The patterns of metal distribution and alteration zonation in magmatic-hydrothermal systems primarily focus on porphyry deposit and other closely associated types,such as skarn,epithermal and distal vein deposits(e.g....The patterns of metal distribution and alteration zonation in magmatic-hydrothermal systems primarily focus on porphyry deposit and other closely associated types,such as skarn,epithermal and distal vein deposits(e.g.,Zheng,2022;Hutchison et al.,2020;Cooke et al.,2011;Hedenquist et al.,1998).展开更多
Gestational diabetes mellitus(GDM)is a metabolic disorder,recognised during 24-28 weeks of pregnancy.GDM is linked with adverse newborn outcomes such as macrosomia,premature delivery,metabolic disorder,cardiovascular,...Gestational diabetes mellitus(GDM)is a metabolic disorder,recognised during 24-28 weeks of pregnancy.GDM is linked with adverse newborn outcomes such as macrosomia,premature delivery,metabolic disorder,cardiovascular,and neurological disorders.Recent investigations have focused on the correlation of genetic factors such asβ-cell function and insulin secretary genes(transcription factor 7 like 2,potassium voltage-gated channel subfamily q member 1,adipo-nectin etc.)on maternal metabolism during gestation leading to GDM.Epigenetic alterations like DNA methylation,histone modification,and miRNA expression can influence gene expression and play a dominant role in feto-maternal meta-bolic pathways.Interactions between genes and environment,resulting in differ-ential gene expression patterns may lead to GDM.Researchers suggested that GDM women are more susceptible to insulin resistance,which alters intrauterine surroundings,resulting hyperglycemia and hyperinsulinemia.Epigenetic modi-fications in genes affecting neuroendocrine activities,and metabolism,increase the risk of obesity and type 2 diabetes in offspring.There is currently no treatment or effective preventive method for GDM,since the molecular processes of insulin resistance are not well understood.The present review was undertaken to un-derstand the pathophysiology of GDM and its effects on adverse neonatal out-comes.In addition,the study of genetic and epigenetic alterations will provide lead to researchers in the search for predictive molecular biomarkers.展开更多
BACKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in the...BACKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in these patients.However,their actual prevalence and pathophysiology remain to be elucidated.AIM To determine the prevalence of SMAs and to assess the significance of circulating myokines as biomarkers in patients with MASLD.METHODS Skeletal muscle strength and muscle mass were measured in a cross-sectional study in a cohort of 62 patients fulfilling MASLD criteria,recruited from the outpatient clinics of a tertiary level hospital.The degree of fibrosis and liver steatosis was studied using abdominal ultrasound and transitional elastography.Anthropometric and metabolic characteristics as well as serum levels of different myokines were also determined in the MASLD cohort.Statistical analysis was performed comparing results according to liver fibrosis and steatosis.RESULTS No significant differences were found in both skeletal muscle strength and skeletal muscle mass in patients with MASLD between different stages of liver fibrosis.Interestingly,serum levels of fibroblast growth factor-21(FGF21)were significantly higher in patients with MASLD with advanced hepatic fibrosis(F3-F4)than in those with lower fibrosis stages(F0-F2)(197.49±198.27 pg/mL vs 95.62±83.67 pg/mL;P=0.049).In addition,patients with MASLD with severe hepatosteatosis(S3)exhibited significantly higher serum levels of irisin(1116.87±1161.86 pg/mL)than those with lower grades(S1-S2)(385.21±375.98 pg/mL;P=0.001).CONCLUSION SMAs were uncommon in the patients with MASLD studied.Higher serum levels of irisin and FGF21 were detected in patients with advanced liver steatosis and fibrosis,respectively,with potential implications as biomarkers.展开更多
Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability worldwide.Advances in assistive technology,rehabilitative interventions,and...Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability worldwide.Advances in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth decade.These survival changes have led neurotrauma researchers to examine how SCI interacts with brain aging.Public health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.展开更多
In the Fatira(Abu Zawal)mine area,located in the northern Eastern Desert of Egypt,fieldwork and mineralogical analysis,integrated with machine learning techniques applied to Landsat-8 OLI,ASTER,and Sentinel-2 multi-sp...In the Fatira(Abu Zawal)mine area,located in the northern Eastern Desert of Egypt,fieldwork and mineralogical analysis,integrated with machine learning techniques applied to Landsat-8 OLI,ASTER,and Sentinel-2 multi-spectral imagery(MSI)data delineate gold-sulfide mineralization in altered rocks.Gold(Au)anomalies in hydrothermal breccias and quartz veins are associated with NE-oriented felsite dykes and silicified granitic rocks.Two main alteration types are identified:a pyrite-sericite-quartz and a sulfide-chlorite-carbonate assemblage,locally with dispersed free-milling Au specks.Dimensionality reduction techniques,including principal component analysis(PCA)and independent component analysis(ICA),enabled mapping of alteration types.Sentinel-2 PC125 composite images offered efficient lithological differentiation,while supervised classifications,i.e.,the support vector machine(SVM)of Landsat-8 yielded an accuracy of 88.55%and a Kappa value of 0.86.ASTER mineral indices contributed to map hydrothermal alteration mineral phases,including sericite,muscovite,kaolinite,and iron oxides.Results indicate that post-magmatic epigenetic hydrothermal activity significantly contributed to the Au-sulfide mineralization in the Fatira area,distinguishing it from the more prevalent orogenic gold deposits in the region.展开更多
The Disuga Cu deposit,located in the eastern porphyry belt of the Zhongdian arc,southwest China,provides a window into magmatic-hydrothermal processes controlling porphyry Cu mineralization.Based on zircon U-Pb geochr...The Disuga Cu deposit,located in the eastern porphyry belt of the Zhongdian arc,southwest China,provides a window into magmatic-hydrothermal processes controlling porphyry Cu mineralization.Based on zircon U-Pb geochronology,hydrothermal mineral chemistry,short-wave infrared spectroscopy,and mass balance modeling,this study investigated the alteration zonation and element mobility in the Disuga Cu deposit.Zircon U-Pb ages of the ore-hosting quartz dioritic porphyries(222.4±3.1 and 219.3±2.4 Ma)are similar to those of Late Triassic subduction-related magmatism.High zircon-crystallization temperatures(727±26℃)and elevated oxygen fugacity(ΔFMQ+2.0)confirm these porphyries were favorable for mineralization.Hydrothermal sericite(Si=6.49 atoms per formula unit[apfu];Al^(Ⅵ)=3.39 apfu)and chlorite(Fe/(Fe+Mg)=0.59-0.63)compositions indicate an acidic reduced fluid.Three distinct hydrothermal stages were identified:(1)phyllic alteration(370℃);(2)propylitic alteration(315℃);and(3)low-temperature hydrothermal alteration(242℃).Mass balance calculations show that the Cu migration rate(155.6%/114.4%)in the propylitic/phyllic alteration zones was higher than that of Mo(14.3%;limited to the propylitic alteration zone).The alteration mineralization assemblages indicate the occurrence of deep potassic alteration zones and porphyry Cu-(Mo)mineralization in the Disuga area.展开更多
The Dabaoshan porphyry Cu deposit(420 kilotons(kt)of Cu@0.36%)is located in South China.The newly discovered Cu orebodies are hosted in the dacite porphyry adjacent to a granodiorite porphyry.The alteration and minera...The Dabaoshan porphyry Cu deposit(420 kilotons(kt)of Cu@0.36%)is located in South China.The newly discovered Cu orebodies are hosted in the dacite porphyry adjacent to a granodiorite porphyry.The alteration and mineralization timing and stages of the porphyry Cu deposit were not well-constrained.In this study,we combine field mapping,petrography,whole-rock geochemistry,hydrothermal rutile U-Pb dating and Cu isotopes to synthesize an ore model at Dabaoshan.In situ hydrothermal rutile U-Pb dating yields an age of 159±13 Ma,which brackets the timing of porphyry Cu mineralization.From top to bottom,the alteration zones in Dabaoshan are divided into quartz-sericite,biotite,chlorite-epidote,and chlorite-sericite subzones.Veins are classified into four stages(Stage 1 to 4)with Stage 4 quartz-sericite-chalcopyrite veins being the main Cu ore-bearing veins.The mineralized dacite porphyry has high SiO_(2),but low MgO,CaO,and Na_(2)O contents.The chalcopyrite hosted in veins exhibitsδ^(65)Cu=values ranging from−1.29‰to 0.51‰.Such copper isotope fractionation is attributed to vapor-brine phase separation,and mixing of fluids from different geochemical reservoirs.The timing of Cu mineralization and hydrothermal alteration support that the Jurassic granodiorite porphyry is an ore-forming intrusion at Dabaoshan.展开更多
The immunomodulatory function of estrogen within the ovary remains a subject of ongoing debate,and the neonatal ovarian immune microenvironment,particularly its modulation by estrogen,has not been comprehensively char...The immunomodulatory function of estrogen within the ovary remains a subject of ongoing debate,and the neonatal ovarian immune microenvironment,particularly its modulation by estrogen,has not been comprehensively characterized.In this study,the effects of 17β-estradiol(E_(2)),a key regulator of immune function,were investigated using single-cell transcriptomic profiling of C57BL/6J neonatal mouse ovaries after E_(2)treatment.Results revealed dynamic alterations in the proportion of immune cell types after E_(2)treatment,accompanied by changes in cytokine and chemokine expression.Detailed analyses of gene expression,cell states,and developmental trajectories across distinct cell types indicated that E_(2)treatment influenced cell differentiation and development.Notably,E_(2)treatment reduced the abundance of macrophages and promoted a phenotypic transition from M1 to M2 macrophages.These findings demonstrate that the neonatal mouse ovarian immune microenvironment is sensitive to estrogenic modulation,which governs both the distribution and functional specialization of resident immune cells,offering novel mechanistic insights into the immunomodulatory roles of estrogen across various immune cell types.展开更多
While viral infections can disturb the host gut microbiome,the dynamic alterations in microbial composition following infection remain poorly characterized.This study identified SRV-8-infected monkeys and classified t...While viral infections can disturb the host gut microbiome,the dynamic alterations in microbial composition following infection remain poorly characterized.This study identified SRV-8-infected monkeys and classified them into five groups based on infection progression.16S rRNA amplicon sequencing revealed significant alterations in the relative and inferred absolute abundance of bacterial genera UCG-002,Agathobacter,Coprococcus,and Holdemanella during the early stage of SRV-8 infection,coinciding with provirus formation.These microbial shifts were accompanied by functional modifications in bacterial communities at the same stage.In contrast,ITS amplicon sequencing indicated no significant differences in fungal composition between healthy wild-type and SRV-8-infected monkeys.Spearman correlation analyses demonstrated close interactions between intestinal bacteria and fungi following SRV-8 infection.Additionally,SRV-8 seropositive groups exhibited significantly elevated mRNA expression levels of pro-inflammatory(TNF-α,IFN-γ,IL-1β,and IL-6)and anti-inflammatory(IL-10)cytokine genes,highlighting close associations between inflammatory cytokines and immune responses.Overall,these findings provide a comprehensive characterization of bacterial and fungal microbiota dynamics and inflammatory cytokine responses associated with SRV-8 infection,clarifying the pathobiological mechanisms underlying SRV-8 infection from the perspective of the gut microbiome.展开更多
Osteoarthritis(OA)is one of the most common degenerative and age-related diseases in joints,which affects 654 million people worldwide.Current therapies could not fundamentally reverse the pathologic process of OA due...Osteoarthritis(OA)is one of the most common degenerative and age-related diseases in joints,which affects 654 million people worldwide.Current therapies could not fundamentally reverse the pathologic process of OA due to the complex pathogenesis.Although OA mechanisms have been investigated on a large scale over the past decade,the OA pathology correlated with aging-associated changes is still largely unrevealed.Therefore,in-depth analysis of the aging microenvironment and aging-related molecular mechanisms in OA may offer additional strategies for clinical prevention and treatment.In this review,we discuss the potential pathogenesis of OA in light of aging-associated changes and summarize three main components of the aging microenvironment of the OA joint:immune homeostatic imbalance,cellular senescence,and stem cell exhaustion,which could be induced by aging and further exacerbate OA progression.Additionally,it is emphasized that immune homeostatic imbalance appears before established OA,which occurs in the early stage and is the therapeutic window of opportunity for better clinical outcomes.Importantly,we evaluate recent therapeutic targets and promising interventions against these components,as well as the challenges and prospects for precise and individualized therapies of OA patients,which we believe would guide the construction of novel combined strategies targeting aging-related factors against OA for better treatments in the future.展开更多
Metabolic dysfunction-associated steatotic liver disease is increasingly understood to be closely linked with skeletal muscle alterations,such as sarcopenia,myoste-atosis,and metabolic dysregulation,which play a key r...Metabolic dysfunction-associated steatotic liver disease is increasingly understood to be closely linked with skeletal muscle alterations,such as sarcopenia,myoste-atosis,and metabolic dysregulation,which play a key role in its pathogenesis and progression.Recent literature,including an article by Isakov,highlights the bidirectional interactions between muscle and liver,underscoring shared mechanisms such as insulin resistance,inflammation,and myokine imbalance.This letter reflects on key findings from the review,noting strengths such as its integration of mechanistic insights,discussion of emerging biomarkers,and emphasis on lifestyle and pharmacological interventions.It also identifies areas for further development,including standardization of diagnostic criteria and more rigorous evaluation of translational data.As muscle health gains promi-nence in metabolic dysfunction-associated steatotic liver disease research,multidisciplinary strategies that target both hepatic and muscular systems may offer more effective avenues for prevention and treatment.展开更多
Alteration is regarded as significant information for mineral exploration. In this study, ETM＋ remote sensing data are used for recognizing and extracting alteration zones in northwestern Yunnan （云南）, China. The ...Alteration is regarded as significant information for mineral exploration. In this study, ETM＋ remote sensing data are used for recognizing and extracting alteration zones in northwestern Yunnan （云南）, China. The principal component analysis （PCA） of ETM＋ bands 1, 4, 5, and 7 was employed for OH alteration extractions. The PCA of ETM＋ bands 1, 3, 4, and 5 was used for extracting Fe^2＋ （Fe^3＋） alterations. Interfering factors, such as vegetation, snow, and shadows, were masked. Alteration components were defined in the principal components （PCs） by the contributions of their diagnostic spectral bands. The zones of alteration identified from remote sensing were analyzed in detail along with geological surveys and field verification. The results show that the OH^- alteration is a main indicator of K-feldspar, phyllic, and prophilized alterations. These alterations are closely related to porphyry copper deposits. The Fe^2＋ （Fe^3＋） alteration indicates pyritization, which is mainly related to hydrothermal or skarn type polymetallic deposits.展开更多
Eight indica ( Oryza sativa L.) environment-sensitive genic male-sterile (EGMS) lines, 2-2S, K1405S, F131S, 2136S, Pei-Ai 64S, 1290S, GD-IS and N17S, were sequentially seeded with 10-15 d interval at three sites, Wuha...Eight indica ( Oryza sativa L.) environment-sensitive genic male-sterile (EGMS) lines, 2-2S, K1405S, F131S, 2136S, Pei-Ai 64S, 1290S, GD-IS and N17S, were sequentially seeded with 10-15 d interval at three sites, Wuhan in 1997, Guiyang in 1997 and Sanya in 1997 and 1998, China. The results of investigations on self-sterilities showed that all of eight EGMS lines had stable sterile periods of longer than 30 d at Wuhan. They can be used for seed production of two-line hybrid rice, but can not reproduce themselves. Their stable sterile periods were shorter than 30 d at Guiyang, they can reproduce themselves and can not be used for hybrid seed production. In Sanya, their stable sterile periods were longer than 150 d, all of eight lines can be used for seed production in summer and autumn and reproduce themselves in winter. The fertility of all eight lines were sensitive to temperature. The sensitive stages, sensitive duration and critical point of temperatures (CPT) of fertility alteration in various lines were different. The sensitive stages of 2-2S and K1405S were from 18 d to 9 d before heading, the sensitive durations were 7-10 d and the CPTs were 23.7-24.5 degreesC. The sensitive stage, sensitive duration and CPT of F131S were from 17 to 5 d before heading, 13 d and 24.3-24.7 degreesC, respectively. The sensitive stage, sensitive duration and CPT of 2136S were from 18 to 12 d before heading, 7 d and 24.6-25.1 degreesC:, respectively. The sensitive stages, sensitive durations of Pei-Ai 64S, 1290S, N17S and GD-1S were from 24 to 13 d before heading and 10-13 d. And their CPTs were 24.6-25.1 degreesC, 25.5-26.2 degreesC, 25.4-26.1 degreesC,, and 24.1-24.7 degreesC, respectively.展开更多
Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possi...Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC.展开更多
This paper elucidates the relationship between landslides, geologic structures, and hydrothermal alteration zones based primarily on X-ray powder diffraction and uniaxial compressive strength tests on weakly weathered...This paper elucidates the relationship between landslides, geologic structures, and hydrothermal alteration zones based primarily on X-ray powder diffraction and uniaxial compressive strength tests on weakly weathered and hydrothermally altered rocks from the Ohekisawa-Shikerebembetsugawa landslide area in Teshikaga Town, Hokkaido, Japan. The OHS （Ohekisawa slide） occurred on a dip slope of sedimentary rocks from the Upper Miocene Shikerepe Formation within a homocline, and also on weathered and hydrothermally altered rocks within the boundary area between the hydrothermal smectite zone and smectite-bearing mordenite zone. The SHS （Shikerebembetsugawa slide） occurred on a dip slope of sedimentary rocks from the Upper Miocene Hanakushibe Formation within wavy folds and was also controlled by a cap rock of Teshikaga Volcano Somma Lava. The SHS occurred also on weathered and hydrothermally altered rocks within the boundary area between the hydrothermal smectite zone and smectite-bearing laumontite zone. The mechanical properties of smectite, smectite-bearing mordenite, and smectite-bearing laumontite zone weakly weathered rocks indicate that they are very weak, soft rocks. These landslides are regarded as HAZLs （hydrothermal alteration zone landslides）. The hydrothermal alteration yielding smectite is thus closely related to these two ancient landslides, suggesting that the potential for HAZLs within a hydrothermal area can be assessed based on the swelling clay mineral-beating hydrothermal alteration types, dip slope, and cap rock.展开更多
The studies on hydrothermal alteration-induced eff ects in surface and subsurface rocks provide useful information in the characterization and exploitation of a geothermal reservoir.Generally,these studies are based o...The studies on hydrothermal alteration-induced eff ects in surface and subsurface rocks provide useful information in the characterization and exploitation of a geothermal reservoir.Generally,these studies are based on traditional,and reliable methods like petrography(primary and secondary minerals,and grade of alteration),and geochemistry(mobility of elements,changes in mass and concentration of elements,and fluid inclusions).Recently,apart from these established methods,some methods based on the geochemical(Chemical Index of Alteration,CIA;Weathering Index of Parkar,WIP;Loss on Ignition,LOI;and Sulfur,S)and rock magnetic properties(magnetic susceptibility,χlf;and percentage frequency-dependent susceptibility,χfd%)are also being applied in the identification of whether a rock is an altered or a fresh one.The Acoculco Geothermal Field(AGF),Mexico,is characterized by high temperature and very low permeability,and it is considered a promissory Enhanced Geothermal System.The following changes are observed in the rocks as a result of an increase in hydrothermal alteration:(1)an increase in CIA,LOI,and S values,and a decrease in WIP;(2)an increase in quartz and quartz polymorph minerals(silicification),and clay minerals(argillization);and(3)decrease inχlf values.At AGF,the most altered surface acid rocks are characterized by entirely quartz and its polymorphs,and clay minerals.The present study also indicates the applicability of the binary plots of major elements(felsic vs mafic component)and rock magnetic parameters(χlf vs.χfd%).The rock withχfd%value of 2-10 andχlf value<0.5×10^(-6)m^(3) kg^(-1)indicate the presence of single domain and stable single domain grains,which in turn suggests that it is an altered rock.These methods are simple to apply,rapid,reliable,and have the potential to become eff ective tools for the identifi cation of hydrothermally altered rocks during the initial stage of geothermal exploration.展开更多
The incidence of esophageal adenocarcinoma(EAC) has increased in recent decades, and its 5-year survival rate is less than 20%. As a well-established precursor, patients with Barrett's esophagus(BE) have a persist...The incidence of esophageal adenocarcinoma(EAC) has increased in recent decades, and its 5-year survival rate is less than 20%. As a well-established precursor, patients with Barrett's esophagus(BE) have a persistent risk of progression to EAC. Many researchers have already identified some factors that may contribute to the development of BE and EAC, and the identified risks include gastroesophageal reflux(GER), male sex, older age, central obesity,tobacco smoking, Helicobacter pylori(H. pylori) eradication, and the administration of proton pump inhibitors(PPIs) and antibiotics. The human gut harbors trillions of microorganisms, the majority of which are bacteria. These microorganisms benefit the human host in many ways, such as helping in digestion, assisting in the synthesis of certain vitamins, promoting the development of the gastrointestinal immune system, regulating metabolism and preventing invasion by specific pathogens. In contrast, microbial dysbiosis may play important roles in various diseases, such as inflammation and cancers. The composition of the microbiota located in the normal esophagus is relatively conserved without distinct microbial preferences in the upper, middle and lower esophagus. Six major phyla constitute the esophageal microbiota, including Firmicutes,Bacteroides, Actinobacteria, Proteobacteria, Fusobacteria and TM7, similar to the oral microbiota. Streptococcus dominates the esophageal microbiota. However, the microbiota varies in different esophageal diseases compared to that in the healthy esophagus. The type Ⅰ microbiota, which is primarily composed of gram-positive bacteria, is closely associated with the normal esophagus, while type Ⅱ microbiota has enriched gram-negative bacteria and is mainly associated with the abnormal esophagus. These increased gram-negative anaerobes/microaerophiles include Veillonella, Prevotella, Haemophilus, Neisseria, Granulicatella and Fusobacterium, many of which are associated with BE. The microbial diversity in the esophagus is decreased in EAC patients, and Lactobacillus fermentum is enriched compared to that in controls and BE patients. Furthermore, the microbiota may be associated with BE and EAC by interacting with their risk factors, including central obesity, GER, H. pylori, administration of PPIs and antibiotics. Therefore, a large gap in research must be bridged to elucidate the associations among these factors. Some studies have already proposed several potential mechanisms by which the microbiota participates in human carcinogenesis by complicated interactions with the human host immune system and signaling pathways. The activation of the LPS-TLR4-NF-κB pathway may contribute to inflammation and malignant transformation. This exciting field of gastrointestinal microbiota allows us to unravel the mystery of carcinogenesis from another perspective. Further studies are needed to explore whether the microbiota changes before or after disease onset, to improve our understanding of the pathogenesis, and to find novel targets for prevention, diagnosis and therapy, which could offer more cost-effective and relatively safe choices.展开更多
The multispectral commercial satellite-WorldView-3(WV-3) has the highest spatial, spectral and radiation resolutions among the satellites currently and can generate good data in the shortwave infrared(SWIR). The study...The multispectral commercial satellite-WorldView-3(WV-3) has the highest spatial, spectral and radiation resolutions among the satellites currently and can generate good data in the shortwave infrared(SWIR). The study area is located in the Pobei area of Xinjiang Uygur Autonomous Region, which is rich in mineral resources. The spectral analyses of some typical altered hydroxy-bearing, iron-bearing, and carbonate-bearing minerals could establish several Principal Component Analysis(PCA) models and mineral indices, using the visible and near infrared(VNIR) and the shortwave infrared(SWIR) subsystems of WV-3 data. In addition, the Spectral Angle Method and the spectrum index tool of ENVI software were used to extract the relevant alteration information. The WV-3 data is well suited for identifying hydroxy-bearing alteration with rich SWIR bands which distinguish Al-OH-bearing from MgOH-bearing alteration. Hence, this study provides a basis for the prediction of mineral resources in the Pobei area and sets the foundation for WV-3 data to be used as an important tool in extracting alteration information and prospecting practices.展开更多
Reservoir wettability plays an important role in various oil recovery processes.The origin and evolution of reservoir wettability were critically reviewed to better understand the complexity of wettability due to inte...Reservoir wettability plays an important role in various oil recovery processes.The origin and evolution of reservoir wettability were critically reviewed to better understand the complexity of wettability due to interactions in crude oil-brine-rock system,with introduction of different wetting states and their influence on fluid distribution in pore spaces.The effect of wettability on oil recovery of waterflooding was then summarized from past and recent research to emphasize the importance of wettability in oil displacement by brine.The mechanism of wettability alteration by different surfactants in both carbonate and sandstone reservoirs was analyzed,concerning their distinct surface chemistry,and different interaction patterns of surfactants with components on rock surface.Other concerns such as the combined effect of wettability alteration and interfacial tension （IFT） reduction on the imbibition process was also taken into account.Generally,surfactant induced wettability alteration for enhanced oil recovery is still in the stage of laboratory investigation.The successful application of this technique relies on a comprehensive survey of target reservoir conditions,and could be expected especially in low permeability fractured reservoirs and forced imbibition process.展开更多
Taking the gold ore deposit concentrating area of Jiaodong area in Shandong, China for an example, based on geological analysis, and applying Gresens’ equation, Grant’s isocon diagram and O’hara microelement ca...Taking the gold ore deposit concentrating area of Jiaodong area in Shandong, China for an example, based on geological analysis, and applying Gresens’ equation, Grant’s isocon diagram and O’hara microelement calculation method, a thorough study on shear alteration, mass transfer and gold mineralization was carried out. The authors also made mathematic simulation and geochemical analysis. The work reveals temporal spatial changing regularities of temperature field and velocity field of fluids, and also reveals fluid transport chemical reaction coupling metallogenic dynamics of the Jiaojia gold ore concentrating area. During shear alteration process of the Jiaodong gold ore concentrating area, all kinds of components transferred with different amounts, fluid rock ratio was rather high and volume strain was of dilation type. Fast flow of ore forming fluid favors the occurrence of mixed fluid. Shear fractured zones are places where there was strong transportation reaction coupling mineralization. Ore bodies were located in dilation space of shear structure where there was the greatest fluid flux. After the emplacement of the rock body, a convex heat field was formed around the rock body. It is one of the main metallogenic forces. The major reason for mineralization is the mobilization, migration and enrichment of ore forming elements induced by shear compressive extensional tectonism. Inclusion gold dominant low grade ores were formed in the early ore forming stage, while high grade ores, which contained fissure gold and polymetallic veinlets, were formed in late ore forming stage.展开更多
基金supported by the National Natural Science Foundation of China(Nos.42122012,U2444208)the Inner Mongolia Academician Project(No.2022-TZH03)the Fundamental Research Funds for the Central Universities(No.2652023001)。
文摘The patterns of metal distribution and alteration zonation in magmatic-hydrothermal systems primarily focus on porphyry deposit and other closely associated types,such as skarn,epithermal and distal vein deposits(e.g.,Zheng,2022;Hutchison et al.,2020;Cooke et al.,2011;Hedenquist et al.,1998).
基金Supported by Maulana Azad National Fellowship,University Grants Commission,New Delhi,and Department of Biotechnology,New Delhi,No.AS[82-27/2019(SA III)]DBT-BUILDER-University of Lucknow Interdisciplinary Life Science Programme for Advance Research and Education(Level II),No.TG(BT/INF/22/SP47623/2022).
文摘Gestational diabetes mellitus(GDM)is a metabolic disorder,recognised during 24-28 weeks of pregnancy.GDM is linked with adverse newborn outcomes such as macrosomia,premature delivery,metabolic disorder,cardiovascular,and neurological disorders.Recent investigations have focused on the correlation of genetic factors such asβ-cell function and insulin secretary genes(transcription factor 7 like 2,potassium voltage-gated channel subfamily q member 1,adipo-nectin etc.)on maternal metabolism during gestation leading to GDM.Epigenetic alterations like DNA methylation,histone modification,and miRNA expression can influence gene expression and play a dominant role in feto-maternal meta-bolic pathways.Interactions between genes and environment,resulting in differ-ential gene expression patterns may lead to GDM.Researchers suggested that GDM women are more susceptible to insulin resistance,which alters intrauterine surroundings,resulting hyperglycemia and hyperinsulinemia.Epigenetic modi-fications in genes affecting neuroendocrine activities,and metabolism,increase the risk of obesity and type 2 diabetes in offspring.There is currently no treatment or effective preventive method for GDM,since the molecular processes of insulin resistance are not well understood.The present review was undertaken to un-derstand the pathophysiology of GDM and its effects on adverse neonatal out-comes.In addition,the study of genetic and epigenetic alterations will provide lead to researchers in the search for predictive molecular biomarkers.
文摘BACKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in these patients.However,their actual prevalence and pathophysiology remain to be elucidated.AIM To determine the prevalence of SMAs and to assess the significance of circulating myokines as biomarkers in patients with MASLD.METHODS Skeletal muscle strength and muscle mass were measured in a cross-sectional study in a cohort of 62 patients fulfilling MASLD criteria,recruited from the outpatient clinics of a tertiary level hospital.The degree of fibrosis and liver steatosis was studied using abdominal ultrasound and transitional elastography.Anthropometric and metabolic characteristics as well as serum levels of different myokines were also determined in the MASLD cohort.Statistical analysis was performed comparing results according to liver fibrosis and steatosis.RESULTS No significant differences were found in both skeletal muscle strength and skeletal muscle mass in patients with MASLD between different stages of liver fibrosis.Interestingly,serum levels of fibroblast growth factor-21(FGF21)were significantly higher in patients with MASLD with advanced hepatic fibrosis(F3-F4)than in those with lower fibrosis stages(F0-F2)(197.49±198.27 pg/mL vs 95.62±83.67 pg/mL;P=0.049).In addition,patients with MASLD with severe hepatosteatosis(S3)exhibited significantly higher serum levels of irisin(1116.87±1161.86 pg/mL)than those with lower grades(S1-S2)(385.21±375.98 pg/mL;P=0.001).CONCLUSION SMAs were uncommon in the patients with MASLD studied.Higher serum levels of irisin and FGF21 were detected in patients with advanced liver steatosis and fibrosis,respectively,with potential implications as biomarkers.
基金supported by NIH funding(RF1NS110637,2RF1NS094527,R01NS110635)to JW.
文摘Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability worldwide.Advances in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth decade.These survival changes have led neurotrauma researchers to examine how SCI interacts with brain aging.Public health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.
基金the National Science Foundation of China (Grant No. NSFC: 92162213)the Geology Department Faculty of Science of Al-Azhar University (Assiut Branch)+2 种基金the China Scholarship CouncilChang'an UniversityIstanbul Technical University's Scientific Research Project (BAP Project ID: 45396, code: FHD-2024-45396)
文摘In the Fatira(Abu Zawal)mine area,located in the northern Eastern Desert of Egypt,fieldwork and mineralogical analysis,integrated with machine learning techniques applied to Landsat-8 OLI,ASTER,and Sentinel-2 multi-spectral imagery(MSI)data delineate gold-sulfide mineralization in altered rocks.Gold(Au)anomalies in hydrothermal breccias and quartz veins are associated with NE-oriented felsite dykes and silicified granitic rocks.Two main alteration types are identified:a pyrite-sericite-quartz and a sulfide-chlorite-carbonate assemblage,locally with dispersed free-milling Au specks.Dimensionality reduction techniques,including principal component analysis(PCA)and independent component analysis(ICA),enabled mapping of alteration types.Sentinel-2 PC125 composite images offered efficient lithological differentiation,while supervised classifications,i.e.,the support vector machine(SVM)of Landsat-8 yielded an accuracy of 88.55%and a Kappa value of 0.86.ASTER mineral indices contributed to map hydrothermal alteration mineral phases,including sericite,muscovite,kaolinite,and iron oxides.Results indicate that post-magmatic epigenetic hydrothermal activity significantly contributed to the Au-sulfide mineralization in the Fatira area,distinguishing it from the more prevalent orogenic gold deposits in the region.
基金granted by the Deep Earth Probe and Mineral Resource Exploration-National Science and Technology Major Project(Grant No.2024ZD1001602)a Second Tibetan Plateau Scientific Expedition and Research project(Grant No.2021QZKK0301)+1 种基金the National Natural Science Foundation of China(Grant No.42022021)the Jiangxi Provincial Youth Fund(Grant No.20224BAB213051).
文摘The Disuga Cu deposit,located in the eastern porphyry belt of the Zhongdian arc,southwest China,provides a window into magmatic-hydrothermal processes controlling porphyry Cu mineralization.Based on zircon U-Pb geochronology,hydrothermal mineral chemistry,short-wave infrared spectroscopy,and mass balance modeling,this study investigated the alteration zonation and element mobility in the Disuga Cu deposit.Zircon U-Pb ages of the ore-hosting quartz dioritic porphyries(222.4±3.1 and 219.3±2.4 Ma)are similar to those of Late Triassic subduction-related magmatism.High zircon-crystallization temperatures(727±26℃)and elevated oxygen fugacity(ΔFMQ+2.0)confirm these porphyries were favorable for mineralization.Hydrothermal sericite(Si=6.49 atoms per formula unit[apfu];Al^(Ⅵ)=3.39 apfu)and chlorite(Fe/(Fe+Mg)=0.59-0.63)compositions indicate an acidic reduced fluid.Three distinct hydrothermal stages were identified:(1)phyllic alteration(370℃);(2)propylitic alteration(315℃);and(3)low-temperature hydrothermal alteration(242℃).Mass balance calculations show that the Cu migration rate(155.6%/114.4%)in the propylitic/phyllic alteration zones was higher than that of Mo(14.3%;limited to the propylitic alteration zone).The alteration mineralization assemblages indicate the occurrence of deep potassic alteration zones and porphyry Cu-(Mo)mineralization in the Disuga area.
基金funded by the China Geological Survey(Grant Nos.DD20190379,DD20221695 and DD20221684)a collaboration program(2019-2024)between the Institute of Mineral Resources(Chinese Academy of Geological Sciences)and the Guangdong Dabaoshan Mining Co.,Ltd.
文摘The Dabaoshan porphyry Cu deposit(420 kilotons(kt)of Cu@0.36%)is located in South China.The newly discovered Cu orebodies are hosted in the dacite porphyry adjacent to a granodiorite porphyry.The alteration and mineralization timing and stages of the porphyry Cu deposit were not well-constrained.In this study,we combine field mapping,petrography,whole-rock geochemistry,hydrothermal rutile U-Pb dating and Cu isotopes to synthesize an ore model at Dabaoshan.In situ hydrothermal rutile U-Pb dating yields an age of 159±13 Ma,which brackets the timing of porphyry Cu mineralization.From top to bottom,the alteration zones in Dabaoshan are divided into quartz-sericite,biotite,chlorite-epidote,and chlorite-sericite subzones.Veins are classified into four stages(Stage 1 to 4)with Stage 4 quartz-sericite-chalcopyrite veins being the main Cu ore-bearing veins.The mineralized dacite porphyry has high SiO_(2),but low MgO,CaO,and Na_(2)O contents.The chalcopyrite hosted in veins exhibitsδ^(65)Cu=values ranging from−1.29‰to 0.51‰.Such copper isotope fractionation is attributed to vapor-brine phase separation,and mixing of fluids from different geochemical reservoirs.The timing of Cu mineralization and hydrothermal alteration support that the Jurassic granodiorite porphyry is an ore-forming intrusion at Dabaoshan.
基金supported by the National Natural Science Foundation of China(32072941)。
文摘The immunomodulatory function of estrogen within the ovary remains a subject of ongoing debate,and the neonatal ovarian immune microenvironment,particularly its modulation by estrogen,has not been comprehensively characterized.In this study,the effects of 17β-estradiol(E_(2)),a key regulator of immune function,were investigated using single-cell transcriptomic profiling of C57BL/6J neonatal mouse ovaries after E_(2)treatment.Results revealed dynamic alterations in the proportion of immune cell types after E_(2)treatment,accompanied by changes in cytokine and chemokine expression.Detailed analyses of gene expression,cell states,and developmental trajectories across distinct cell types indicated that E_(2)treatment influenced cell differentiation and development.Notably,E_(2)treatment reduced the abundance of macrophages and promoted a phenotypic transition from M1 to M2 macrophages.These findings demonstrate that the neonatal mouse ovarian immune microenvironment is sensitive to estrogenic modulation,which governs both the distribution and functional specialization of resident immune cells,offering novel mechanistic insights into the immunomodulatory roles of estrogen across various immune cell types.
基金supported by the National Science and Technology Innovation 2030 Major Program(2021ZD0200900)National Key Research and Development Program of China(2022YFF0710901)+3 种基金National Natural Science Foundation of China(82021001,31825018)Biological Resources Program of the Chinese Academy of Sciences(KFJBRP-005)111 Project D18007a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘While viral infections can disturb the host gut microbiome,the dynamic alterations in microbial composition following infection remain poorly characterized.This study identified SRV-8-infected monkeys and classified them into five groups based on infection progression.16S rRNA amplicon sequencing revealed significant alterations in the relative and inferred absolute abundance of bacterial genera UCG-002,Agathobacter,Coprococcus,and Holdemanella during the early stage of SRV-8 infection,coinciding with provirus formation.These microbial shifts were accompanied by functional modifications in bacterial communities at the same stage.In contrast,ITS amplicon sequencing indicated no significant differences in fungal composition between healthy wild-type and SRV-8-infected monkeys.Spearman correlation analyses demonstrated close interactions between intestinal bacteria and fungi following SRV-8 infection.Additionally,SRV-8 seropositive groups exhibited significantly elevated mRNA expression levels of pro-inflammatory(TNF-α,IFN-γ,IL-1β,and IL-6)and anti-inflammatory(IL-10)cytokine genes,highlighting close associations between inflammatory cytokines and immune responses.Overall,these findings provide a comprehensive characterization of bacterial and fungal microbiota dynamics and inflammatory cytokine responses associated with SRV-8 infection,clarifying the pathobiological mechanisms underlying SRV-8 infection from the perspective of the gut microbiome.
基金supported by grants from National Natural Science Foundation of China(32370892)Science and Technology Commission of Shanghai Municipality(23141901200)+3 种基金Shanghai Natural Science Foundation(24ZR1450100)Health Commission of Shanghai Municipality(2022JC029)Biomaterials and Regenerative Medicine Institute Cooperative Research Project,Shanghai Jiaotong University School of Medicine(2022LHA11)Talent-Introduction Program of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine(2022YJRC05).
文摘Osteoarthritis(OA)is one of the most common degenerative and age-related diseases in joints,which affects 654 million people worldwide.Current therapies could not fundamentally reverse the pathologic process of OA due to the complex pathogenesis.Although OA mechanisms have been investigated on a large scale over the past decade,the OA pathology correlated with aging-associated changes is still largely unrevealed.Therefore,in-depth analysis of the aging microenvironment and aging-related molecular mechanisms in OA may offer additional strategies for clinical prevention and treatment.In this review,we discuss the potential pathogenesis of OA in light of aging-associated changes and summarize three main components of the aging microenvironment of the OA joint:immune homeostatic imbalance,cellular senescence,and stem cell exhaustion,which could be induced by aging and further exacerbate OA progression.Additionally,it is emphasized that immune homeostatic imbalance appears before established OA,which occurs in the early stage and is the therapeutic window of opportunity for better clinical outcomes.Importantly,we evaluate recent therapeutic targets and promising interventions against these components,as well as the challenges and prospects for precise and individualized therapies of OA patients,which we believe would guide the construction of novel combined strategies targeting aging-related factors against OA for better treatments in the future.
文摘Metabolic dysfunction-associated steatotic liver disease is increasingly understood to be closely linked with skeletal muscle alterations,such as sarcopenia,myoste-atosis,and metabolic dysregulation,which play a key role in its pathogenesis and progression.Recent literature,including an article by Isakov,highlights the bidirectional interactions between muscle and liver,underscoring shared mechanisms such as insulin resistance,inflammation,and myokine imbalance.This letter reflects on key findings from the review,noting strengths such as its integration of mechanistic insights,discussion of emerging biomarkers,and emphasis on lifestyle and pharmacological interventions.It also identifies areas for further development,including standardization of diagnostic criteria and more rigorous evaluation of translational data.As muscle health gains promi-nence in metabolic dysfunction-associated steatotic liver disease research,multidisciplinary strategies that target both hepatic and muscular systems may offer more effective avenues for prevention and treatment.
基金supported by the project "Remote Sensing Alteration Abnormity Extraction from Geological Survey in Northwestern Yunnan, China" from China Geological Survey
文摘Alteration is regarded as significant information for mineral exploration. In this study, ETM＋ remote sensing data are used for recognizing and extracting alteration zones in northwestern Yunnan （云南）, China. The principal component analysis （PCA） of ETM＋ bands 1, 4, 5, and 7 was employed for OH alteration extractions. The PCA of ETM＋ bands 1, 3, 4, and 5 was used for extracting Fe^2＋ （Fe^3＋） alterations. Interfering factors, such as vegetation, snow, and shadows, were masked. Alteration components were defined in the principal components （PCs） by the contributions of their diagnostic spectral bands. The zones of alteration identified from remote sensing were analyzed in detail along with geological surveys and field verification. The results show that the OH^- alteration is a main indicator of K-feldspar, phyllic, and prophilized alterations. These alterations are closely related to porphyry copper deposits. The Fe^2＋ （Fe^3＋） alteration indicates pyritization, which is mainly related to hydrothermal or skarn type polymetallic deposits.
文摘Eight indica ( Oryza sativa L.) environment-sensitive genic male-sterile (EGMS) lines, 2-2S, K1405S, F131S, 2136S, Pei-Ai 64S, 1290S, GD-IS and N17S, were sequentially seeded with 10-15 d interval at three sites, Wuhan in 1997, Guiyang in 1997 and Sanya in 1997 and 1998, China. The results of investigations on self-sterilities showed that all of eight EGMS lines had stable sterile periods of longer than 30 d at Wuhan. They can be used for seed production of two-line hybrid rice, but can not reproduce themselves. Their stable sterile periods were shorter than 30 d at Guiyang, they can reproduce themselves and can not be used for hybrid seed production. In Sanya, their stable sterile periods were longer than 150 d, all of eight lines can be used for seed production in summer and autumn and reproduce themselves in winter. The fertility of all eight lines were sensitive to temperature. The sensitive stages, sensitive duration and critical point of temperatures (CPT) of fertility alteration in various lines were different. The sensitive stages of 2-2S and K1405S were from 18 d to 9 d before heading, the sensitive durations were 7-10 d and the CPTs were 23.7-24.5 degreesC. The sensitive stage, sensitive duration and CPT of F131S were from 17 to 5 d before heading, 13 d and 24.3-24.7 degreesC, respectively. The sensitive stage, sensitive duration and CPT of 2136S were from 18 to 12 d before heading, 7 d and 24.6-25.1 degreesC:, respectively. The sensitive stages, sensitive durations of Pei-Ai 64S, 1290S, N17S and GD-1S were from 24 to 13 d before heading and 10-13 d. And their CPTs were 24.6-25.1 degreesC, 25.5-26.2 degreesC, 25.4-26.1 degreesC,, and 24.1-24.7 degreesC, respectively.
基金Supported by A grant from the Polish Ministry of Science and Higher EducationNo.N N402 423838
文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC.
文摘This paper elucidates the relationship between landslides, geologic structures, and hydrothermal alteration zones based primarily on X-ray powder diffraction and uniaxial compressive strength tests on weakly weathered and hydrothermally altered rocks from the Ohekisawa-Shikerebembetsugawa landslide area in Teshikaga Town, Hokkaido, Japan. The OHS （Ohekisawa slide） occurred on a dip slope of sedimentary rocks from the Upper Miocene Shikerepe Formation within a homocline, and also on weathered and hydrothermally altered rocks within the boundary area between the hydrothermal smectite zone and smectite-bearing mordenite zone. The SHS （Shikerebembetsugawa slide） occurred on a dip slope of sedimentary rocks from the Upper Miocene Hanakushibe Formation within wavy folds and was also controlled by a cap rock of Teshikaga Volcano Somma Lava. The SHS occurred also on weathered and hydrothermally altered rocks within the boundary area between the hydrothermal smectite zone and smectite-bearing laumontite zone. The mechanical properties of smectite, smectite-bearing mordenite, and smectite-bearing laumontite zone weakly weathered rocks indicate that they are very weak, soft rocks. These landslides are regarded as HAZLs （hydrothermal alteration zone landslides）. The hydrothermal alteration yielding smectite is thus closely related to these two ancient landslides, suggesting that the potential for HAZLs within a hydrothermal area can be assessed based on the swelling clay mineral-beating hydrothermal alteration types, dip slope, and cap rock.
基金Rock magnetic instruments used in this work are procured with the funding from CEMIE Geo project 207032(Fondo de Sustentabilidad Energética de CONACy T-SENER,Government of Mexico)。
文摘The studies on hydrothermal alteration-induced eff ects in surface and subsurface rocks provide useful information in the characterization and exploitation of a geothermal reservoir.Generally,these studies are based on traditional,and reliable methods like petrography(primary and secondary minerals,and grade of alteration),and geochemistry(mobility of elements,changes in mass and concentration of elements,and fluid inclusions).Recently,apart from these established methods,some methods based on the geochemical(Chemical Index of Alteration,CIA;Weathering Index of Parkar,WIP;Loss on Ignition,LOI;and Sulfur,S)and rock magnetic properties(magnetic susceptibility,χlf;and percentage frequency-dependent susceptibility,χfd%)are also being applied in the identification of whether a rock is an altered or a fresh one.The Acoculco Geothermal Field(AGF),Mexico,is characterized by high temperature and very low permeability,and it is considered a promissory Enhanced Geothermal System.The following changes are observed in the rocks as a result of an increase in hydrothermal alteration:(1)an increase in CIA,LOI,and S values,and a decrease in WIP;(2)an increase in quartz and quartz polymorph minerals(silicification),and clay minerals(argillization);and(3)decrease inχlf values.At AGF,the most altered surface acid rocks are characterized by entirely quartz and its polymorphs,and clay minerals.The present study also indicates the applicability of the binary plots of major elements(felsic vs mafic component)and rock magnetic parameters(χlf vs.χfd%).The rock withχfd%value of 2-10 andχlf value<0.5×10^(-6)m^(3) kg^(-1)indicate the presence of single domain and stable single domain grains,which in turn suggests that it is an altered rock.These methods are simple to apply,rapid,reliable,and have the potential to become eff ective tools for the identifi cation of hydrothermally altered rocks during the initial stage of geothermal exploration.
基金the National Natural Science Foundation of China,No.81702067Shaanxi Natural Science Foundation of China,No.2018JQ8029Shaanxi Natural Science Foundation of China,No.2017JQ8041
文摘The incidence of esophageal adenocarcinoma(EAC) has increased in recent decades, and its 5-year survival rate is less than 20%. As a well-established precursor, patients with Barrett's esophagus(BE) have a persistent risk of progression to EAC. Many researchers have already identified some factors that may contribute to the development of BE and EAC, and the identified risks include gastroesophageal reflux(GER), male sex, older age, central obesity,tobacco smoking, Helicobacter pylori(H. pylori) eradication, and the administration of proton pump inhibitors(PPIs) and antibiotics. The human gut harbors trillions of microorganisms, the majority of which are bacteria. These microorganisms benefit the human host in many ways, such as helping in digestion, assisting in the synthesis of certain vitamins, promoting the development of the gastrointestinal immune system, regulating metabolism and preventing invasion by specific pathogens. In contrast, microbial dysbiosis may play important roles in various diseases, such as inflammation and cancers. The composition of the microbiota located in the normal esophagus is relatively conserved without distinct microbial preferences in the upper, middle and lower esophagus. Six major phyla constitute the esophageal microbiota, including Firmicutes,Bacteroides, Actinobacteria, Proteobacteria, Fusobacteria and TM7, similar to the oral microbiota. Streptococcus dominates the esophageal microbiota. However, the microbiota varies in different esophageal diseases compared to that in the healthy esophagus. The type Ⅰ microbiota, which is primarily composed of gram-positive bacteria, is closely associated with the normal esophagus, while type Ⅱ microbiota has enriched gram-negative bacteria and is mainly associated with the abnormal esophagus. These increased gram-negative anaerobes/microaerophiles include Veillonella, Prevotella, Haemophilus, Neisseria, Granulicatella and Fusobacterium, many of which are associated with BE. The microbial diversity in the esophagus is decreased in EAC patients, and Lactobacillus fermentum is enriched compared to that in controls and BE patients. Furthermore, the microbiota may be associated with BE and EAC by interacting with their risk factors, including central obesity, GER, H. pylori, administration of PPIs and antibiotics. Therefore, a large gap in research must be bridged to elucidate the associations among these factors. Some studies have already proposed several potential mechanisms by which the microbiota participates in human carcinogenesis by complicated interactions with the human host immune system and signaling pathways. The activation of the LPS-TLR4-NF-κB pathway may contribute to inflammation and malignant transformation. This exciting field of gastrointestinal microbiota allows us to unravel the mystery of carcinogenesis from another perspective. Further studies are needed to explore whether the microbiota changes before or after disease onset, to improve our understanding of the pathogenesis, and to find novel targets for prevention, diagnosis and therapy, which could offer more cost-effective and relatively safe choices.
基金supported by the “Iron and manganese resources investigation projection” from the Chinese Academy of Geological Sciences(Grant No.12120115037901)
文摘The multispectral commercial satellite-WorldView-3(WV-3) has the highest spatial, spectral and radiation resolutions among the satellites currently and can generate good data in the shortwave infrared(SWIR). The study area is located in the Pobei area of Xinjiang Uygur Autonomous Region, which is rich in mineral resources. The spectral analyses of some typical altered hydroxy-bearing, iron-bearing, and carbonate-bearing minerals could establish several Principal Component Analysis(PCA) models and mineral indices, using the visible and near infrared(VNIR) and the shortwave infrared(SWIR) subsystems of WV-3 data. In addition, the Spectral Angle Method and the spectrum index tool of ENVI software were used to extract the relevant alteration information. The WV-3 data is well suited for identifying hydroxy-bearing alteration with rich SWIR bands which distinguish Al-OH-bearing from MgOH-bearing alteration. Hence, this study provides a basis for the prediction of mineral resources in the Pobei area and sets the foundation for WV-3 data to be used as an important tool in extracting alteration information and prospecting practices.
文摘Reservoir wettability plays an important role in various oil recovery processes.The origin and evolution of reservoir wettability were critically reviewed to better understand the complexity of wettability due to interactions in crude oil-brine-rock system,with introduction of different wetting states and their influence on fluid distribution in pore spaces.The effect of wettability on oil recovery of waterflooding was then summarized from past and recent research to emphasize the importance of wettability in oil displacement by brine.The mechanism of wettability alteration by different surfactants in both carbonate and sandstone reservoirs was analyzed,concerning their distinct surface chemistry,and different interaction patterns of surfactants with components on rock surface.Other concerns such as the combined effect of wettability alteration and interfacial tension （IFT） reduction on the imbibition process was also taken into account.Generally,surfactant induced wettability alteration for enhanced oil recovery is still in the stage of laboratory investigation.The successful application of this technique relies on a comprehensive survey of target reservoir conditions,and could be expected especially in low permeability fractured reservoirs and forced imbibition process.
基金The study is supported by the National Climbing Program of China( No.95 -pre-2 5 and 95 -pre-3 9) "10 0 Beyond Century Scie
文摘Taking the gold ore deposit concentrating area of Jiaodong area in Shandong, China for an example, based on geological analysis, and applying Gresens’ equation, Grant’s isocon diagram and O’hara microelement calculation method, a thorough study on shear alteration, mass transfer and gold mineralization was carried out. The authors also made mathematic simulation and geochemical analysis. The work reveals temporal spatial changing regularities of temperature field and velocity field of fluids, and also reveals fluid transport chemical reaction coupling metallogenic dynamics of the Jiaojia gold ore concentrating area. During shear alteration process of the Jiaodong gold ore concentrating area, all kinds of components transferred with different amounts, fluid rock ratio was rather high and volume strain was of dilation type. Fast flow of ore forming fluid favors the occurrence of mixed fluid. Shear fractured zones are places where there was strong transportation reaction coupling mineralization. Ore bodies were located in dilation space of shear structure where there was the greatest fluid flux. After the emplacement of the rock body, a convex heat field was formed around the rock body. It is one of the main metallogenic forces. The major reason for mineralization is the mobilization, migration and enrichment of ore forming elements induced by shear compressive extensional tectonism. Inclusion gold dominant low grade ores were formed in the early ore forming stage, while high grade ores, which contained fissure gold and polymetallic veinlets, were formed in late ore forming stage.
