A round 2010,academic circles witnessed a surge in Al research fueled by break-throughs such as the ImageNet project,a publicly available large-scale image database.The field reached a tipping point in 2016 when Googl...A round 2010,academic circles witnessed a surge in Al research fueled by break-throughs such as the ImageNet project,a publicly available large-scale image database.The field reached a tipping point in 2016 when Google’s AlphaGo defeated Go world champion Lee Se-dol and gained widespread public attention with the release of OpenAI's ChatGPT in November 2022.Just one year after ChatGPT’s debut,Chinese Al firm DeepSeek launched its open-source general large model,a milestone in the evolution of Al technology.展开更多
Surface-enhanced Raman scattering(SERS)is a non-invasive spectroscopic technique that provides specific chemical fingerprint information for biomarkers in cancer and pathogen diagnosis.However,the SERS strategies are ...Surface-enhanced Raman scattering(SERS)is a non-invasive spectroscopic technique that provides specific chemical fingerprint information for biomarkers in cancer and pathogen diagnosis.However,the SERS strategies are limited by the non-specific interactions between substrates and co-existing substances in biological matrices and the challenges of obtaining molecular fingerprint information from the complex vibrational spectrum.In recent years,the rapid development of novel substrates with high SERS activity has opened up new opportunities for their applications in cancer and pathogen diagnosis.The aim of this review is to present the recent progress and perspectives of novel SERS-based substrates for cancer and pathogen diagnostic applications.First,we will introduce recently developed SERS-active nanomaterials and discuss the influencing factors of the SERS signals.Second,the advantages of SERS in the diagnosis of cancer and pathogens will be given.Third,we will review the latest breakthroughs in cancer and pathogen detection research with SERS technology,as well as the new opportunities for SERS applications brought about by artificial intelligence(Al)technology.In addition,the novel microfluidic-SERS platforms for cancer and pathogens diagnosis will also be discussed.Finally,we will summarize the challenges and future perspectives of SERS technology in the field of early cancer diagnosis and rapid pathogen detection.It is highly expected that this review could benefit a comprehensive understanding of the research status of the SERS-active nanomaterials and arouse the research enthusiasm for them,leading to accelerated clinical translation of SERS technology in cancer and pathogen diagnosis.展开更多
Purpose:In response to contemporary global challenges in politics,economics,and technology,coupled with escalating uncertainties,there arises an imperative to reconstruct an innovative and dynamic education system cen...Purpose:In response to contemporary global challenges in politics,economics,and technology,coupled with escalating uncertainties,there arises an imperative to reconstruct an innovative and dynamic education system centered around the advancement of human well-being and sustainable development.Design/Approach/Methods:Drawing upon empirical data from reputable international organizations,such as the United Nations,United Nations Educational,Scientific and Cultural Organization(UNESCO),the World Bank,and the Organisation for Economic Co-operation and Development(OECD),this study analyzes the uncertainties confronting world development.Furthermore,it elucidates the challenges and opportunities embedded in educational reform,delving into the complexities of contemporary uncertainties.Findings:First,the enduring repercussions of the pandemic,including the persistent effects of"long COVID,"heightened geopolitical insecurities,repercussions of sluggish global economic growth,and challenges and opportunities posed by smart technology to economic and social development collectively contribute to an increasingly uncertain global landscape.Second,the inherent conservatism of the prevailing educational systems poses challenges in adapting to the evolving needs of social development.The uncertainty in economic and social development weakens societal support for educational reform,and a deteriorating labor market compels the reevaluation of the education system rooted in industrialism,facing transformative challenges from generative artificial intelligence.Finally,recognizing the urgent need for revolutionary changes in human education,this study advocates for the expeditious reshaping of a new humanistic education paradigm.OriginalityNalue:This study envisions a novel educational model capable of addressing the challenges posed by intelligent technology and emphasizes the creation of an open and dynamic education system by proposing a reconstruction of the education system oriented toward promoting human health and sustainable development.This study systematically examines the diverse uncertainties confronting human development,critically reflects on the inadequacies of the modern education system rooted in industrialism,and issues a cautionary call for the transition toward an intelligent education system.展开更多
文摘A round 2010,academic circles witnessed a surge in Al research fueled by break-throughs such as the ImageNet project,a publicly available large-scale image database.The field reached a tipping point in 2016 when Google’s AlphaGo defeated Go world champion Lee Se-dol and gained widespread public attention with the release of OpenAI's ChatGPT in November 2022.Just one year after ChatGPT’s debut,Chinese Al firm DeepSeek launched its open-source general large model,a milestone in the evolution of Al technology.
基金This work was supported by National Natural Science Foundation of China(Nos.62401053 and 12374390)the Fundamental Research Funds for the Central Universities,the member of Youth Innovation Promotion Association Foundation of CAS,China(No.2023310)the Key Scientific and Technological Special Project of Ningbo City(No.2023Z209).
文摘Surface-enhanced Raman scattering(SERS)is a non-invasive spectroscopic technique that provides specific chemical fingerprint information for biomarkers in cancer and pathogen diagnosis.However,the SERS strategies are limited by the non-specific interactions between substrates and co-existing substances in biological matrices and the challenges of obtaining molecular fingerprint information from the complex vibrational spectrum.In recent years,the rapid development of novel substrates with high SERS activity has opened up new opportunities for their applications in cancer and pathogen diagnosis.The aim of this review is to present the recent progress and perspectives of novel SERS-based substrates for cancer and pathogen diagnostic applications.First,we will introduce recently developed SERS-active nanomaterials and discuss the influencing factors of the SERS signals.Second,the advantages of SERS in the diagnosis of cancer and pathogens will be given.Third,we will review the latest breakthroughs in cancer and pathogen detection research with SERS technology,as well as the new opportunities for SERS applications brought about by artificial intelligence(Al)technology.In addition,the novel microfluidic-SERS platforms for cancer and pathogens diagnosis will also be discussed.Finally,we will summarize the challenges and future perspectives of SERS technology in the field of early cancer diagnosis and rapid pathogen detection.It is highly expected that this review could benefit a comprehensive understanding of the research status of the SERS-active nanomaterials and arouse the research enthusiasm for them,leading to accelerated clinical translation of SERS technology in cancer and pathogen diagnosis.
基金supported by the National Social Science Fund of China(grant number VGA200001).
文摘Purpose:In response to contemporary global challenges in politics,economics,and technology,coupled with escalating uncertainties,there arises an imperative to reconstruct an innovative and dynamic education system centered around the advancement of human well-being and sustainable development.Design/Approach/Methods:Drawing upon empirical data from reputable international organizations,such as the United Nations,United Nations Educational,Scientific and Cultural Organization(UNESCO),the World Bank,and the Organisation for Economic Co-operation and Development(OECD),this study analyzes the uncertainties confronting world development.Furthermore,it elucidates the challenges and opportunities embedded in educational reform,delving into the complexities of contemporary uncertainties.Findings:First,the enduring repercussions of the pandemic,including the persistent effects of"long COVID,"heightened geopolitical insecurities,repercussions of sluggish global economic growth,and challenges and opportunities posed by smart technology to economic and social development collectively contribute to an increasingly uncertain global landscape.Second,the inherent conservatism of the prevailing educational systems poses challenges in adapting to the evolving needs of social development.The uncertainty in economic and social development weakens societal support for educational reform,and a deteriorating labor market compels the reevaluation of the education system rooted in industrialism,facing transformative challenges from generative artificial intelligence.Finally,recognizing the urgent need for revolutionary changes in human education,this study advocates for the expeditious reshaping of a new humanistic education paradigm.OriginalityNalue:This study envisions a novel educational model capable of addressing the challenges posed by intelligent technology and emphasizes the creation of an open and dynamic education system by proposing a reconstruction of the education system oriented toward promoting human health and sustainable development.This study systematically examines the diverse uncertainties confronting human development,critically reflects on the inadequacies of the modern education system rooted in industrialism,and issues a cautionary call for the transition toward an intelligent education system.
