Background: The high protein (HP) breakfast reduced gastric emptying and the most satiat-ing macronutrient appears to be dietary protein. Few studies have investigated the effects of protein to energy ratio in breakfa...Background: The high protein (HP) breakfast reduced gastric emptying and the most satiat-ing macronutrient appears to be dietary protein. Few studies have investigated the effects of protein to energy ratio in breakfast on mood, alertness and attention. Objective: This study was designed to investigate whether the HP breakfast is more beneficial to mood, alertness and attention of the healthy undergraduate student than adequate-protein (AP) breakfast through the rising body temperature and re-maining stable blood glucose or through other physiologic processes. Methods: Thirteen healthy male undergraduate students (18 - 23 y) were studied in a double-blind, randomized crossover design. Blood samples, body tem-perature, satiety, mood and Continuous Per-formance Test (CPT) were assessed after the consumption of two isocaloric breakfasts that differed in their protein and carbohydrate con-tent: an HP breakfast (50%, 30%, and 20% of energy from protein, carbohydrate, and fat, re-spectively) or an AP breakfast (10%, 70%, and 20% of energy from protein, carbohydrate, and fat, respectively). Results: Consumption of an HP breakfast resulted in more steady glucose and insulin than AP breakfast consumption (p < 0.05). Satiety scores and body temperature were higher after HP breakfast consumption (p < 0.05). And most important, the positive mood and CPT scores were higher after HP breakfast than after AP breakfast intake (p < 0.05). Conclusion: HP breakfast can effectively stabilize postprandial serum glucose concentration and elevate post-prandial temperature of healthy male under-graduate students. Our present findings dem-onstrate the relationship between HP breakfast and mood, alertness and attention. This study indicated that HP breakfast may enhance human performance probably by increasing the thermic effect of a food and elevating body temperature.展开更多
In order to classify the alertness status, 19 channels of electroencephalogram(EEG) signals from 5 subjects were acquired during daytime nap. Ten different types of features(including time domain features, frequency d...In order to classify the alertness status, 19 channels of electroencephalogram(EEG) signals from 5 subjects were acquired during daytime nap. Ten different types of features(including time domain features, frequency domain features and nonlinear features) were extracted from EEG signals, and an improved self-organizing map(ISOM) neuron network was proposed, which successfully identify three different brain status of the subjects: awareness, drowsiness and sleep. Compared with traditional SOM, the experiment results show that the ISOM generates much better classification accuracy, reaching as high as 89.59%.展开更多
Objective To report the development,validation,and findings of the Multi-dimensional Attention Rating Scale(MARS),a self-report tool crafted to evaluate six-dimension attention levels.Methods The MARS was developed ba...Objective To report the development,validation,and findings of the Multi-dimensional Attention Rating Scale(MARS),a self-report tool crafted to evaluate six-dimension attention levels.Methods The MARS was developed based on Classical Test Theory(CTT).Totally 202 highly educated healthy adult participants were recruited for reliability and validity tests.Reliability was measured using Cronbach's alpha and test-retest reliability.Structural validity was explored using principal component analysis.Criterion validity was analyzed by correlating MARS scores with the Toronto Hospital Alertness Test(THAT),the Attentional Control Scale(ACS),and the Attention Network Test(ANT).Results The MARS comprises 12 items spanning six distinct dimensions of attention:focused attention,sustained attention,shifting attention,selective attention,divided attention,and response inhibition.As assessed by six experts,the content validation index(CVI)was 0.95,the Cronbach's alpha for the MARS was 0.78,and the test-retest reliability was 0.81.Four factors were identified(cumulative variance contribution rate 68.79%).The total score of MARS was correlated positively with THAT(r=0.60,P<0.01)and ACS(r=0.78,P<0.01)and negatively with ANT's reaction time for alerting(r=−0.31,P=0.049).Conclusion The MARS can reliably and validly assess six-dimension attention levels in real-world settings and is expected to be a new tool for assessing multi-dimensional attention impairments in different mental disorders.展开更多
Accurate prediction of drug-induced adverse drug reactions(ADRs)is crucial for drug safety evaluation,as it directly impacts public health and safety.While various models have shown promising results in predicting ADR...Accurate prediction of drug-induced adverse drug reactions(ADRs)is crucial for drug safety evaluation,as it directly impacts public health and safety.While various models have shown promising results in predicting ADRs,their accuracy still needs improvement.Additionally,many existing models often lack interpretability when linking molecular structures to specific ADRs and frequently rely on manually selected molecular fingerprints,which can introduce bias.To address these challenges,we propose ToxBERT,an efficient transformer encoder model that leverages attention and masking mechanisms for simplified molecular input line entry system(SMILES)representations.Our results demonstrate that ToxBERT achieved area under the receiver operating characteristic curve(AUROC)scores of 0.839,0.759,and 0.664 for predicting drug-induced QT prolongation(DIQT),rhabdomyolysis,and liver injury,respectively,outperforming previous studies.Furthermore,ToxBERT can identify drug substructures that are closely associated with specific ADRs.These findings indicate that ToxBERT is not only a valuable tool for understanding the mechanisms underlying specific drug-induced ADRs but also for mitigating potential ADRs in the drug discovery pipeline.展开更多
The increasing prevalence of violent incidents in public spaces has created an urgent need for intelligent surveillance systems capable of detecting dangerous objects in real time.While traditional video surveillance ...The increasing prevalence of violent incidents in public spaces has created an urgent need for intelligent surveillance systems capable of detecting dangerous objects in real time.While traditional video surveillance relies on human monitoring,this approach suffers from limitations such as fatigue and delayed response times.This study addresses these challenges by developing an automated detection system using advanced deep learning techniques to enhance public safety.Our approach leverages state-of-the-art convolutional neural networks(CNNs),specifically You Only Look Once version 4(YOLOv4)and EfficientDet,for real-time object detection.The system was trained on a comprehensive dataset of over 50,000 images,enhanced through data augmentation techniques to improve robustness across varying lighting conditions and viewing angles.Cloud-based deployment on Amazon Web Services(AWS)ensured scalability and efficient processing.Experimental evaluations demonstrated high performance,with YOLOv4 achieving 92%accuracy and processing images in 0.45 s,while EfficientDet reached 93%accuracy with a slightly longer processing time of 0.55 s per image.Field tests in high-traffic environments such as train stations and shopping malls confirmed the system’s reliability,with a false alarm rate of only 4.5%.The integration of automatic alerts enabled rapid security responses to potential threats.The proposed CNN-based system provides an effective solution for real-time detection of dangerous objects in video surveillance,significantly improving response times and public safety.While YOLOv4 proved more suitable for speed-critical applications,EfficientDet offered marginally better accuracy.Future work will focus on optimizing the system for low-light conditions and further reducing false positives.This research contributes to the advancement of AI-driven surveillance technologies,offering a scalable framework adaptable to various security scenarios.展开更多
Light plays an essential role in psychobiological and psychophysiological processes,such as alertness.The alerting effect is influenced by light characteristics and the timing of interventions.This meta-analysis is th...Light plays an essential role in psychobiological and psychophysiological processes,such as alertness.The alerting effect is influenced by light characteristics and the timing of interventions.This meta-analysis is the first to systematically review the effect of light intervention on alertness and to discuss the optimal protocol for light intervention.In this meta-analysis,registered at PROSPERO(Registration ID:CRD42020181485),we conducted a systematic search of the Web of Science,PubMed,and PsycINFO databases for studies published in English prior to August 2021.The outcomes included both subjective and objective alertness.Subgroup analyses considered a variety of factors,such as wavelength,correlated color temperature(CCT),light illuminance,and timing of interventions(daytime,night-time,or all day).Twenty-seven crossover studies and two parallel-group studies were included in this meta-analysis,with a total of 1210 healthy participants(636(52%)male,mean age 25.62 years).The results revealed that light intervention had a positive effect on both subjective alertness(standardized mean difference(SMD)=-0.28,95%confidence interval(CI):-0.49 to-0.06,P=0.01)and objective alertness in healthy subjects(SMD=-0.34,95%CI:-0.68 to-0.01,P=0.04).The subgroup analysis revealed that cold light was better than warm light in improving subjective alertness(SMD=-0.37,95%CI:-0.65 to-0.10,P=0.007,I2=26%)and objective alertness(SMD=-0.36,95%CI:-0.66 to-0.07,P=0.02,I2=0).Both daytime(SMD=-0.22,95%CI:-0.37 to-0.07,P=0.005,I2=74%)and night-time(SMD=-0.32,95%CI:-0.61 to-0.02,P=0.04,I2=0)light exposure improved subjective alertness.The results of this meta-analysis and systematic review indicate that light exposure is associated with significant improvement in subjective and objective alertness.In addition,light exposure with a higher CCT was more effective in improving alertness than light exposure with a lower CCT.Our results also suggest that both daytime and night-time light exposure can improve subjective alertness.展开更多
文摘Background: The high protein (HP) breakfast reduced gastric emptying and the most satiat-ing macronutrient appears to be dietary protein. Few studies have investigated the effects of protein to energy ratio in breakfast on mood, alertness and attention. Objective: This study was designed to investigate whether the HP breakfast is more beneficial to mood, alertness and attention of the healthy undergraduate student than adequate-protein (AP) breakfast through the rising body temperature and re-maining stable blood glucose or through other physiologic processes. Methods: Thirteen healthy male undergraduate students (18 - 23 y) were studied in a double-blind, randomized crossover design. Blood samples, body tem-perature, satiety, mood and Continuous Per-formance Test (CPT) were assessed after the consumption of two isocaloric breakfasts that differed in their protein and carbohydrate con-tent: an HP breakfast (50%, 30%, and 20% of energy from protein, carbohydrate, and fat, re-spectively) or an AP breakfast (10%, 70%, and 20% of energy from protein, carbohydrate, and fat, respectively). Results: Consumption of an HP breakfast resulted in more steady glucose and insulin than AP breakfast consumption (p < 0.05). Satiety scores and body temperature were higher after HP breakfast consumption (p < 0.05). And most important, the positive mood and CPT scores were higher after HP breakfast than after AP breakfast intake (p < 0.05). Conclusion: HP breakfast can effectively stabilize postprandial serum glucose concentration and elevate post-prandial temperature of healthy male under-graduate students. Our present findings dem-onstrate the relationship between HP breakfast and mood, alertness and attention. This study indicated that HP breakfast may enhance human performance probably by increasing the thermic effect of a food and elevating body temperature.
基金Supported by National Natural Science Foundation of China(No.51007063)
文摘In order to classify the alertness status, 19 channels of electroencephalogram(EEG) signals from 5 subjects were acquired during daytime nap. Ten different types of features(including time domain features, frequency domain features and nonlinear features) were extracted from EEG signals, and an improved self-organizing map(ISOM) neuron network was proposed, which successfully identify three different brain status of the subjects: awareness, drowsiness and sleep. Compared with traditional SOM, the experiment results show that the ISOM generates much better classification accuracy, reaching as high as 89.59%.
文摘Objective To report the development,validation,and findings of the Multi-dimensional Attention Rating Scale(MARS),a self-report tool crafted to evaluate six-dimension attention levels.Methods The MARS was developed based on Classical Test Theory(CTT).Totally 202 highly educated healthy adult participants were recruited for reliability and validity tests.Reliability was measured using Cronbach's alpha and test-retest reliability.Structural validity was explored using principal component analysis.Criterion validity was analyzed by correlating MARS scores with the Toronto Hospital Alertness Test(THAT),the Attentional Control Scale(ACS),and the Attention Network Test(ANT).Results The MARS comprises 12 items spanning six distinct dimensions of attention:focused attention,sustained attention,shifting attention,selective attention,divided attention,and response inhibition.As assessed by six experts,the content validation index(CVI)was 0.95,the Cronbach's alpha for the MARS was 0.78,and the test-retest reliability was 0.81.Four factors were identified(cumulative variance contribution rate 68.79%).The total score of MARS was correlated positively with THAT(r=0.60,P<0.01)and ACS(r=0.78,P<0.01)and negatively with ANT's reaction time for alerting(r=−0.31,P=0.049).Conclusion The MARS can reliably and validly assess six-dimension attention levels in real-world settings and is expected to be a new tool for assessing multi-dimensional attention impairments in different mental disorders.
基金supported by the National Natural Science Foundation of China(Grant Nos.:22173065 and 21575094).
文摘Accurate prediction of drug-induced adverse drug reactions(ADRs)is crucial for drug safety evaluation,as it directly impacts public health and safety.While various models have shown promising results in predicting ADRs,their accuracy still needs improvement.Additionally,many existing models often lack interpretability when linking molecular structures to specific ADRs and frequently rely on manually selected molecular fingerprints,which can introduce bias.To address these challenges,we propose ToxBERT,an efficient transformer encoder model that leverages attention and masking mechanisms for simplified molecular input line entry system(SMILES)representations.Our results demonstrate that ToxBERT achieved area under the receiver operating characteristic curve(AUROC)scores of 0.839,0.759,and 0.664 for predicting drug-induced QT prolongation(DIQT),rhabdomyolysis,and liver injury,respectively,outperforming previous studies.Furthermore,ToxBERT can identify drug substructures that are closely associated with specific ADRs.These findings indicate that ToxBERT is not only a valuable tool for understanding the mechanisms underlying specific drug-induced ADRs but also for mitigating potential ADRs in the drug discovery pipeline.
文摘The increasing prevalence of violent incidents in public spaces has created an urgent need for intelligent surveillance systems capable of detecting dangerous objects in real time.While traditional video surveillance relies on human monitoring,this approach suffers from limitations such as fatigue and delayed response times.This study addresses these challenges by developing an automated detection system using advanced deep learning techniques to enhance public safety.Our approach leverages state-of-the-art convolutional neural networks(CNNs),specifically You Only Look Once version 4(YOLOv4)and EfficientDet,for real-time object detection.The system was trained on a comprehensive dataset of over 50,000 images,enhanced through data augmentation techniques to improve robustness across varying lighting conditions and viewing angles.Cloud-based deployment on Amazon Web Services(AWS)ensured scalability and efficient processing.Experimental evaluations demonstrated high performance,with YOLOv4 achieving 92%accuracy and processing images in 0.45 s,while EfficientDet reached 93%accuracy with a slightly longer processing time of 0.55 s per image.Field tests in high-traffic environments such as train stations and shopping malls confirmed the system’s reliability,with a false alarm rate of only 4.5%.The integration of automatic alerts enabled rapid security responses to potential threats.The proposed CNN-based system provides an effective solution for real-time detection of dangerous objects in video surveillance,significantly improving response times and public safety.While YOLOv4 proved more suitable for speed-critical applications,EfficientDet offered marginally better accuracy.Future work will focus on optimizing the system for low-light conditions and further reducing false positives.This research contributes to the advancement of AI-driven surveillance technologies,offering a scalable framework adaptable to various security scenarios.
基金supported by the National Natural Science Foundation of China,No.82172530(to QT)Science and Technology Program of Guangdong,No.2018B030334001(to CRR)Guangzhou Science and Technology Project,No.202007030012(to QT).
文摘Light plays an essential role in psychobiological and psychophysiological processes,such as alertness.The alerting effect is influenced by light characteristics and the timing of interventions.This meta-analysis is the first to systematically review the effect of light intervention on alertness and to discuss the optimal protocol for light intervention.In this meta-analysis,registered at PROSPERO(Registration ID:CRD42020181485),we conducted a systematic search of the Web of Science,PubMed,and PsycINFO databases for studies published in English prior to August 2021.The outcomes included both subjective and objective alertness.Subgroup analyses considered a variety of factors,such as wavelength,correlated color temperature(CCT),light illuminance,and timing of interventions(daytime,night-time,or all day).Twenty-seven crossover studies and two parallel-group studies were included in this meta-analysis,with a total of 1210 healthy participants(636(52%)male,mean age 25.62 years).The results revealed that light intervention had a positive effect on both subjective alertness(standardized mean difference(SMD)=-0.28,95%confidence interval(CI):-0.49 to-0.06,P=0.01)and objective alertness in healthy subjects(SMD=-0.34,95%CI:-0.68 to-0.01,P=0.04).The subgroup analysis revealed that cold light was better than warm light in improving subjective alertness(SMD=-0.37,95%CI:-0.65 to-0.10,P=0.007,I2=26%)and objective alertness(SMD=-0.36,95%CI:-0.66 to-0.07,P=0.02,I2=0).Both daytime(SMD=-0.22,95%CI:-0.37 to-0.07,P=0.005,I2=74%)and night-time(SMD=-0.32,95%CI:-0.61 to-0.02,P=0.04,I2=0)light exposure improved subjective alertness.The results of this meta-analysis and systematic review indicate that light exposure is associated with significant improvement in subjective and objective alertness.In addition,light exposure with a higher CCT was more effective in improving alertness than light exposure with a lower CCT.Our results also suggest that both daytime and night-time light exposure can improve subjective alertness.
