Peutz-Jeghers syndrome(PJS)is a polygenic autosomal dominant disease characterized by multiple gastrointestinal polyps and pigmentation of the mucosa and skin.While there are a few reports regarding successful treatme...Peutz-Jeghers syndrome(PJS)is a polygenic autosomal dominant disease characterized by multiple gastrointestinal polyps and pigmentation of the mucosa and skin.While there are a few reports regarding successful treatment of intestinal polyps in PJS,there is little research regarding treatment of mucocutaneous melanosis.This study investigated the many advantages of using a Q-switched alexandrite laser to treat mucocutaneous melanosis.In this case,a 19-year-old male with PJS presented with labial lentigines and received two Q-switched alexandrite laser treatments in 2018.Subsequently,the efficacy of the treatment was evaluated.The result of the evaluation was that,after the two laser treatments,the labial lentigines were successfully removed,and there were no complications.展开更多
In order to determine the appropriate treatment interval, 267 patients who underwent 3 sessions of treatment with Q-switched alexandrite laser were divided into 4 groups according to treatment interval, and their clin...In order to determine the appropriate treatment interval, 267 patients who underwent 3 sessions of treatment with Q-switched alexandrite laser were divided into 4 groups according to treatment interval, and their clinical responses were compared. Among them, 187 were asked about the process of pigment fading. Moreover, light and transmission electron microscopy were performed. It was noted that the clinical response of the 5 - 6 month interval group was significantly better than that of the 3 - 4 month group, but showed no significant difference from that of the 7 - 8 or ≥ 9 month group. 80.21% of investigated patients stated that marked pigment fading could no longer be observed 7 months after irradiation. 4 months after irradiation, the degenerated melanosomes and cell debris were still scattered among collagen fibers, scavenged gradually by macrophage. In conclusion, an appropriate treatment interval is 5 - 6 months.展开更多
Background and Objective: Unwanted hair growth is a discomforting issue affecting both genders. People have tried various methods to get rid of this situation. This study aims to evaluate the efficacy and safety of a ...Background and Objective: Unwanted hair growth is a discomforting issue affecting both genders. People have tried various methods to get rid of this situation. This study aims to evaluate the efficacy and safety of a combined Alexandrite and Nd:YAG laser treatment for permanent hair removal, drawing insights from existing literature. Materials and Methods:This study included a total of 2127 patients (302 males, 1825 females) aged 18 - 65, with complete data, who underwent hair removal treatment between December 2018 and April 2021. These patients were treated using the Duetta laser system (Quanta system, Samarate, Italy), combining Alexandrite 755 nm and Nd:YAG 1064 nm wavelengths. The patients’ skin types were classified according to the Fitzpatrick classification scale. Target area/areas for laser hair removal was/were determined. Laser parameters, pulse counts, pain levels assessed through the Visual Pain Scale (VPS), and patient satisfaction were documented based on skin types. Findings: Across various skin types, Types I - II exhibited the highest treatment success rates (87%), with the axillary region achieving the highest rate (83%) and the face region achieving the lowest rate (75%). Pain scale analysis indicated that 98% of patients tolerated the procedure well. Patient satisfaction levels exceeded 90%. Evaluation of complication rates revealed minimal occurrences. Conclusion: The combined Alexandrite and Nd:YAG laser system demonstrates both efficacy and safety across diverse skin types, attributed to its notable success rates, minimal adverse effects, and high patient tolerance.展开更多
Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser(QSNYL),755-nm alexandrite nanosecond laser(QSAL),and 694-nm nanosecond ruby laser(QSRL),are clinically available for the treatment of acquired bilat...Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser(QSNYL),755-nm alexandrite nanosecond laser(QSAL),and 694-nm nanosecond ruby laser(QSRL),are clinically available for the treatment of acquired bilateral nevus of Ota-like macules(ABNOM).However,no reliable evidence from large-scale comparative studies identifies which type of laser works best.This study aims to determine the differences in the effectiveness,complications,and risk factors of QSNYL,QSAL,and QSRL in the treatment of ABNOM,further to provide evidence for clinician to make optimal choice according to the condition of patients.Methods:We collected the data from 685 ABNOM patients,including clinical features,medical treatments,and follow-up,since 1999 to 2014.The Kruskal-Wallis test was used to compare therapeutic differences between the three groups.The risk factors were analyzed using univariate analysis(x2 test)and multivariate logistic regression analysis.Results:The overall treatment efficiency of the QSNYL group(52.5%)and QSAL group(51.9%)was higher than that of the QSRL group(39.5%)(x2=17.468,P<0.001).The onset time of the QSRL and QSAL groups was shorter than that of the QSNYL group.The factors influencing efficacy in the QSNYL group were age at first treatment,number of treatments,coexistence with melesma,and the presence of hyperpigmentation;in the QSAL group was the number of treatments;and in the QSRL group was the number of treatments and hyperpigmentation.The prevalence of hyperpigrnentation in the QSNYL group(30.5%)and the QSAL group(27.5%)was lower than that of the QSRL group(47.3%)(X2=6.576,P<0.001).Concluslon:The QSNYL,QSAL,and QSRL are all effective and safe treatments for ABNOM.Considering the overall efficacy,duration of treatment,side effects,and risk factors,the QSAL is an optimal choice for ABNOM treatment.展开更多
文摘Peutz-Jeghers syndrome(PJS)is a polygenic autosomal dominant disease characterized by multiple gastrointestinal polyps and pigmentation of the mucosa and skin.While there are a few reports regarding successful treatment of intestinal polyps in PJS,there is little research regarding treatment of mucocutaneous melanosis.This study investigated the many advantages of using a Q-switched alexandrite laser to treat mucocutaneous melanosis.In this case,a 19-year-old male with PJS presented with labial lentigines and received two Q-switched alexandrite laser treatments in 2018.Subsequently,the efficacy of the treatment was evaluated.The result of the evaluation was that,after the two laser treatments,the labial lentigines were successfully removed,and there were no complications.
基金This work was supported by the Shanghai Municipal Natural Science under the Grant (97-181).
文摘In order to determine the appropriate treatment interval, 267 patients who underwent 3 sessions of treatment with Q-switched alexandrite laser were divided into 4 groups according to treatment interval, and their clinical responses were compared. Among them, 187 were asked about the process of pigment fading. Moreover, light and transmission electron microscopy were performed. It was noted that the clinical response of the 5 - 6 month interval group was significantly better than that of the 3 - 4 month group, but showed no significant difference from that of the 7 - 8 or ≥ 9 month group. 80.21% of investigated patients stated that marked pigment fading could no longer be observed 7 months after irradiation. 4 months after irradiation, the degenerated melanosomes and cell debris were still scattered among collagen fibers, scavenged gradually by macrophage. In conclusion, an appropriate treatment interval is 5 - 6 months.
文摘Background and Objective: Unwanted hair growth is a discomforting issue affecting both genders. People have tried various methods to get rid of this situation. This study aims to evaluate the efficacy and safety of a combined Alexandrite and Nd:YAG laser treatment for permanent hair removal, drawing insights from existing literature. Materials and Methods:This study included a total of 2127 patients (302 males, 1825 females) aged 18 - 65, with complete data, who underwent hair removal treatment between December 2018 and April 2021. These patients were treated using the Duetta laser system (Quanta system, Samarate, Italy), combining Alexandrite 755 nm and Nd:YAG 1064 nm wavelengths. The patients’ skin types were classified according to the Fitzpatrick classification scale. Target area/areas for laser hair removal was/were determined. Laser parameters, pulse counts, pain levels assessed through the Visual Pain Scale (VPS), and patient satisfaction were documented based on skin types. Findings: Across various skin types, Types I - II exhibited the highest treatment success rates (87%), with the axillary region achieving the highest rate (83%) and the face region achieving the lowest rate (75%). Pain scale analysis indicated that 98% of patients tolerated the procedure well. Patient satisfaction levels exceeded 90%. Evaluation of complication rates revealed minimal occurrences. Conclusion: The combined Alexandrite and Nd:YAG laser system demonstrates both efficacy and safety across diverse skin types, attributed to its notable success rates, minimal adverse effects, and high patient tolerance.
基金supported by grants from National Nature Science Foundation of China(No.81502739)Jiang Su National Nature Science Foundation(No.BK20150068)Medical Science and Technology Innovation Project of Chinese Academy of Medical Sciences(No.CIFMS-2017-I2M-1-017)
文摘Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser(QSNYL),755-nm alexandrite nanosecond laser(QSAL),and 694-nm nanosecond ruby laser(QSRL),are clinically available for the treatment of acquired bilateral nevus of Ota-like macules(ABNOM).However,no reliable evidence from large-scale comparative studies identifies which type of laser works best.This study aims to determine the differences in the effectiveness,complications,and risk factors of QSNYL,QSAL,and QSRL in the treatment of ABNOM,further to provide evidence for clinician to make optimal choice according to the condition of patients.Methods:We collected the data from 685 ABNOM patients,including clinical features,medical treatments,and follow-up,since 1999 to 2014.The Kruskal-Wallis test was used to compare therapeutic differences between the three groups.The risk factors were analyzed using univariate analysis(x2 test)and multivariate logistic regression analysis.Results:The overall treatment efficiency of the QSNYL group(52.5%)and QSAL group(51.9%)was higher than that of the QSRL group(39.5%)(x2=17.468,P<0.001).The onset time of the QSRL and QSAL groups was shorter than that of the QSNYL group.The factors influencing efficacy in the QSNYL group were age at first treatment,number of treatments,coexistence with melesma,and the presence of hyperpigmentation;in the QSAL group was the number of treatments;and in the QSRL group was the number of treatments and hyperpigmentation.The prevalence of hyperpigrnentation in the QSNYL group(30.5%)and the QSAL group(27.5%)was lower than that of the QSRL group(47.3%)(X2=6.576,P<0.001).Concluslon:The QSNYL,QSAL,and QSRL are all effective and safe treatments for ABNOM.Considering the overall efficacy,duration of treatment,side effects,and risk factors,the QSAL is an optimal choice for ABNOM treatment.
