目前临床上大多使用Child-Pugh分级来评估肝癌患者的肝功能及治疗相关的预后预测,但由于Child-Pugh分级评价指标中的腹水及白蛋白水平存在关联,且腹水及肝性脑病分度存在较大主观性,降低了评分的客观性和精确性。ALBI分级是Philip J. Jo...目前临床上大多使用Child-Pugh分级来评估肝癌患者的肝功能及治疗相关的预后预测,但由于Child-Pugh分级评价指标中的腹水及白蛋白水平存在关联,且腹水及肝性脑病分度存在较大主观性,降低了评分的客观性和精确性。ALBI分级是Philip J. Johnson等人于2014年提出的评估肝功能的新方法,是一个仅包含白蛋白和胆红素两项客观指标的统计模型。本文就近年来ALBI分级在肝癌患者疗效和预后的评估、ALBI的改良及与其他预后评分的结合予以总结并进行综述。展开更多
Objective: We studied the feasibility of using Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) linked with Brief Intervention (ALBI) in treating Substance Use Disorder in Nigeria. There is a clear ...Objective: We studied the feasibility of using Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) linked with Brief Intervention (ALBI) in treating Substance Use Disorder in Nigeria. There is a clear gap in meeting the needs for treatment and care for people with drug use disorders in Nigeria with many users reporting a self-perceived need for treatment and about 40% of them wanting to receive drug treatment but were unable to access such services. Methods: ASSIST questionnaire was used to gather baseline data, and ALBI along with Motivational Interviewing (MI) was used to intervene for 6 weeks following which ASSIST score was repeated and compared with baseline. Results: Majority of the participants were aged 21 - 30 years, mostly males with (61.3%) lacking steady jobs. Lifetime prevalence of any drug use was (88.2%). Three months prevalence was nicotine (72.0%), alcohol (66.7%), cannabis (47.3%), opioids (11.8%) among others. The ASSIST scores were mostly on the severe ranges. ASSIST result after six weeks showed marked reduction. The Mean Difference (MD) in the ASSIST scores after intervention was significant for tobacco, opioids, alcohol, and cannabis. The Cohen’s D effect size was large for tobacco (1.08), alcohol (0.92) and cannabis (0.73) but low for other substances. Conclusion: ALBI along with MI was helpful in combating the menace of substance use.展开更多
目的分析白蛋白-胆红素(ALBI)分级对肝细胞癌(HCC)患者经肝动脉化疗栓塞术(TACE)后肝功能变化及其预后的评估价值。方法计算机检索PubMed、The Cochrane Library、EMbase、Web of Science、OVID、知网、万方、维普及中国生物医学文献数...目的分析白蛋白-胆红素(ALBI)分级对肝细胞癌(HCC)患者经肝动脉化疗栓塞术(TACE)后肝功能变化及其预后的评估价值。方法计算机检索PubMed、The Cochrane Library、EMbase、Web of Science、OVID、知网、万方、维普及中国生物医学文献数据库,收集所有关于ALBI分级对TACE治疗HCC患者肝功能变化及其预后评估的相关性研究,检索时间为数据库建立至2020年12月。对纳入文献进行质量评价及数据提取后,采用RevMan 5.3软件进行Meta分析。各研究间的异质性采用χ2检验判断;用HR或OR及其对应的95%CI评价结局指标;通过漏斗图评价发表偏倚。结果共纳入18篇文献,9940例患者。Meta分析结果显示:较高ALBI等级的HCC患者TACE后总生存期(OS)短于较低ALBI等级患者(2^(nd) vs 1^(st):HR=1.48,95%CI:1.39~1.57,P<0.00001;3^(rd) vs 1^(st):HR=2.45,95%CI:1.92~3.13,P<0.00001;3^(rd) vs 2^(nd):HR=1.91,95%CI:1.71~2.13,P<0.00001)。2次TACE累积导致的ALBI恶化程度高于1次TACE(OR=1.91,95%CI:1.27~2.88,P<0.05),3次TACE累积导致的ALBI恶化程度高于1次TACE(OR=3.21,95%CI:1.95~5.28,P<0.05),3次TACE累积导致的ALBI恶化程度高于2次TACE(OR=1.70,95%CI:1.07~2.70,P<0.05)。此外,ALBI可以预测TACE后慢加急性肝衰竭(ACLF)的发生(OR=4.57,95%CI:2.76~7.57,P<0.00001)。结论重复TACE治疗可导致肝功能持续恶化,并且ALBI分级对于评估TACE的预后及预测ACLF发生风险具有重要临床价值。展开更多
Equilibrium moisture contents (EMC) of wood species are very necessary in the utilization of these in service. This study investigated the EMC of five lesser utilized species of Ghana and compared it with that of thre...Equilibrium moisture contents (EMC) of wood species are very necessary in the utilization of these in service. This study investigated the EMC of five lesser utilized species of Ghana and compared it with that of three European species. Sixteen randomly sampled specimens of each of the eight species (heartwood and sapwood) with dimensions 3 cm × 3 cm × 3 cm were exposed at various relative humidity conditions of 30%, 45%, 60%, 75% and 90% in a temperature and humidity-controlled climate chamber at a temperature of 25°C in accordance to German standard DIN 52182. The species are Albies alba, Fagus sylvatica and Picea abies which are European species and Amphimas pterocarpoides, Antiaris toxicaria, Canarium schweinfurthii, Celtis zenkeri and Cola gigantea are wood species from Ghana. Internal wood temperature and humidity were measured with datalogger. Samples were considered to have reached equilibrium at any given humidity when the daily weight changes were less than 0.1 mg according to German standard DIN 52183. After the last measurements of the weight changes, the samples were dried at 103°C until there was a constant weight. The five tropical hardwoods had low sorption values recorded and high sorption values for the European species and this could be attributed to differences in the microstructure of these woods.展开更多
文摘目前临床上大多使用Child-Pugh分级来评估肝癌患者的肝功能及治疗相关的预后预测,但由于Child-Pugh分级评价指标中的腹水及白蛋白水平存在关联,且腹水及肝性脑病分度存在较大主观性,降低了评分的客观性和精确性。ALBI分级是Philip J. Johnson等人于2014年提出的评估肝功能的新方法,是一个仅包含白蛋白和胆红素两项客观指标的统计模型。本文就近年来ALBI分级在肝癌患者疗效和预后的评估、ALBI的改良及与其他预后评分的结合予以总结并进行综述。
文摘Objective: We studied the feasibility of using Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) linked with Brief Intervention (ALBI) in treating Substance Use Disorder in Nigeria. There is a clear gap in meeting the needs for treatment and care for people with drug use disorders in Nigeria with many users reporting a self-perceived need for treatment and about 40% of them wanting to receive drug treatment but were unable to access such services. Methods: ASSIST questionnaire was used to gather baseline data, and ALBI along with Motivational Interviewing (MI) was used to intervene for 6 weeks following which ASSIST score was repeated and compared with baseline. Results: Majority of the participants were aged 21 - 30 years, mostly males with (61.3%) lacking steady jobs. Lifetime prevalence of any drug use was (88.2%). Three months prevalence was nicotine (72.0%), alcohol (66.7%), cannabis (47.3%), opioids (11.8%) among others. The ASSIST scores were mostly on the severe ranges. ASSIST result after six weeks showed marked reduction. The Mean Difference (MD) in the ASSIST scores after intervention was significant for tobacco, opioids, alcohol, and cannabis. The Cohen’s D effect size was large for tobacco (1.08), alcohol (0.92) and cannabis (0.73) but low for other substances. Conclusion: ALBI along with MI was helpful in combating the menace of substance use.
文摘目的分析白蛋白-胆红素(ALBI)分级对肝细胞癌(HCC)患者经肝动脉化疗栓塞术(TACE)后肝功能变化及其预后的评估价值。方法计算机检索PubMed、The Cochrane Library、EMbase、Web of Science、OVID、知网、万方、维普及中国生物医学文献数据库,收集所有关于ALBI分级对TACE治疗HCC患者肝功能变化及其预后评估的相关性研究,检索时间为数据库建立至2020年12月。对纳入文献进行质量评价及数据提取后,采用RevMan 5.3软件进行Meta分析。各研究间的异质性采用χ2检验判断;用HR或OR及其对应的95%CI评价结局指标;通过漏斗图评价发表偏倚。结果共纳入18篇文献,9940例患者。Meta分析结果显示:较高ALBI等级的HCC患者TACE后总生存期(OS)短于较低ALBI等级患者(2^(nd) vs 1^(st):HR=1.48,95%CI:1.39~1.57,P<0.00001;3^(rd) vs 1^(st):HR=2.45,95%CI:1.92~3.13,P<0.00001;3^(rd) vs 2^(nd):HR=1.91,95%CI:1.71~2.13,P<0.00001)。2次TACE累积导致的ALBI恶化程度高于1次TACE(OR=1.91,95%CI:1.27~2.88,P<0.05),3次TACE累积导致的ALBI恶化程度高于1次TACE(OR=3.21,95%CI:1.95~5.28,P<0.05),3次TACE累积导致的ALBI恶化程度高于2次TACE(OR=1.70,95%CI:1.07~2.70,P<0.05)。此外,ALBI可以预测TACE后慢加急性肝衰竭(ACLF)的发生(OR=4.57,95%CI:2.76~7.57,P<0.00001)。结论重复TACE治疗可导致肝功能持续恶化,并且ALBI分级对于评估TACE的预后及预测ACLF发生风险具有重要临床价值。
文摘Equilibrium moisture contents (EMC) of wood species are very necessary in the utilization of these in service. This study investigated the EMC of five lesser utilized species of Ghana and compared it with that of three European species. Sixteen randomly sampled specimens of each of the eight species (heartwood and sapwood) with dimensions 3 cm × 3 cm × 3 cm were exposed at various relative humidity conditions of 30%, 45%, 60%, 75% and 90% in a temperature and humidity-controlled climate chamber at a temperature of 25°C in accordance to German standard DIN 52182. The species are Albies alba, Fagus sylvatica and Picea abies which are European species and Amphimas pterocarpoides, Antiaris toxicaria, Canarium schweinfurthii, Celtis zenkeri and Cola gigantea are wood species from Ghana. Internal wood temperature and humidity were measured with datalogger. Samples were considered to have reached equilibrium at any given humidity when the daily weight changes were less than 0.1 mg according to German standard DIN 52183. After the last measurements of the weight changes, the samples were dried at 103°C until there was a constant weight. The five tropical hardwoods had low sorption values recorded and high sorption values for the European species and this could be attributed to differences in the microstructure of these woods.
