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miRNA的发现之旅--2024年诺贝尔生理学或医学奖解读 被引量:2
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作者 梁英 于文强 《自然杂志》 CAS 2024年第6期421-428,共8页
2024年诺贝尔生理学或医学奖授予美国科学家维克多·安博斯(Victor Ambros)与加里·鲁弗肯(Gary Ruvkun),以表彰其在微小RNA(miRNA)领域的卓越贡献。miRNA是一类长度约22个核苷酸的非编码RNA,通过特定机制在转录后水平调控基因... 2024年诺贝尔生理学或医学奖授予美国科学家维克多·安博斯(Victor Ambros)与加里·鲁弗肯(Gary Ruvkun),以表彰其在微小RNA(miRNA)领域的卓越贡献。miRNA是一类长度约22个核苷酸的非编码RNA,通过特定机制在转录后水平调控基因表达,参与多种生物学过程。两位科学家的研究不仅奠定了miRNA在基因调控中的核心地位,也为医学应用开辟了新途径。本文不仅阐述了miRNA的经典负性调控机制及其生理功能,还深入探索了细胞核内一类新兴的核激活RNA(NamiRNA),这类特殊的miRNA通过特异性地靶向增强子区域,展现出独特的激活作用。这一创新性发现不仅极大地拓宽了miRNA研究的视野,更为细胞核内miRNA的激活机制研究开启了一个崭新的时代。miRNA作为肿瘤诊断标志物和治疗靶点展现出巨大潜力,但仍面临挑战。随着研究深入,miRNA有望在医学领域实现更多突破,为疾病治疗提供新策略。 展开更多
关键词 微小RNA 核激活RNA 维克多·安博斯 加里·鲁弗肯 标志物 功能
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Assessment of Sea Water Inundation Along Daboo Creek Area in Indus Delta Region, Pakistan
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作者 ZIA Ibrahim ZAFAR Hina +2 位作者 SHAHZAD Muhammad I. MERAJ Mohsin KAZMI Jamil H. 《Journal of Ocean University of China》 SCIE CAS CSCD 2017年第6期1055-1060,共6页
Indus Deltaic Region(IDR) in Pakistan is an erosion vulnerable coast due to the high deep water wave energy. Livelihood of millions of people depends on the fisheries and mangrove forests in IDR. IDR consists of many ... Indus Deltaic Region(IDR) in Pakistan is an erosion vulnerable coast due to the high deep water wave energy. Livelihood of millions of people depends on the fisheries and mangrove forests in IDR. IDR consists of many creeks where Daboo is a major creek located at southeast of the largest city of Pakistan, Karachi. Unfortunately, there has been no detailed study to analyze the damages of sea water intrusion at a large temporal and spatial scale. Therefore, this study is designed to estimate the effects of sea water inundation based on changing sea water surface salinity and sea surface temperature(SST). Sea surface salinity and SST data from two different surveys in Daboo creek during 1986 and 2010 are analyzed to estimate the damages and extent of sea water intrusion. Mean salinity has increased 33.33% whereas mean SST decreased 13.79% from 1987 to 2010. Spatio-temporal analysis of creek area using LANDSAT 5 Thematic mapper(TM) data for the years 1987 and 2010 shows significant amount of erosion at macro scale. Creek area has increased approximately 9.93%(260.86 m^2 per year) which is roughly equal to 60 extensive sized shrimp farms. Further Land Use Land Cover(LULC) analyses for years 2001 and 2014 using LANDSAT 7 Enhanced Thematic Mapper Plus(ETM+) has indicated 42.3% decrease in cultivated land. Wet mud flats have spread out at the inner mouth of creek with enormous increase of 123.3%. Significant sea water intrusion has increased the area of barren land by 37.9%. This also resulted in overall decrease of 6.7% in area covered by mangroves. Therefore, this study recorded a significant evidence of sea water intrusion in IDR that has caused serious damages to community living in the area, economical losses. Additionally, it has also changed the environment by reducing creek biological productivity as reported by earlier studies over other regions of the world. 展开更多
关键词 sea water INTRUSION SST SALINITY ambro CREEK CTD
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微小RNA,大时代:安布罗斯与鲁夫昆的科研征途及启示
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作者 陈彪 焦宇昊 +5 位作者 申梦茹 彭安婷 朱玥玮 芮杨梦琳 王春秀 郝锌颖 《科技导报》 2025年第17期141-144,共4页
维克托·安布罗斯和加里·鲁夫昆因发现“miRNA及其在转录后基因调控中的作用”而获2024年诺贝尔生理学或医学奖。梳理了2人发现miRNA及其调控作用的科研之路,总结出追寻兴趣深入、不惧暂时驻足、学会化繁为简3点对于科研人员... 维克托·安布罗斯和加里·鲁夫昆因发现“miRNA及其在转录后基因调控中的作用”而获2024年诺贝尔生理学或医学奖。梳理了2人发现miRNA及其调控作用的科研之路,总结出追寻兴趣深入、不惧暂时驻足、学会化繁为简3点对于科研人员勇攀科研高峰至关重要的影响因素。 展开更多
关键词 诺贝尔生理学或医学奖 维克托·安布罗斯 加里·鲁夫昆 miRNA
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