The SafeAmpCase is an innovative 3D-printed solution developed to address critical challenges in transporting and storing fragile glass drug ampoules during emergencies.This study employs a multidisciplinary approach...The SafeAmpCase is an innovative 3D-printed solution developed to address critical challenges in transporting and storing fragile glass drug ampoules during emergencies.This study employs a multidisciplinary approach—integrating biomedical engineering,advanced materials science,and emergency medicine expertise—to develop a compact,durable,and user-friendly ampoule case.A key innovation lies in the strategic selection of thermoplastic polyurethane(TPU)as the material,leveraging its superior impact resistance,flexibility,and noise-damping characteristics to ensure reliability under performance in demanding real-world conditions.To optimize the 3D printing process,key parameters,including printing temperature(220-250℃),volumetric flow rate(3-20 mm^(3)/s),retraction speed(30-90 mm/s),and retraction length(0.4-1.2 mm),were systematically adjusted using calibration models.The final optimized parameters(245℃,7 mm^(3)/s,90 mm/s,and 1.2 mm)reduced production time by 43%while preserving structural integrity.American Society for Testing and Materials(ASTM)international standard drop tests confirmed the case’s exceptional impact resistance,demonstrating a 90%reduction in ampoule breakage compared to polylactic acid plus.Further refinements,guided by feedback from 25 emergency professionals,resulted in medicationspecific color coding and an enhanced locking mechanism for usability in high-pressure situations.The final SafeAmpCase model withstood 18 consecutive drop trials without ampoule breakage,confirming its robustness in field conditions.This research underscores the transformative potential of additive manufacturing in developing customized,high-performance solutions for critical healthcare applications,setting a new benchmark for biomedical device design and rapid prototyping.展开更多
A wide range of objects have been inserted into the urinary bladder and urethra.Most foreign bodies in the lower genitourinary tract are self-inserted via the urethra as the result of erotic impulses,psychometric prob...A wide range of objects have been inserted into the urinary bladder and urethra.Most foreign bodies in the lower genitourinary tract are self-inserted via the urethra as the result of erotic impulses,psychometric problems,sexual curiosity,or sexual practice while intoxicated.Here we report the case of a 32-year-old female with alleged history of insertion of glass ampoule in the urethra by the husband in eroticism which was removed with open surgery.This is the first case of its kind as per the literature available.展开更多
Objective: to analyze the existing problems in the clinical use and management of psychotropic drugs and narcotic drugs of Class I and the corresponding treatment measures. Methods: to understand the problems existing...Objective: to analyze the existing problems in the clinical use and management of psychotropic drugs and narcotic drugs of Class I and the corresponding treatment measures. Methods: to understand the problems existing in the clinical use and management of Class I psychotropic drugs and narcotic drugs, including: ampoule bottles were not recovered in time or effectively, medical records were used instead of "Special card for narcotic drugs", the remaining drugs were not returned free of charge, and pharmaceutical personnel were not counted effectively. Results: according to the existing problems, corresponding intervention measures were taken to ensure the standardized use of Class I psychotropic drugs and narcotic drugs. Conclusion: standardizing the use of anesthesia and psychotropic drugs has a very positive effect on the daily work of hospitals and the good operation of society.展开更多
基金Open access funding provided by Ben-Gurion University.
文摘The SafeAmpCase is an innovative 3D-printed solution developed to address critical challenges in transporting and storing fragile glass drug ampoules during emergencies.This study employs a multidisciplinary approach—integrating biomedical engineering,advanced materials science,and emergency medicine expertise—to develop a compact,durable,and user-friendly ampoule case.A key innovation lies in the strategic selection of thermoplastic polyurethane(TPU)as the material,leveraging its superior impact resistance,flexibility,and noise-damping characteristics to ensure reliability under performance in demanding real-world conditions.To optimize the 3D printing process,key parameters,including printing temperature(220-250℃),volumetric flow rate(3-20 mm^(3)/s),retraction speed(30-90 mm/s),and retraction length(0.4-1.2 mm),were systematically adjusted using calibration models.The final optimized parameters(245℃,7 mm^(3)/s,90 mm/s,and 1.2 mm)reduced production time by 43%while preserving structural integrity.American Society for Testing and Materials(ASTM)international standard drop tests confirmed the case’s exceptional impact resistance,demonstrating a 90%reduction in ampoule breakage compared to polylactic acid plus.Further refinements,guided by feedback from 25 emergency professionals,resulted in medicationspecific color coding and an enhanced locking mechanism for usability in high-pressure situations.The final SafeAmpCase model withstood 18 consecutive drop trials without ampoule breakage,confirming its robustness in field conditions.This research underscores the transformative potential of additive manufacturing in developing customized,high-performance solutions for critical healthcare applications,setting a new benchmark for biomedical device design and rapid prototyping.
文摘A wide range of objects have been inserted into the urinary bladder and urethra.Most foreign bodies in the lower genitourinary tract are self-inserted via the urethra as the result of erotic impulses,psychometric problems,sexual curiosity,or sexual practice while intoxicated.Here we report the case of a 32-year-old female with alleged history of insertion of glass ampoule in the urethra by the husband in eroticism which was removed with open surgery.This is the first case of its kind as per the literature available.
文摘Objective: to analyze the existing problems in the clinical use and management of psychotropic drugs and narcotic drugs of Class I and the corresponding treatment measures. Methods: to understand the problems existing in the clinical use and management of Class I psychotropic drugs and narcotic drugs, including: ampoule bottles were not recovered in time or effectively, medical records were used instead of "Special card for narcotic drugs", the remaining drugs were not returned free of charge, and pharmaceutical personnel were not counted effectively. Results: according to the existing problems, corresponding intervention measures were taken to ensure the standardized use of Class I psychotropic drugs and narcotic drugs. Conclusion: standardizing the use of anesthesia and psychotropic drugs has a very positive effect on the daily work of hospitals and the good operation of society.
