The preparation of electromagnetic(EM)wave absorption materials provided with the characteristics of thin matching thickness,broad bandwidth,and mighty absorption intensity is an efficient solution to current EM pollu...The preparation of electromagnetic(EM)wave absorption materials provided with the characteristics of thin matching thickness,broad bandwidth,and mighty absorption intensity is an efficient solution to current EM pollution.Herein,Graphene nanosheets(GN)were firstly fabricated via a facile high-energy ball milling method,subsequently high-purity 1T-MoS_(2) petals were uniformly anchored on the surface of GN to prepare 1T-MoS_(2)@GN nanocomposites.Plentiful multiple reflection and scattering of EM waves in a distinctive multidimensional structure formed by GN and 1T-MoS_(2),copious polarization loss consisting of interfacial polarization loss and dipolar polarization loss severally derived from multitudinous heterointerfaces and profuse electric dipoles in 1T-MoS_(2)@GN,and mighty conduction loss originated from plentiful induced current in 1T-MoS_(2)@GN generated via the migration of massive electrons,all of which endowed 1T-MoS_(2)@GN nanocomposites with exceptional EM wave absorption performances.The minimum reflection loss(RLmin)of 1T-MoS_(2)@GN reached–50.14 dB at a thickness of only 2.10 mm,and the effective absorption bandwidth(EAB)was up to 6.72 GHz at an ultra-thin matching thickness of 1.84 mm.Moreover,the radar scattering cross section(RCS)reduction value of 36.18 dB m2 at 0°could be achieved as well,which ulteriorly validated the tremendous potential of 1T-MoS_(2)@GN nanocomposites in practical applications.展开更多
As a novel 2D material,Ti_(3)C_(2)T_(x)-MXene has become a major area of interest in the field of microwave absorption(MA).However,the MA effect of common Ti_(3)C_(2)T_(x)-MXene is not prominent and often requires com...As a novel 2D material,Ti_(3)C_(2)T_(x)-MXene has become a major area of interest in the field of microwave absorption(MA).However,the MA effect of common Ti_(3)C_(2)T_(x)-MXene is not prominent and often requires complex processes or combinations of other ma-terials to achieve enhanced performance.In this context,a kind of gradient woodpile structure using common Ti_(3)C_(2)T_(x)-MXene as MA ma-terial was designed and manufactured through direct ink writing(DIW)3D printing.The minimum reflection loss(RL_(min))of the Ti_(3)C_(2)T_(x)-MXene-based gradient woodpile structures with a thickness of less than 3 mm can reach-70 dB,showing considerable improve-ment compared with that of a completely filled structure.In addition,the effective absorption bandwidth(EAB)reaches 7.73 GHz.This study demonstrates that a Ti_(3)C_(2)T_(x)-MXene material with excellent MA performance and tunable frequency band can be successfully fab-ricated with a macroscopic structural design and through DIW 3D printing without complex material hybridization and modification,of-fering broad application prospects by reducing electromagnetic wave radiation and interference.展开更多
BACKGROUND Poor glycaemic control in patients with type 2 diabetes mellitus(T2DM)is often accompanied by multiple complications,including diabetic nephropathy(DN),diabetic retinopathy(DR),diabetic peripheral neuropath...BACKGROUND Poor glycaemic control in patients with type 2 diabetes mellitus(T2DM)is often accompanied by multiple complications,including diabetic nephropathy(DN),diabetic retinopathy(DR),diabetic peripheral neuropathy(DPN),and cardiac structural abnormality left ventricular hypertrophy(LVH).Early identification of high-risk populations for these complications and the implementation of intervention measures are crucial for improving patient outcomes.Serum alpha-1-microglobulin(α1-MG),a multifunctional protein synthesized by the liver and lymphocytes,has been considered a potential biomarker of diabetes-related diseases in recent years.AIM To investigate the associations of serumα1-MG with DN,DR,DPN,and LVH in T2DM patients and its predictive value.METHODS This retrospective study included 5045 T2DM patients.The study participants were stratified into quartiles according to their serumα1-MG levels.Multivariate logistic regression,restricted cubic spline,and explainable machine learning models were employed for risk assessment and feature importance evaluation.RESULTS Increasedα1-MG levels were observed in patients with DN,DR,DPN,and LVH(all P<0.001).Multivariate logistic regression revealed that each standard deviation increase inα1-MG was associated with an 84%increase in DN risk(OR:1.84,95%CI:1.62-2.10,P<0.001),a 17%increase in DR risk(OR:1.17,95%CI:1.07-1.28,P<0.001),a 14%increase in DPN risk(OR:1.14,95%CI:1.03-1.27,P=0.014),and a 28%increase in LVH risk(OR:1.28,95%CI:1.18-1.38,P<0.001).Subgroup analyses and machine learning confirmed the associations of elevatedα1-MG with these complications in T2DM patients.CONCLUSION Elevated serumα1-MG levels were independently associated with increased risks of DN,DR,DPN,and LVH in T2DM patients,suggesting its potential as a predictive biomarker.展开更多
BACKGROUND Achievement of endoscopic healing(EH)is significant in the clinical practice of inflammatory bowel disease as it is correlated with improved prognosis.Existing biomarkers,including C-reactive protein(CRP),h...BACKGROUND Achievement of endoscopic healing(EH)is significant in the clinical practice of inflammatory bowel disease as it is correlated with improved prognosis.Existing biomarkers,including C-reactive protein(CRP),have relatively low accuracy for predicting EH,especially in small intestinal lesions in Crohn’s disease(CD);thus,noninvasive and more accurate biomarkers are required.Leucine-rich alpha-2 glycoprotein(LRG),a 50-kD protein,is produced under inflammatory conditions and has been reported to be useful in assessing disease activity in inflammatory bowel disease.However,the usefulness of LRG in small intestinal lesions in CD remains inconclusive.AIM To determine the usefulness of LRG for EH in small bowel lesions in CD and compare it with CRP.METHODS This study included 133 consecutive patients with CD who underwent balloonassisted enteroscopy between June 2021 and March 2024 at Shiga University of Medical Science Hospital(Otsu,Japan).We retrospectively analyzed endoscopic scores in each of the ileum and colon and four markers including LRG,CRP,albumin,and Harvey-Bradshaw index(HBI).Spearman’s rank correlation coefficient and receiver operating characteristic analysis were performed.RESULTS Either active ileal or colonic lesions exhibited significant differences in LRG,CRP,albumin,and HBI compared with EH.CRP,albumin,and HBI showed a worse correlation with endoscopic activity in the ileum than that in the colon;however,LRG did not show a worse correlation(colon,r=0.5218;ileum,r=0.5602).Receiver operating characteristic analysis revealed that LRG for EH in the ileum and colon had the same cutoff values of 12.4μg/mL.Comparing the areas under the curve of LRG and CRP for predicting EH in the ileum revealed a significantly higher areas under the curve of LRG(95%confidence interval,0.017-0.194;P=0.024),whereas the two showed no significant difference in the colon.CONCLUSION LRG is a useful biomarker in assessing the endoscopic activity of CD and is more useful than CRP in the small intestine.展开更多
The study by Ohno et al provides valuable insights into the role of leucine-rich alpha-2-glycoprotein(LRG)as a potential biomarker for identifying small bowel lesions in Crohn's disease(CD).However,several methodo...The study by Ohno et al provides valuable insights into the role of leucine-rich alpha-2-glycoprotein(LRG)as a potential biomarker for identifying small bowel lesions in Crohn's disease(CD).However,several methodological challenges hinder its immediate use in clinical practice.Notably,the current research was retrospective,lacks comparative studies with fecal calprotectin,and did not provide long-term predictive data.Further prospective studies are needed to improve the applicability of LRG.Moreover,integrating LRG with additional biomarkers and employing artificial intelligence techniques may improve its effectiveness in disease monitoring.Future research should address interobserver variability,assess LRG's cost-effectiveness,and standardize endoscopic healing definitions to ensure broader applicability.Advancing these areas is vital for establishing LRG's role in precision medicine strategies for the management of CD.展开更多
Laplace–Fourier(L-F)domain finite-difference(FD)forward modeling is an important foundation for L-F domain full-waveform inversion(FWI).An optimal modeling method can improve the efficiency and accuracy of FWI.A fl e...Laplace–Fourier(L-F)domain finite-difference(FD)forward modeling is an important foundation for L-F domain full-waveform inversion(FWI).An optimal modeling method can improve the efficiency and accuracy of FWI.A fl exible FD stencil,which requires pairing and centrosymmetricity of the involved gridpoints,is used on the basis of the 2D L-F domain acoustic wave equation.The L-F domain numerical dispersion analysis is then performed by minimizing the phase error of the normalized numerical phase and attenuation propagation velocities to obtain the optimization coefficients.An optimal FD forward modeling method is finally developed for the L-F domain acoustic wave equation and applied to the traditional standard 9-point scheme and 7-and 9-point schemes,where the latter two schemes are used in discontinuous-grid FD modeling.Numerical experiments show that the optimal L-F domain FD modeling method not only has high accuracy but can also be applied to equal and unequal directional sampling intervals and discontinuous-grid FD modeling to reduce computational cost.展开更多
The magnetic loss plays a key role in electromagnetic waves(EMW)absorption.However,the magnetic loss ability would obviously draw at high frequency,and the component lacks the dielectric loss ability,resulting in poor...The magnetic loss plays a key role in electromagnetic waves(EMW)absorption.However,the magnetic loss ability would obviously draw at high frequency,and the component lacks the dielectric loss ability,resulting in poor EMW absorption.In this work,we design a core-shell-structured Fe@Sm_(2)Fe_(17)dual magnetic nanoparticle.The 200-nm Sm_(2)Fe_(17)nanoparticles play a key role in maintaining relatively high magnetic loss ability even at high frequency.And the introduction of 3-μm Fe cubes can optimize the dielectric parameters by the interface polarization and thus enhance the impedance matching.Meanwhile,Fe cubes with easy axis vertical to six planes can absorb the EMW with different directions,leading to the enhancement of the EMW attenuation.Especially,the Fe cubes can align the moment of Sm_(2)Fe_(17)nanoparticles,which can increase exchange-coupling interaction between them to further improve the magnetic loss capacity and broaden the effective absorption bandwidth(EAB).Furthermore,the small-sized Sm_(2)Fe_(17)nanoparticles provide a rough surface,which promotes multiple reflections and scattering of the incident EMW.As a result,the optimal EMW attenuation performance with a minimum reflection loss exceeding-51.4 dB and a broadened EAB up to 6.6 GHz at 1.4 mm was achieved in Fe@Sm_(2)Fe_(17)composites with Sm/Fe of 1:12.Our work provides profound insights into developing well-coordinated magnetic-dielectric nanocomposites for EMW absorption engineering.展开更多
The effective construction of electromagnetic(EM)wave absorption materials with thin matching thickness,broad bandwidth,and remarkable absorption is a great solution to EM pollution,which is a hot topic in current env...The effective construction of electromagnetic(EM)wave absorption materials with thin matching thickness,broad bandwidth,and remarkable absorption is a great solution to EM pollution,which is a hot topic in current environmental governance.In this study,N-doped reduced graphene oxide(N-rGO)was first prepared using a facile hydrothermal method.Then,high-purity 1T-MoS_(2)petals were homogeneously anchored to the wrinkled surface of N-rGO to fabricate 1T-MoS_(2)@N-rGO nanocomposites.The numerous electric di-poles and profuse heterointerfaces in 1T-MoS_(2)@N-rGO would induced the multiple reflection and scattering of EM waves in a distinct-ive multidimensional structure formed by two-dimensional N-rGO and 1T-MoS_(2)microspheres with plentiful thin nanosheets,remarkable conduction loss derived from the migration of massive electrons in a well-constructed conductive network formed by 1T-MoS_(2)@N-rGO,and abundant polarization loss(including dipolar polarization loss and interfacial polarization loss).All of these gave the 1T-MoS_(2)@N-rGO nanocomposites superior EM wave absorption performances.The effective absorption bandwidth of 1T-MoS_(2)@N-rGO reached 6.48 GHz with a relatively thin matching thickness of 1.84 mm,and a minimum reflection loss of-52.24 dB was achieved at 3.84 mm.Additionally,the radar scattering cross-section reduction value of 1T-MoS_(2)@N-rGO was up to 35.42 dB·m^(2) at 0°,which further verified the huge potential of our fabricated 1T-MoS_(2)@N-rGO nanocomposites in practical applications.展开更多
The rational design of composition and microstructure is a proven strategy for developing multifunctional high-performance electromagnetic wave(EMW)absorbers.In this study,a sandwich-structured multilayer nanoplate-li...The rational design of composition and microstructure is a proven strategy for developing multifunctional high-performance electromagnetic wave(EMW)absorbers.In this study,a sandwich-structured multilayer nanoplate-like Bi_(2)Fe_(4)O_(9)@Polypyrrole(BFO@PPy)heterostructure was successfully designed and fabricated using an efficient microwave hydrothermal method and an in situ polymerization process.Specifically,Bi_(2)Fe_(4)O_(9)enhances the chemical activity of ammonium persulfate,which in turn initiates the polymerization of pyrrole monomers,resulting in the formation of BFO@PPy heterostructures.The thickness of the PPy coating layer in the BFO@PPy composite can be precisely controlled at the nanoscale,optimizing electromagnetic parameters,conduction losses and interface polarization loss.The fabricated BFO@PPy composite achieves a minimum reflection loss(RL_(min))of-57.8 dB at a thickness of 2.5 mm and an effective absorption bandwidth(EAB)of 6.96 GHz.Furthermore,the EMW absorption performance and mechanism were systematically validated through theoretical calculations,radar cross-sectional simulations(RCS),and first-principles analysis.Notably,the RCS simulation of a 1:1 scale F-22 Raptor fighter model provides a realistic evaluation of the composite's EMW absorption potential in military applications.The efficient fabrication method and superior electromagnetic absorption performance make BFO@PPy a promising candidate for use in complex electromagnetic environments and military domains.Additionally,the BFO@PPy composite exhibits rapid electrothermal conversion at a low voltage(3V),achieving active infrared camouflage within a controllable temperature range,further highlighting its multifunctional properties.展开更多
In this work,we study wave state transitions of the(2+1)-dimensional Kortewegde Vries-Sawada-Kotera-Ramani(2KdVSKR)equation by analyzing the characteristic line and phase shift.By converting the wave parameters of the...In this work,we study wave state transitions of the(2+1)-dimensional Kortewegde Vries-Sawada-Kotera-Ramani(2KdVSKR)equation by analyzing the characteristic line and phase shift.By converting the wave parameters of the N-soliton solution into complex numbers,the breath wave solution is constructed.The lump wave solution is derived through the long wave limit method.Then,by choosing appropriate parameter values,we acquire a number of transformed nonlinear waves whose gradient relation is discussed according to the ratio of the wave parameters.Furthermore,we reveal transition mechanisms of the waves by exploring the nonlinear superposition of the solitary and periodic wave components.Subsequently,locality,oscillation properties and evolutionary phenomenon of the transformed waves are presented.And we also prove the change in the geometrical properties of the characteristic lines leads to the phenomena of wave evolution.Finally,for higher-order waves,a range of interaction models are depicted along with their evolutionary phenomena.And we demonstrate that their diversity is due to the fact that the solitary and periodic wave components produce different phase shifts caused by time evolution and collisions.展开更多
Polarization-dependent loss is important to the highly electromagnetic wave absorption(EWA)performance.Recently,metal–Nx moieties have been discovered to trigger polarization loss,but the physical origin and other po...Polarization-dependent loss is important to the highly electromagnetic wave absorption(EWA)performance.Recently,metal–Nx moieties have been discovered to trigger polarization loss,but the physical origin and other possible related loss mechanisms still need to be deeply explored.In this article,we reveal that the FeN_(4)moiety from iron phthalocyanine(FePc)can coordinate with Ti_(3)C_(2)T_(x)through Ti–OH groups,inducing dipole polarization and synchronous magnetic modulation in Fe/TiO_(2)/Ti_(3)C_(2)T_(x)composites.Interestingly,using the enhanced electric dipole moment and increased number of unpaired electrons in Fe atoms,the dipole polarization loss and possible magnetic response can be rapidly confirmed and evaluated.As a result,the minimum reflection loss(RLmin)of Fe/TiO_(2)/Ti_(3)C_(2)T_(x)composites reaches−67.12 dB at 6.72 GHz with a thickness of 3.32 mm.This study elaborates the EWA mechanism based on the atomic scale,and provides a new idea to design efficient EWA materials.展开更多
Shear-wave velocity is a key parameter for calibrating monitoring time-lapse 4D seismic data during CO2-EOR （Enhanced Oil Recovery） and CO2 sequestration. However, actual S-wave velocity data are lacking, especially...Shear-wave velocity is a key parameter for calibrating monitoring time-lapse 4D seismic data during CO2-EOR （Enhanced Oil Recovery） and CO2 sequestration. However, actual S-wave velocity data are lacking, especially in 4D data for CO2 sequestration because wells are closed after the CO2 injection and seismic monitoring is continued but no well log data are acquired. When CO2 is injected into a reservoir, the pressure and saturation of the reservoirs change as well as the elastic parameters of the reservoir rocks. We propose a method to predict the S-wave velocity in reservoirs at different pressures and porosities based on the Hertz-Mindlin and Gassmann equations. Because the coordination number is unknown in the Hertz Mindlin equation, we propose a new method to predict it. Thus, we use data at different CO2 injection stages in the Gao89 well block, Shengli Oilfield. First, the sand and mud beds are separated based on the structural characteristics of the thin sand beds and then the S-wave velocity as a function of reservoir pressure and porosity is calculated. Finally, synthetic seismic seismograms are generated based on the predicted P- and S-wave velocities at different stages of CO2 injection.展开更多
目的探讨WASP家族富含脯氨酸同源蛋白1(WASP-family verprolin-homologous protein 1,WAVE1)及基质金属蛋白酶-2(matrix metalloproteinases-2,MMP-2)和基质金属蛋白酶-9(MMP-9)在卵巢癌的表达及临床意义。方法采用免疫组化SABC三步法检...目的探讨WASP家族富含脯氨酸同源蛋白1(WASP-family verprolin-homologous protein 1,WAVE1)及基质金属蛋白酶-2(matrix metalloproteinases-2,MMP-2)和基质金属蛋白酶-9(MMP-9)在卵巢癌的表达及临床意义。方法采用免疫组化SABC三步法检测47例卵巢癌、30例卵巢良性肿瘤和21例正常卵巢组织中WAVE1、MMP-2、MMP-9的表达,并对卵巢癌组织WAVE1与MMP-2、MMP-9的表达进行相关性分析。结果①WAVE1、MMP-2及MMP-9在卵巢癌中的表达均高于在正常卵巢组织及卵巢良性组织中的表达,差异有统计学意义(P<0.05);Spearman相关分析显示,WAVE1和MMP-2、MMP-9两两表达成正相关(r=0.773,r=0.664,P<0.05)。②WAVE1的表达与卵巢癌的临床分期、组织分化及Ca-125水平有关(P<0.05),与年龄、肿瘤的直径无关(P>0.05)。MMP-2、MMP-9表达与卵巢癌的临床分期有关(P<0.05),与年龄、组织分化、Ca-125水平及肿瘤直径无关(P>0.05)。结论 WAVE1和MMP-2、MMP-9在卵巢癌中呈现高表达,早期联合筛查WAVE1和MMP-2、MMP-9指标对卵巢癌病情演变和预后评估有着重要的临床意义。展开更多
基金supported by the PhD Start-up Fund of the Science and Technology Department of Liaoning Province(No.2022-BS-306)the General Cultivation Scientific Research Project of Bohai University(No.0522xn058)the PhD Research Startup Foundation of Bohai University(No.0521bs021).
文摘The preparation of electromagnetic(EM)wave absorption materials provided with the characteristics of thin matching thickness,broad bandwidth,and mighty absorption intensity is an efficient solution to current EM pollution.Herein,Graphene nanosheets(GN)were firstly fabricated via a facile high-energy ball milling method,subsequently high-purity 1T-MoS_(2) petals were uniformly anchored on the surface of GN to prepare 1T-MoS_(2)@GN nanocomposites.Plentiful multiple reflection and scattering of EM waves in a distinctive multidimensional structure formed by GN and 1T-MoS_(2),copious polarization loss consisting of interfacial polarization loss and dipolar polarization loss severally derived from multitudinous heterointerfaces and profuse electric dipoles in 1T-MoS_(2)@GN,and mighty conduction loss originated from plentiful induced current in 1T-MoS_(2)@GN generated via the migration of massive electrons,all of which endowed 1T-MoS_(2)@GN nanocomposites with exceptional EM wave absorption performances.The minimum reflection loss(RLmin)of 1T-MoS_(2)@GN reached–50.14 dB at a thickness of only 2.10 mm,and the effective absorption bandwidth(EAB)was up to 6.72 GHz at an ultra-thin matching thickness of 1.84 mm.Moreover,the radar scattering cross section(RCS)reduction value of 36.18 dB m2 at 0°could be achieved as well,which ulteriorly validated the tremendous potential of 1T-MoS_(2)@GN nanocomposites in practical applications.
基金support from the National Key Research and Development Program of China(No.2021YFB3701503)the Key Research and Development Program of Ningbo,China(No.2023Z107).
文摘As a novel 2D material,Ti_(3)C_(2)T_(x)-MXene has become a major area of interest in the field of microwave absorption(MA).However,the MA effect of common Ti_(3)C_(2)T_(x)-MXene is not prominent and often requires complex processes or combinations of other ma-terials to achieve enhanced performance.In this context,a kind of gradient woodpile structure using common Ti_(3)C_(2)T_(x)-MXene as MA ma-terial was designed and manufactured through direct ink writing(DIW)3D printing.The minimum reflection loss(RL_(min))of the Ti_(3)C_(2)T_(x)-MXene-based gradient woodpile structures with a thickness of less than 3 mm can reach-70 dB,showing considerable improve-ment compared with that of a completely filled structure.In addition,the effective absorption bandwidth(EAB)reaches 7.73 GHz.This study demonstrates that a Ti_(3)C_(2)T_(x)-MXene material with excellent MA performance and tunable frequency band can be successfully fab-ricated with a macroscopic structural design and through DIW 3D printing without complex material hybridization and modification,of-fering broad application prospects by reducing electromagnetic wave radiation and interference.
文摘BACKGROUND Poor glycaemic control in patients with type 2 diabetes mellitus(T2DM)is often accompanied by multiple complications,including diabetic nephropathy(DN),diabetic retinopathy(DR),diabetic peripheral neuropathy(DPN),and cardiac structural abnormality left ventricular hypertrophy(LVH).Early identification of high-risk populations for these complications and the implementation of intervention measures are crucial for improving patient outcomes.Serum alpha-1-microglobulin(α1-MG),a multifunctional protein synthesized by the liver and lymphocytes,has been considered a potential biomarker of diabetes-related diseases in recent years.AIM To investigate the associations of serumα1-MG with DN,DR,DPN,and LVH in T2DM patients and its predictive value.METHODS This retrospective study included 5045 T2DM patients.The study participants were stratified into quartiles according to their serumα1-MG levels.Multivariate logistic regression,restricted cubic spline,and explainable machine learning models were employed for risk assessment and feature importance evaluation.RESULTS Increasedα1-MG levels were observed in patients with DN,DR,DPN,and LVH(all P<0.001).Multivariate logistic regression revealed that each standard deviation increase inα1-MG was associated with an 84%increase in DN risk(OR:1.84,95%CI:1.62-2.10,P<0.001),a 17%increase in DR risk(OR:1.17,95%CI:1.07-1.28,P<0.001),a 14%increase in DPN risk(OR:1.14,95%CI:1.03-1.27,P=0.014),and a 28%increase in LVH risk(OR:1.28,95%CI:1.18-1.38,P<0.001).Subgroup analyses and machine learning confirmed the associations of elevatedα1-MG with these complications in T2DM patients.CONCLUSION Elevated serumα1-MG levels were independently associated with increased risks of DN,DR,DPN,and LVH in T2DM patients,suggesting its potential as a predictive biomarker.
基金Supported by the Grants-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science,and Technology of Japan,No.21K15947 and No.23K07435.
文摘BACKGROUND Achievement of endoscopic healing(EH)is significant in the clinical practice of inflammatory bowel disease as it is correlated with improved prognosis.Existing biomarkers,including C-reactive protein(CRP),have relatively low accuracy for predicting EH,especially in small intestinal lesions in Crohn’s disease(CD);thus,noninvasive and more accurate biomarkers are required.Leucine-rich alpha-2 glycoprotein(LRG),a 50-kD protein,is produced under inflammatory conditions and has been reported to be useful in assessing disease activity in inflammatory bowel disease.However,the usefulness of LRG in small intestinal lesions in CD remains inconclusive.AIM To determine the usefulness of LRG for EH in small bowel lesions in CD and compare it with CRP.METHODS This study included 133 consecutive patients with CD who underwent balloonassisted enteroscopy between June 2021 and March 2024 at Shiga University of Medical Science Hospital(Otsu,Japan).We retrospectively analyzed endoscopic scores in each of the ileum and colon and four markers including LRG,CRP,albumin,and Harvey-Bradshaw index(HBI).Spearman’s rank correlation coefficient and receiver operating characteristic analysis were performed.RESULTS Either active ileal or colonic lesions exhibited significant differences in LRG,CRP,albumin,and HBI compared with EH.CRP,albumin,and HBI showed a worse correlation with endoscopic activity in the ileum than that in the colon;however,LRG did not show a worse correlation(colon,r=0.5218;ileum,r=0.5602).Receiver operating characteristic analysis revealed that LRG for EH in the ileum and colon had the same cutoff values of 12.4μg/mL.Comparing the areas under the curve of LRG and CRP for predicting EH in the ileum revealed a significantly higher areas under the curve of LRG(95%confidence interval,0.017-0.194;P=0.024),whereas the two showed no significant difference in the colon.CONCLUSION LRG is a useful biomarker in assessing the endoscopic activity of CD and is more useful than CRP in the small intestine.
文摘The study by Ohno et al provides valuable insights into the role of leucine-rich alpha-2-glycoprotein(LRG)as a potential biomarker for identifying small bowel lesions in Crohn's disease(CD).However,several methodological challenges hinder its immediate use in clinical practice.Notably,the current research was retrospective,lacks comparative studies with fecal calprotectin,and did not provide long-term predictive data.Further prospective studies are needed to improve the applicability of LRG.Moreover,integrating LRG with additional biomarkers and employing artificial intelligence techniques may improve its effectiveness in disease monitoring.Future research should address interobserver variability,assess LRG's cost-effectiveness,and standardize endoscopic healing definitions to ensure broader applicability.Advancing these areas is vital for establishing LRG's role in precision medicine strategies for the management of CD.
基金National Natural Science Foundation of China(no.41604037)Natural Science Foundation of Hubei Province(no.2022CFB125)+2 种基金Open Fund of Key Laboratory of Exploration Technologies for Oil and Gas Resources(Yangtze University)Ministry of Education(no.K2021-09)College Students'Innovation and Entrepreneurship Training Program(no.2019053)。
文摘Laplace–Fourier(L-F)domain finite-difference(FD)forward modeling is an important foundation for L-F domain full-waveform inversion(FWI).An optimal modeling method can improve the efficiency and accuracy of FWI.A fl exible FD stencil,which requires pairing and centrosymmetricity of the involved gridpoints,is used on the basis of the 2D L-F domain acoustic wave equation.The L-F domain numerical dispersion analysis is then performed by minimizing the phase error of the normalized numerical phase and attenuation propagation velocities to obtain the optimization coefficients.An optimal FD forward modeling method is finally developed for the L-F domain acoustic wave equation and applied to the traditional standard 9-point scheme and 7-and 9-point schemes,where the latter two schemes are used in discontinuous-grid FD modeling.Numerical experiments show that the optimal L-F domain FD modeling method not only has high accuracy but can also be applied to equal and unequal directional sampling intervals and discontinuous-grid FD modeling to reduce computational cost.
基金financially supported by the National Key Research and Development Program of China(No.2022YFB3505900)
文摘The magnetic loss plays a key role in electromagnetic waves(EMW)absorption.However,the magnetic loss ability would obviously draw at high frequency,and the component lacks the dielectric loss ability,resulting in poor EMW absorption.In this work,we design a core-shell-structured Fe@Sm_(2)Fe_(17)dual magnetic nanoparticle.The 200-nm Sm_(2)Fe_(17)nanoparticles play a key role in maintaining relatively high magnetic loss ability even at high frequency.And the introduction of 3-μm Fe cubes can optimize the dielectric parameters by the interface polarization and thus enhance the impedance matching.Meanwhile,Fe cubes with easy axis vertical to six planes can absorb the EMW with different directions,leading to the enhancement of the EMW attenuation.Especially,the Fe cubes can align the moment of Sm_(2)Fe_(17)nanoparticles,which can increase exchange-coupling interaction between them to further improve the magnetic loss capacity and broaden the effective absorption bandwidth(EAB).Furthermore,the small-sized Sm_(2)Fe_(17)nanoparticles provide a rough surface,which promotes multiple reflections and scattering of the incident EMW.As a result,the optimal EMW attenuation performance with a minimum reflection loss exceeding-51.4 dB and a broadened EAB up to 6.6 GHz at 1.4 mm was achieved in Fe@Sm_(2)Fe_(17)composites with Sm/Fe of 1:12.Our work provides profound insights into developing well-coordinated magnetic-dielectric nanocomposites for EMW absorption engineering.
基金supported by the PhD Start-up Fund of Science and Technology Department of Liaoning Province,China(No.2022-BS-306)the General Cultivation Scientific Research Project of Bohai University,China(No.0522xn058)+2 种基金the PhD Research Startup Foundation of Bohai University,China(No.0521bs021)the Youth Project of Natural Science Foundation of Hunan Province,China(No.2022JJ40338)the Scientific Research Youth Project by Education Department of Hunan Province,China(No.22B0556).
文摘The effective construction of electromagnetic(EM)wave absorption materials with thin matching thickness,broad bandwidth,and remarkable absorption is a great solution to EM pollution,which is a hot topic in current environmental governance.In this study,N-doped reduced graphene oxide(N-rGO)was first prepared using a facile hydrothermal method.Then,high-purity 1T-MoS_(2)petals were homogeneously anchored to the wrinkled surface of N-rGO to fabricate 1T-MoS_(2)@N-rGO nanocomposites.The numerous electric di-poles and profuse heterointerfaces in 1T-MoS_(2)@N-rGO would induced the multiple reflection and scattering of EM waves in a distinct-ive multidimensional structure formed by two-dimensional N-rGO and 1T-MoS_(2)microspheres with plentiful thin nanosheets,remarkable conduction loss derived from the migration of massive electrons in a well-constructed conductive network formed by 1T-MoS_(2)@N-rGO,and abundant polarization loss(including dipolar polarization loss and interfacial polarization loss).All of these gave the 1T-MoS_(2)@N-rGO nanocomposites superior EM wave absorption performances.The effective absorption bandwidth of 1T-MoS_(2)@N-rGO reached 6.48 GHz with a relatively thin matching thickness of 1.84 mm,and a minimum reflection loss of-52.24 dB was achieved at 3.84 mm.Additionally,the radar scattering cross-section reduction value of 1T-MoS_(2)@N-rGO was up to 35.42 dB·m^(2) at 0°,which further verified the huge potential of our fabricated 1T-MoS_(2)@N-rGO nanocomposites in practical applications.
基金financially supported by the Natural Science Foundation of China(NSFC,No.22165032)Beijing Natural Science Foundation(No.2242032)
文摘The rational design of composition and microstructure is a proven strategy for developing multifunctional high-performance electromagnetic wave(EMW)absorbers.In this study,a sandwich-structured multilayer nanoplate-like Bi_(2)Fe_(4)O_(9)@Polypyrrole(BFO@PPy)heterostructure was successfully designed and fabricated using an efficient microwave hydrothermal method and an in situ polymerization process.Specifically,Bi_(2)Fe_(4)O_(9)enhances the chemical activity of ammonium persulfate,which in turn initiates the polymerization of pyrrole monomers,resulting in the formation of BFO@PPy heterostructures.The thickness of the PPy coating layer in the BFO@PPy composite can be precisely controlled at the nanoscale,optimizing electromagnetic parameters,conduction losses and interface polarization loss.The fabricated BFO@PPy composite achieves a minimum reflection loss(RL_(min))of-57.8 dB at a thickness of 2.5 mm and an effective absorption bandwidth(EAB)of 6.96 GHz.Furthermore,the EMW absorption performance and mechanism were systematically validated through theoretical calculations,radar cross-sectional simulations(RCS),and first-principles analysis.Notably,the RCS simulation of a 1:1 scale F-22 Raptor fighter model provides a realistic evaluation of the composite's EMW absorption potential in military applications.The efficient fabrication method and superior electromagnetic absorption performance make BFO@PPy a promising candidate for use in complex electromagnetic environments and military domains.Additionally,the BFO@PPy composite exhibits rapid electrothermal conversion at a low voltage(3V),achieving active infrared camouflage within a controllable temperature range,further highlighting its multifunctional properties.
基金supported by the National Natural Science Foundation of China(12371255,11975306)the Xuzhou Basic Research Program Project(KC23048)+1 种基金the Six Talent Peaks Project in Jiangsu Province(JY-059)the 333 Project in Jiangsu Province and the Fundamental Research Funds for the Central Universities of CUMT(2024ZDPYJQ1003).
文摘In this work,we study wave state transitions of the(2+1)-dimensional Kortewegde Vries-Sawada-Kotera-Ramani(2KdVSKR)equation by analyzing the characteristic line and phase shift.By converting the wave parameters of the N-soliton solution into complex numbers,the breath wave solution is constructed.The lump wave solution is derived through the long wave limit method.Then,by choosing appropriate parameter values,we acquire a number of transformed nonlinear waves whose gradient relation is discussed according to the ratio of the wave parameters.Furthermore,we reveal transition mechanisms of the waves by exploring the nonlinear superposition of the solitary and periodic wave components.Subsequently,locality,oscillation properties and evolutionary phenomenon of the transformed waves are presented.And we also prove the change in the geometrical properties of the characteristic lines leads to the phenomena of wave evolution.Finally,for higher-order waves,a range of interaction models are depicted along with their evolutionary phenomena.And we demonstrate that their diversity is due to the fact that the solitary and periodic wave components produce different phase shifts caused by time evolution and collisions.
基金supported by the Taishan Young Scholar Program(tsqn202306267)the National Natural Science Foundation of China(51802168)the Natural Science Foundation of Shandong Province(ZR2024ME182,ZR2021ME122)。
文摘Polarization-dependent loss is important to the highly electromagnetic wave absorption(EWA)performance.Recently,metal–Nx moieties have been discovered to trigger polarization loss,but the physical origin and other possible related loss mechanisms still need to be deeply explored.In this article,we reveal that the FeN_(4)moiety from iron phthalocyanine(FePc)can coordinate with Ti_(3)C_(2)T_(x)through Ti–OH groups,inducing dipole polarization and synchronous magnetic modulation in Fe/TiO_(2)/Ti_(3)C_(2)T_(x)composites.Interestingly,using the enhanced electric dipole moment and increased number of unpaired electrons in Fe atoms,the dipole polarization loss and possible magnetic response can be rapidly confirmed and evaluated.As a result,the minimum reflection loss(RLmin)of Fe/TiO_(2)/Ti_(3)C_(2)T_(x)composites reaches−67.12 dB at 6.72 GHz with a thickness of 3.32 mm.This study elaborates the EWA mechanism based on the atomic scale,and provides a new idea to design efficient EWA materials.
基金supported by the National High Techology Research and Development Program(No.2012AA050103)
文摘Shear-wave velocity is a key parameter for calibrating monitoring time-lapse 4D seismic data during CO2-EOR （Enhanced Oil Recovery） and CO2 sequestration. However, actual S-wave velocity data are lacking, especially in 4D data for CO2 sequestration because wells are closed after the CO2 injection and seismic monitoring is continued but no well log data are acquired. When CO2 is injected into a reservoir, the pressure and saturation of the reservoirs change as well as the elastic parameters of the reservoir rocks. We propose a method to predict the S-wave velocity in reservoirs at different pressures and porosities based on the Hertz-Mindlin and Gassmann equations. Because the coordination number is unknown in the Hertz Mindlin equation, we propose a new method to predict it. Thus, we use data at different CO2 injection stages in the Gao89 well block, Shengli Oilfield. First, the sand and mud beds are separated based on the structural characteristics of the thin sand beds and then the S-wave velocity as a function of reservoir pressure and porosity is calculated. Finally, synthetic seismic seismograms are generated based on the predicted P- and S-wave velocities at different stages of CO2 injection.
