<strong>Background:</strong> Anxiety disorders are the most common mental disorders, typically treated with psychotherapy and medication. These treatments are not suitable for, acceptable to, or effective ...<strong>Background:</strong> Anxiety disorders are the most common mental disorders, typically treated with psychotherapy and medication. These treatments are not suitable for, acceptable to, or effective for everyone. Alpha-Stim AID is a Cranial Electrotherapy Stimulation (CES) treatment with evidence of effectiveness in treating anxiety disorders. <strong>Objective:</strong> The aim of this paper is to present outcomes on anxiety, depression, and quality of life of Alpha-Stim use in primary care patients in the United Kingdom’s (UK) National Health Service (NHS) who reported symptoms of anxiety. <strong>Methods: </strong>Open label patient cohort design. Self-report measures: PHQ-9 (depression), GAD-7 (anxiety) and EQ-5D-5L (health related quality of life). Twenty-three patients with symptoms of anxiety completed a six-week course of Alpha-Stim intervention. <strong>Results:</strong> Reliable improvement and remission rates respectively were 60.9% and 17.4% for the GAD-7;42.9% and 22.7% for the PHQ-9. Significant improvement and medium/large effect sizes (n2 = 0.59 and 0.56 respectively). EQ-5D-5L results showed significant improvements in quality of life. Perceived quality of life doubled with an improvement of 0.36 on the health index score, this intervention adds 3.64 Quality Adjusted Life Years (QALYs). <strong>Limitations:</strong> The study was not an RCT, there was no control group. <strong>Conclusions:</strong> Alpha-Stim AID CES can be delivered through a UK primary care practice, and can have a significant impact on symptoms of anxiety and depression, and improve quality of life in primary care patients with anxiety symptoms. Further feasibility studies in primary care and sufficiently powered RCT are required.展开更多
目的:探讨安神定抽合剂联合针灸、安思定微电流刺激仪治疗儿童抽动障碍的临床疗效。方法:将2018年8月-2020年2月在泰州市中医院儿科就诊的90例儿童抽动障碍脾虚痰聚证入组,随机分成A组(予中药安神定抽合剂)、B组(予盐酸硫必利片)、C组(...目的:探讨安神定抽合剂联合针灸、安思定微电流刺激仪治疗儿童抽动障碍的临床疗效。方法:将2018年8月-2020年2月在泰州市中医院儿科就诊的90例儿童抽动障碍脾虚痰聚证入组,随机分成A组(予中药安神定抽合剂)、B组(予盐酸硫必利片)、C组(予中药安神定抽合剂加针灸,以及安思定微电流刺激仪),每组各30例,治疗疗程:12周。结果:三组治疗后总有效率比较,差异无统计学意义(P> 0.05),治疗后中医证候评分比较,C组和A组优于B组,差异有统计学意义(P <0.05),治疗后耶鲁综合抽动严重程度量表(Yale Global Tie Severityb Scale,YGTSS)评分比较,C组优于其他两组,差异有统计学意义(P <0.05),B组不良反应发生率高于其他两组,差异有统计学意义(P <0.05)。结论:中药安神定抽合剂联合针灸以及安思定微电流刺激仪治疗儿童抽动障碍脾虚痰聚证的临床疗效显著,比单纯中药治疗的疗程更短,比单纯西药治疗的安全性更好,值得临床推广应用。展开更多
文摘<strong>Background:</strong> Anxiety disorders are the most common mental disorders, typically treated with psychotherapy and medication. These treatments are not suitable for, acceptable to, or effective for everyone. Alpha-Stim AID is a Cranial Electrotherapy Stimulation (CES) treatment with evidence of effectiveness in treating anxiety disorders. <strong>Objective:</strong> The aim of this paper is to present outcomes on anxiety, depression, and quality of life of Alpha-Stim use in primary care patients in the United Kingdom’s (UK) National Health Service (NHS) who reported symptoms of anxiety. <strong>Methods: </strong>Open label patient cohort design. Self-report measures: PHQ-9 (depression), GAD-7 (anxiety) and EQ-5D-5L (health related quality of life). Twenty-three patients with symptoms of anxiety completed a six-week course of Alpha-Stim intervention. <strong>Results:</strong> Reliable improvement and remission rates respectively were 60.9% and 17.4% for the GAD-7;42.9% and 22.7% for the PHQ-9. Significant improvement and medium/large effect sizes (n2 = 0.59 and 0.56 respectively). EQ-5D-5L results showed significant improvements in quality of life. Perceived quality of life doubled with an improvement of 0.36 on the health index score, this intervention adds 3.64 Quality Adjusted Life Years (QALYs). <strong>Limitations:</strong> The study was not an RCT, there was no control group. <strong>Conclusions:</strong> Alpha-Stim AID CES can be delivered through a UK primary care practice, and can have a significant impact on symptoms of anxiety and depression, and improve quality of life in primary care patients with anxiety symptoms. Further feasibility studies in primary care and sufficiently powered RCT are required.
文摘目的:探讨安神定抽合剂联合针灸、安思定微电流刺激仪治疗儿童抽动障碍的临床疗效。方法:将2018年8月-2020年2月在泰州市中医院儿科就诊的90例儿童抽动障碍脾虚痰聚证入组,随机分成A组(予中药安神定抽合剂)、B组(予盐酸硫必利片)、C组(予中药安神定抽合剂加针灸,以及安思定微电流刺激仪),每组各30例,治疗疗程:12周。结果:三组治疗后总有效率比较,差异无统计学意义(P> 0.05),治疗后中医证候评分比较,C组和A组优于B组,差异有统计学意义(P <0.05),治疗后耶鲁综合抽动严重程度量表(Yale Global Tie Severityb Scale,YGTSS)评分比较,C组优于其他两组,差异有统计学意义(P <0.05),B组不良反应发生率高于其他两组,差异有统计学意义(P <0.05)。结论:中药安神定抽合剂联合针灸以及安思定微电流刺激仪治疗儿童抽动障碍脾虚痰聚证的临床疗效显著,比单纯中药治疗的疗程更短,比单纯西药治疗的安全性更好,值得临床推广应用。
