,need to be considered in the evaluation of the greenness of analytical assays.In this study,we propose a greenness evaluation metric for analytical methods(GEMAM).The new greenness metric is simple,flexible,and comprehensive.The evaluation criteria are based on both the 12 principles of GAC(SIGNIFICANCE)and the 10 factors of sample preparation,and the results are presented on a 0–10 scale.The GEMAM calculation process is easy to perform,and its results are easy to interpret.The output of GEMAM is a pictogram that can provide both qualitative and quantitative information based on color and number.展开更多
Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined...Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined laboratory analytical indicators associated with positive blood culture results.Methods Blood cultures collected from Peking Union Medical College Hospital between January 1,2020,and December 31,2022,were retrospectively analyzed.The mode of transportation(piping logistics delivery vs.staff),source of blood cultures(outpatient/emergency department vs.inpatient department),rotation of personnel,and time of reception(8:00–19:59 vs.20:00–07:59)were compared between blood culture-positive and-negative results.Results Between 2020 and 2022,the total positive rate of blood culture was 8.07%.The positive rate of blood cultures in the outpatient/emergency department was significantly higher than that in the inpatient department(12.46%vs.5.83%;P<0.0001).The time-to-detection of blood cultures was significantly affected by the delivery mode and personnel rotation.The blood culture positive rate of the total pre-analytical time within 1 h was significantly higher than that within 1–2 h or>2 h(P<0.0170).Conclusion Laboratory analytical indicators such as patient source,transportation mode,and personnel rotation significantly impacted the positive detection rate or time of blood culture.展开更多
A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which ca...A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which can accurately describe the strain and stress states in IF.Based on strain analysis,the model can predict the material thickness distribution and neck height after IF.By considering contact area,strain characteristics,material thickness changes,and friction,the model can predict specific moments and corresponding values of maximum axial forming force and maximum horizontal forming force during IF.In addition,an IF experiment involving different tool diameters,flanging diameters,and opening hole diameters is conducted.On the basis of the experimental strain paths,the strain characteristics of different deformation zones are studied,and the stable strain ratio is quantitatively described through two dimensionless parameters:relative tool diameter and relative hole diameter.Then,the changing of material thickness and forming force in IF,and the variation of minimum material thickness,neck height,maximum axial forming force,and maximum horizontal forming force with flanging parameters are studied,and the reliability of the analytical model is verified in this process.Finally,the influence of the horizontal forming force on the tool design and the fluctuation of the forming force are explained.展开更多
Waterproof performance of gaskets between segments is the focus of shield tunnels.This paper proposed an analytical method for determining seepage characteristics at tunnel-gasketed joints based on the hydraulic fract...Waterproof performance of gaskets between segments is the focus of shield tunnels.This paper proposed an analytical method for determining seepage characteristics at tunnel-gasketed joints based on the hydraulic fracturing theories.First,the mathematical model was established,and the seepage governing equation and boundary conditions were obtained.Second,three dimensionless parameters were introduced for simplifying the expressions,and the seepage governing equations were normalized.Third,analytical expressions were derived for the interface opening and liquid pressure.Moreover,the influencing factors of seepage process at the gasketed interface were analyzed.Parametric analyses revealed that,in the normalized criterion of liquid viscosity,the liquid tip coordinate was influenced by the degree of negative pressure in the liquid lag region,which was related to the initial contact stress.The coordinate of the liquid tip affected the liquid pressure distribution and the interface opening,which were analyzed under different liquid tip coordinate conditions.Finally,under two limit states,comparative analysis showed that the results of the variation trend of the proposed method agree well with those of previous research.Overall,the proposed analytical method provides a novel solution for the design of the waterproof in shield tunnels.展开更多
Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by...Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.展开更多
A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance m...A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance method.Firstly,an altitude-energy profile is designed,and the bank angle is derived analytically as the initial iteration value for the predictor-corrector method.The predictor-corrector guidance method has been improved by deriving an analytical form for predicting the range-to-go error,which greatly accelerates the iterative speed.Then,a segmented guidance algorithm is proposed.The above analytically predictor-corrector guidance method is adopted when the energy exceeds an energy threshold.When the energy is less than the threshold,the equidistant test method is used to calculate the bank angle command,which ensures guidance accuracy as well as computational efficiency.Additionally,an adaptive guidance cycle strategy is applied to reduce the computational time of the reentry guidance trajectory.Finally,the accuracy and robustness of the proposed method are verified through a series of simulations and Monte-Carlo experiments.Compared with the traditional integral method,the proposed method requires 75%less computation time on average and achieves a lower landing error.展开更多
Underhand cut-and-fill mining has been widely used in underground mining operations,especially when the rock mass or orebody is of poor quality or prone to rockburst due to high stress.In such cases,mining workers sho...Underhand cut-and-fill mining has been widely used in underground mining operations,especially when the rock mass or orebody is of poor quality or prone to rockburst due to high stress.In such cases,mining workers should carry out all production activities under the cemented backfill roof or sill mat instead of a highly fractured and unstable rock roof or a strong rock roof with a high potential of rockburst.Therefore,the stability and required strength of the sill mat are critical issues for mining engineers.In 1991,Mitchell considered that sill mat could fail by caving,sliding,rotation,and flexure.Mitchell also proposed an analytical solution to determine the minimum required strength of the sill mat for each type of failure based on two stiff or immobile rock walls.However,recent publications using numerical modeling and field measurements indicate that the compressive stresses in the sill mat induced by rock wall closure due to a stope excavation beneath the sill mat can be significant.It is thus highly necessary to investigate the required strength of the sill mat by considering rock wall closure.In this study,the crushing failure of sill mat due to rock wall closure generated by underground excavation and a new failure mode called"crushing and caving”is revealed by numerical modeling.An analytical solution corresponding to each failure mode is then developed to estimate the minimum required cohesion(cmin)of the sill mat.A criterion is also proposed to determine if the sill mat fails by crushing or crushing-and-caving failure.The proposed analytical solution does not involve any correction coefficients.The validity of the proposed analytical solution is demonstrated by numerical modeling.The proposed analytical solution can thus be employed to predict the cmin of sill mat subjected to wall closure generated by underlying stope excavation.展开更多
The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies ...The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies using vari‑ous analytical methods have identified peculiar trends in various illnesses,with Firmicutes being the most prevalent phylum,followed by Bacteroidetes,Proteobacteria,and Actinobacteria.However,more Firmicutes and fewer Bac‑teroidetes have been observed in cats infected with Feline coronavirus.Alterations in the composition of these gut microbiota can be solved by microbiota modification through dietary fiber,probiotics,and fecal microbiota transplan‑tation.Therefore,it is critical to understand the composition of the gut microbiota,the changes in and roles of the gut environment,and the importance of these concepts for overall health while considering the exchange of microbes between humans and domestic animals.This review provides comprehensive information on feline gut microbiota composition,modulation,and analytic methods used for characterizing the gut microbiota.展开更多
Enhancing ecological security for sustainable social,economic,and environmental development is a key focus of current research and a practical necessity for ecological management.However,the integration of retrospecti...Enhancing ecological security for sustainable social,economic,and environmental development is a key focus of current research and a practical necessity for ecological management.However,the integration of retrospective ecological security assessments with future trend predictions and fine-scale targeted regulations remains inadequate,limiting effective ecological governance and sustainable regional development.Guided by Social-Economic-Natural Complex Ecosystems(SENCE)theory,this study proposes an analytical framework that integrates ecological security assessment,prediction,and zoning management.The Daqing River Basin,a typical river basin in the North China Plain,was selected as a case study.The results indicate that overall ecological security in the Daqing River Basin improved from a“Moderate”level to a“Relatively Safe”level between 2000 and 2020;however,spatial heterogeneity persisted,with higher ecological security in northwestern and eastern regions and lower ecological security in the central region.Approximately 62% of the Basin experienced an improvement in ecological security level,except in the major urban areas of Beijing,Tianjin,and Hebei,where ecological security deteriorated.From 2025 to 2040,the overall ecological security of the Daqing River Basin is expected to improve and remain at the“Relatively Safe”level.However,spatial heterogeneity will be further aggravated as the ecological security of major urban areas continues to deteriorate.Ecological security management zones and regulation strategies are proposed at the regional and county scales to emphasize integrated regulation for the entire basin and major urban areas.The proposed analytical framework provides valuable insights for advancing theoretical research on ecological security.The case study offers a practical reference for ecological security enhancement in river basins and other regions facing significant human-land conflicts.展开更多
We read the recent minireview by Ding et al.This review provided a structured introduction to the applications of artificial intelligence(AI)in gastrointestinal endoscopy while emphasizing the technical solutions for ...We read the recent minireview by Ding et al.This review provided a structured introduction to the applications of artificial intelligence(AI)in gastrointestinal endoscopy while emphasizing the technical solutions for imaging hurdles.However,we identified some areas that were lacking analytical depth.Specifically,the review oversimplified machine learning and deep learning models(e.g.,generative adversarial networks misclassification)and failed to deeply analyze the explanations for missed tumor rates and the critical role of data quality/bias.In this article,we stress that the potential of AI extends beyond diagnostics and highlight its emerging and crucial role in endoscopist training,skill development,and proficiency enhancement.We conclude that future AI adoption depends on robust multicenter trials and the implementation of AI-assisted educational platforms.展开更多
Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents followi...Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents following land reclamation.Tidal equa-tions are analytically solved using infinite series,deriving expressions for tidal levels and currents in narrow bays with varying topog-raphy.Tidal levels,influenced by topographic variations,are characterized by amplitude and phase lag of their complex amplitude.These levels demonstrate high sensitivity to longitudinal slope variations but remain relatively stable under lateral slope changes.Un-der constant topographic slopes,even minor changes in bay length can drastically modify amplitude and phase lag,highlighting the sensitivity of tidal dynamics to geometric alterations.Tidal velocity notably increases with steeper longitudinal slopes and modestly rises with elevated lateral slopes.However,changes in longitudinal and lateral slopes do not considerably alter flow patterns.While external forces predominantly regulate tidal velocity with negligible effects on flow patterns,endogenous resistance influences veloci-ty but minimally impacts flow structure.These findings enhance the understanding of tidal responses to geometric and topographic changes,providing valuable guidance for land reclamation projects and coastal management strategies.展开更多
In this study,an analytical investigation is carried out to assess the impact of magnetic field-dependent(MFD)viscosity on the momentum and heat transfers inside the boundary layer of a Jeffrey fluid flowing over a ho...In this study,an analytical investigation is carried out to assess the impact of magnetic field-dependent(MFD)viscosity on the momentum and heat transfers inside the boundary layer of a Jeffrey fluid flowing over a horizontally elongating sheet,while taking into account the effects of ohmic dissipation.By applying similarity transformations,the original nonlinear governing equations with partial derivatives are transformed into ordinary differential equations.Analytical expressions for the momentum and energy equations are derived,incorporating the influence of MFD viscosity on the Jeffrey fluid.Then the impact of different parameters is assessed,including magnetic viscosity,magnetic interaction,retardation time,Deborah number,and Eckert number,on the velocity and temperature profiles in the boundary layer.The findings reveal that an increase in magnetic viscosity leads to a decrease in the local Nusselt number,thereby impairing heat transfer.Moreover,a higher retardation time enhances the local Nusselt number by thinning the momentum and thermal boundary layers,while a higher Deborah number decreases the local Nusselt number due to the reduction in fluid viscosity.展开更多
Flume experiments play a pivotal role in studying wave propagation,with wave elements typically assumed to remain constant in the perpendicular direction.However,evident cross wave phenomena were observed within flume...Flume experiments play a pivotal role in studying wave propagation,with wave elements typically assumed to remain constant in the perpendicular direction.However,evident cross wave phenomena were observed within flumes under certain conditions.This paper presents new analytical solutions for both primary and cross waves on double shoals in a flume via linear shallow-water equations,which may be used to idealize dynamic experimental configurations of coral reefs.The primary waves on double shoals are described by the associated Legendre functions,whereas the ultimate solutions are derived by considering the incident and reflected waves in front of a bathymetry and the transmitted waves positioned behind it.The effects of the angular frequency and topographic parameters on the primary waves are subsequently analyzed.Cross waves on double shoals constitute a type of topographically trapped wave whose solutions are formulated by combining the first and second types of the associated Legendre functions.The angular frequency is not only determined by the wavenumber but also influenced by the topographic parameters.Numerical experiments are conducted to investigate the generation mechanism of cross waves.The consistency between the numerical results and analytical solutions confirms the validity of the new analytical framework of cross waves on double shoals.展开更多
Fluid imbibition from hydraulic fractures into shale formations is mainly affected by a combination of capillary forces and viscous resistance,both of which are closely related to the pore geometry.This study establis...Fluid imbibition from hydraulic fractures into shale formations is mainly affected by a combination of capillary forces and viscous resistance,both of which are closely related to the pore geometry.This study established five self-imbibition models with idealized pore structures and conducted a comparative analysis of these models.These models include circular,square,and equilateral triangular capillaries;a triangular star-shaped cross-section formed by three tangent spherical particles;and a traditional porous medium representation method.All these models are derived based on Newton’s second law,where capillary pressure is described by the Young-Laplace equation and viscous resistance is characterized by the Hagen-Poiret equation and Darcy’s law.All derived models predict that the fluid imbibition distance is proportional to the square root of time,in accordance with the classical Lucas-Washburn law.However,different pore structures exhibit significantly different characteristic imbibition rates.Compared to the single pore model,the conventional Darcy’s law-based model for porous media predicts significantly lower imbibition rates,which is consistent with the relatively slower uptake rates in actual shale nanoscale pore networks.These findings emphasize the important role played by pore geometry in fluid imbibition dynamics and further point to the need for optimizing pore structure to extend fluid imbibition duration in shale reservoirs in practical operations.展开更多
In the underhand cut-and-fill mining method,a sill mat(i.e.an artificial horizontal pillar)constructed by cemented backfill is essential to prevent mine workers from being directly exposed under problematic rock roofs...In the underhand cut-and-fill mining method,a sill mat(i.e.an artificial horizontal pillar)constructed by cemented backfill is essential to prevent mine workers from being directly exposed under problematic rock roofs.A critical issue is to determine the minimum required strength of the sill mat to ensure a safe and cost-effective design.Until now,Mitchell’s analytical solution is the only available option,considering two stiff and immobile rock walls.Unavoidable rock wall closure associated with stope excavation below the sill mat was neglected.This,along with other undefined parameters,explains why Mitchell’s solution is rarely used in sill mat design.A new analytical solution for determining the minimum required strength of the sill mat accounting for wall closure is necessary.In this study,a closed-form analytical solution for estimating rock wall closure generated by stope excavation below a sill mat is developed by using Salamon’s and Flamant’s models.The proposed analytical solution does not contain any coefficients of correction or calibration.Despite several assumptions(or somewhat of oversimplifications)necessary to render a simple analytical solution possible,good agreements are obtained between the rock wall closures predicted by applying the proposed analytical solution and those obtained numerically with FLAC3D for many cases with arbitrarily chosen geometrical and material parameters.The proposed analytical solution is therefore validated and can be used to evaluate the rock wall closure generated by stope excavation below a sill mat.展开更多
Selective laser melting(SLM)plays a critical role in additive manufacturing,particularly in the fabrication of complex high-precision components.This study selects the AlSi10Mg alloy for its extensive use in the aeros...Selective laser melting(SLM)plays a critical role in additive manufacturing,particularly in the fabrication of complex high-precision components.This study selects the AlSi10Mg alloy for its extensive use in the aerospace and automotive industries,which require lightweight structures with superior thermal and mechanical properties.The thermal load induces residual tensile stress,leading to a decline in the geometric accuracy of the workpiece and causing cracks that reduce the fatigue life of the alloy.The rapid movement of the laser heat source during the material formation creates a localized and inhomogeneous temperature field in the powder bed.Significant temperature gradients are generated,resulting in thermal stresses and distortions within the part,affecting the quality of the molding.Therefore,understanding the effects of processing parameters and scanning strategies on the temperature field in SLM is crucial.To address these issues,this study proposes a multiscale method for predicting the complex transient temperature field during the manufacturing process based on the heat-conduction equation.Considering the influence of temperature on the material properties,a temperature-prediction model for discontinuous scanning paths in SLM and a temperature field-calculation model for irregular scanning paths are developed.The models are validated using finite-element results and are in excellent agreement.The analytical model is then used to investigate the effects of the laser power,scanning speed,and scanning spacing on the temperature distribution.The results reveal that the peak temperature decreases exponentially with increasing scanning speed and increases linearly with increasing laser power.In addition,with increasing scanning spacing,the peak temperature of the adjacent tracks near the observation point decreases linearly.These findings are critical for optimizing the SLM-process parameters and improving the material-forming quality.展开更多
Concerning the capture problem against arbitrary maneuvering targets,whose overload is high maneuvering but upper bounded and velocity has advantages,this paper elucidates a three-dimensional multi-constraint analytic...Concerning the capture problem against arbitrary maneuvering targets,whose overload is high maneuvering but upper bounded and velocity has advantages,this paper elucidates a three-dimensional multi-constraint analytical capture zone,exhibiting prominent guiding significance to the initial states of the terminal guidance.Unlike most existing capture zone studies,which are represented by initial relative velocity,the proposed capture zone investigates the initial velocity heading angle and side-window angle.First,the asymptotic fast convergence anti-interference guidance law is presented via motion camouflage theory,and it meets the Field of View(FOV)constraint by theoretical analysis.On this basis,the capture zone is derived with overload limits based on the Lyapunov-based function.Then,it is converted to the form defined by the velocity heading and side-window angles,considering the FOV constraint.Finally,the sensitivity of the capture zone to the designed guidance algorithm’s different influencing factors and the gain boundary are deduced and analyzed to provide a theoretical basis for augmenting the analytical capture zone during a practical engagement.The findings reveal the capture zone correlation mechanism of terminal guidance law and give academic support to the subsequent acquisition of arbitrary maneuvering targets,which has potential application value.展开更多
For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model f...For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model for such vehicles,using aerodynamic load as the control variable,and introduces a framework for solving the guidance laws.This framework unifies the design process of guidance laws for both the glide and cruise phases.By decomposing the longitudinal guidance task into position control and velocity control,and minimizing energy consumption as the objective function,the method provides an analytical solution for velocity control load through the calculation of costate variables.This approach requires only the current state and terminal state parameters to determine the guidance law solution.Furthermore,by transforming path constraints into aerodynamic load constraints and solving backwards to obtain the angle of attack,bank angle,and throttle setting,this method ensures a smooth transition from the glide phase to the cruise phase,guaranteeing the successful completion of the guidance task.Finally,the effectiveness and practicality of the proposed method are validated through case simulations and analysis.展开更多
This study presents a novel methodology to obtain an approximate analytical solution for an isotropic homo-geneous elastic medium with displacement and traction boundary conditions.The solution is derived through solv...This study presents a novel methodology to obtain an approximate analytical solution for an isotropic homo-geneous elastic medium with displacement and traction boundary conditions.The solution is derived through solving a specific numerical problem under the scope of the linear finite element method(LFEM),so the method is termed computational method for analytical solutions with finite elements(CMAS-FE).The primary objective of the CMAS-FE is to construct analytical expressions for displacements and reaction forces at nodes,as well as for strains and stresses at elemental quadrature points,all of which are formulated as infinite series solutions of various orders of Poisson’s ratios.Like the conventional LFEM,the CMAS-FE forms global sparse linear equations,but the Young’s modulus and Poisson’s ratio remain variables(or symbols).By employing a direct inverse method to solve these symbolic linear systems,an analytical expression of the displacement field can be constructed.The CMAS-FE is validated via patch and bending tests,which demonstrate convergence with mesh and term refine-ment.Furthermore,the CMAS-FE is applied to obtain the bending stiffness of a beam structure and to estimate an approximate stress intensity factor for a straight crack within a square-shaped plate.展开更多
文摘1.Discipline origins In 1984,“analytical pharmacology”was firstly used in the paper entitled“The future of analytical pharmacologyda personal view”by Dr.J.S.Cridland,director of a clinical pharmacological laboratory at Department of Pharmacology,University of Cape Town.He proposed“Analytical pharmacology is at present usually a tool of clinical pharmacology”,which is mainly used for therapeutic drug monitoring,analysis of clinical pharmacokinetics,and toxicological screening to provide a basis for reasonable medication and clinical dose adjustment[1].In 1984,W.J.Black,Director of Wellcome Research Laboratories,was offered a personal Chair at King's College Hospital School of Medicine and Dentistry,part of King's College London.He chose“Analytical Pharmacology”as a title for the Chair[2].
基金financially supported by the National Natural Science Foundation of China(Grant Nos.:81603182 and 81703607)the Fundamental Research Funds for the Central Universities,China(Grant Nos.:DUT21RC(3)057,DUT23YG226,DUT24MS018,and DUT23YG228)+1 种基金the Natural Science Foundation of Liaoning Province,China(Grant No.:2023-MSBA-018)the Open Funding of Cancer Hospital of Dalian University of Technology,China(Grant No.:2024-ZLKF-33).
文摘The focus of green analytical chemistry(GAC)is to minimize the negative impacts of analytical procedures on human safety,human health,and the environment.Several factors,such as the reagents used,sample collection,sample processing,instruments,energy consumed,and the quantities of hazardous materials and waste generated during analytical procedures,need to be considered in the evaluation of the greenness of analytical assays.In this study,we propose a greenness evaluation metric for analytical methods(GEMAM).The new greenness metric is simple,flexible,and comprehensive.The evaluation criteria are based on both the 12 principles of GAC(SIGNIFICANCE)and the 10 factors of sample preparation,and the results are presented on a 0–10 scale.The GEMAM calculation process is easy to perform,and its results are easy to interpret.The output of GEMAM is a pictogram that can provide both qualitative and quantitative information based on color and number.
基金supported by grants from the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-074)Peking Union Medical College Hospital Research Funding for Postdoc(kyfyjj202320).
文摘Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined laboratory analytical indicators associated with positive blood culture results.Methods Blood cultures collected from Peking Union Medical College Hospital between January 1,2020,and December 31,2022,were retrospectively analyzed.The mode of transportation(piping logistics delivery vs.staff),source of blood cultures(outpatient/emergency department vs.inpatient department),rotation of personnel,and time of reception(8:00–19:59 vs.20:00–07:59)were compared between blood culture-positive and-negative results.Results Between 2020 and 2022,the total positive rate of blood culture was 8.07%.The positive rate of blood cultures in the outpatient/emergency department was significantly higher than that in the inpatient department(12.46%vs.5.83%;P<0.0001).The time-to-detection of blood cultures was significantly affected by the delivery mode and personnel rotation.The blood culture positive rate of the total pre-analytical time within 1 h was significantly higher than that within 1–2 h or>2 h(P<0.0170).Conclusion Laboratory analytical indicators such as patient source,transportation mode,and personnel rotation significantly impacted the positive detection rate or time of blood culture.
基金supported in part by financial support from the National Key R&D Program of China(No.2023YFB3407003)the National Natural Science Foundation of China(No.52375378).
文摘A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which can accurately describe the strain and stress states in IF.Based on strain analysis,the model can predict the material thickness distribution and neck height after IF.By considering contact area,strain characteristics,material thickness changes,and friction,the model can predict specific moments and corresponding values of maximum axial forming force and maximum horizontal forming force during IF.In addition,an IF experiment involving different tool diameters,flanging diameters,and opening hole diameters is conducted.On the basis of the experimental strain paths,the strain characteristics of different deformation zones are studied,and the stable strain ratio is quantitatively described through two dimensionless parameters:relative tool diameter and relative hole diameter.Then,the changing of material thickness and forming force in IF,and the variation of minimum material thickness,neck height,maximum axial forming force,and maximum horizontal forming force with flanging parameters are studied,and the reliability of the analytical model is verified in this process.Finally,the influence of the horizontal forming force on the tool design and the fluctuation of the forming force are explained.
基金Project(52278421)supported by the National Natural Science Foundation of ChinaProject(2024ZZTS0754)supported by the Fundamental Research Funds for the Central Universities of Central South University,China+2 种基金Project(2023CXQD067)supported by the Central South University Innovation-Driven Research Programme,ChinaProject(2022QNRC001)supported by Young Elite Scientists Sponsorship Program by CASTProject(2023TJ-N24)supported by the Youth Talent Program by China Railway Society and the Hunan Provincial Science and Technology Promotion Talent Project。
文摘Waterproof performance of gaskets between segments is the focus of shield tunnels.This paper proposed an analytical method for determining seepage characteristics at tunnel-gasketed joints based on the hydraulic fracturing theories.First,the mathematical model was established,and the seepage governing equation and boundary conditions were obtained.Second,three dimensionless parameters were introduced for simplifying the expressions,and the seepage governing equations were normalized.Third,analytical expressions were derived for the interface opening and liquid pressure.Moreover,the influencing factors of seepage process at the gasketed interface were analyzed.Parametric analyses revealed that,in the normalized criterion of liquid viscosity,the liquid tip coordinate was influenced by the degree of negative pressure in the liquid lag region,which was related to the initial contact stress.The coordinate of the liquid tip affected the liquid pressure distribution and the interface opening,which were analyzed under different liquid tip coordinate conditions.Finally,under two limit states,comparative analysis showed that the results of the variation trend of the proposed method agree well with those of previous research.Overall,the proposed analytical method provides a novel solution for the design of the waterproof in shield tunnels.
文摘Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.
基金National Natural Science Foundation of China(Nos.61773387 and 62022061).
文摘A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance method.Firstly,an altitude-energy profile is designed,and the bank angle is derived analytically as the initial iteration value for the predictor-corrector method.The predictor-corrector guidance method has been improved by deriving an analytical form for predicting the range-to-go error,which greatly accelerates the iterative speed.Then,a segmented guidance algorithm is proposed.The above analytically predictor-corrector guidance method is adopted when the energy exceeds an energy threshold.When the energy is less than the threshold,the equidistant test method is used to calculate the bank angle command,which ensures guidance accuracy as well as computational efficiency.Additionally,an adaptive guidance cycle strategy is applied to reduce the computational time of the reentry guidance trajectory.Finally,the accuracy and robustness of the proposed method are verified through a series of simulations and Monte-Carlo experiments.Compared with the traditional integral method,the proposed method requires 75%less computation time on average and achieves a lower landing error.
基金financial support from the Young Scientist Project of the National Key Research and Development Program of China(Grant No.2021YFC2900600)Beijing Nova Program(Grant No.20220484057)+1 种基金The authors acknowledge the financial support from the Natural Sciences and Engineering Research Council of Canada(Grant No.RGPIN-2018-06902)industrial partners of the Research Institute on Mines and the Environment(RIME UQAT-Polytechnique:https://irme.ca/en/).
文摘Underhand cut-and-fill mining has been widely used in underground mining operations,especially when the rock mass or orebody is of poor quality or prone to rockburst due to high stress.In such cases,mining workers should carry out all production activities under the cemented backfill roof or sill mat instead of a highly fractured and unstable rock roof or a strong rock roof with a high potential of rockburst.Therefore,the stability and required strength of the sill mat are critical issues for mining engineers.In 1991,Mitchell considered that sill mat could fail by caving,sliding,rotation,and flexure.Mitchell also proposed an analytical solution to determine the minimum required strength of the sill mat for each type of failure based on two stiff or immobile rock walls.However,recent publications using numerical modeling and field measurements indicate that the compressive stresses in the sill mat induced by rock wall closure due to a stope excavation beneath the sill mat can be significant.It is thus highly necessary to investigate the required strength of the sill mat by considering rock wall closure.In this study,the crushing failure of sill mat due to rock wall closure generated by underground excavation and a new failure mode called"crushing and caving”is revealed by numerical modeling.An analytical solution corresponding to each failure mode is then developed to estimate the minimum required cohesion(cmin)of the sill mat.A criterion is also proposed to determine if the sill mat fails by crushing or crushing-and-caving failure.The proposed analytical solution does not involve any correction coefficients.The validity of the proposed analytical solution is demonstrated by numerical modeling.The proposed analytical solution can thus be employed to predict the cmin of sill mat subjected to wall closure generated by underlying stope excavation.
基金funded this manuscript for the Central Universities(Grant Nos.2662023DKPY004 and 2662021DKQD005).
文摘The gastrointestinal tract of felines is inhabited by an active and intricate population of microorganisms whose alteration creates disturbances in the immune response and can affect health and disease states.Studies using vari‑ous analytical methods have identified peculiar trends in various illnesses,with Firmicutes being the most prevalent phylum,followed by Bacteroidetes,Proteobacteria,and Actinobacteria.However,more Firmicutes and fewer Bac‑teroidetes have been observed in cats infected with Feline coronavirus.Alterations in the composition of these gut microbiota can be solved by microbiota modification through dietary fiber,probiotics,and fecal microbiota transplan‑tation.Therefore,it is critical to understand the composition of the gut microbiota,the changes in and roles of the gut environment,and the importance of these concepts for overall health while considering the exchange of microbes between humans and domestic animals.This review provides comprehensive information on feline gut microbiota composition,modulation,and analytic methods used for characterizing the gut microbiota.
基金supported by the project of the National Natural Science Foundation of China(42330705).
文摘Enhancing ecological security for sustainable social,economic,and environmental development is a key focus of current research and a practical necessity for ecological management.However,the integration of retrospective ecological security assessments with future trend predictions and fine-scale targeted regulations remains inadequate,limiting effective ecological governance and sustainable regional development.Guided by Social-Economic-Natural Complex Ecosystems(SENCE)theory,this study proposes an analytical framework that integrates ecological security assessment,prediction,and zoning management.The Daqing River Basin,a typical river basin in the North China Plain,was selected as a case study.The results indicate that overall ecological security in the Daqing River Basin improved from a“Moderate”level to a“Relatively Safe”level between 2000 and 2020;however,spatial heterogeneity persisted,with higher ecological security in northwestern and eastern regions and lower ecological security in the central region.Approximately 62% of the Basin experienced an improvement in ecological security level,except in the major urban areas of Beijing,Tianjin,and Hebei,where ecological security deteriorated.From 2025 to 2040,the overall ecological security of the Daqing River Basin is expected to improve and remain at the“Relatively Safe”level.However,spatial heterogeneity will be further aggravated as the ecological security of major urban areas continues to deteriorate.Ecological security management zones and regulation strategies are proposed at the regional and county scales to emphasize integrated regulation for the entire basin and major urban areas.The proposed analytical framework provides valuable insights for advancing theoretical research on ecological security.The case study offers a practical reference for ecological security enhancement in river basins and other regions facing significant human-land conflicts.
文摘We read the recent minireview by Ding et al.This review provided a structured introduction to the applications of artificial intelligence(AI)in gastrointestinal endoscopy while emphasizing the technical solutions for imaging hurdles.However,we identified some areas that were lacking analytical depth.Specifically,the review oversimplified machine learning and deep learning models(e.g.,generative adversarial networks misclassification)and failed to deeply analyze the explanations for missed tumor rates and the critical role of data quality/bias.In this article,we stress that the potential of AI extends beyond diagnostics and highlight its emerging and crucial role in endoscopist training,skill development,and proficiency enhancement.We conclude that future AI adoption depends on robust multicenter trials and the implementation of AI-assisted educational platforms.
基金supported by the National Natural Sci-ence Foundation of China(No.U2106204)the Shanxi Water Conservancy Science and Technology Re-search and Extension Project(No.2023ZF19).
文摘Progressive modifications in submarine topography and shorelines drastically affect tidal dynamics in bays.This study examines the influence of topographic slope,bay length,and driving forces on tidal currents following land reclamation.Tidal equa-tions are analytically solved using infinite series,deriving expressions for tidal levels and currents in narrow bays with varying topog-raphy.Tidal levels,influenced by topographic variations,are characterized by amplitude and phase lag of their complex amplitude.These levels demonstrate high sensitivity to longitudinal slope variations but remain relatively stable under lateral slope changes.Un-der constant topographic slopes,even minor changes in bay length can drastically modify amplitude and phase lag,highlighting the sensitivity of tidal dynamics to geometric alterations.Tidal velocity notably increases with steeper longitudinal slopes and modestly rises with elevated lateral slopes.However,changes in longitudinal and lateral slopes do not considerably alter flow patterns.While external forces predominantly regulate tidal velocity with negligible effects on flow patterns,endogenous resistance influences veloci-ty but minimally impacts flow structure.These findings enhance the understanding of tidal responses to geometric and topographic changes,providing valuable guidance for land reclamation projects and coastal management strategies.
基金supported by the United Arab Emirates University,Al Ain,United Arab Emirates,under Grant No.12R283.
文摘In this study,an analytical investigation is carried out to assess the impact of magnetic field-dependent(MFD)viscosity on the momentum and heat transfers inside the boundary layer of a Jeffrey fluid flowing over a horizontally elongating sheet,while taking into account the effects of ohmic dissipation.By applying similarity transformations,the original nonlinear governing equations with partial derivatives are transformed into ordinary differential equations.Analytical expressions for the momentum and energy equations are derived,incorporating the influence of MFD viscosity on the Jeffrey fluid.Then the impact of different parameters is assessed,including magnetic viscosity,magnetic interaction,retardation time,Deborah number,and Eckert number,on the velocity and temperature profiles in the boundary layer.The findings reveal that an increase in magnetic viscosity leads to a decrease in the local Nusselt number,thereby impairing heat transfer.Moreover,a higher retardation time enhances the local Nusselt number by thinning the momentum and thermal boundary layers,while a higher Deborah number decreases the local Nusselt number due to the reduction in fluid viscosity.
基金financially supported by the National Natural Science Foundation of China (Grant No. 52071128)the Natural Science Foundation of Jiangsu Basic Research Program (Grant No. BK20220082)
文摘Flume experiments play a pivotal role in studying wave propagation,with wave elements typically assumed to remain constant in the perpendicular direction.However,evident cross wave phenomena were observed within flumes under certain conditions.This paper presents new analytical solutions for both primary and cross waves on double shoals in a flume via linear shallow-water equations,which may be used to idealize dynamic experimental configurations of coral reefs.The primary waves on double shoals are described by the associated Legendre functions,whereas the ultimate solutions are derived by considering the incident and reflected waves in front of a bathymetry and the transmitted waves positioned behind it.The effects of the angular frequency and topographic parameters on the primary waves are subsequently analyzed.Cross waves on double shoals constitute a type of topographically trapped wave whose solutions are formulated by combining the first and second types of the associated Legendre functions.The angular frequency is not only determined by the wavenumber but also influenced by the topographic parameters.Numerical experiments are conducted to investigate the generation mechanism of cross waves.The consistency between the numerical results and analytical solutions confirms the validity of the new analytical framework of cross waves on double shoals.
文摘Fluid imbibition from hydraulic fractures into shale formations is mainly affected by a combination of capillary forces and viscous resistance,both of which are closely related to the pore geometry.This study established five self-imbibition models with idealized pore structures and conducted a comparative analysis of these models.These models include circular,square,and equilateral triangular capillaries;a triangular star-shaped cross-section formed by three tangent spherical particles;and a traditional porous medium representation method.All these models are derived based on Newton’s second law,where capillary pressure is described by the Young-Laplace equation and viscous resistance is characterized by the Hagen-Poiret equation and Darcy’s law.All derived models predict that the fluid imbibition distance is proportional to the square root of time,in accordance with the classical Lucas-Washburn law.However,different pore structures exhibit significantly different characteristic imbibition rates.Compared to the single pore model,the conventional Darcy’s law-based model for porous media predicts significantly lower imbibition rates,which is consistent with the relatively slower uptake rates in actual shale nanoscale pore networks.These findings emphasize the important role played by pore geometry in fluid imbibition dynamics and further point to the need for optimizing pore structure to extend fluid imbibition duration in shale reservoirs in practical operations.
基金financial support from the Young Scientist Project of the National Key Research and Development Program of China(Grant No.2021YFC2900600)the Beijing Nova Program(Grant No.20220484057)+1 种基金The authors acknowledge the financial support from the Natural Sciences and Engineering Research Council of Canada(Grant No.RGPIN-2018-06902)industrial partners of the Research Institute on Mines and the Environment(RIME UQAT-Polytechnique:https://irme.ca/en/).
文摘In the underhand cut-and-fill mining method,a sill mat(i.e.an artificial horizontal pillar)constructed by cemented backfill is essential to prevent mine workers from being directly exposed under problematic rock roofs.A critical issue is to determine the minimum required strength of the sill mat to ensure a safe and cost-effective design.Until now,Mitchell’s analytical solution is the only available option,considering two stiff and immobile rock walls.Unavoidable rock wall closure associated with stope excavation below the sill mat was neglected.This,along with other undefined parameters,explains why Mitchell’s solution is rarely used in sill mat design.A new analytical solution for determining the minimum required strength of the sill mat accounting for wall closure is necessary.In this study,a closed-form analytical solution for estimating rock wall closure generated by stope excavation below a sill mat is developed by using Salamon’s and Flamant’s models.The proposed analytical solution does not contain any coefficients of correction or calibration.Despite several assumptions(or somewhat of oversimplifications)necessary to render a simple analytical solution possible,good agreements are obtained between the rock wall closures predicted by applying the proposed analytical solution and those obtained numerically with FLAC3D for many cases with arbitrarily chosen geometrical and material parameters.The proposed analytical solution is therefore validated and can be used to evaluate the rock wall closure generated by stope excavation below a sill mat.
基金supported by National Natural Science Foundation of the China Youth Program(Grant No.52205485)Sichuan Youth Fund Program of China(Grant No.2025ZNSFSC1275)the Young Scientific Research Team Cultivation Program of SUES(Grant No.QNTD202112)。
文摘Selective laser melting(SLM)plays a critical role in additive manufacturing,particularly in the fabrication of complex high-precision components.This study selects the AlSi10Mg alloy for its extensive use in the aerospace and automotive industries,which require lightweight structures with superior thermal and mechanical properties.The thermal load induces residual tensile stress,leading to a decline in the geometric accuracy of the workpiece and causing cracks that reduce the fatigue life of the alloy.The rapid movement of the laser heat source during the material formation creates a localized and inhomogeneous temperature field in the powder bed.Significant temperature gradients are generated,resulting in thermal stresses and distortions within the part,affecting the quality of the molding.Therefore,understanding the effects of processing parameters and scanning strategies on the temperature field in SLM is crucial.To address these issues,this study proposes a multiscale method for predicting the complex transient temperature field during the manufacturing process based on the heat-conduction equation.Considering the influence of temperature on the material properties,a temperature-prediction model for discontinuous scanning paths in SLM and a temperature field-calculation model for irregular scanning paths are developed.The models are validated using finite-element results and are in excellent agreement.The analytical model is then used to investigate the effects of the laser power,scanning speed,and scanning spacing on the temperature distribution.The results reveal that the peak temperature decreases exponentially with increasing scanning speed and increases linearly with increasing laser power.In addition,with increasing scanning spacing,the peak temperature of the adjacent tracks near the observation point decreases linearly.These findings are critical for optimizing the SLM-process parameters and improving the material-forming quality.
文摘Concerning the capture problem against arbitrary maneuvering targets,whose overload is high maneuvering but upper bounded and velocity has advantages,this paper elucidates a three-dimensional multi-constraint analytical capture zone,exhibiting prominent guiding significance to the initial states of the terminal guidance.Unlike most existing capture zone studies,which are represented by initial relative velocity,the proposed capture zone investigates the initial velocity heading angle and side-window angle.First,the asymptotic fast convergence anti-interference guidance law is presented via motion camouflage theory,and it meets the Field of View(FOV)constraint by theoretical analysis.On this basis,the capture zone is derived with overload limits based on the Lyapunov-based function.Then,it is converted to the form defined by the velocity heading and side-window angles,considering the FOV constraint.Finally,the sensitivity of the capture zone to the designed guidance algorithm’s different influencing factors and the gain boundary are deduced and analyzed to provide a theoretical basis for augmenting the analytical capture zone during a practical engagement.The findings reveal the capture zone correlation mechanism of terminal guidance law and give academic support to the subsequent acquisition of arbitrary maneuvering targets,which has potential application value.
基金supported by the National Natural Science Foundation of China(Grant Nos.62473374,62403487 and U2441243).
文摘For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model for such vehicles,using aerodynamic load as the control variable,and introduces a framework for solving the guidance laws.This framework unifies the design process of guidance laws for both the glide and cruise phases.By decomposing the longitudinal guidance task into position control and velocity control,and minimizing energy consumption as the objective function,the method provides an analytical solution for velocity control load through the calculation of costate variables.This approach requires only the current state and terminal state parameters to determine the guidance law solution.Furthermore,by transforming path constraints into aerodynamic load constraints and solving backwards to obtain the angle of attack,bank angle,and throttle setting,this method ensures a smooth transition from the glide phase to the cruise phase,guaranteeing the successful completion of the guidance task.Finally,the effectiveness and practicality of the proposed method are validated through case simulations and analysis.
基金supported by the National Natural Science Foundation of China Excellence Research Group Program for“Multiscale Problems in Nonlinear Mechanics”(Grant No.12588201)the National Key R&D Program of China(Grant No.2023YFA1008901)+1 种基金the National Nat-ural Science Foundation of China(Grant No.12172009)supported by“The Fundamental Research Funds for the Central Universities,Peking University”.
文摘This study presents a novel methodology to obtain an approximate analytical solution for an isotropic homo-geneous elastic medium with displacement and traction boundary conditions.The solution is derived through solving a specific numerical problem under the scope of the linear finite element method(LFEM),so the method is termed computational method for analytical solutions with finite elements(CMAS-FE).The primary objective of the CMAS-FE is to construct analytical expressions for displacements and reaction forces at nodes,as well as for strains and stresses at elemental quadrature points,all of which are formulated as infinite series solutions of various orders of Poisson’s ratios.Like the conventional LFEM,the CMAS-FE forms global sparse linear equations,but the Young’s modulus and Poisson’s ratio remain variables(or symbols).By employing a direct inverse method to solve these symbolic linear systems,an analytical expression of the displacement field can be constructed.The CMAS-FE is validated via patch and bending tests,which demonstrate convergence with mesh and term refine-ment.Furthermore,the CMAS-FE is applied to obtain the bending stiffness of a beam structure and to estimate an approximate stress intensity factor for a straight crack within a square-shaped plate.
